Acyl transferase-like protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl transferase-like protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGH2_LEIDO

TriTrypDb:

LdBPK_353520.1 , LdCL_350040200 , LDHU3_35.4600

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005835	fatty acid synthase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

A0A3Q8IGH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGH2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	3
GO:0006629	lipid metabolic process	3	3
GO:0006631	fatty acid metabolic process	4	3
GO:0006633	fatty acid biosynthetic process	5	3
GO:0008152	metabolic process	1	3
GO:0008610	lipid biosynthetic process	4	3
GO:0009058	biosynthetic process	2	3
GO:0009987	cellular process	1	3
GO:0016053	organic acid biosynthetic process	4	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0032787	monocarboxylic acid metabolic process	6	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044255	cellular lipid metabolic process	3	3
GO:0044281	small molecule metabolic process	2	3
GO:0044283	small molecule biosynthetic process	3	3
GO:0046394	carboxylic acid biosynthetic process	5	3
GO:0071704	organic substance metabolic process	2	3
GO:0072330	monocarboxylic acid biosynthetic process	6	3
GO:1901576	organic substance biosynthetic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0004312	fatty acid synthase activity	5	3
GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	6	1
GO:0016417	S-acyltransferase activity	5	1
GO:0016419	S-malonyltransferase activity	6	1
GO:0016420	malonyltransferase activity	5	1
GO:0016746	acyltransferase activity	3	3
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.530
CLV_C14_Caspase3-7	91	95	PF00656	0.493
CLV_NRD_NRD_1	177	179	PF00675	0.453
CLV_NRD_NRD_1	307	309	PF00675	0.603
CLV_NRD_NRD_1	358	360	PF00675	0.452
CLV_NRD_NRD_1	394	396	PF00675	0.576
CLV_NRD_NRD_1	504	506	PF00675	0.580
CLV_PCSK_KEX2_1	161	163	PF00082	0.335
CLV_PCSK_KEX2_1	307	309	PF00082	0.568
CLV_PCSK_KEX2_1	358	360	PF00082	0.452
CLV_PCSK_KEX2_1	394	396	PF00082	0.616
CLV_PCSK_KEX2_1	425	427	PF00082	0.561
CLV_PCSK_KEX2_1	496	498	PF00082	0.520
CLV_PCSK_KEX2_1	504	506	PF00082	0.429
CLV_PCSK_KEX2_1	71	73	PF00082	0.429
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.378
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.522
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.517
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.441
CLV_PCSK_PC7_1	303	309	PF00082	0.568
CLV_PCSK_SKI1_1	162	166	PF00082	0.335
CLV_PCSK_SKI1_1	199	203	PF00082	0.305
CLV_PCSK_SKI1_1	2	6	PF00082	0.396
CLV_PCSK_SKI1_1	308	312	PF00082	0.581
CLV_PCSK_SKI1_1	369	373	PF00082	0.432
CLV_PCSK_SKI1_1	379	383	PF00082	0.387
CLV_PCSK_SKI1_1	457	461	PF00082	0.505
DEG_Nend_UBRbox_1	1	4	PF02207	0.485
DEG_SPOP_SBC_1	213	217	PF00917	0.411
