LeishMANIAdb
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Amino acid permease

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Amino acid permease
Gene product:
amino acid permease (fragment)
Species:
Leishmania donovani
UniProt:
A0A3Q8IGE6_LEIDO
TriTrypDb:
LdBPK_311830.1 * , LdBPK_311860.1 * , LdCL_310025500 , LDHU3_31.3160
Length:
587

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 6
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 48
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 90
NetGPI no yes: 0, no: 90
Cellular components
Term Name Level Count
GO:0016020 membrane 2 79
GO:0110165 cellular anatomical entity 1 79
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0005886 plasma membrane 3 1
GO:0020016 ciliary pocket 2 1
GO:0020023 kinetoplast 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A0A3Q8IGE6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGE6

Function

Biological processes
Term Name Level Count
GO:0003333 amino acid transmembrane transport 5 11
GO:0006810 transport 3 11
GO:0006865 amino acid transport 5 11
GO:0009987 cellular process 1 11
GO:0015849 organic acid transport 5 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0055085 transmembrane transport 2 11
GO:0071702 organic substance transport 4 11
GO:0071705 nitrogen compound transport 4 11
GO:1903825 organic acid transmembrane transport 3 11
GO:1905039 carboxylic acid transmembrane transport 4 11
GO:0006811 monoatomic ion transport 4 1
GO:0006812 monoatomic cation transport 5 1
GO:0006820 monoatomic anion transport 5 1
GO:0015711 organic anion transport 5 1
GO:0015802 basic amino acid transport 6 1
GO:0015819 lysine transport 6 1
GO:0046942 carboxylic acid transport 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0016787 hydrolase activity 2 3
GO:0005215 transporter activity 1 11
GO:0005342 organic acid transmembrane transporter activity 3 11
GO:0015171 amino acid transmembrane transporter activity 5 11
GO:0015179 L-amino acid transmembrane transporter activity 6 11
GO:0022857 transmembrane transporter activity 2 11
GO:0046943 carboxylic acid transmembrane transporter activity 4 11
GO:0008324 monoatomic cation transmembrane transporter activity 4 1
GO:0008509 monoatomic anion transmembrane transporter activity 4 1
GO:0008514 organic anion transmembrane transporter activity 5 1
GO:0015075 monoatomic ion transmembrane transporter activity 3 1
GO:0015174 basic amino acid transmembrane transporter activity 6 1
GO:0015189 L-lysine transmembrane transporter activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 22 26 PF00656 0.619
CLV_C14_Caspase3-7 446 450 PF00656 0.388
CLV_C14_Caspase3-7 480 484 PF00656 0.531
CLV_C14_Caspase3-7 490 494 PF00656 0.454
CLV_NRD_NRD_1 142 144 PF00675 0.325
CLV_NRD_NRD_1 42 44 PF00675 0.514
CLV_PCSK_KEX2_1 142 144 PF00082 0.325
CLV_PCSK_KEX2_1 42 44 PF00082 0.557
CLV_PCSK_PC7_1 38 44 PF00082 0.592
