Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGD2_LEIDO

TriTrypDb:

LdBPK_330060.1 , LdCL_330005500 , LDHU3_33.0070

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	9
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	9

Expansion

Sequence features

A0A3Q8IGD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.766
CLV_NRD_NRD_1	181	183	PF00675	0.540
CLV_NRD_NRD_1	404	406	PF00675	0.373
CLV_PCSK_KEX2_1	404	406	PF00082	0.370
CLV_PCSK_SKI1_1	141	145	PF00082	0.418
CLV_PCSK_SKI1_1	246	250	PF00082	0.273
CLV_PCSK_SKI1_1	310	314	PF00082	0.438
CLV_PCSK_SKI1_1	405	409	PF00082	0.367
DEG_APCC_DBOX_1	404	412	PF00400	0.471
DEG_SPOP_SBC_1	411	415	PF00917	0.532
DOC_MAPK_gen_1	101	109	PF00069	0.452
DOC_MAPK_gen_1	404	410	PF00069	0.358
DOC_PP1_RVXF_1	341	348	PF00149	0.414
DOC_PP4_FxxP_1	96	99	PF00568	0.493
DOC_USP7_MATH_1	164	168	PF00917	0.525
DOC_USP7_MATH_1	322	326	PF00917	0.402
DOC_USP7_MATH_1	377	381	PF00917	0.466
DOC_USP7_MATH_1	418	422	PF00917	0.360
DOC_WW_Pin1_4	154	159	PF00397	0.443
DOC_WW_Pin1_4	238	243	PF00397	0.471
DOC_WW_Pin1_4	272	277	PF00397	0.423
LIG_14-3-3_CanoR_1	182	187	PF00244	0.478
LIG_14-3-3_CanoR_1	232	242	PF00244	0.519
LIG_14-3-3_CanoR_1	355	359	PF00244	0.512
LIG_14-3-3_CanoR_1	390	397	PF00244	0.468
LIG_14-3-3_CanoR_1	405	411	PF00244	0.324
LIG_CSL_BTD_1	197	200	PF09270	0.354
LIG_CSL_BTD_1	239	242	PF09270	0.484
LIG_FHA_1	146	152	PF00498	0.458
LIG_FHA_1	253	259	PF00498	0.536
LIG_FHA_1	298	304	PF00498	0.350
LIG_FHA_1	355	361	PF00498	0.438
LIG_FHA_1	411	417	PF00498	0.476
LIG_FHA_2	183	189	PF00498	0.492
LIG_FHA_2	311	317	PF00498	0.484
LIG_FHA_2	418	424	PF00498	0.347
LIG_LIR_Apic_2	95	99	PF02991	0.531
LIG_LIR_Gen_1	19	30	PF02991	0.530
LIG_LIR_Gen_1	313	323	PF02991	0.544
LIG_LIR_Gen_1	90	100	PF02991	0.543
LIG_LIR_Nem_3	188	193	PF02991	0.500
LIG_LIR_Nem_3	19	25	PF02991	0.542
LIG_LIR_Nem_3	27	33	PF02991	0.535
LIG_LIR_Nem_3	313	318	PF02991	0.481
LIG_LIR_Nem_3	425	431	PF02991	0.372
LIG_LIR_Nem_3	90	96	PF02991	0.548
LIG_Pex14_2	431	435	PF04695	0.587
LIG_RPA_C_Fungi	399	411	PF08784	0.471
LIG_SH2_CRK	3	7	PF00017	0.704
LIG_SH2_STAT5	127	130	PF00017	0.404
LIG_SH2_STAT5	227	230	PF00017	0.303
LIG_SH3_3	255	261	PF00018	0.331
LIG_SUMO_SIM_anti_2	148	155	PF11976	0.333
LIG_SUMO_SIM_anti_2	330	337	PF11976	0.496
LIG_SUMO_SIM_anti_2	395	401	PF11976	0.481
LIG_SUMO_SIM_par_1	148	155	PF11976	0.411
LIG_SUMO_SIM_par_1	302	308	PF11976	0.343
LIG_SUMO_SIM_par_1	330	337	PF11976	0.463
LIG_SUMO_SIM_par_1	406	415	PF11976	0.403
LIG_TRAF2_1	392	395	PF00917	0.530
LIG_WRC_WIRS_1	153	158	PF05994	0.430
LIG_WRC_WIRS_1	93	98	PF05994	0.498
MOD_CDK_SPxxK_3	238	245	PF00069	0.350
