Myosin heavy chain kinase a-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

myosin heavy chain kinase a-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IGH4_LEIDO

TriTrypDb:

LdBPK_364780.1 , LdCL_360054900 , LDHU3_36.6430

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGH4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	18
GO:0006793	phosphorus metabolic process	3	18
GO:0006796	phosphate-containing compound metabolic process	4	18
GO:0006807	nitrogen compound metabolic process	2	18
GO:0008152	metabolic process	1	18
GO:0009987	cellular process	1	18
GO:0016310	phosphorylation	5	18
GO:0019538	protein metabolic process	3	18
GO:0036211	protein modification process	4	18
GO:0043170	macromolecule metabolic process	3	18
GO:0043412	macromolecule modification	4	18
GO:0044237	cellular metabolic process	2	18
GO:0044238	primary metabolic process	2	18
GO:0071704	organic substance metabolic process	2	18
GO:1901564	organonitrogen compound metabolic process	3	18

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003824	catalytic activity	1	18
GO:0004672	protein kinase activity	3	18
GO:0004674	protein serine/threonine kinase activity	4	18
GO:0004683	calmodulin-dependent protein kinase activity	5	6
GO:0005488	binding	1	18
GO:0005524	ATP binding	5	18
GO:0016301	kinase activity	4	18
GO:0016740	transferase activity	2	18
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	18
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	18
GO:0016905	myosin heavy chain kinase activity	6	6
GO:0017076	purine nucleotide binding	4	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:0140096	catalytic activity, acting on a protein	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18
GO:0003676	nucleic acid binding	3	5
GO:0003746	translation elongation factor activity	4	5
GO:0008135	translation factor activity, RNA binding	3	5
GO:0045182	translation regulator activity	1	5
GO:0090079	translation regulator activity, nucleic acid binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.367
CLV_NRD_NRD_1	78	80	PF00675	0.364
CLV_PCSK_KEX2_1	141	143	PF00082	0.433
CLV_PCSK_KEX2_1	193	195	PF00082	0.363
CLV_PCSK_KEX2_1	78	80	PF00082	0.440
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.467
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.353
CLV_PCSK_SKI1_1	184	188	PF00082	0.396
CLV_PCSK_SKI1_1	23	27	PF00082	0.387
DEG_APCC_DBOX_1	107	115	PF00400	0.346
DEG_Nend_UBRbox_3	1	3	PF02207	0.651
DEG_SPOP_SBC_1	186	190	PF00917	0.440
DEG_SPOP_SBC_1	277	281	PF00917	0.512
DOC_CYCLIN_yClb5_NLxxxL_5	285	293	PF00134	0.402
DOC_MAPK_gen_1	128	136	PF00069	0.245
DOC_MAPK_gen_1	304	311	PF00069	0.474
DOC_MAPK_MEF2A_6	285	293	PF00069	0.513
DOC_USP7_MATH_1	130	134	PF00917	0.480
DOC_USP7_MATH_1	135	139	PF00917	0.497
DOC_USP7_MATH_1	186	190	PF00917	0.434
DOC_USP7_MATH_1	276	280	PF00917	0.550
DOC_USP7_UBL2_3	254	258	PF12436	0.369
DOC_WW_Pin1_4	12	17	PF00397	0.522
DOC_WW_Pin1_4	67	72	PF00397	0.375
LIG_14-3-3_CterR_2	332	335	PF00244	0.574
