LeishMANIAdb
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Putative_cyclase_putative/Pfam:PF04199

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative_cyclase_putative/Pfam:PF04199
Gene product:
Putative cyclase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IGG1_LEIDO
TriTrypDb:
LdBPK_313170.1 , LdCL_310040000 , LDHU3_31.5380
Length:
174

Annotations

Annotations by Jardim et al.

Amino acid metabolism, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGG1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGG1

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 7
GO:0006520 amino acid metabolic process 3 7
GO:0006568 tryptophan metabolic process 5 7
GO:0006569 tryptophan catabolic process 5 7
GO:0006576 biogenic amine metabolic process 5 7
GO:0006586 indolalkylamine metabolic process 5 7
GO:0006725 cellular aromatic compound metabolic process 3 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009056 catabolic process 2 7
GO:0009063 amino acid catabolic process 4 7
GO:0009072 aromatic amino acid metabolic process 4 7
GO:0009074 aromatic amino acid family catabolic process 5 7
GO:0009308 amine metabolic process 4 7
GO:0009987 cellular process 1 7
GO:0016054 organic acid catabolic process 4 7
GO:0019439 aromatic compound catabolic process 4 7
GO:0019441 tryptophan catabolic process to kynurenine 5 7
GO:0019752 carboxylic acid metabolic process 5 7
GO:0034641 cellular nitrogen compound metabolic process 3 7
GO:0042180 cellular ketone metabolic process 3 7
GO:0042430 indole-containing compound metabolic process 4 7
GO:0042436 indole-containing compound catabolic process 5 7
GO:0042537 benzene-containing compound metabolic process 4 7
GO:0043436 oxoacid metabolic process 4 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0044248 cellular catabolic process 3 7
GO:0044270 cellular nitrogen compound catabolic process 4 7
GO:0044281 small molecule metabolic process 2 7
GO:0044282 small molecule catabolic process 3 7
GO:0046395 carboxylic acid catabolic process 5 7
GO:0046483 heterocycle metabolic process 3 7
GO:0046700 heterocycle catabolic process 4 7
GO:0070189 kynurenine metabolic process 4 7
GO:0071704 organic substance metabolic process 2 7
GO:1901360 organic cyclic compound metabolic process 3 7
GO:1901361 organic cyclic compound catabolic process 4 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:1901565 organonitrogen compound catabolic process 4 7
GO:1901575 organic substance catabolic process 3 7
GO:1901605 alpha-amino acid metabolic process 4 7
GO:1901606 alpha-amino acid catabolic process 5 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0004061 arylformamidase activity 5 7
GO:0016787 hydrolase activity 2 7
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3 7
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 49 53 PF00656 0.252
CLV_PCSK_SKI1_1 124 128 PF00082 0.547
CLV_PCSK_SKI1_1 90 94 PF00082 0.665
DEG_Nend_UBRbox_1 1 4 PF02207 0.478
DOC_CYCLIN_RxL_1 121 128 PF00134 0.503
DOC_CYCLIN_RxL_1 87 96 PF00134 0.524
DOC_MAPK_MEF2A_6 2 10 PF00069 0.264
DOC_MAPK_MEF2A_6 71 79 PF00069 0.256
DOC_PP1_RVXF_1 88 95 PF00149 0.528
DOC_PP2B_LxvP_1 6 9 PF13499 0.252
DOC_PP4_FxxP_1 72 75 PF00568 0.252
DOC_USP7_MATH_1 82 86 PF00917 0.285
DOC_WW_Pin1_4 160 165 PF00397 0.498
LIG_14-3-3_CanoR_1 129 135 PF00244 0.497
LIG_APCC_ABBAyCdc20_2 90 96 PF00400 0.529
LIG_BRCT_BRCA1_1 146 150 PF00533 0.505
LIG_Clathr_ClatBox_1 137 141 PF01394 0.477
LIG_FHA_1 120 126 PF00498 0.576
LIG_FHA_1 133 139 PF00498 0.470
LIG_FHA_2 131 137 PF00498 0.487
LIG_FHA_2 47 53 PF00498 0.252
LIG_LIR_Apic_2 149 154 PF02991 0.512
LIG_LIR_Apic_2 70 75 PF02991 0.252
LIG_LIR_Gen_1 133 140 PF02991 0.468
LIG_LIR_Nem_3 133 137 PF02991 0.495
LIG_LIR_Nem_3 146 151 PF02991 0.509
LIG_SH2_CRK 151 155 PF00017 0.504
LIG_SH2_NCK_1 95 99 PF00017 0.479
LIG_SH2_STAP1 134 138 PF00017 0.470
LIG_SH2_STAT5 134 137 PF00017 0.494
LIG_SH3_3 111 117 PF00018 0.559
LIG_SH3_3 48 54 PF00018 0.252
LIG_SUMO_SIM_par_1 2 7 PF11976 0.252
LIG_TRAF2_1 117 120 PF00917 0.551
LIG_TYR_ITIM 132 137 PF00017 0.496
LIG_TYR_ITIM 93 98 PF00017 0.562
MOD_CDC14_SPxK_1 163 166 PF00782 0.521
MOD_CDK_SPxK_1 160 166 PF00069 0.503
MOD_GSK3_1 23 30 PF00069 0.252
MOD_GSK3_1 42 49 PF00069 0.252
MOD_NEK2_1 125 130 PF00069 0.556
MOD_PKA_2 23 29 PF00069 0.231
MOD_Plk_1 4 10 PF00069 0.252
MOD_Plk_1 82 88 PF00069 0.490
MOD_ProDKin_1 160 166 PF00069 0.503
TRG_DiLeu_BaEn_1 121 126 PF01217 0.499
TRG_DiLeu_LyEn_5 121 126 PF01217 0.499
TRG_ENDOCYTIC_2 11 14 PF00928 0.252
TRG_ENDOCYTIC_2 134 137 PF00928 0.494
TRG_ENDOCYTIC_2 95 98 PF00928 0.563
TRG_ER_diArg_1 155 158 PF00400 0.568