MOD_CK1_1	152	158	PF00069	0.430
MOD_CK1_1	167	173	PF00069	0.268
MOD_CK1_1	176	182	PF00069	0.371
MOD_CK1_1	252	258	PF00069	0.423
MOD_CK1_1	275	281	PF00069	0.386
MOD_CK1_1	305	311	PF00069	0.423
MOD_CK1_1	409	415	PF00069	0.479
MOD_CK2_1	310	316	PF00069	0.405
MOD_CK2_1	389	395	PF00069	0.489
MOD_GlcNHglycan	164	167	PF01048	0.333
MOD_GlcNHglycan	277	280	PF01048	0.467
MOD_GlcNHglycan	307	310	PF01048	0.423
MOD_GlcNHglycan	351	355	PF01048	0.405
MOD_GlcNHglycan	391	394	PF01048	0.553
MOD_GSK3_1	145	152	PF00069	0.335
MOD_GSK3_1	164	171	PF00069	0.168
MOD_GSK3_1	216	223	PF00069	0.420
MOD_GSK3_1	248	255	PF00069	0.413
MOD_GSK3_1	268	275	PF00069	0.440
MOD_GSK3_1	350	357	PF00069	0.460
MOD_GSK3_1	406	413	PF00069	0.431
MOD_GSK3_1	418	425	PF00069	0.333
MOD_N-GLC_1	328	333	PF02516	0.452
MOD_NEK2_1	168	173	PF00069	0.345
MOD_NEK2_1	216	221	PF00069	0.413
MOD_NEK2_1	334	339	PF00069	0.306
MOD_NEK2_1	406	411	PF00069	0.371
MOD_NEK2_1	431	436	PF00069	0.543
MOD_PKA_1	182	188	PF00069	0.518
MOD_PKA_2	354	360	PF00069	0.506
MOD_PKA_2	389	395	PF00069	0.482
MOD_Plk_1	168	174	PF00069	0.398
MOD_Plk_1	328	334	PF00069	0.470
MOD_Plk_4	149	155	PF00069	0.369
MOD_Plk_4	192	198	PF00069	0.349
MOD_Plk_4	199	205	PF00069	0.356
MOD_Plk_4	220	226	PF00069	0.468
MOD_Plk_4	329	335	PF00069	0.488
MOD_Plk_4	360	366	PF00069	0.358
MOD_Plk_4	406	412	PF00069	0.420
MOD_Plk_4	92	98	PF00069	0.512
MOD_ProDKin_1	154	160	PF00069	0.292
MOD_ProDKin_1	238	244	PF00069	0.332
MOD_ProDKin_1	272	278	PF00069	0.422
MOD_SUMO_rev_2	176	185	PF00179	0.493
MOD_SUMO_rev_2	241	247	PF00179	0.350
MOD_SUMO_rev_2	380	384	PF00179	0.286
TRG_DiLeu_BaEn_1	192	197	PF01217	0.352
TRG_DiLeu_BaEn_1	330	335	PF01217	0.447
TRG_DiLeu_BaEn_1	395	400	PF01217	0.416
TRG_DiLeu_BaEn_4	124	130	PF01217	0.505
TRG_DiLeu_BaEn_4	65	71	PF01217	0.744
TRG_ENDOCYTIC_2	190	193	PF00928	0.507
TRG_ER_diArg_1	404	406	PF00400	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN2	Leptomonas seymouri	24%	84%
A0A0N1PC28	Leptomonas seymouri	75%	100%
A0A0S4JA64	Bodo saltans	25%	74%
A0A0S4JE21	Bodo saltans	25%	100%
A0A0S4JL38	Bodo saltans	30%	81%
A0A0S4JPK4	Bodo saltans	26%	73%
A0A0S4JQ88	Bodo saltans	49%	100%
A0A0S4JQ93	Bodo saltans	24%	79%
A0A0S4JRK0	Bodo saltans	23%	76%
A0A0S4KJ87	Bodo saltans	23%	73%
A0A1X0NVZ7	Trypanosomatidae	22%	84%
A0A1X0P016	Trypanosomatidae	22%	72%
A0A1X0P1V8	Trypanosomatidae	24%	94%
A0A1X0P2J6	Trypanosomatidae	37%	78%
A0A3Q8IGC4	Leishmania donovani	24%	100%
A0A3R7KUH0	Trypanosoma rangeli	24%	100%
A0A3R7N6M9	Trypanosoma rangeli	23%	84%
A0A3S5ISA7	Trypanosoma rangeli	55%	99%
A0A3S7WR72	Leishmania donovani	25%	100%
A0CH87	Paramecium tetraurelia	22%	100%
A0DB19	Paramecium tetraurelia	22%	100%
A1L271	Danio rerio	24%	100%
A2RRU3	Rattus norvegicus	22%	83%
A4H666	Leishmania braziliensis	25%	100%
A4HDT7	Leishmania braziliensis	24%	84%
A4HL42	Leishmania braziliensis	79%	100%
A4HUJ0	Leishmania infantum	25%	100%
A4I135	Leishmania infantum	24%	100%
A4I8M2	Leishmania infantum	100%	100%
A7RWD2	Nematostella vectensis	25%	100%
A7S338	Nematostella vectensis	21%	100%
A8NEG8	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	25%	100%
A8X8C6	Caenorhabditis briggsae	22%	100%
A8XZJ9	Caenorhabditis briggsae	20%	100%
B0LSW3	Felis catus	22%	100%
B0XAF3	Culex quinquefasciatus	23%	100%
B3MC74	Drosophila ananassae	25%	100%
B3MJV8	Drosophila ananassae	24%	100%
B3NQR5	Drosophila erecta	24%	100%
B3P4F8	Drosophila erecta	24%	88%
B3S4I5	Trichoplax adhaerens	24%	100%
B4GDM7	Drosophila persimilis	25%	100%
B4HRQ6	Drosophila sechellia	25%	100%
B4JW81	Drosophila grimshawi	25%	100%
B4KKN1	Drosophila mojavensis	24%	100%
B4KTK4	Drosophila mojavensis	24%	100%
B4LJT7	Drosophila virilis	24%	100%
B4LS78	Drosophila virilis	22%	100%
B4MY77	Drosophila willistoni	24%	100%
B4P7Q3	Drosophila yakuba	25%	100%
B4QFZ8	Drosophila simulans	25%	100%
B4QTL6	Drosophila simulans	24%	88%
B5X3C4	Salmo salar	21%	100%
B5X3Z6	Salmo salar	22%	100%
B5X9P2	Salmo salar	24%	100%
B6Q4Z5	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	22%	66%
B7PS00	Ixodes scapularis	23%	100%
B7QKS1	Ixodes scapularis	24%	100%
C3XVT5	Branchiostoma floridae	22%	100%
C4Q0P6	Schistosoma mansoni	23%	100%
C4YFX2	Candida albicans (strain WO-1)	23%	85%
C9ZPU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	85%
C9ZW72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	71%
D0A054	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	74%
D3BUN1	Polysphondylium pallidum (strain ATCC 26659 / Pp 5 / PN500)	23%	100%
D3ZW91	Rattus norvegicus	23%	91%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	84%
E9B3I3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
F1LTR1	Rattus norvegicus	27%	85%
G0SC29	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	24%	84%
O13982	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
O14301	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	73%
O14775	Homo sapiens	25%	100%
O43172	Homo sapiens	23%	84%
O43660	Homo sapiens	21%	85%
O45040	Homarus americanus	23%	100%
O54929	Mus musculus	24%	100%
O74855	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	87%
O75083	Homo sapiens	24%	72%
O76071	Homo sapiens	24%	100%
O76734	Dictyostelium discoideum	21%	75%
O80990	Arabidopsis thaliana	23%	100%
O88342	Mus musculus	23%	72%
O93277	Gallus gallus	23%	72%
P0CS42	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	23%	100%
