Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGD4_LEIDO

TriTrypDb:

LdBPK_271490.1 , LdCL_270021500 , LDHU3_27.2230

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGD4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.388
CLV_C14_Caspase3-7	263	267	PF00656	0.513
CLV_NRD_NRD_1	107	109	PF00675	0.466
CLV_NRD_NRD_1	11	13	PF00675	0.449
CLV_NRD_NRD_1	163	165	PF00675	0.697
CLV_NRD_NRD_1	200	202	PF00675	0.456
CLV_NRD_NRD_1	3	5	PF00675	0.554
CLV_NRD_NRD_1	353	355	PF00675	0.379
CLV_NRD_NRD_1	431	433	PF00675	0.548
CLV_PCSK_FUR_1	105	109	PF00082	0.415
CLV_PCSK_KEX2_1	107	109	PF00082	0.466
CLV_PCSK_KEX2_1	11	13	PF00082	0.449
CLV_PCSK_KEX2_1	163	165	PF00082	0.662
CLV_PCSK_KEX2_1	200	202	PF00082	0.456
CLV_PCSK_KEX2_1	3	5	PF00082	0.554
CLV_PCSK_KEX2_1	352	354	PF00082	0.387
CLV_PCSK_KEX2_1	431	433	PF00082	0.548
CLV_PCSK_SKI1_1	108	112	PF00082	0.573
CLV_PCSK_SKI1_1	121	125	PF00082	0.372
CLV_PCSK_SKI1_1	133	137	PF00082	0.349
CLV_PCSK_SKI1_1	139	143	PF00082	0.282
CLV_PCSK_SKI1_1	200	204	PF00082	0.332
DEG_APCC_DBOX_1	95	103	PF00400	0.428
DEG_Nend_Nbox_1	1	3	PF02207	0.674
DOC_CDC14_PxL_1	265	273	PF14671	0.513
DOC_CYCLIN_RxL_1	195	209	PF00134	0.453
DOC_MAPK_gen_1	200	207	PF00069	0.439
DOC_MAPK_gen_1	3	9	PF00069	0.604
DOC_MAPK_MEF2A_6	200	207	PF00069	0.345
DOC_MAPK_NFAT4_5	200	208	PF00069	0.349
DOC_PP1_RVXF_1	119	125	PF00149	0.509
DOC_PP4_FxxP_1	272	275	PF00568	0.676
DOC_USP7_MATH_1	334	338	PF00917	0.447
DOC_WW_Pin1_4	17	22	PF00397	0.509
DOC_WW_Pin1_4	330	335	PF00397	0.472
DOC_WW_Pin1_4	422	427	PF00397	0.500
LIG_14-3-3_CanoR_1	152	157	PF00244	0.404
LIG_14-3-3_CanoR_1	218	227	PF00244	0.586
LIG_14-3-3_CanoR_1	353	359	PF00244	0.433
LIG_14-3-3_CanoR_1	77	85	PF00244	0.470
LIG_Actin_WH2_2	378	396	PF00022	0.374
LIG_AP2alpha_1	149	153	PF02296	0.334
LIG_APCC_ABBA_1	63	68	PF00400	0.399
LIG_BIR_III_2	266	270	PF00653	0.546
LIG_BIR_III_2	289	293	PF00653	0.634
LIG_BIR_III_2	317	321	PF00653	0.424
LIG_BRCT_BRCA1_1	136	140	PF00533	0.509
LIG_CaM_IQ_9	150	166	PF13499	0.519
LIG_CSL_BTD_1	18	21	PF09270	0.512
LIG_CtBP_PxDLS_1	421	425	PF00389	0.545
LIG_FHA_1	130	136	PF00498	0.436
LIG_FHA_1	256	262	PF00498	0.542
LIG_FHA_1	29	35	PF00498	0.514
LIG_FHA_2	129	135	PF00498	0.421
LIG_FHA_2	230	236	PF00498	0.535
LIG_FHA_2	33	39	PF00498	0.548
LIG_FHA_2	369	375	PF00498	0.428
LIG_FHA_2	396	402	PF00498	0.401
LIG_FHA_2	425	431	PF00498	0.561
LIG_GBD_Chelix_1	260	268	PF00786	0.554
LIG_HCF-1_HBM_1	173	176	PF13415	0.427
LIG_LIR_Gen_1	151	161	PF02991	0.368
LIG_LIR_Gen_1	365	375	PF02991	0.399
LIG_LIR_Nem_3	151	156	PF02991	0.353
LIG_LIR_Nem_3	173	179	PF02991	0.441
LIG_LIR_Nem_3	196	202	PF02991	0.374
LIG_LIR_Nem_3	365	370	PF02991	0.512
LIG_LIR_Nem_3	387	393	PF02991	0.382
LIG_MYND_1	269	273	PF01753	0.622
LIG_Pex14_2	149	153	PF04695	0.334