DOC_CYCLIN_RxL_1	159	167	PF00134	0.447
DOC_CYCLIN_RxL_1	376	385	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.399
DOC_MAPK_gen_1	338	346	PF00069	0.422
DOC_MAPK_gen_1	394	401	PF00069	0.545
DOC_MAPK_gen_1	435	444	PF00069	0.621
DOC_MAPK_gen_1	514	522	PF00069	0.527
DOC_MAPK_MEF2A_6	339	348	PF00069	0.424
DOC_MAPK_MEF2A_6	514	522	PF00069	0.527
DOC_MAPK_RevD_3	147	162	PF00069	0.335
DOC_PP1_RVXF_1	197	203	PF00149	0.305
DOC_USP7_MATH_1	134	138	PF00917	0.335
DOC_USP7_MATH_1	213	217	PF00917	0.447
DOC_USP7_MATH_1	268	272	PF00917	0.447
DOC_USP7_MATH_1	293	297	PF00917	0.659
DOC_USP7_MATH_1	351	355	PF00917	0.375
DOC_USP7_MATH_1	58	62	PF00917	0.454
DOC_WW_Pin1_4	148	153	PF00397	0.355
DOC_WW_Pin1_4	181	186	PF00397	0.421
DOC_WW_Pin1_4	315	320	PF00397	0.533
DOC_WW_Pin1_4	491	496	PF00397	0.494
LIG_14-3-3_CanoR_1	303	307	PF00244	0.589
LIG_14-3-3_CanoR_1	33	39	PF00244	0.441
LIG_14-3-3_CanoR_1	497	503	PF00244	0.489
LIG_14-3-3_CanoR_1	504	509	PF00244	0.458
LIG_14-3-3_CanoR_1	516	521	PF00244	0.525
LIG_14-3-3_CanoR_1	72	80	PF00244	0.375
LIG_14-3-3_CanoR_1	85	93	PF00244	0.311
LIG_Actin_WH2_2	343	360	PF00022	0.442
LIG_BRCT_BRCA1_1	499	503	PF00533	0.532
LIG_BRCT_BRCA1_1	60	64	PF00533	0.441
LIG_FHA_1	316	322	PF00498	0.550
LIG_FHA_1	403	409	PF00498	0.508
LIG_FHA_1	439	445	PF00498	0.486
LIG_FHA_1	458	464	PF00498	0.194
LIG_FHA_1	73	79	PF00498	0.424
LIG_FHA_1	85	91	PF00498	0.441
LIG_FHA_2	326	332	PF00498	0.564
LIG_FHA_2	474	480	PF00498	0.459
LIG_FHA_2	89	95	PF00498	0.441
LIG_IRF3_LxIS_1	378	385	PF10401	0.375
LIG_LIR_Apic_2	341	345	PF02991	0.412
LIG_LIR_Gen_1	140	149	PF02991	0.335
LIG_LIR_Gen_1	215	226	PF02991	0.377
LIG_LIR_LC3C_4	439	444	PF02991	0.506
LIG_LIR_Nem_3	140	144	PF02991	0.377
LIG_LIR_Nem_3	198	204	PF02991	0.346
LIG_LIR_Nem_3	215	221	PF02991	0.249
LIG_LIR_Nem_3	304	309	PF02991	0.576
LIG_LIR_Nem_3	341	346	PF02991	0.415
LIG_LIR_Nem_3	362	367	PF02991	0.388
LIG_LRP6_Inhibitor_1	221	227	PF00058	0.402
LIG_NRBOX	377	383	PF00104	0.417
LIG_PALB2_WD40_1	338	346	PF16756	0.465
LIG_PCNA_TLS_4	358	365	PF02747	0.435
LIG_SH2_STAT3	101	104	PF00017	0.426
LIG_SH2_STAT3	126	129	PF00017	0.402
LIG_SH2_STAT5	101	104	PF00017	0.398
LIG_SH2_STAT5	231	234	PF00017	0.328
LIG_SH3_3	146	152	PF00018	0.355
LIG_SH3_3	405	411	PF00018	0.515
LIG_SUMO_SIM_anti_2	215	223	PF11976	0.354
LIG_SUMO_SIM_par_1	380	385	PF11976	0.382
LIG_SUMO_SIM_par_1	439	446	PF11976	0.577
LIG_TRAF2_1	328	331	PF00917	0.621
LIG_TRAF2_1	477	480	PF00917	0.523
LIG_TYR_ITIM	113	118	PF00017	0.451
LIG_UBA3_1	381	386	PF00899	0.510
LIG_WRC_WIRS_1	444	449	PF05994	0.557
MOD_CDC14_SPxK_1	184	187	PF00782	0.480
MOD_CDC14_SPxK_1	494	497	PF00782	0.528
MOD_CDK_SPK_2	491	496	PF00069	0.488
MOD_CDK_SPxK_1	181	187	PF00069	0.436
MOD_CDK_SPxK_1	491	497	PF00069	0.504
MOD_CK1_1	151	157	PF00069	0.424
MOD_CK1_1	191	197	PF00069	0.402
MOD_CK1_1	263	269	PF00069	0.525
