Denn domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

denn domain-containing protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IGE3_LEIDO

TriTrypDb:

LdBPK_353010.1 , LdCL_350035000 , LDHU3_35.3880

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.413
CLV_NRD_NRD_1	21	23	PF00675	0.604
CLV_NRD_NRD_1	504	506	PF00675	0.560
CLV_PCSK_FUR_1	370	374	PF00082	0.489
CLV_PCSK_KEX2_1	365	367	PF00082	0.518
CLV_PCSK_KEX2_1	372	374	PF00082	0.469
CLV_PCSK_KEX2_1	399	401	PF00082	0.401
CLV_PCSK_KEX2_1	504	506	PF00082	0.560
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.474
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.436
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.354
CLV_PCSK_SKI1_1	156	160	PF00082	0.367
CLV_PCSK_SKI1_1	372	376	PF00082	0.557
CLV_PCSK_SKI1_1	399	403	PF00082	0.457
CLV_PCSK_SKI1_1	424	428	PF00082	0.454
DEG_APCC_DBOX_1	285	293	PF00400	0.329
DEG_APCC_DBOX_1	325	333	PF00400	0.451
DEG_SCF_FBW7_1	70	76	PF00400	0.404
DOC_CDC14_PxL_1	77	85	PF14671	0.460
DOC_CKS1_1	173	178	PF01111	0.374
DOC_CKS1_1	70	75	PF01111	0.457
DOC_MAPK_FxFP_2	203	206	PF00069	0.283
DOC_PP1_RVXF_1	62	68	PF00149	0.413
DOC_PP1_SILK_1	329	334	PF00149	0.421
DOC_PP2B_LxvP_1	244	247	PF13499	0.317
DOC_PP2B_LxvP_1	266	269	PF13499	0.258
DOC_PP4_FxxP_1	173	176	PF00568	0.296
DOC_PP4_FxxP_1	183	186	PF00568	0.237
DOC_PP4_FxxP_1	203	206	PF00568	0.131
DOC_USP7_MATH_1	27	31	PF00917	0.567
DOC_USP7_MATH_1	288	292	PF00917	0.317
DOC_USP7_MATH_1	73	77	PF00917	0.463
DOC_USP7_UBL2_3	159	163	PF12436	0.374
DOC_WW_Pin1_4	128	133	PF00397	0.284
DOC_WW_Pin1_4	163	168	PF00397	0.265
DOC_WW_Pin1_4	172	177	PF00397	0.282
DOC_WW_Pin1_4	401	406	PF00397	0.473
DOC_WW_Pin1_4	554	559	PF00397	0.658
DOC_WW_Pin1_4	69	74	PF00397	0.452
LIG_14-3-3_CanoR_1	189	194	PF00244	0.276
LIG_14-3-3_CanoR_1	514	524	PF00244	0.630
LIG_APCC_ABBA_1	427	432	PF00400	0.399
LIG_BRCT_BRCA1_1	100	104	PF00533	0.318
LIG_BRCT_BRCA1_1	31	35	PF00533	0.522
LIG_BRCT_BRCA1_1	378	382	PF00533	0.429
LIG_BRCT_BRCA1_2	378	384	PF00533	0.359
LIG_CtBP_PxDLS_1	176	180	PF00389	0.374
LIG_deltaCOP1_diTrp_1	409	415	PF00928	0.414
LIG_eIF4E_1	140	146	PF01652	0.374
LIG_FHA_1	101	107	PF00498	0.350
LIG_FHA_1	117	123	PF00498	0.283
LIG_FHA_1	194	200	PF00498	0.279
LIG_FHA_1	258	264	PF00498	0.311
LIG_FHA_1	276	282	PF00498	0.433
LIG_FHA_1	460	466	PF00498	0.521
LIG_FHA_1	73	79	PF00498	0.486
LIG_FHA_2	1	7	PF00498	0.647
LIG_FHA_2	173	179	PF00498	0.374
LIG_FHA_2	339	345	PF00498	0.341
LIG_GBD_Chelix_1	273	281	PF00786	0.259
LIG_HOMEOBOX	248	251	PF00046	0.282
LIG_LIR_Apic_2	182	186	PF02991	0.322