CLV_PCSK_SKI1_1 136 140 PF00082 0.296
CLV_PCSK_SKI1_1 143 147 PF00082 0.294
CLV_PCSK_SKI1_1 200 204 PF00082 0.334
CLV_PCSK_SKI1_1 255 259 PF00082 0.521
CLV_PCSK_SKI1_1 315 319 PF00082 0.302
CLV_PCSK_SKI1_1 346 350 PF00082 0.450
CLV_PCSK_SKI1_1 351 355 PF00082 0.451
DEG_APCC_DBOX_1 387 395 PF00400 0.455
DEG_SPOP_SBC_1 19 23 PF00917 0.612
DOC_AGCK_PIF_2 338 343 PF00069 0.354
DOC_MAPK_FxFP_2 538 541 PF00069 0.361
DOC_MAPK_gen_1 42 49 PF00069 0.576
DOC_MAPK_MEF2A_6 200 208 PF00069 0.332
DOC_MAPK_MEF2A_6 224 233 PF00069 0.495
DOC_PP1_RVXF_1 186 193 PF00149 0.188
DOC_PP2B_LxvP_1 214 217 PF13499 0.300
DOC_PP2B_LxvP_1 516 519 PF13499 0.323
DOC_PP2B_LxvP_1 87 90 PF13499 0.364
DOC_PP4_FxxP_1 538 541 PF00568 0.322
DOC_USP7_MATH_1 120 124 PF00917 0.519
DOC_USP7_MATH_1 251 255 PF00917 0.319
DOC_USP7_MATH_1 36 40 PF00917 0.770
DOC_USP7_MATH_1 387 391 PF00917 0.558
DOC_USP7_MATH_1 41 45 PF00917 0.672
DOC_USP7_MATH_1 439 443 PF00917 0.528
DOC_USP7_MATH_1 78 82 PF00917 0.322
DOC_USP7_MATH_1 92 96 PF00917 0.312
LIG_14-3-3_CanoR_1 127 132 PF00244 0.559
LIG_14-3-3_CanoR_1 143 149 PF00244 0.407
LIG_14-3-3_CanoR_1 200 205 PF00244 0.339
LIG_14-3-3_CanoR_1 224 233 PF00244 0.476
LIG_14-3-3_CanoR_1 278 284 PF00244 0.344
LIG_14-3-3_CanoR_1 312 318 PF00244 0.515
LIG_14-3-3_CanoR_1 388 392 PF00244 0.496
LIG_Actin_WH2_2 209 226 PF00022 0.317
LIG_BIR_II_1 1 5 PF00653 0.704
LIG_BRCT_BRCA1_1 531 535 PF00533 0.328
LIG_BRCT_BRCA1_1 547 551 PF00533 0.489
LIG_BRCT_BRCA1_1 71 75 PF00533 0.349
LIG_eIF4E_1 561 567 PF01652 0.554
LIG_FHA_1 201 207 PF00498 0.374
LIG_FHA_1 230 236 PF00498 0.338
LIG_FHA_1 271 277 PF00498 0.341
LIG_FHA_1 328 334 PF00498 0.284
LIG_FHA_1 487 493 PF00498 0.513
LIG_FHA_1 562 568 PF00498 0.320
LIG_FHA_2 20 26 PF00498 0.672
LIG_FHA_2 464 470 PF00498 0.525
LIG_FHA_2 488 494 PF00498 0.498
LIG_FHA_2 580 586 PF00498 0.248
LIG_Integrin_RGD_1 8 10 PF01839 0.402
LIG_LIR_Gen_1 109 119 PF02991 0.364
LIG_LIR_Gen_1 330 340 PF02991 0.486
LIG_LIR_Gen_1 532 543 PF02991 0.360
LIG_LIR_Gen_1 564 573 PF02991 0.323
LIG_LIR_Gen_1 582 587 PF02991 0.468
LIG_LIR_Nem_3 109 114 PF02991 0.338
LIG_LIR_Nem_3 130 134 PF02991 0.498
LIG_LIR_Nem_3 232 236 PF02991 0.293
LIG_LIR_Nem_3 330 335 PF02991 0.321
LIG_LIR_Nem_3 336 341 PF02991 0.300
LIG_LIR_Nem_3 390 395 PF02991 0.491
LIG_LIR_Nem_3 485 491 PF02991 0.378
LIG_LIR_Nem_3 532 538 PF02991 0.374
LIG_LIR_Nem_3 564 568 PF02991 0.328
LIG_LIR_Nem_3 582 587 PF02991 0.511
LIG_PALB2_WD40_1 554 562 PF16756 0.563
LIG_PDZ_Class_3 582 587 PF00595 0.466
LIG_Pex14_2 152 156 PF04695 0.342
LIG_Pex14_2 233 237 PF04695 0.343
LIG_Pex14_2 540 544 PF04695 0.385
LIG_PTB_Apo_2 491 498 PF02174 0.544
LIG_SH2_CRK 380 384 PF00017 0.276
LIG_SH2_GRB2like 561 564 PF00017 0.554
LIG_SH2_PTP2 332 335 PF00017 0.331
LIG_SH2_PTP2 369 372 PF00017 0.352
LIG_SH2_PTP2 62 65 PF00017 0.474
LIG_SH2_SRC 165 168 PF00017 0.304
LIG_SH2_SRC 393 396 PF00017 0.545
LIG_SH2_SRC 481 484 PF00017 0.375
LIG_SH2_SRC 62 65 PF00017 0.454
LIG_SH2_STAP1 144 148 PF00017 0.552
LIG_SH2_STAP1 225 229 PF00017 0.330
LIG_SH2_STAP1 488 492 PF00017 0.372
LIG_SH2_STAT3 294 297 PF00017 0.294
LIG_SH2_STAT5 110 113 PF00017 0.327
LIG_SH2_STAT5 117 120 PF00017 0.337
LIG_SH2_STAT5 148 151 PF00017 0.322
LIG_SH2_STAT5 165 168 PF00017 0.337
LIG_SH2_STAT5 236 239 PF00017 0.325
LIG_SH2_STAT5 294 297 PF00017 0.246
LIG_SH2_STAT5 332 335 PF00017 0.338
LIG_SH2_STAT5 340 343 PF00017 0.353
LIG_SH2_STAT5 369 372 PF00017 0.373
LIG_SH2_STAT5 393 396 PF00017 0.511
LIG_SH2_STAT5 481 484 PF00017 0.559
LIG_SH2_STAT5 488 491 PF00017 0.530
LIG_SH2_STAT5 561 564 PF00017 0.475
LIG_SH2_STAT5 565 568 PF00017 0.326
LIG_SH2_STAT5 62 65 PF00017 0.501
LIG_SH3_3 207 213 PF00018 0.425
LIG_SH3_3 60 66 PF00018 0.572
LIG_Sin3_3 379 386 PF02671 0.417
LIG_SUMO_SIM_anti_2 352 357 PF11976 0.235
LIG_SUMO_SIM_anti_2 564 570 PF11976 0.324
LIG_SUMO_SIM_par_1 117 124 PF11976 0.324
LIG_SUMO_SIM_par_1 502 508 PF11976 0.293
LIG_TRAF2_1 359 362 PF00917 0.352
LIG_TRAF2_2 463 468 PF00917 0.378
LIG_TYR_ITIM 108 113 PF00017 0.339
LIG_TYR_ITIM 367 372 PF00017 0.362
LIG_TYR_ITIM 378 383 PF00017 0.334
LIG_TYR_ITSM 328 335 PF00017 0.412
LIG_TYR_ITSM 580 587 PF00017 0.397
LIG_UBA3_1 211 218 PF00899 0.369
LIG_WRC_WIRS_1 128 133 PF05994 0.533
MOD_CK1_1 112 118 PF00069 0.355
MOD_CK1_1 123 129 PF00069 0.498
MOD_CK1_1 2 8 PF00069 0.662
MOD_CK1_1 508 514 PF00069 0.368
MOD_CK2_1 463 469 PF00069 0.599
MOD_CK2_1 579 585 PF00069 0.373
MOD_GlcNHglycan 226 229 PF01048 0.337
MOD_GlcNHglycan 259 262 PF01048 0.578
MOD_GlcNHglycan 319 322 PF01048 0.365
MOD_GlcNHglycan 43 46 PF01048 0.360
MOD_GlcNHglycan 531 534 PF01048 0.299
MOD_GlcNHglycan 547 550 PF01048 0.293
MOD_GlcNHglycan 71 74 PF01048 0.318
MOD_GlcNHglycan 78 81 PF01048 0.316
MOD_GlcNHglycan 94 97 PF01048 0.467
MOD_GSK3_1 123 130 PF00069 0.489
MOD_GSK3_1 279 286 PF00069 0.343
MOD_GSK3_1 311 318 PF00069 0.529
MOD_GSK3_1 420 427 PF00069 0.598
MOD_GSK3_1 482 489 PF00069 0.541
MOD_GSK3_1 545 552 PF00069 0.495
MOD_GSK3_1 557 564 PF00069 0.496
MOD_GSK3_1 579 586 PF00069 0.295
MOD_LATS_1 18 24 PF00433 0.609
MOD_N-GLC_1 402 407 PF02516 0.189
MOD_N-GLC_1 549 554 PF02516 0.298
MOD_NEK2_1 192 197 PF00069 0.318
MOD_NEK2_1 250 255 PF00069 0.351
MOD_NEK2_1 276 281 PF00069 0.274
MOD_NEK2_1 317 322 PF00069 0.520
MOD_NEK2_1 327 332 PF00069 0.342
MOD_NEK2_1 349 354 PF00069 0.328
MOD_NEK2_1 454 459 PF00069 0.382
MOD_NEK2_1 505 510 PF00069 0.346
MOD_NEK2_1 527 532 PF00069 0.295
MOD_NEK2_2 387 392 PF00069 0.514
MOD_NEK2_2 439 444 PF00069 0.373
MOD_PIKK_1 193 199 PF00454 0.367
MOD_PIKK_1 26 32 PF00454 0.711
MOD_PIKK_1 36 42 PF00454 0.648
MOD_PIKK_1 461 467 PF00454 0.541
MOD_PKA_2 19 25 PF00069 0.733
MOD_PKA_2 311 317 PF00069 0.488
MOD_PKA_2 387 393 PF00069 0.524
MOD_PKA_2 41 47 PF00069 0.719
MOD_PKB_1 400 408 PF00069 0.537
MOD_Plk_1 123 129 PF00069 0.551
MOD_Plk_1 420 426 PF00069 0.382