LIG_REV1ctd_RIR_1	154	164	PF16727	0.429
LIG_REV1ctd_RIR_1	388	398	PF16727	0.371
LIG_SH2_NCK_1	87	91	PF00017	0.423
LIG_SH2_STAP1	55	59	PF00017	0.421
LIG_SH2_STAT5	176	179	PF00017	0.371
LIG_SH2_STAT5	325	328	PF00017	0.385
LIG_SH3_2	426	431	PF14604	0.500
LIG_SH3_3	267	273	PF00018	0.612
LIG_SH3_3	423	429	PF00018	0.475
LIG_SH3_3	43	49	PF00018	0.429
LIG_TRAF2_1	35	38	PF00917	0.436
LIG_TYR_ITIM	85	90	PF00017	0.398
LIG_WRC_WIRS_1	153	158	PF05994	0.407
MOD_CK1_1	412	418	PF00069	0.604
MOD_CK1_1	80	86	PF00069	0.472
MOD_CK2_1	111	117	PF00069	0.615
MOD_CK2_1	128	134	PF00069	0.363
MOD_CK2_1	175	181	PF00069	0.341
MOD_CK2_1	229	235	PF00069	0.508
MOD_CK2_1	32	38	PF00069	0.443
MOD_CK2_1	368	374	PF00069	0.464
MOD_CK2_1	395	401	PF00069	0.398
MOD_CK2_1	424	430	PF00069	0.634
MOD_CK2_1	85	91	PF00069	0.398
MOD_GlcNHglycan	113	116	PF01048	0.541
MOD_GlcNHglycan	136	139	PF01048	0.425
MOD_GlcNHglycan	25	28	PF01048	0.565
MOD_GlcNHglycan	255	258	PF01048	0.587
MOD_GlcNHglycan	412	415	PF01048	0.624
MOD_GlcNHglycan	81	85	PF01048	0.433
MOD_GSK3_1	17	24	PF00069	0.498
MOD_GSK3_1	28	35	PF00069	0.476
MOD_GSK3_1	330	337	PF00069	0.413
MOD_GSK3_1	69	76	PF00069	0.496
MOD_N-GLC_1	21	26	PF02516	0.618
MOD_NEK2_1	111	116	PF00069	0.628
MOD_NEK2_1	69	74	PF00069	0.474
MOD_PKA_2	219	225	PF00069	0.523
MOD_PKA_2	229	235	PF00069	0.555
MOD_PKA_2	407	413	PF00069	0.463
MOD_PKB_1	352	360	PF00069	0.428
MOD_PKB_1	75	83	PF00069	0.538
MOD_Plk_1	338	344	PF00069	0.432
MOD_Plk_1	80	86	PF00069	0.465
MOD_Plk_2-3	206	212	PF00069	0.386
MOD_Plk_4	152	158	PF00069	0.410
MOD_ProDKin_1	17	23	PF00069	0.511
MOD_ProDKin_1	330	336	PF00069	0.468
MOD_ProDKin_1	422	428	PF00069	0.497
MOD_SUMO_rev_2	129	138	PF00179	0.518
TRG_AP2beta_CARGO_1	151	160	PF09066	0.422
TRG_DiLeu_BaEn_1	401	406	PF01217	0.437
TRG_ENDOCYTIC_2	176	179	PF00928	0.443
TRG_ENDOCYTIC_2	199	202	PF00928	0.348
TRG_ENDOCYTIC_2	367	370	PF00928	0.394
TRG_ENDOCYTIC_2	44	47	PF00928	0.418
TRG_ENDOCYTIC_2	87	90	PF00928	0.402
TRG_ER_diArg_1	146	149	PF00400	0.437
TRG_ER_diArg_1	199	201	PF00400	0.435
TRG_ER_diArg_1	2	4	PF00400	0.578
TRG_ER_diArg_1	217	220	PF00400	0.322
TRG_ER_diArg_1	352	354	PF00400	0.387
TRG_ER_diArg_1	431	433	PF00400	0.548
TRG_ER_diArg_1	75	78	PF00400	0.520
TRG_NES_CRM1_1	384	397	PF08389	0.376
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	201	206	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE13	Leptomonas seymouri	62%	89%
A0A1X0P4A4	Trypanosomatidae	48%	91%
A0A381ML35	Leishmania infantum	100%	100%
A0A3Q8IQ02	Leishmania donovani	100%	100%
A0A3R7LRX2	Trypanosoma rangeli	52%	97%
A4HFT4	Leishmania braziliensis	84%	100%
D0A626	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
E9ADD6	Leishmania major	97%	100%
E9AZ61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%