Regulator_of_chromosome_condensation_(RCC1)_repea t_putative/Pfam:PF00415/Pfam:PF13540

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

regulator of chromosome condensation 1-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IGE7_LEIDO

TriTrypDb:

LdBPK_364260.1 , LdCL_360049700 , LDHU3_36.5690

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0031010	ISWI-type complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0070603	SWI/SNF superfamily-type complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1904949	ATPase complex	3	1

Expansion

Sequence features

A0A3Q8IGE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGE7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	217	219	PF00675	0.382
CLV_NRD_NRD_1	316	318	PF00675	0.360
CLV_NRD_NRD_1	65	67	PF00675	0.397
CLV_PCSK_KEX2_1	217	219	PF00082	0.551
CLV_PCSK_KEX2_1	638	640	PF00082	0.595
CLV_PCSK_KEX2_1	65	67	PF00082	0.369
CLV_PCSK_PC1ET2_1	638	640	PF00082	0.595
CLV_PCSK_SKI1_1	638	642	PF00082	0.600
CLV_PCSK_SKI1_1	65	69	PF00082	0.574
DEG_APCC_KENBOX_2	336	340	PF00400	0.474
DEG_Nend_Nbox_1	1	3	PF02207	0.303
DEG_SPOP_SBC_1	155	159	PF00917	0.362
DEG_SPOP_SBC_1	48	52	PF00917	0.673
DEG_SPOP_SBC_1	589	593	PF00917	0.592
DOC_CKS1_1	253	258	PF01111	0.411
DOC_CYCLIN_yCln2_LP_2	420	426	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.556
DOC_MAPK_gen_1	264	272	PF00069	0.301
DOC_MAPK_MEF2A_6	266	274	PF00069	0.298
DOC_PP1_RVXF_1	309	315	PF00149	0.267
DOC_PP1_RVXF_1	639	645	PF00149	0.495
DOC_PP2B_LxvP_1	173	176	PF13499	0.480
DOC_USP7_MATH_1	370	374	PF00917	0.440
DOC_USP7_MATH_1	408	412	PF00917	0.487
DOC_USP7_MATH_1	46	50	PF00917	0.715
DOC_USP7_MATH_1	479	483	PF00917	0.715
DOC_USP7_MATH_1	579	583	PF00917	0.760
DOC_USP7_MATH_1	589	593	PF00917	0.702
DOC_USP7_MATH_1	616	620	PF00917	0.727
DOC_USP7_MATH_1	86	90	PF00917	0.404
DOC_USP7_MATH_1	98	102	PF00917	0.453
DOC_USP7_UBL2_3	459	463	PF12436	0.749
DOC_WW_Pin1_4	252	257	PF00397	0.360
DOC_WW_Pin1_4	29	34	PF00397	0.455
DOC_WW_Pin1_4	628	633	PF00397	0.738
LIG_14-3-3_CanoR_1	447	452	PF00244	0.688
LIG_14-3-3_CanoR_1	558	567	PF00244	0.407
LIG_14-3-3_CanoR_1	65	74	PF00244	0.384
LIG_APCC_ABBA_1	654	659	PF00400	0.513
LIG_BRCT_BRCA1_1	5	9	PF00533	0.365
LIG_BRCT_BRCA1_1	601	605	PF00533	0.568
LIG_CaM_IQ_9	57	73	PF13499	0.448
LIG_deltaCOP1_diTrp_1	643	649	PF00928	0.484
LIG_FHA_1	157	163	PF00498	0.410
LIG_FHA_1	241	247	PF00498	0.408
LIG_FHA_1	253	259	PF00498	0.392
LIG_FHA_1	331	337	PF00498	0.276
LIG_FHA_1	366	372	PF00498	0.420
LIG_FHA_1	432	438	PF00498	0.333
LIG_FHA_1	596	602	PF00498	0.763
LIG_FHA_2	266	272	PF00498	0.433
LIG_FHA_2	287	293	PF00498	0.266
LIG_FHA_2	466	472	PF00498	0.620
LIG_FHA_2	567	573	PF00498	0.520
LIG_FHA_2	660	666	PF00498	0.560
LIG_LIR_Apic_2	681	687	PF02991	0.580
