WD domain, G-beta repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGG9_LEIDO

TriTrypDb:

LdBPK_330780.1 , LdCL_330013300 , LDHU3_33.1090

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0005840	ribosome	5	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IGG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGG9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006356	regulation of transcription by RNA polymerase I	7	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045943	positive regulation of transcription by RNA polymerase I	8	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	359	363	PF00656	0.699
CLV_C14_Caspase3-7	448	452	PF00656	0.546
CLV_NRD_NRD_1	356	358	PF00675	0.463
CLV_PCSK_KEX2_1	356	358	PF00082	0.513
CLV_PCSK_SKI1_1	132	136	PF00082	0.430
CLV_PCSK_SKI1_1	94	98	PF00082	0.370
DOC_CKS1_1	133	138	PF01111	0.423
DOC_CYCLIN_RxL_1	90	100	PF00134	0.585
DOC_MAPK_gen_1	90	98	PF00069	0.562
DOC_MAPK_RevD_3	342	357	PF00069	0.505
DOC_PP4_FxxP_1	119	122	PF00568	0.414
DOC_USP7_MATH_1	122	126	PF00917	0.427
DOC_USP7_MATH_1	151	155	PF00917	0.382
DOC_USP7_MATH_1	21	25	PF00917	0.707
DOC_USP7_MATH_1	331	335	PF00917	0.645
DOC_USP7_MATH_1	336	340	PF00917	0.591
DOC_USP7_MATH_1	54	58	PF00917	0.711
DOC_USP7_MATH_1	65	69	PF00917	0.685
DOC_WW_Pin1_4	132	137	PF00397	0.427
DOC_WW_Pin1_4	164	169	PF00397	0.418
DOC_WW_Pin1_4	19	24	PF00397	0.722
DOC_WW_Pin1_4	66	71	PF00397	0.755
LIG_14-3-3_CanoR_1	357	367	PF00244	0.609
LIG_14-3-3_CanoR_1	84	93	PF00244	0.395
LIG_14-3-3_CanoR_1	94	99	PF00244	0.502
LIG_Actin_WH2_2	22	40	PF00022	0.686
LIG_AP2alpha_2	313	315	PF02296	0.716
LIG_BIR_II_1	1	5	PF00653	0.612
LIG_BRCT_BRCA1_1	227	231	PF00533	0.509
LIG_FHA_1	118	124	PF00498	0.478
LIG_FHA_1	129	135	PF00498	0.353
LIG_FHA_1	220	226	PF00498	0.491
LIG_FHA_1	247	253	PF00498	0.578
LIG_FHA_1	382	388	PF00498	0.490
LIG_LIR_Apic_2	118	122	PF02991	0.407
LIG_PDZ_Class_3	510	515	PF00595	0.624
LIG_SH2_CRK	180	184	PF00017	0.545
LIG_SH2_NCK_1	299	303	PF00017	0.550
LIG_SH2_NCK_1	9	13	PF00017	0.641
LIG_SH2_SRC	419	422	PF00017	0.613
LIG_SH2_SRC	9	12	PF00017	0.618
LIG_SH2_STAP1	299	303	PF00017	0.550
LIG_SH2_STAT3	126	129	PF00017	0.574
LIG_SH2_STAT5	158	161	PF00017	0.418
LIG_SH2_STAT5	180	183	PF00017	0.406
LIG_SH2_STAT5	417	420	PF00017	0.556
LIG_SH3_2	304	309	PF14604	0.742
LIG_SH3_3	130	136	PF00018	0.459
LIG_SH3_3	17	23	PF00018	0.663
LIG_SH3_3	301	307	PF00018	0.723
LIG_SH3_3	495	501	PF00018	0.664
LIG_SH3_3	64	70	PF00018	0.555
LIG_TRFH_1	126	130	PF08558	0.328
LIG_TYR_ITIM	178	183	PF00017	0.546
LIG_UBA3_1	188	195	PF00899	0.510
LIG_UBA3_1	323	329	PF00899	0.619
MOD_CDK_SPK_2	68	73	PF00069	0.545
MOD_CDK_SPxxK_3	66	73	PF00069	0.562
MOD_CK1_1	154	160	PF00069	0.415
MOD_CK1_1	2	8	PF00069	0.738
MOD_CK1_1	254	260	PF00069	0.518
MOD_CK1_1	334	340	PF00069	0.587
MOD_CK1_1	396	402	PF00069	0.410
MOD_CK1_1	45	51	PF00069	0.676
MOD_CK1_1	68	74	PF00069	0.693
MOD_CK2_1	2	8	PF00069	0.727
MOD_CK2_1	36	42	PF00069	0.739
MOD_DYRK1A_RPxSP_1	132	136	PF00069	0.462
MOD_GlcNHglycan	141	144	PF01048	0.514
MOD_GlcNHglycan	173	176	PF01048	0.462
MOD_GlcNHglycan	227	230	PF01048	0.452
MOD_GlcNHglycan	242	245	PF01048	0.530
MOD_GlcNHglycan	270	273	PF01048	0.344
MOD_GlcNHglycan	336	339	PF01048	0.645
MOD_GlcNHglycan	347	350	PF01048	0.545
MOD_GlcNHglycan	38	41	PF01048	0.630
MOD_GlcNHglycan	4	7	PF01048	0.771
MOD_GlcNHglycan	44	47	PF01048	0.575
MOD_GlcNHglycan	459	462	PF01048	0.497
MOD_GlcNHglycan	63	66	PF01048	0.641
MOD_GlcNHglycan	73	76	PF01048	0.717
MOD_GSK3_1	128	135	PF00069	0.428
MOD_GSK3_1	15	22	PF00069	0.679
MOD_GSK3_1	215	222	PF00069	0.513
MOD_GSK3_1	240	247	PF00069	0.641
MOD_GSK3_1	25	32	PF00069	0.645
MOD_GSK3_1	358	365	PF00069	0.614
MOD_GSK3_1	381	388	PF00069	0.571
MOD_GSK3_1	392	399	PF00069	0.576
MOD_GSK3_1	54	61	PF00069	0.674
MOD_GSK3_1	97	104	PF00069	0.522
MOD_N-GLC_1	42	47	PF02516	0.631
MOD_NEK2_1	1	6	PF00069	0.771
MOD_NEK2_1	225	230	PF00069	0.622
MOD_NEK2_1	246	251	PF00069	0.611
MOD_NEK2_1	25	30	PF00069	0.674
MOD_NEK2_1	36	41	PF00069	0.585
MOD_NEK2_1	382	387	PF00069	0.617
MOD_NEK2_1	398	403	PF00069	0.508
MOD_PIKK_1	215	221	PF00454	0.496
MOD_PK_1	232	238	PF00069	0.555
MOD_PKA_1	356	362	PF00069	0.610
MOD_PKA_2	139	145	PF00069	0.496
MOD_PKA_2	171	177	PF00069	0.497
MOD_PKA_2	356	362	PF00069	0.558
MOD_PKA_2	406	412	PF00069	0.600
MOD_PKB_1	92	100	PF00069	0.555
MOD_Plk_1	117	123	PF00069	0.565
MOD_Plk_1	154	160	PF00069	0.401
MOD_Plk_1	382	388	PF00069	0.614
MOD_Plk_4	154	160	PF00069	0.381
MOD_Plk_4	25	31	PF00069	0.688
MOD_Plk_4	393	399	PF00069	0.499
MOD_Plk_4	425	431	PF00069	0.490
MOD_ProDKin_1	132	138	PF00069	0.437
MOD_ProDKin_1	164	170	PF00069	0.413
MOD_ProDKin_1	19	25	PF00069	0.723
MOD_ProDKin_1	66	72	PF00069	0.756
TRG_ENDOCYTIC_2	180	183	PF00928	0.406
TRG_ER_diArg_1	355	357	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT4	Leptomonas seymouri	60%	100%
A0A1X0P1X3	Trypanosomatidae	40%	93%
A0A422P2K2	Trypanosoma rangeli	45%	100%
A4HLB3	Leishmania braziliensis	81%	100%
A4I8T9	Leishmania infantum	99%	100%
D0A4T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B3Q5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
Q4Q4D2	Leishmania major	93%	100%
V5DG89	Trypanosoma cruzi	43%	100%