P0CS43	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	23%	100%
P0CY34	Candida albicans (strain SC5314 / ATCC MYA-2876)	23%	85%
P11017	Bos taurus	24%	100%
P16520	Homo sapiens	25%	100%
P17343	Caenorhabditis elegans	25%	100%
P23232	Loligo forbesii	25%	100%
P25382	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	20%	85%
P35184	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P43033	Bos taurus	22%	100%
P43034	Homo sapiens	22%	100%
P52287	Rattus norvegicus	25%	100%
P54313	Rattus norvegicus	24%	100%
P61964	Homo sapiens	26%	100%
P61965	Mus musculus	26%	100%
P62879	Homo sapiens	24%	100%
P62880	Mus musculus	24%	100%
P62881	Mus musculus	24%	100%
P62882	Rattus norvegicus	24%	100%
P63004	Rattus norvegicus	22%	100%
P63005	Mus musculus	22%	100%
P73594	Synechocystis sp. (strain PCC 6803 / Kazusa)	25%	100%
P78706	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	72%
P79147	Canis lupus familiaris	24%	100%
P87053	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	72%
Q05048	Homo sapiens	22%	100%
Q09715	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	71%
Q0P593	Bos taurus	26%	100%
Q0V8J1	Bos taurus	24%	100%
Q13685	Homo sapiens	24%	100%
Q17GR9	Aedes aegypti	23%	100%
Q20636	Caenorhabditis elegans	22%	100%
Q229Z6	Tetrahymena thermophila (strain SB210)	21%	69%
Q28D01	Xenopus tropicalis	27%	71%
Q28DW0	Xenopus tropicalis	24%	100%
Q28I85	Xenopus tropicalis	25%	99%
Q292E8	Drosophila pseudoobscura pseudoobscura	25%	100%
Q2KIG2	Bos taurus	26%	100%
Q2KJH4	Bos taurus	23%	72%
Q2TBP4	Bos taurus	22%	100%
Q32PJ6	Bos taurus	24%	100%
Q3KQ62	Xenopus laevis	21%	100%
Q3MHE2	Bos taurus	23%	84%
Q3SZK1	Bos taurus	24%	100%
Q3Y8L7	Chlamydomonas reinhardtii	25%	98%
Q498M4	Rattus norvegicus	26%	100%
Q4Q0T1	Leishmania major	26%	86%
Q4Q4L7	Leishmania major	93%	100%
Q4QAA4	Leishmania major	24%	84%
Q4QHD6	Leishmania major	25%	100%
Q4R8E7	Macaca fascicularis	27%	100%
Q4RJN5	Tetraodon nigroviridis	22%	100%
Q4V7Z1	Xenopus laevis	24%	93%
Q4V8C4	Rattus norvegicus	26%	100%
Q54KL5	Dictyostelium discoideum	24%	100%
Q55AR8	Dictyostelium discoideum	23%	100%
Q58D20	Bos taurus	24%	90%
Q58DT8	Bos taurus	22%	100%
Q5BJQ6	Rattus norvegicus	22%	100%
Q5BK30	Rattus norvegicus	27%	100%
Q5FWQ6	Xenopus laevis	26%	100%
Q5GIS3	Pinctada fucata	24%	100%
Q5IS43	Pan troglodytes	22%	100%
Q5M786	Xenopus tropicalis	25%	100%
Q5M7T1	Rattus norvegicus	23%	100%
Q5NVD0	Pongo abelii	23%	84%
Q5R8K2	Pongo abelii	22%	100%
Q5R9T6	Pongo abelii	24%	100%
Q5RCG7	Pongo abelii	24%	100%
Q5RDY7	Pongo abelii	24%	100%
Q5RE95	Pongo abelii	27%	100%
Q5REG7	Pongo abelii	22%	100%
Q5RFF8	Pongo abelii	25%	90%