LIG_LIR_Gen_1	167	176	PF02991	0.388
LIG_LIR_Gen_1	192	200	PF02991	0.440
LIG_LIR_Gen_1	482	491	PF02991	0.516
LIG_LIR_Nem_3	115	119	PF02991	0.417
LIG_LIR_Nem_3	167	173	PF02991	0.355
LIG_LIR_Nem_3	192	196	PF02991	0.351
LIG_LIR_Nem_3	226	232	PF02991	0.281
LIG_LIR_Nem_3	292	298	PF02991	0.266
LIG_LIR_Nem_3	482	486	PF02991	0.516
LIG_MYND_1	305	309	PF01753	0.411
LIG_NRBOX	508	514	PF00104	0.431
LIG_PCNA_yPIPBox_3	337	346	PF02747	0.396
LIG_PTB_Apo_2	110	117	PF02174	0.474
LIG_PTB_Phospho_1	110	116	PF10480	0.395
LIG_REV1ctd_RIR_1	292	301	PF16727	0.393
LIG_REV1ctd_RIR_1	346	355	PF16727	0.484
LIG_SH2_CRK	116	120	PF00017	0.404
LIG_SH2_CRK	399	403	PF00017	0.444
LIG_SH2_NCK_1	439	443	PF00017	0.365
LIG_SH2_PTP2	684	687	PF00017	0.580
LIG_SH2_SRC	189	192	PF00017	0.489
LIG_SH2_SRC	28	31	PF00017	0.378
LIG_SH2_SRC	505	508	PF00017	0.553
LIG_SH2_STAP1	126	130	PF00017	0.347
LIG_SH2_STAT3	525	528	PF00017	0.549
LIG_SH2_STAT3	7	10	PF00017	0.399
LIG_SH2_STAT5	163	166	PF00017	0.360
LIG_SH2_STAT5	28	31	PF00017	0.421
LIG_SH2_STAT5	288	291	PF00017	0.266
LIG_SH2_STAT5	347	350	PF00017	0.392
LIG_SH2_STAT5	392	395	PF00017	0.336
LIG_SH2_STAT5	399	402	PF00017	0.425
LIG_SH2_STAT5	516	519	PF00017	0.370
LIG_SH2_STAT5	525	528	PF00017	0.397
LIG_SH2_STAT5	684	687	PF00017	0.549
LIG_SH3_1	527	533	PF00018	0.533
LIG_SH3_2	530	535	PF14604	0.592
LIG_SH3_3	15	21	PF00018	0.554
LIG_SH3_3	250	256	PF00018	0.263
LIG_SH3_3	27	33	PF00018	0.385
LIG_SH3_3	309	315	PF00018	0.270
LIG_SH3_3	361	367	PF00018	0.474
LIG_SH3_3	442	448	PF00018	0.545
LIG_SH3_3	482	488	PF00018	0.539
LIG_SH3_3	527	533	PF00018	0.480
LIG_SH3_3	629	635	PF00018	0.686
LIG_SH3_CIN85_PxpxPR_1	530	535	PF14604	0.563
LIG_SUMO_SIM_par_1	330	338	PF11976	0.300
LIG_SUMO_SIM_par_1	597	603	PF11976	0.496
LIG_SUMO_SIM_par_1	650	662	PF11976	0.559
LIG_TRAF2_1	469	472	PF00917	0.736
LIG_TRAF2_1	501	504	PF00917	0.638
LIG_TRAF2_1	59	62	PF00917	0.522
LIG_TRAF2_1	622	625	PF00917	0.664
LIG_WW_3	314	318	PF00397	0.360
LIG_WW_3	532	536	PF00397	0.648
MOD_CDK_SPK_2	631	636	PF00069	0.602
MOD_CDK_SPxxK_3	631	638	PF00069	0.671
MOD_CK1_1	12	18	PF00069	0.554
MOD_CK1_1	431	437	PF00069	0.397
MOD_CK1_1	49	55	PF00069	0.737
MOD_CK1_1	590	596	PF00069	0.669
MOD_CK1_1	631	637	PF00069	0.672
MOD_CK2_1	220	226	PF00069	0.279
MOD_CK2_1	265	271	PF00069	0.397
MOD_CK2_1	286	292	PF00069	0.298
MOD_CK2_1	465	471	PF00069	0.764
MOD_CK2_1	56	62	PF00069	0.427
MOD_CK2_1	655	661	PF00069	0.510
MOD_Cter_Amidation	636	639	PF01082	0.632
MOD_GlcNHglycan	207	210	PF01048	0.446
MOD_GlcNHglycan	40	43	PF01048	0.706
MOD_GlcNHglycan	430	433	PF01048	0.419
MOD_GlcNHglycan	464	468	PF01048	0.775
MOD_GlcNHglycan	592	595	PF01048	0.730
MOD_GlcNHglycan	618	621	PF01048	0.738
MOD_GSK3_1	150	157	PF00069	0.290