LIG_LIR_Apic_2	200	206	PF02991	0.317
LIG_LIR_Apic_2	66	70	PF02991	0.355
LIG_LIR_Gen_1	101	106	PF02991	0.409
LIG_LIR_Gen_1	209	220	PF02991	0.282
LIG_LIR_Gen_1	249	258	PF02991	0.359
LIG_LIR_Gen_1	351	361	PF02991	0.315
LIG_LIR_Gen_1	379	386	PF02991	0.368
LIG_LIR_Gen_1	388	398	PF02991	0.291
LIG_LIR_Gen_1	9	19	PF02991	0.576
LIG_LIR_Nem_3	101	105	PF02991	0.405
LIG_LIR_Nem_3	16	21	PF02991	0.594
LIG_LIR_Nem_3	209	215	PF02991	0.314
LIG_LIR_Nem_3	249	253	PF02991	0.300
LIG_LIR_Nem_3	347	352	PF02991	0.299
LIG_LIR_Nem_3	355	360	PF02991	0.319
LIG_LIR_Nem_3	379	385	PF02991	0.352
LIG_LIR_Nem_3	388	394	PF02991	0.290
LIG_LIR_Nem_3	456	461	PF02991	0.485
LIG_LIR_Nem_3	9	14	PF02991	0.649
LIG_LYPXL_SIV_4	70	78	PF13949	0.411
LIG_LYPXL_yS_3	80	83	PF13949	0.362
LIG_MLH1_MIPbox_1	378	382	PF16413	0.355
LIG_Pex14_1	135	139	PF04695	0.258
LIG_Pex14_1	67	71	PF04695	0.386
LIG_REV1ctd_RIR_1	136	145	PF16727	0.317
LIG_REV1ctd_RIR_1	379	388	PF16727	0.444
LIG_SH2_CRK	102	106	PF00017	0.405
LIG_SH2_CRK	187	191	PF00017	0.258
LIG_SH2_CRK	353	357	PF00017	0.297
LIG_SH2_GRB2like	308	311	PF00017	0.432
LIG_SH2_NCK_1	71	75	PF00017	0.542
LIG_SH2_STAP1	102	106	PF00017	0.405
LIG_SH2_STAP1	353	357	PF00017	0.331
LIG_SH2_STAP1	431	435	PF00017	0.501
LIG_SH2_STAP1	448	452	PF00017	0.389
LIG_SH2_STAT5	102	105	PF00017	0.343
LIG_SH2_STAT5	144	147	PF00017	0.324
LIG_SH2_STAT5	272	275	PF00017	0.258
LIG_SH2_STAT5	71	74	PF00017	0.542
LIG_SH2_STAT5	95	98	PF00017	0.516
LIG_SH3_3	162	168	PF00018	0.227
LIG_SH3_3	253	259	PF00018	0.258
LIG_SH3_3	67	73	PF00018	0.437
LIG_SUMO_SIM_anti_2	260	267	PF11976	0.259
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.455
LIG_SUMO_SIM_par_1	125	131	PF11976	0.282
LIG_SUMO_SIM_par_1	528	536	PF11976	0.503
LIG_TRAF2_1	58	61	PF00917	0.451
LIG_TYR_ITIM	100	105	PF00017	0.409
LIG_TYR_ITIM	142	147	PF00017	0.329
LIG_TYR_ITIM	78	83	PF00017	0.419
LIG_UBA3_1	331	338	PF00899	0.447
LIG_UBA3_1	356	365	PF00899	0.436
LIG_WRC_WIRS_1	190	195	PF05994	0.258
LIG_WW_1	269	272	PF00397	0.374
MOD_CK1_1	232	238	PF00069	0.357
MOD_CK1_1	404	410	PF00069	0.538
MOD_CK1_1	454	460	PF00069	0.459
MOD_CK1_1	490	496	PF00069	0.668
MOD_CK1_1	550	556	PF00069	0.598
MOD_CK1_1	91	97	PF00069	0.391
MOD_CK2_1	27	33	PF00069	0.458
MOD_CK2_1	515	521	PF00069	0.677
MOD_CK2_1	536	542	PF00069	0.585
MOD_CK2_1	55	61	PF00069	0.514
MOD_Cter_Amidation	363	366	PF01082	0.466
MOD_Cter_Amidation	502	505	PF01082	0.587
MOD_GlcNHglycan	168	171	PF01048	0.258
MOD_GlcNHglycan	318	321	PF01048	0.397
MOD_GlcNHglycan	322	325	PF01048	0.334
MOD_GlcNHglycan	518	521	PF01048	0.607
MOD_GlcNHglycan	538	541	PF01048	0.650