LIG_BRCT_BRCA1_1	164	168	PF00533	0.339
LIG_BRCT_BRCA1_2	164	170	PF00533	0.339
LIG_FHA_1	151	157	PF00498	0.301
LIG_FHA_1	310	316	PF00498	0.597
LIG_FHA_1	68	74	PF00498	0.326
LIG_FHA_2	176	182	PF00498	0.432
LIG_FHA_2	186	192	PF00498	0.444
LIG_FHA_2	207	213	PF00498	0.368
LIG_FHA_2	317	323	PF00498	0.472
LIG_LIR_Gen_1	203	211	PF02991	0.353
LIG_LIR_Nem_3	143	148	PF02991	0.398
LIG_LIR_Nem_3	165	171	PF02991	0.401
LIG_LIR_Nem_3	203	208	PF02991	0.353
LIG_PCNA_yPIPBox_3	249	258	PF02747	0.440
LIG_Pex14_2	102	106	PF04695	0.328
LIG_REV1ctd_RIR_1	143	153	PF16727	0.353
LIG_SH2_GRB2like	89	92	PF00017	0.434
LIG_SH2_STAP1	326	330	PF00017	0.604
LIG_SH2_STAT3	148	151	PF00017	0.440
LIG_SH2_STAT5	125	128	PF00017	0.440
LIG_SH2_STAT5	24	27	PF00017	0.388
LIG_SH2_STAT5	89	92	PF00017	0.334
LIG_SH3_3	124	130	PF00018	0.404
LIG_SH3_3	156	162	PF00018	0.317
LIG_TRAF2_1	10	13	PF00917	0.684
LIG_TRAF2_1	284	287	PF00917	0.496
LIG_TRAF2_1	314	317	PF00917	0.530
LIG_UBA3_1	39	47	PF00899	0.473
MOD_CK1_1	147	153	PF00069	0.355
MOD_CK1_1	206	212	PF00069	0.349
MOD_CK1_1	213	219	PF00069	0.339
MOD_CK2_1	175	181	PF00069	0.434
MOD_CK2_1	185	191	PF00069	0.435
MOD_CK2_1	206	212	PF00069	0.386
MOD_CK2_1	316	322	PF00069	0.508
MOD_GlcNHglycan	164	167	PF01048	0.471
MOD_GlcNHglycan	212	215	PF01048	0.386
MOD_GSK3_1	140	147	PF00069	0.415
MOD_GSK3_1	162	169	PF00069	0.348
MOD_GSK3_1	206	213	PF00069	0.343
MOD_N-GLC_1	117	122	PF02516	0.383
MOD_N-GLC_1	79	84	PF02516	0.394
MOD_NEK2_1	210	215	PF00069	0.339
MOD_NEK2_1	328	333	PF00069	0.558
MOD_PIKK_1	135	141	PF00454	0.443
MOD_PIKK_1	147	153	PF00454	0.379
MOD_PIKK_1	2	8	PF00454	0.668
MOD_PIKK_1	296	302	PF00454	0.587
MOD_PKA_1	140	146	PF00069	0.282
MOD_PKA_1	193	199	PF00069	0.458
MOD_PKA_2	130	136	PF00069	0.429
MOD_PKA_2	193	199	PF00069	0.458
MOD_Plk_1	117	123	PF00069	0.394
MOD_Plk_2-3	316	322	PF00069	0.580
MOD_Plk_4	213	219	PF00069	0.353
MOD_ProDKin_1	12	18	PF00069	0.499
MOD_ProDKin_1	67	73	PF00069	0.375
MOD_SUMO_for_1	284	287	PF00179	0.440
MOD_SUMO_rev_2	177	186	PF00179	0.394
MOD_SUMO_rev_2	237	242	PF00179	0.403
TRG_DiLeu_BaEn_1	35	40	PF01217	0.503
TRG_DiLeu_BaEn_4	286	292	PF01217	0.464
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.410
TRG_ER_diArg_1	303	306	PF00400	0.497
TRG_ER_diArg_1	77	79	PF00400	0.440
TRG_Pf-PMV_PEXEL_1	266	271	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L4	Leptomonas seymouri	78%	100%
A0A0S4IVQ7	Bodo saltans	32%	77%
A0A0S4J072	Bodo saltans	55%	78%
A0A1X0NJ27	Trypanosomatidae	57%	96%
A0A3Q8IJS7	Leishmania donovani	54%	91%
A4HPX1	Leishmania braziliensis	55%	100%
A4HPX3	Leishmania braziliensis	88%	100%
A4IDN3	Leishmania infantum	54%	100%
A4IDN5	Leishmania infantum	100%	100%
C9ZME6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
C9ZWN7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9ATN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9ATN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q0U3	Leishmania major	95%	100%
Q4Q0W0	Leishmania major	54%	100%
V5AN54	Trypanosoma cruzi	57%	100%