Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGH3_LEIDO

TriTrypDb:

LdBPK_323490.1 , LdCL_320040800 , LDHU3_32.4420

Length:

240

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	5
GO:0016020	membrane	2	4

Expansion

Sequence features

A0A3Q8IGH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGH3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.376
CLV_PCSK_KEX2_1	159	161	PF00082	0.365
CLV_PCSK_KEX2_1	172	174	PF00082	0.461
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.480
CLV_PCSK_SKI1_1	121	125	PF00082	0.368
CLV_PCSK_SKI1_1	160	164	PF00082	0.420
CLV_PCSK_SKI1_1	173	177	PF00082	0.403
DOC_CKS1_1	223	228	PF01111	0.676
DOC_CYCLIN_RxL_1	140	151	PF00134	0.593
DOC_CYCLIN_RxL_1	156	167	PF00134	0.602
DOC_PP1_RVXF_1	88	94	PF00149	0.544
DOC_WW_Pin1_4	222	227	PF00397	0.663
DOC_WW_Pin1_4	5	10	PF00397	0.571
LIG_14-3-3_CanoR_1	160	170	PF00244	0.595
LIG_BIR_II_1	1	5	PF00653	0.541
LIG_EH1_1	155	163	PF00400	0.579
LIG_eIF4E_1	42	48	PF01652	0.457
LIG_FHA_1	174	180	PF00498	0.648
LIG_FHA_1	208	214	PF00498	0.712
LIG_FHA_2	178	184	PF00498	0.638
LIG_FHA_2	41	47	PF00498	0.386
LIG_GLEBS_BUB3_1	57	65	PF00400	0.448
LIG_LIR_Gen_1	130	141	PF02991	0.541
LIG_LIR_Nem_3	130	136	PF02991	0.538
LIG_SH2_CRK	133	137	PF00017	0.573
LIG_SH2_STAT5	42	45	PF00017	0.389
LIG_SH2_STAT5	85	88	PF00017	0.418
LIG_SH3_1	233	239	PF00018	0.635
LIG_SH3_3	220	226	PF00018	0.658
LIG_SH3_3	233	239	PF00018	0.694
LIG_SH3_3	72	78	PF00018	0.287
LIG_SH3_3	96	102	PF00018	0.656
LIG_SUMO_SIM_par_1	142	149	PF11976	0.589
LIG_TRAF2_1	180	183	PF00917	0.636
LIG_TYR_ITIM	131	136	PF00017	0.554
LIG_WRC_WIRS_1	71	76	PF05994	0.363
MOD_CK1_1	152	158	PF00069	0.573
MOD_CK1_1	164	170	PF00069	0.611
MOD_CK1_1	3	9	PF00069	0.566
MOD_CK2_1	177	183	PF00069	0.631
MOD_GlcNHglycan	166	169	PF01048	0.420
MOD_GlcNHglycan	199	202	PF01048	0.487
MOD_GlcNHglycan	27	30	PF01048	0.720
MOD_GlcNHglycan	3	6	PF01048	0.728
MOD_GlcNHglycan	87	90	PF01048	0.513
MOD_GSK3_1	1	8	PF00069	0.547
MOD_GSK3_1	107	114	PF00069	0.676
MOD_GSK3_1	173	180	PF00069	0.649
MOD_GSK3_1	36	43	PF00069	0.416
MOD_N-GLC_1	152	157	PF02516	0.383
MOD_N-GLC_1	197	202	PF02516	0.456
MOD_NEK2_1	1	6	PF00069	0.568
MOD_NEK2_1	124	129	PF00069	0.533
MOD_NEK2_1	161	166	PF00069	0.585
MOD_NEK2_1	171	176	PF00069	0.634
MOD_PIKK_1	161	167	PF00454	0.577
MOD_PIKK_1	202	208	PF00454	0.735
MOD_PIKK_1	234	240	PF00454	0.795
MOD_PKA_2	107	113	PF00069	0.684
MOD_PKA_2	149	155	PF00069	0.654
MOD_PKA_2	202	208	PF00069	0.708
MOD_Plk_1	152	158	PF00069	0.583
MOD_Plk_4	107	113	PF00069	0.598
MOD_Plk_4	70	76	PF00069	0.298
MOD_ProDKin_1	222	228	PF00069	0.664
MOD_ProDKin_1	5	11	PF00069	0.571
TRG_DiLeu_BaEn_1	183	188	PF01217	0.618
TRG_DiLeu_BaEn_1	61	66	PF01217	0.439
TRG_DiLeu_LyEn_5	183	188	PF01217	0.673
TRG_ENDOCYTIC_2	133	136	PF00928	0.558
TRG_ENDOCYTIC_2	232	235	PF00928	0.678
TRG_ER_diArg_1	158	160	PF00400	0.577
TRG_NES_CRM1_1	22	36	PF08389	0.452
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIX5	Leptomonas seymouri	87%	100%
A0A0S4J8L9	Bodo saltans	54%	100%
A0A1X0NRU5	Trypanosomatidae	66%	100%
A0A422P2X7	Trypanosoma rangeli	65%	100%
A4HKX4	Leishmania braziliensis	89%	100%
A4I8F4	Leishmania infantum	100%	100%
D0AAR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9B3B2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q4U3	Leishmania major	98%	100%
V5BVM8	Trypanosoma cruzi	68%	100%