MOD_GSK3_1	162	169	PF00069	0.266
MOD_GSK3_1	185	192	PF00069	0.496
MOD_GSK3_1	205	212	PF00069	0.190
MOD_GSK3_1	220	227	PF00069	0.309
MOD_GSK3_1	248	255	PF00069	0.432
MOD_GSK3_1	366	373	PF00069	0.417
MOD_GSK3_1	44	51	PF00069	0.703
MOD_GSK3_1	463	470	PF00069	0.697
MOD_GSK3_1	475	482	PF00069	0.655
MOD_GSK3_1	52	59	PF00069	0.633
MOD_GSK3_1	595	602	PF00069	0.633
MOD_GSK3_1	655	662	PF00069	0.507
MOD_N-GLC_1	209	214	PF02516	0.320
MOD_N-GLC_1	403	408	PF02516	0.434
MOD_N-GLC_1	44	49	PF02516	0.639
MOD_NEK2_1	139	144	PF00069	0.505
MOD_NEK2_1	3	8	PF00069	0.355
MOD_NEK2_1	341	346	PF00069	0.485
MOD_NEK2_1	9	14	PF00069	0.514
MOD_NEK2_2	166	171	PF00069	0.387
MOD_PIKK_1	191	197	PF00454	0.489
MOD_PIKK_1	240	246	PF00454	0.287
MOD_PIKK_1	383	389	PF00454	0.384
MOD_PIKK_1	410	416	PF00454	0.428
MOD_PIKK_1	608	614	PF00454	0.783
MOD_PIKK_1	9	15	PF00454	0.414
MOD_PKA_1	65	71	PF00069	0.321
MOD_PKA_2	150	156	PF00069	0.360
MOD_PKA_2	265	271	PF00069	0.432
MOD_PKA_2	377	383	PF00069	0.325
MOD_PKA_2	38	44	PF00069	0.699
MOD_PKA_2	65	71	PF00069	0.321
MOD_Plk_1	166	172	PF00069	0.281
MOD_Plk_1	209	215	PF00069	0.320
MOD_Plk_1	330	336	PF00069	0.266
MOD_Plk_1	659	665	PF00069	0.553
MOD_Plk_2-3	56	62	PF00069	0.482
MOD_Plk_2-3	659	665	PF00069	0.532
MOD_Plk_4	139	145	PF00069	0.430
MOD_Plk_4	150	156	PF00069	0.222
MOD_Plk_4	265	271	PF00069	0.346
MOD_Plk_4	330	336	PF00069	0.266
MOD_Plk_4	341	347	PF00069	0.433
MOD_Plk_4	359	365	PF00069	0.581
MOD_Plk_4	431	437	PF00069	0.359
MOD_Plk_4	441	447	PF00069	0.477
MOD_Plk_4	566	572	PF00069	0.460
MOD_Plk_4	595	601	PF00069	0.626
MOD_Plk_4	652	658	PF00069	0.575
MOD_Plk_4	86	92	PF00069	0.442
MOD_ProDKin_1	252	258	PF00069	0.360
MOD_ProDKin_1	29	35	PF00069	0.454
MOD_ProDKin_1	628	634	PF00069	0.734
MOD_SUMO_for_1	462	465	PF00179	0.719
MOD_SUMO_for_1	640	643	PF00179	0.597
MOD_SUMO_rev_2	451	460	PF00179	0.726
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.484
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.312
TRG_ENDOCYTIC_2	116	119	PF00928	0.437
TRG_ENDOCYTIC_2	229	232	PF00928	0.281
TRG_ENDOCYTIC_2	399	402	PF00928	0.432
TRG_ER_diArg_1	264	267	PF00400	0.328
TRG_ER_diArg_1	36	39	PF00400	0.587
TRG_ER_diArg_1	64	66	PF00400	0.388
TRG_NES_CRM1_1	62	73	PF08389	0.435
TRG_NLS_MonoExtC_3	637	643	PF00514	0.604
TRG_NLS_MonoExtN_4	635	642	PF00514	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4I0	Leptomonas seymouri	67%	100%
A0A0S4JSE7	Bodo saltans	32%	100%
A0A1X0P381	Trypanosomatidae	43%	100%
A0A3S5IS08	Trypanosoma rangeli	45%	100%
A4HPS4	Leishmania braziliensis	83%	100%
A4ICY9	Leishmania infantum	100%	100%
D0A8N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ATI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q109	Leishmania major	93%	100%
V5DNG6	Trypanosoma cruzi	44%	100%