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2A0 Leptomonas seymouri 73% 88%
A0KA00 Burkholderia cenocepacia (strain HI2424) 27% 82%
A0REX1 Bacillus thuringiensis (strain Al Hakam) 26% 83%
A1TLB1 Acidovorax citrulli (strain AAC00-1) 28% 81%
A1V195 Burkholderia mallei (strain SAVP1) 27% 82%
A2S926 Burkholderia mallei (strain NCTC 10229) 27% 82%
A3MHE3 Burkholderia mallei (strain NCTC 10247) 27% 82%
A3N6H4 Burkholderia pseudomallei (strain 668) 27% 82%
A3NS57 Burkholderia pseudomallei (strain 1106a) 27% 82%
A4HJU5 Leishmania braziliensis 87% 100%
A4I7B0 Leishmania infantum 100% 100%
A4IT60 Geobacillus thermodenitrificans (strain NG80-2) 23% 83%
A4JHD7 Burkholderia vietnamiensis (strain G4 / LMG 22486) 27% 82%
A6V681 Pseudomonas aeruginosa (strain PA7) 27% 82%
A7GPY2 Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98) 26% 83%
A9AGH3 Burkholderia multivorans (strain ATCC 17616 / 249) 27% 82%
A9VHP8 Bacillus mycoides (strain KBAB4) 26% 83%
B1JXI7 Burkholderia cenocepacia (strain MC0-3) 28% 82%
B1YVH0 Burkholderia ambifaria (strain MC40-6) 29% 82%
B2SY84 Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN) 25% 82%
B3R5Q1 Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1) 25% 81%
B4E9I9 Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) 29% 82%
E9B2A4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q02LM8 Pseudomonas aeruginosa (strain UCBPP-PA14) 26% 82%
Q0APM5 Maricaulis maris (strain MCS10) 22% 83%
Q0BCE2 Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) 29% 82%
Q0K7X9 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) 27% 81%
Q126P9 Polaromonas sp. (strain JS666 / ATCC BAA-500) 25% 79%
Q13UP0 Paraburkholderia xenovorans (strain LB400) 25% 82%
Q1BU36 Burkholderia cenocepacia (strain AU 1054) 27% 82%
Q1GTB8 Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) 25% 83%
Q2S2F5 Salinibacter ruber (strain DSM 13855 / M31) 30% 82%
Q2T0N2 Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264) 27% 82%
Q39DG4 Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383) 28% 82%
Q3JVD6 Burkholderia pseudomallei (strain 1710b) 27% 82%
Q474J5 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) 27% 79%
Q4KIP4 Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) 27% 80%
Q4Q5V2 Leishmania major 95% 100%
Q58193 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 30% 94%
Q62M97 Burkholderia mallei (strain ATCC 23344) 27% 82%
Q63AJ1 Bacillus cereus (strain ZK / E33L) 26% 83%
Q63WP3 Burkholderia pseudomallei (strain K96243) 27% 82%
Q6HHX8 Bacillus thuringiensis subsp. konkukian (strain 97-27) 26% 83%
Q736W4 Bacillus cereus (strain ATCC 10987 / NRS 248) 26% 83%
Q81CK1 Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) 27% 83%
Q81PP9 Bacillus anthracis 25% 83%
Q8Y1D0 Ralstonia solanacearum (strain GMI1000) 28% 83%
Q9I234 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 26% 82%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS