Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IGD6_LEIDO

TriTrypDb:

LdBPK_311630.1 , LdCL_310023400 , LDHU3_31.2840

Length:

811

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	15
GO:0042995	cell projection	2	15
GO:0043226	organelle	2	15
GO:0043227	membrane-bounded organelle	3	15
GO:0110165	cellular anatomical entity	1	15
GO:0120025	plasma membrane bounded cell projection	3	15
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	2

Expansion

Sequence features

A0A3Q8IGD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGD6

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006457	protein folding	2	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007021	tubulin complex assembly	6	1
GO:0007023	post-chaperonin tubulin folding pathway	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0043014	alpha-tubulin binding	5	1
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.377
CLV_C14_Caspase3-7	454	458	PF00656	0.489
CLV_NRD_NRD_1	286	288	PF00675	0.352
CLV_NRD_NRD_1	31	33	PF00675	0.683
CLV_NRD_NRD_1	60	62	PF00675	0.675
CLV_NRD_NRD_1	654	656	PF00675	0.451
CLV_NRD_NRD_1	765	767	PF00675	0.355
CLV_PCSK_FUR_1	58	62	PF00082	0.545
CLV_PCSK_KEX2_1	286	288	PF00082	0.329
CLV_PCSK_KEX2_1	31	33	PF00082	0.683
CLV_PCSK_KEX2_1	60	62	PF00082	0.675
CLV_PCSK_KEX2_1	654	656	PF00082	0.363
CLV_PCSK_KEX2_1	787	789	PF00082	0.429
CLV_PCSK_PC1ET2_1	787	789	PF00082	0.366
CLV_PCSK_SKI1_1	196	200	PF00082	0.481
CLV_PCSK_SKI1_1	420	424	PF00082	0.422
CLV_PCSK_SKI1_1	517	521	PF00082	0.273
CLV_PCSK_SKI1_1	551	555	PF00082	0.392
CLV_PCSK_SKI1_1	766	770	PF00082	0.473
CLV_PCSK_SKI1_1	802	806	PF00082	0.499
DEG_APCC_DBOX_1	272	280	PF00400	0.354
DEG_SCF_FBW7_1	658	665	PF00400	0.295
DEG_SPOP_SBC_1	90	94	PF00917	0.452
DOC_CDC14_PxL_1	372	380	PF14671	0.320
DOC_CDC14_PxL_1	510	518	PF14671	0.335
DOC_CYCLIN_RxL_1	417	425	PF00134	0.567
DOC_CYCLIN_RxL_1	512	525	PF00134	0.378
DOC_MAPK_gen_1	34	43	PF00069	0.752
DOC_MAPK_gen_1	512	521	PF00069	0.420
DOC_MAPK_gen_1	766	775	PF00069	0.323
DOC_MAPK_MEF2A_6	36	45	PF00069	0.451
DOC_MAPK_MEF2A_6	512	520	PF00069	0.332
DOC_MAPK_MEF2A_6	741	750	PF00069	0.306
DOC_MAPK_MEF2A_6	766	775	PF00069	0.346
DOC_MAPK_NFAT4_5	766	774	PF00069	0.321
DOC_PP1_RVXF_1	433	440	PF00149	0.329
DOC_PP2B_LxvP_1	109	112	PF13499	0.525
DOC_PP2B_LxvP_1	267	270	PF13499	0.485
DOC_USP7_MATH_1	136	140	PF00917	0.440
DOC_USP7_MATH_1	22	26	PF00917	0.615
DOC_USP7_MATH_1	233	237	PF00917	0.354
DOC_USP7_MATH_1	30	34	PF00917	0.594
DOC_USP7_MATH_1	51	55	PF00917	0.528
DOC_USP7_MATH_1	662	666	PF00917	0.427
DOC_USP7_MATH_1	671	675	PF00917	0.328
DOC_USP7_MATH_1	730	734	PF00917	0.382
DOC_USP7_MATH_1	90	94	PF00917	0.642
DOC_USP7_MATH_2	177	183	PF00917	0.399
DOC_USP7_UBL2_3	192	196	PF12436	0.336
DOC_USP7_UBL2_3	770	774	PF12436	0.498
DOC_WW_Pin1_4	171	176	PF00397	0.483
DOC_WW_Pin1_4	24	29	PF00397	0.608
DOC_WW_Pin1_4	620	625	PF00397	0.321
DOC_WW_Pin1_4	658	663	PF00397	0.287
DOC_WW_Pin1_4	98	103	PF00397	0.528
LIG_14-3-3_CanoR_1	149	155	PF00244	0.622
LIG_14-3-3_CanoR_1	273	282	PF00244	0.452
LIG_14-3-3_CanoR_1	36	43	PF00244	0.554
LIG_14-3-3_CanoR_1	420	425	PF00244	0.504
LIG_14-3-3_CanoR_1	466	471	PF00244	0.387
LIG_14-3-3_CanoR_1	479	484	PF00244	0.405
LIG_14-3-3_CanoR_1	638	642	PF00244	0.411
LIG_14-3-3_CanoR_1	667	675	PF00244	0.510
LIG_14-3-3_CanoR_1	700	705	PF00244	0.320
LIG_14-3-3_CanoR_1	89	97	PF00244	0.522
LIG_Actin_WH2_2	202	219	PF00022	0.364
LIG_Actin_WH2_2	67	85	PF00022	0.451
LIG_Actin_WH2_2	686	702	PF00022	0.318
LIG_BIR_II_1	1	5	PF00653	0.507
LIG_BIR_III_2	50	54	PF00653	0.486
LIG_BRCT_BRCA1_1	551	555	PF00533	0.368
LIG_BRCT_BRCA1_1	702	706	PF00533	0.369
LIG_Clathr_ClatBox_1	421	425	PF01394	0.314
LIG_Clathr_ClatBox_1	736	740	PF01394	0.322
LIG_FHA_1	104	110	PF00498	0.726
LIG_FHA_1	142	148	PF00498	0.690
LIG_FHA_1	197	203	PF00498	0.426
LIG_FHA_1	213	219	PF00498	0.367
LIG_FHA_1	446	452	PF00498	0.461
LIG_FHA_1	92	98	PF00498	0.591
LIG_FHA_2	174	180	PF00498	0.466
LIG_FHA_2	377	383	PF00498	0.520
LIG_FHA_2	452	458	PF00498	0.513
LIG_FHA_2	467	473	PF00498	0.300
LIG_FHA_2	567	573	PF00498	0.333
LIG_FHA_2	681	687	PF00498	0.363
LIG_Integrin_isoDGR_2	264	266	PF01839	0.496
LIG_LIR_Gen_1	399	410	PF02991	0.424
LIG_LIR_Gen_1	44	53	PF02991	0.637
LIG_LIR_Gen_1	542	553	PF02991	0.377
LIG_LIR_Gen_1	703	712	PF02991	0.396
LIG_LIR_Gen_1	751	759	PF02991	0.329
LIG_LIR_Gen_1	777	786	PF02991	0.351
LIG_LIR_Nem_3	399	405	PF02991	0.424
LIG_LIR_Nem_3	44	48	PF02991	0.636
LIG_LIR_Nem_3	462	467	PF02991	0.427
LIG_LIR_Nem_3	542	548	PF02991	0.350
LIG_LIR_Nem_3	552	557	PF02991	0.301
LIG_LIR_Nem_3	687	693	PF02991	0.390
LIG_LIR_Nem_3	703	709	PF02991	0.308
LIG_LIR_Nem_3	751	755	PF02991	0.562
LIG_LIR_Nem_3	777	783	PF02991	0.420
LIG_LRP6_Inhibitor_1	429	435	PF00058	0.308
LIG_MLH1_MIPbox_1	551	555	PF16413	0.368
LIG_NRBOX	153	159	PF00104	0.439
LIG_NRBOX	417	423	PF00104	0.328
LIG_NRBOX	515	521	PF00104	0.278
LIG_PCNA_yPIPBox_3	149	158	PF02747	0.454
LIG_Rb_LxCxE_1	156	176	PF01857	0.361
LIG_SH2_CRK	752	756	PF00017	0.352
LIG_SH2_GRB2like	402	405	PF00017	0.307
LIG_SH2_NCK_1	210	214	PF00017	0.309
LIG_SH2_NCK_1	780	784	PF00017	0.355
LIG_SH2_SRC	780	783	PF00017	0.353
LIG_SH2_STAP1	210	214	PF00017	0.412
LIG_SH2_STAP1	780	784	PF00017	0.355
LIG_SH2_STAT5	377	380	PF00017	0.343
LIG_SH2_STAT5	402	405	PF00017	0.307
LIG_SH2_STAT5	752	755	PF00017	0.343
LIG_SH2_STAT5	785	788	PF00017	0.425
LIG_SH3_3	172	178	PF00018	0.424
LIG_SUMO_SIM_anti_2	528	533	PF11976	0.506
LIG_SUMO_SIM_anti_2	7	14	PF11976	0.503
LIG_SUMO_SIM_anti_2	806	811	PF11976	0.479
LIG_SUMO_SIM_par_1	419	425	PF11976	0.559
LIG_SUMO_SIM_par_1	447	454	PF11976	0.509
LIG_SUMO_SIM_par_1	517	522	PF11976	0.294
LIG_TRAF2_1	608	611	PF00917	0.336
LIG_TYR_ITIM	400	405	PF00017	0.312
LIG_TYR_ITIM	750	755	PF00017	0.329
LIG_TYR_ITIM	778	783	PF00017	0.325
LIG_UBA3_1	400	407	PF00899	0.320
LIG_UBA3_1	518	523	PF00899	0.376
LIG_UBA3_1	768	774	PF00899	0.331
LIG_WRC_WIRS_1	205	210	PF05994	0.343
MOD_CDK_SPxxK_3	24	31	PF00069	0.603
MOD_CK1_1	171	177	PF00069	0.452
MOD_CK1_1	2	8	PF00069	0.590
MOD_CK1_1	212	218	PF00069	0.479
MOD_CK1_1	445	451	PF00069	0.498
MOD_CK1_1	561	567	PF00069	0.335
MOD_CK1_1	593	599	PF00069	0.409
MOD_CK1_1	640	646	PF00069	0.350
MOD_CK1_1	665	671	PF00069	0.517
MOD_CK1_1	85	91	PF00069	0.725
MOD_CK2_1	150	156	PF00069	0.509
MOD_CK2_1	173	179	PF00069	0.537
MOD_CK2_1	233	239	PF00069	0.341
MOD_CK2_1	479	485	PF00069	0.438
MOD_CK2_1	605	611	PF00069	0.481
MOD_CK2_1	716	722	PF00069	0.347
MOD_Cter_Amidation	58	61	PF01082	0.548
MOD_GlcNHglycan	103	106	PF01048	0.628
MOD_GlcNHglycan	133	136	PF01048	0.478
MOD_GlcNHglycan	138	141	PF01048	0.497
MOD_GlcNHglycan	170	173	PF01048	0.466
MOD_GlcNHglycan	211	214	PF01048	0.303
MOD_GlcNHglycan	313	316	PF01048	0.335
MOD_GlcNHglycan	457	460	PF01048	0.503
MOD_GlcNHglycan	550	554	PF01048	0.383
MOD_GlcNHglycan	560	563	PF01048	0.290
MOD_GlcNHglycan	669	672	PF01048	0.492
MOD_GlcNHglycan	756	759	PF01048	0.336
MOD_GlcNHglycan	84	87	PF01048	0.662
MOD_GSK3_1	136	143	PF00069	0.640
MOD_GSK3_1	204	211	PF00069	0.420
MOD_GSK3_1	274	281	PF00069	0.487
MOD_GSK3_1	30	37	PF00069	0.803
MOD_GSK3_1	307	314	PF00069	0.367
MOD_GSK3_1	382	389	PF00069	0.484
MOD_GSK3_1	405	412	PF00069	0.419
MOD_GSK3_1	416	423	PF00069	0.398
MOD_GSK3_1	447	454	PF00069	0.432
MOD_GSK3_1	471	478	PF00069	0.359
MOD_GSK3_1	521	528	PF00069	0.330
MOD_GSK3_1	589	596	PF00069	0.381
MOD_GSK3_1	620	627	PF00069	0.558
MOD_GSK3_1	636	643	PF00069	0.359
MOD_GSK3_1	658	665	PF00069	0.439
MOD_GSK3_1	667	674	PF00069	0.398
MOD_GSK3_1	700	707	PF00069	0.301
MOD_GSK3_1	725	732	PF00069	0.469
MOD_GSK3_1	750	757	PF00069	0.382
MOD_GSK3_1	85	92	PF00069	0.429
MOD_LATS_1	477	483	PF00433	0.264
MOD_N-GLC_1	150	155	PF02516	0.415
MOD_N-GLC_1	168	173	PF02516	0.336
MOD_N-GLC_1	244	249	PF02516	0.314
MOD_N-GLC_1	678	683	PF02516	0.424
MOD_N-GLC_1	748	753	PF02516	0.457
MOD_NEK2_1	103	108	PF00069	0.653
MOD_NEK2_1	150	155	PF00069	0.570
MOD_NEK2_1	208	213	PF00069	0.350
MOD_NEK2_1	288	293	PF00069	0.431
MOD_NEK2_1	307	312	PF00069	0.293
MOD_NEK2_1	335	340	PF00069	0.322
MOD_NEK2_1	381	386	PF00069	0.439
MOD_NEK2_1	394	399	PF00069	0.430
MOD_NEK2_1	405	410	PF00069	0.355
MOD_NEK2_1	41	46	PF00069	0.607
MOD_NEK2_1	440	445	PF00069	0.433
MOD_NEK2_1	451	456	PF00069	0.383
MOD_NEK2_1	475	480	PF00069	0.493
MOD_NEK2_1	497	502	PF00069	0.474
MOD_NEK2_1	519	524	PF00069	0.452
MOD_NEK2_1	555	560	PF00069	0.368
MOD_NEK2_1	614	619	PF00069	0.473
MOD_NEK2_1	626	631	PF00069	0.471
MOD_NEK2_1	636	641	PF00069	0.405
MOD_NEK2_1	678	683	PF00069	0.339
MOD_NEK2_1	704	709	PF00069	0.431
MOD_NEK2_1	748	753	PF00069	0.346
MOD_NEK2_1	82	87	PF00069	0.675
MOD_NEK2_2	244	249	PF00069	0.311
MOD_NEK2_2	637	642	PF00069	0.509
MOD_NEK2_2	662	667	PF00069	0.406
MOD_NEK2_2	671	676	PF00069	0.278
MOD_PIKK_1	113	119	PF00454	0.506
MOD_PIKK_1	394	400	PF00454	0.327
MOD_PIKK_1	707	713	PF00454	0.304
MOD_PK_1	479	485	PF00069	0.271
MOD_PKA_2	30	36	PF00069	0.690
MOD_PKA_2	340	346	PF00069	0.346
MOD_PKA_2	478	484	PF00069	0.389
MOD_PKA_2	637	643	PF00069	0.524
MOD_PKA_2	760	766	PF00069	0.482
MOD_PKA_2	82	88	PF00069	0.500
MOD_PKB_1	32	40	PF00069	0.546
MOD_Plk_1	150	156	PF00069	0.684
MOD_Plk_1	244	250	PF00069	0.339
MOD_Plk_1	435	441	PF00069	0.334
MOD_Plk_1	471	477	PF00069	0.485
MOD_Plk_1	549	555	PF00069	0.391
MOD_Plk_1	564	570	PF00069	0.263
MOD_Plk_1	748	754	PF00069	0.448
MOD_Plk_1	805	811	PF00069	0.482
MOD_Plk_2-3	525	531	PF00069	0.323
MOD_Plk_2-3	605	611	PF00069	0.348
MOD_Plk_4	204	210	PF00069	0.431
MOD_Plk_4	249	255	PF00069	0.502
MOD_Plk_4	383	389	PF00069	0.357
MOD_Plk_4	396	402	PF00069	0.366
MOD_Plk_4	435	441	PF00069	0.349
MOD_Plk_4	451	457	PF00069	0.342
MOD_Plk_4	497	503	PF00069	0.401
MOD_Plk_4	805	811	PF00069	0.497
MOD_ProDKin_1	171	177	PF00069	0.482
MOD_ProDKin_1	24	30	PF00069	0.607
MOD_ProDKin_1	620	626	PF00069	0.319
MOD_ProDKin_1	658	664	PF00069	0.293
MOD_ProDKin_1	98	104	PF00069	0.526
MOD_SUMO_for_1	533	536	PF00179	0.307
MOD_SUMO_rev_2	536	546	PF00179	0.336
TRG_DiLeu_BaEn_2	203	209	PF01217	0.345
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.327
TRG_DiLeu_BaLyEn_6	583	588	PF01217	0.396
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.329
TRG_ENDOCYTIC_2	402	405	PF00928	0.307
TRG_ENDOCYTIC_2	752	755	PF00928	0.343
TRG_ENDOCYTIC_2	780	783	PF00928	0.521
TRG_ER_diArg_1	107	110	PF00400	0.528
TRG_ER_diArg_1	285	287	PF00400	0.333
TRG_ER_diArg_1	31	34	PF00400	0.566
TRG_ER_diArg_1	339	342	PF00400	0.353
TRG_ER_diArg_1	58	61	PF00400	0.679
TRG_ER_diArg_1	653	655	PF00400	0.450
TRG_LysEnd_GGAAcLL_1	806	811	PF00790	0.479
TRG_NES_CRM1_1	413	425	PF08389	0.316
TRG_NES_CRM1_1	511	525	PF08389	0.314
TRG_Pf-PMV_PEXEL_1	420	425	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	607	611	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P1M5	Trypanosomatidae	26%	92%
A0A3S5ISR4	Trypanosoma rangeli	26%	97%
A0A451EJK8	Leishmania donovani	25%	76%
A4H3R1	Leishmania braziliensis	23%	100%
A4I6T8	Leishmania infantum	100%	100%
D0A4F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	96%
E9AG21	Leishmania infantum	25%	80%
E9AIU4	Leishmania braziliensis	77%	100%
E9AJN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	83%
E9B1W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q6A2	Leishmania major	94%	100%
Q4QJ80	Leishmania major	24%	100%
V5BKI3	Trypanosoma cruzi	26%	97%