MOD_CK1_1	302	308	PF00069	0.693
MOD_CK1_1	507	513	PF00069	0.503
MOD_CK1_1	524	530	PF00069	0.535
MOD_CK2_1	134	140	PF00069	0.322
MOD_CK2_1	214	220	PF00069	0.333
MOD_CK2_1	317	323	PF00069	0.570
MOD_CK2_1	325	331	PF00069	0.581
MOD_CK2_1	416	422	PF00069	0.555
MOD_CK2_1	473	479	PF00069	0.523
MOD_GlcNHglycan	256	259	PF01048	0.646
MOD_GlcNHglycan	295	298	PF01048	0.640
MOD_GlcNHglycan	334	337	PF01048	0.417
MOD_GlcNHglycan	418	421	PF01048	0.514
MOD_GlcNHglycan	448	451	PF01048	0.484
MOD_GlcNHglycan	7	10	PF01048	0.335
MOD_GSK3_1	208	215	PF00069	0.371
MOD_GSK3_1	263	270	PF00069	0.468
MOD_GSK3_1	503	510	PF00069	0.500
MOD_GSK3_1	512	519	PF00069	0.522
MOD_GSK3_1	520	527	PF00069	0.531
MOD_GSK3_1	80	87	PF00069	0.381
MOD_N-GLC_1	156	161	PF02516	0.266
MOD_N-GLC_1	188	193	PF02516	0.428
MOD_N-GLC_1	402	407	PF02516	0.375
MOD_N-GLC_1	497	502	PF02516	0.541
MOD_NEK2_1	156	161	PF00069	0.363
MOD_NEK2_1	17	22	PF00069	0.368
MOD_NEK2_1	212	217	PF00069	0.333
MOD_NEK2_1	292	297	PF00069	0.551
MOD_NEK2_1	352	357	PF00069	0.381
MOD_NEK2_1	399	404	PF00069	0.405
MOD_NEK2_1	416	421	PF00069	0.299
MOD_NEK2_1	438	443	PF00069	0.552
MOD_NEK2_1	5	10	PF00069	0.364
MOD_NEK2_1	503	508	PF00069	0.365
MOD_NEK2_1	520	525	PF00069	0.472
MOD_NEK2_1	80	85	PF00069	0.399
MOD_NEK2_1	97	102	PF00069	0.262
MOD_NEK2_2	268	273	PF00069	0.524
MOD_PIKK_1	100	106	PF00454	0.367
MOD_PK_1	514	520	PF00069	0.478
MOD_PKA_1	338	344	PF00069	0.424
MOD_PKA_1	496	502	PF00069	0.514
MOD_PKA_1	504	510	PF00069	0.416
MOD_PKA_2	302	308	PF00069	0.591
MOD_PKA_2	32	38	PF00069	0.383
MOD_PKA_2	496	502	PF00069	0.500
MOD_PKA_2	503	509	PF00069	0.450
MOD_PKA_2	84	90	PF00069	0.413
MOD_PKB_1	514	522	PF00069	0.391
MOD_Plk_1	139	145	PF00069	0.346
MOD_Plk_1	156	162	PF00069	0.335
MOD_Plk_1	322	328	PF00069	0.587
MOD_Plk_1	438	444	PF00069	0.554
MOD_Plk_4	17	23	PF00069	0.419
MOD_Plk_4	214	220	PF00069	0.328
MOD_Plk_4	260	266	PF00069	0.520
MOD_Plk_4	338	344	PF00069	0.424
MOD_Plk_4	438	444	PF00069	0.556
MOD_Plk_4	504	510	PF00069	0.578
MOD_Plk_4	97	103	PF00069	0.389
MOD_ProDKin_1	148	154	PF00069	0.355
MOD_ProDKin_1	181	187	PF00069	0.421
MOD_ProDKin_1	315	321	PF00069	0.539
MOD_ProDKin_1	491	497	PF00069	0.504
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.563
TRG_ENDOCYTIC_2	115	118	PF00928	0.442
TRG_ER_diArg_1	306	308	PF00400	0.580
TRG_ER_diArg_1	357	359	PF00400	0.431
TRG_ER_diArg_1	394	396	PF00400	0.600
TRG_ER_diArg_1	503	505	PF00400	0.569
TRG_Pf-PMV_PEXEL_1	162	167	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJM7	Leptomonas seymouri	67%	94%
A0A0S4IR28	Bodo saltans	38%	99%
A0A1X0P5F7	Trypanosomatidae	53%	97%
A0A422NRA5	Trypanosoma rangeli	50%	99%
A4HN14	Leishmania braziliensis	82%	100%
A4IBN7	Leishmania infantum	99%	100%
C9ZYZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
E9AFH1	Leishmania major	94%	100%
E9B6M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%