MOD_Plk_1 486 492 PF00069 0.546
MOD_Plk_1 549 555 PF00069 0.466
MOD_Plk_2-3 487 493 PF00069 0.555
MOD_Plk_4 200 206 PF00069 0.326
MOD_Plk_4 229 235 PF00069 0.301
MOD_Plk_4 270 276 PF00069 0.347
MOD_Plk_4 279 285 PF00069 0.329
MOD_Plk_4 327 333 PF00069 0.299
MOD_Plk_4 349 355 PF00069 0.271
MOD_Plk_4 387 393 PF00069 0.491
MOD_Plk_4 487 493 PF00069 0.502
MOD_Plk_4 508 514 PF00069 0.334
MOD_Plk_4 520 526 PF00069 0.301
MOD_Plk_4 561 567 PF00069 0.508
MOD_Plk_4 579 585 PF00069 0.254
MOD_SUMO_rev_2 260 269 PF00179 0.333
TRG_DiLeu_BaEn_2 410 416 PF01217 0.388
TRG_DiLeu_BaEn_3 361 367 PF01217 0.346
TRG_ENDOCYTIC_2 110 113 PF00928 0.335
TRG_ENDOCYTIC_2 236 239 PF00928 0.331
TRG_ENDOCYTIC_2 332 335 PF00928 0.342
TRG_ENDOCYTIC_2 340 343 PF00928 0.307
TRG_ENDOCYTIC_2 369 372 PF00928 0.344
TRG_ENDOCYTIC_2 380 383 PF00928 0.304
TRG_ENDOCYTIC_2 392 395 PF00928 0.499
TRG_ENDOCYTIC_2 565 568 PF00928 0.323
TRG_ENDOCYTIC_2 584 587 PF00928 0.448
TRG_ENDOCYTIC_2 62 65 PF00928 0.636
TRG_ER_diArg_1 142 144 PF00400 0.564
TRG_ER_diArg_1 401 404 PF00400 0.514
TRG_ER_diArg_1 41 43 PF00400 0.646

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2L5 Leptomonas seymouri 32% 100%
A0A0N1IJ81 Leptomonas seymouri 20% 100%
A0A0N1PA98 Leptomonas seymouri 65% 96%
A0A0S4IV32 Bodo saltans 23% 100%
A0A0S4JU02 Bodo saltans 34% 100%
A0A3Q8ICL1 Leishmania donovani 91% 100%
A0A3Q8IDG8 Leishmania donovani 35% 100%
A0A3Q8IG00 Leishmania donovani 40% 100%
A0A3Q8IHH7 Leishmania donovani 20% 100%
A0A3Q8IJH2 Leishmania donovani 34% 100%
A0A3Q8IJX8 Leishmania donovani 34% 100%
A0A3Q8ILE0 Leishmania donovani 34% 100%
A0A3Q8IQG8 Leishmania donovani 25% 100%
A0A3R7JSA0 Trypanosoma rangeli 44% 100%
A0A3R7MWF1 Trypanosoma rangeli 22% 100%
A0A3R7N1H9 Trypanosoma rangeli 43% 100%
A0A3S7WQ39 Leishmania donovani 36% 100%
A0A3S7X443 Leishmania donovani 35% 100%
A0A3S7X4A1 Leishmania donovani 34% 100%
A0A3S7X4L2 Leishmania donovani 92% 97%
A0A3S7X4N4 Leishmania donovani 92% 97%
A0A3S7X4P0 Leishmania donovani 91% 97%
A0A3S7XA86 Leishmania donovani 23% 100%
A0A3S7XCE3 Leishmania donovani 22% 100%
A0A422MW74 Trypanosoma rangeli 37% 100%
A0A422N608 Trypanosoma rangeli 43% 100%
A4H565 Leishmania braziliensis 35% 100%
A4HC75 Leishmania braziliensis 35% 100%
A4HFJ2 Leishmania braziliensis 32% 100%
A4HFT5 Leishmania braziliensis 37% 100%
A4HJ06 Leishmania braziliensis 32% 100%
A4HJ07 Leishmania braziliensis 35% 100%
A4HJ09 Leishmania braziliensis 34% 100%
A4HJ35 Leishmania braziliensis 38% 100%
A4HJ37 Leishmania braziliensis 36% 100%
A4HJ63 Leishmania braziliensis 33% 100%
A4HJF8 Leishmania braziliensis 77% 100%
A4HJF9 Leishmania braziliensis 75% 99%
A4HJG1 Leishmania braziliensis 76% 99%
A4HJG3 Leishmania braziliensis 77% 100%
A4HJG5 Leishmania braziliensis 76% 100%
A4HKQ7 Leishmania braziliensis 33% 100%
A4HNJ6 Leishmania braziliensis 24% 100%
A4HNJ7 Leishmania braziliensis 23% 100%
A4HNQ0 Leishmania braziliensis 24% 100%