Q5RKI0	Rattus norvegicus	23%	72%
Q5SP67	Danio rerio	27%	76%
Q5XGI5	Xenopus tropicalis	20%	100%
Q61011	Mus musculus	25%	100%
Q61FW2	Caenorhabditis briggsae	28%	74%
Q61ZF6	Caenorhabditis briggsae	25%	100%
Q6BU94	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	100%
Q6CKX3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	100%
Q6CP71	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	96%
Q6DRF9	Danio rerio	22%	100%
Q6FJS0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	20%	96%
Q6NZH4	Xenopus tropicalis	22%	100%
Q6P0D9	Danio rerio	23%	100%
Q6P2Y2	Xenopus tropicalis	26%	100%
Q6P5M2	Danio rerio	25%	100%
Q6PAX7	Xenopus laevis	23%	72%
Q6PBY0	Danio rerio	24%	100%
Q6PH57	Danio rerio	24%	100%
Q6PNB6	Oryctolagus cuniculus	25%	100%
Q75LV5	Oryza sativa subsp. japonica	24%	85%
Q7K0L4	Drosophila melanogaster	25%	69%
Q7K1Y4	Drosophila melanogaster	25%	100%
Q7SZM9	Xenopus laevis	22%	84%
Q7T0P4	Xenopus laevis	25%	99%
Q7T394	Danio rerio	21%	100%
Q7YR70	Canis lupus familiaris	24%	100%
Q7ZXK9	Xenopus laevis	22%	92%
Q803D2	Danio rerio	22%	100%
Q80ZD0	Tamias striatus	25%	100%
Q86VZ2	Homo sapiens	27%	100%
Q8C6G8	Mus musculus	27%	68%
Q8HXX0	Macaca fascicularis	22%	100%
Q8I0F4	Dictyostelium discoideum	22%	100%
Q8JZX3	Mus musculus	23%	100%
Q8K450	Mus musculus	23%	68%
Q8N136	Homo sapiens	27%	100%
Q8N9V3	Homo sapiens	25%	92%
Q8NAA4	Homo sapiens	24%	70%
Q8NBT0	Homo sapiens	22%	100%
Q8T088	Drosophila melanogaster	24%	88%
Q8VEJ4	Mus musculus	25%	90%
Q8W117	Arabidopsis thaliana	21%	85%
Q90ZL4	Xenopus laevis	22%	100%
Q922V4	Mus musculus	21%	85%
Q93794	Caenorhabditis elegans	27%	74%
Q93847	Caenorhabditis elegans	21%	100%
Q99KN2	Mus musculus	25%	100%
Q99LC2	Mus musculus	22%	100%
Q9BQ87	Homo sapiens	24%	84%
Q9CX97	Mus musculus	23%	100%
Q9D7H2	Mus musculus	27%	100%
Q9DAW6	Mus musculus	23%	84%
Q9FN19	Arabidopsis thaliana	23%	71%
Q9FND4	Arabidopsis thaliana	25%	83%
Q9FNN2	Arabidopsis thaliana	26%	74%
Q9GL51	Sus scrofa	22%	100%
Q9H6Y2	Homo sapiens	24%	100%
Q9M2Z2	Arabidopsis thaliana	24%	100%
Q9NDC9	Caenorhabditis elegans	22%	100%
Q9NVX2	Homo sapiens	25%	90%
Q9NYS7	Homo sapiens	23%	100%
Q9PTR5	Gallus gallus	22%	100%
Q9QXE7	Mus musculus	24%	83%
Q9SXY1	Arabidopsis thaliana	23%	90%
Q9UT85	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	86%
Q9UTC7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	94%
Q9UUG8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	73%
Q9V3J8	Drosophila melanogaster	25%	100%
Q9VU68	Drosophila melanogaster	22%	72%
Q9W7F2	Xenopus laevis	23%	72%
Q9WUC8	Rattus norvegicus	21%	85%
V5BEB2	Trypanosoma cruzi	24%	81%
V5BJG9	Trypanosoma cruzi	54%	98%
V5BP59	Trypanosoma cruzi	27%	100%