MOD_GlcNHglycan	57	60	PF01048	0.474
MOD_GlcNHglycan	90	93	PF01048	0.360
MOD_GSK3_1	100	107	PF00069	0.339
MOD_GSK3_1	189	196	PF00069	0.279
MOD_GSK3_1	23	30	PF00069	0.554
MOD_GSK3_1	316	323	PF00069	0.378
MOD_GSK3_1	344	351	PF00069	0.338
MOD_GSK3_1	385	392	PF00069	0.355
MOD_GSK3_1	532	539	PF00069	0.724
MOD_GSK3_1	550	557	PF00069	0.649
MOD_GSK3_1	65	72	PF00069	0.371
MOD_LATS_1	336	342	PF00433	0.495
MOD_N-GLC_1	14	19	PF02516	0.528
MOD_N-GLC_1	229	234	PF02516	0.374
MOD_N-GLC_1	309	314	PF02516	0.490
MOD_NEK2_1	100	105	PF00069	0.335
MOD_NEK2_1	106	111	PF00069	0.448
MOD_NEK2_1	145	150	PF00069	0.271
MOD_NEK2_1	179	184	PF00069	0.334
MOD_NEK2_1	193	198	PF00069	0.216
MOD_NEK2_1	348	353	PF00069	0.336
MOD_NEK2_1	375	380	PF00069	0.443
MOD_NEK2_1	385	390	PF00069	0.292
MOD_NEK2_1	547	552	PF00069	0.593
MOD_NEK2_1	88	93	PF00069	0.369
MOD_NEK2_2	352	357	PF00069	0.411
MOD_NEK2_2	376	381	PF00069	0.391
MOD_PIKK_1	276	282	PF00454	0.258
MOD_PIKK_1	385	391	PF00454	0.315
MOD_PIKK_1	6	12	PF00454	0.532
MOD_PKA_1	23	29	PF00069	0.551
MOD_Plk_1	14	20	PF00069	0.519
MOD_Plk_1	229	235	PF00069	0.374
MOD_Plk_1	338	344	PF00069	0.426
MOD_Plk_1	40	46	PF00069	0.336
MOD_Plk_1	496	502	PF00069	0.587
MOD_Plk_1	547	553	PF00069	0.591
MOD_Plk_4	100	106	PF00069	0.295
MOD_Plk_4	14	20	PF00069	0.623
MOD_Plk_4	189	195	PF00069	0.279
MOD_Plk_4	258	264	PF00069	0.237
MOD_Plk_4	288	294	PF00069	0.329
MOD_Plk_4	327	333	PF00069	0.489
MOD_Plk_4	344	350	PF00069	0.201
MOD_Plk_4	352	358	PF00069	0.297
MOD_Plk_4	376	382	PF00069	0.418
MOD_Plk_4	496	502	PF00069	0.644
MOD_Plk_4	73	79	PF00069	0.412
MOD_ProDKin_1	128	134	PF00069	0.284
MOD_ProDKin_1	163	169	PF00069	0.265
MOD_ProDKin_1	172	178	PF00069	0.282
MOD_ProDKin_1	401	407	PF00069	0.479
MOD_ProDKin_1	69	75	PF00069	0.452
MOD_SUMO_rev_2	395	401	PF00179	0.470
TRG_ENDOCYTIC_2	102	105	PF00928	0.399
TRG_ENDOCYTIC_2	144	147	PF00928	0.329
TRG_ENDOCYTIC_2	187	190	PF00928	0.258
TRG_ENDOCYTIC_2	353	356	PF00928	0.333
TRG_ENDOCYTIC_2	431	434	PF00928	0.376
TRG_ENDOCYTIC_2	80	83	PF00928	0.362
TRG_ER_diArg_1	332	335	PF00400	0.430
TRG_ER_diArg_1	504	506	PF00400	0.560
TRG_NES_CRM1_1	209	221	PF08389	0.317
TRG_NES_CRM1_1	280	290	PF08389	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV44	Leptomonas seymouri	74%	98%
A0A1X0P6A9	Trypanosomatidae	53%	98%
A0A3R7NUK9	Trypanosoma rangeli	55%	100%
A4HMW3	Leishmania braziliensis	87%	100%
A4IBI4	Leishmania infantum	100%	100%
E9AFC0	Leishmania major	97%	100%
E9B6H5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q3U1T9	Mus musculus	25%	73%
Q6P3S1	Homo sapiens	24%	72%
V5DUS4	Trypanosoma cruzi	53%	100%