A4HTE2 Leishmania infantum 36% 100%
A4HZQ0 Leishmania infantum 34% 100%
A4I6I1 Leishmania infantum 34% 100%
A4I6J9 Leishmania infantum 34% 100%
A4I6L3 Leishmania infantum 40% 100%
A4I6L4 Leishmania infantum 34% 100%
A4I6W4 Leishmania infantum 93% 100%
A4I887 Leishmania infantum 34% 100%
A4I914 Leishmania infantum 20% 95%
A4IC53 Leishmania infantum 23% 100%
A4IC66 Leishmania infantum 22% 100%
A4ICC3 Leishmania infantum 23% 100%
A4ICU5 Leishmania infantum 25% 100%
C9ZMB9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZMD2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
C9ZMD4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
C9ZWQ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
C9ZWQ9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
C9ZWR0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
D0AAF6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
D0AAF8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E8NHF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E8NHS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 99%
E9ADD7 Leishmania major 34% 100%
E9AG08 Leishmania major 22% 100%
E9AG09 Leishmania major 22% 100%
E9AHL1 Leishmania infantum 92% 100%
E9AHL2 Leishmania infantum 99% 100%
E9AHL3 Leishmania infantum 91% 100%
E9ALD5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9ASF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AUB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9AVK6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9AZ62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B1I4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B1I6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B1K7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9B1K8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B1N8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B1N9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B1X9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9B1Y0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
E9B345 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B3X9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 20% 95%
E9B761 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9B762 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
P40074 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P40501 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 100%
Q4Q072 Leishmania major 23% 100%
Q4Q236 Leishmania major 26% 100%
Q4Q509 Leishmania major 34% 100%
Q4Q680 Leishmania major 87% 100%
Q4Q682 Leishmania major 91% 100%
Q4Q683 Leishmania major 87% 100%
Q4Q6H5 Leishmania major 34% 100%
Q4Q6K6 Leishmania major 40% 100%
Q4Q6M9 Leishmania major 35% 100%
Q4QBX3 Leishmania major 34% 100%
Q4QIH0 Leishmania major 33% 100%
Q8R1S9 Mus musculus 22% 100%
V5BA72 Trypanosoma cruzi 31% 100%
V5BH70 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS