Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGD8_LEIDO

TriTrypDb:

LdBPK_364080.1 , LdCL_360047800 , LDHU3_36.5470

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	7
GO:0031974	membrane-enclosed lumen	2	7
GO:0043233	organelle lumen	3	7
GO:0070013	intracellular organelle lumen	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3Q8IGD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGD8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.685
CLV_NRD_NRD_1	25	27	PF00675	0.620
CLV_NRD_NRD_1	298	300	PF00675	0.372
CLV_NRD_NRD_1	46	48	PF00675	0.684
CLV_NRD_NRD_1	89	91	PF00675	0.520
CLV_PCSK_KEX2_1	214	216	PF00082	0.583
CLV_PCSK_KEX2_1	25	27	PF00082	0.620
CLV_PCSK_KEX2_1	46	48	PF00082	0.684
CLV_PCSK_KEX2_1	5	7	PF00082	0.697
CLV_PCSK_KEX2_1	89	91	PF00082	0.520
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.583
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.697
CLV_PCSK_PC7_1	210	216	PF00082	0.422
CLV_PCSK_SKI1_1	285	289	PF00082	0.472
CLV_PCSK_SKI1_1	378	382	PF00082	0.441
DEG_APCC_DBOX_1	214	222	PF00400	0.412
DEG_APCC_DBOX_1	350	358	PF00400	0.467
DEG_Nend_Nbox_1	1	3	PF02207	0.567
DEG_SCF_TRCP1_1	126	132	PF00400	0.587
DOC_CYCLIN_RxL_1	375	383	PF00134	0.437
DOC_MAPK_MEF2A_6	253	260	PF00069	0.377
DOC_PP2B_LxvP_1	112	115	PF13499	0.576
DOC_PP4_FxxP_1	372	375	PF00568	0.488
DOC_USP7_MATH_1	14	18	PF00917	0.653
DOC_USP7_MATH_1	148	152	PF00917	0.651
DOC_USP7_MATH_1	159	163	PF00917	0.750
DOC_USP7_MATH_1	64	68	PF00917	0.494
DOC_WW_Pin1_4	106	111	PF00397	0.663
DOC_WW_Pin1_4	115	120	PF00397	0.574
DOC_WW_Pin1_4	178	183	PF00397	0.638
LIG_14-3-3_CanoR_1	335	341	PF00244	0.429
LIG_14-3-3_CanoR_1	46	55	PF00244	0.605
LIG_14-3-3_CterR_2	390	394	PF00244	0.504
LIG_BRCT_BRCA1_1	338	342	PF00533	0.364
LIG_Clathr_ClatBox_1	373	377	PF01394	0.479
LIG_deltaCOP1_diTrp_1	332	340	PF00928	0.428
LIG_FHA_1	103	109	PF00498	0.569
LIG_FHA_1	147	153	PF00498	0.576
LIG_FHA_1	49	55	PF00498	0.630
LIG_FHA_2	187	193	PF00498	0.567
LIG_FHA_2	238	244	PF00498	0.477
LIG_LIR_Apic_2	369	375	PF02991	0.500
LIG_LIR_Apic_2	91	96	PF02991	0.541
LIG_LIR_Gen_1	319	329	PF02991	0.364
LIG_LIR_Nem_3	243	247	PF02991	0.391
LIG_LIR_Nem_3	339	343	PF02991	0.370
LIG_PTB_Apo_2	315	322	PF02174	0.379
LIG_PTB_Phospho_1	315	321	PF10480	0.377
LIG_Rb_pABgroove_1	315	323	PF01858	0.454
LIG_SH2_CRK	304	308	PF00017	0.382
LIG_SH2_CRK	93	97	PF00017	0.527
LIG_SH2_NCK_1	93	97	PF00017	0.525
LIG_SH2_SRC	343	346	PF00017	0.329
LIG_SH2_STAT5	343	346	PF00017	0.363
LIG_SH2_STAT5	349	352	PF00017	0.397
LIG_SH2_STAT5	93	96	PF00017	0.549
LIG_SH3_1	5	11	PF00018	0.573
LIG_SH3_1	93	99	PF00018	0.527
LIG_SH3_3	18	24	PF00018	0.543
LIG_SH3_3	180	186	PF00018	0.599
LIG_SH3_3	273	279	PF00018	0.392
LIG_SH3_3	5	11	PF00018	0.703
LIG_SH3_3	93	99	PF00018	0.532
LIG_SUMO_SIM_anti_2	38	43	PF11976	0.648
LIG_TRAF2_1	281	284	PF00917	0.398
LIG_TRAF2_1	29	32	PF00917	0.625
LIG_TRAF2_1	50	53	PF00917	0.572
LIG_UBA3_1	76	82	PF00899	0.430
LIG_WRC_WIRS_1	238	243	PF05994	0.486
LIG_WW_3	231	235	PF00397	0.578
MOD_CK1_1	134	140	PF00069	0.630
MOD_CK1_1	150	156	PF00069	0.645
MOD_CK1_1	261	267	PF00069	0.361
MOD_CK2_1	159	165	PF00069	0.677
MOD_CK2_1	181	187	PF00069	0.592
MOD_CK2_1	278	284	PF00069	0.417
MOD_CK2_1	47	53	PF00069	0.619
MOD_CMANNOS	333	336	PF00535	0.345
MOD_Cter_Amidation	44	47	PF01082	0.668
MOD_GlcNHglycan	126	129	PF01048	0.694
MOD_GlcNHglycan	133	136	PF01048	0.800
MOD_GlcNHglycan	16	19	PF01048	0.632
MOD_GlcNHglycan	280	283	PF01048	0.505
MOD_GSK3_1	102	109	PF00069	0.692
MOD_GSK3_1	130	137	PF00069	0.692
MOD_GSK3_1	146	153	PF00069	0.723
MOD_GSK3_1	164	171	PF00069	0.640
MOD_GSK3_1	31	38	PF00069	0.607
MOD_N-GLC_1	129	134	PF02516	0.724
MOD_PIKK_1	150	156	PF00454	0.675
MOD_PIKK_1	159	165	PF00454	0.608
MOD_PIKK_1	181	187	PF00454	0.636
MOD_PIKK_1	56	62	PF00454	0.475
MOD_PK_1	138	144	PF00069	0.690
MOD_PKA_2	103	109	PF00069	0.621
MOD_PKA_2	14	20	PF00069	0.693
MOD_PKA_2	175	181	PF00069	0.680
MOD_PKA_2	45	51	PF00069	0.719
MOD_Plk_1	186	192	PF00069	0.634
MOD_Plk_1	31	37	PF00069	0.624
MOD_Plk_1	56	62	PF00069	0.497
MOD_Plk_4	31	37	PF00069	0.541
MOD_Plk_4	336	342	PF00069	0.355
MOD_ProDKin_1	106	112	PF00069	0.662
MOD_ProDKin_1	115	121	PF00069	0.576
MOD_ProDKin_1	178	184	PF00069	0.636
TRG_DiLeu_BaEn_1	284	289	PF01217	0.385
TRG_DiLeu_BaEn_1	369	374	PF01217	0.498
TRG_DiLeu_BaEn_4	369	375	PF01217	0.500
TRG_ENDOCYTIC_2	321	324	PF00928	0.364
TRG_ENDOCYTIC_2	74	77	PF00928	0.497
TRG_ENDOCYTIC_2	81	84	PF00928	0.473
TRG_ER_diArg_1	215	218	PF00400	0.440
TRG_ER_diArg_1	24	26	PF00400	0.620
TRG_ER_diArg_1	88	90	PF00400	0.516
TRG_Pf-PMV_PEXEL_1	47	52	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBQ8	Leptomonas seymouri	60%	100%
A4HPQ6	Leishmania braziliensis	79%	98%
A4ID07	Leishmania infantum	99%	100%
E9ATH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q126	Leishmania major	91%	100%