CrcB-like protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CrcB-like protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGC8_LEIDO

TriTrypDb:

LdBPK_312690.1 , LdCL_310034900 , LDHU3_31.4770

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	8
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3Q8IGC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGC8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006820	monoatomic anion transport	5	1
GO:0009987	cellular process	1	1
GO:0015698	inorganic anion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098661	inorganic anion transmembrane transport	5	1
GO:1903424	fluoride transmembrane transport	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	8
GO:0008509	monoatomic anion transmembrane transporter activity	4	8
GO:0015075	monoatomic ion transmembrane transporter activity	3	8
GO:0015103	inorganic anion transmembrane transporter activity	4	8
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	8
GO:0022857	transmembrane transporter activity	2	8
GO:1903425	fluoride transmembrane transporter activity	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.368
CLV_NRD_NRD_1	388	390	PF00675	0.345
CLV_NRD_NRD_1	58	60	PF00675	0.472
CLV_PCSK_KEX2_1	293	295	PF00082	0.228
CLV_PCSK_KEX2_1	388	390	PF00082	0.368
CLV_PCSK_KEX2_1	58	60	PF00082	0.472
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.225
CLV_PCSK_SKI1_1	109	113	PF00082	0.450
CLV_PCSK_SKI1_1	17	21	PF00082	0.417
CLV_PCSK_SKI1_1	284	288	PF00082	0.299
DEG_APCC_DBOX_1	359	367	PF00400	0.225
DEG_Nend_UBRbox_3	1	3	PF02207	0.639
DEG_ODPH_VHL_1	276	289	PF01847	0.337
DOC_MAPK_MEF2A_6	233	242	PF00069	0.468
DOC_MAPK_MEF2A_6	284	291	PF00069	0.316
DOC_PP1_RVXF_1	206	213	PF00149	0.526
DOC_USP7_MATH_1	368	372	PF00917	0.316
DOC_USP7_MATH_1	73	77	PF00917	0.636
DOC_USP7_UBL2_3	114	118	PF12436	0.263
DOC_WW_Pin1_4	116	121	PF00397	0.147
DOC_WW_Pin1_4	217	222	PF00397	0.530
DOC_WW_Pin1_4	247	252	PF00397	0.264
DOC_WW_Pin1_4	30	35	PF00397	0.646
DOC_WW_Pin1_4	66	71	PF00397	0.620
DOC_WW_Pin1_4	76	81	PF00397	0.554
LIG_14-3-3_CanoR_1	264	273	PF00244	0.390
LIG_14-3-3_CanoR_1	284	290	PF00244	0.412
LIG_14-3-3_CanoR_1	3	7	PF00244	0.633
LIG_14-3-3_CterR_2	388	392	PF00244	0.607
LIG_BRCT_BRCA1_1	118	122	PF00533	0.173
LIG_BRCT_BRCA1_1	370	374	PF00533	0.262
LIG_BRCT_BRCA1_2	118	124	PF00533	0.173
LIG_Clathr_ClatBox_2	220	225	PF01394	0.551
LIG_EVH1_1	71	75	PF00568	0.570
LIG_FHA_1	192	198	PF00498	0.314
LIG_FHA_1	222	228	PF00498	0.518
LIG_FHA_1	281	287	PF00498	0.440
LIG_FHA_2	179	185	PF00498	0.334
LIG_GBD_Chelix_1	305	313	PF00786	0.341
LIG_LIR_Gen_1	165	174	PF02991	0.340
LIG_LIR_Gen_1	184	191	PF02991	0.212
LIG_LIR_Gen_1	327	338	PF02991	0.232
LIG_LIR_Gen_1	371	381	PF02991	0.262
LIG_LIR_Nem_3	119	125	PF02991	0.191
LIG_LIR_Nem_3	154	158	PF02991	0.381
LIG_LIR_Nem_3	165	169	PF02991	0.340
LIG_LIR_Nem_3	184	189	PF02991	0.251
LIG_LIR_Nem_3	327	333	PF02991	0.282
LIG_LIR_Nem_3	371	377	PF02991	0.364
LIG_LIR_Nem_3	82	88	PF02991	0.529
LIG_MLH1_MIPbox_1	118	122	PF16413	0.173
LIG_NRBOX	309	315	PF00104	0.262
LIG_Pex14_2	136	140	PF04695	0.247
LIG_Pex14_2	162	166	PF04695	0.337
LIG_SH2_CRK	125	129	PF00017	0.250
LIG_SH2_CRK	155	159	PF00017	0.389
LIG_SH2_CRK	367	371	PF00017	0.257
LIG_SH2_CRK	88	92	PF00017	0.425
LIG_SH2_NCK_1	367	371	PF00017	0.316
LIG_SH2_PTP2	127	130	PF00017	0.337
LIG_SH2_SRC	365	368	PF00017	0.226
LIG_SH2_STAP1	88	92	PF00017	0.440
LIG_SH2_STAT3	65	68	PF00017	0.669
LIG_SH2_STAT5	127	130	PF00017	0.279
LIG_SH2_STAT5	257	260	PF00017	0.362
LIG_SH2_STAT5	365	368	PF00017	0.238
LIG_SH2_STAT5	81	84	PF00017	0.536
LIG_SH3_3	117	123	PF00018	0.225
LIG_SH3_3	141	147	PF00018	0.285
LIG_SH3_3	215	221	PF00018	0.580
LIG_SH3_3	245	251	PF00018	0.152
LIG_SH3_3	378	384	PF00018	0.262
LIG_SH3_3	67	73	PF00018	0.697
LIG_SH3_4	17	24	PF00018	0.595
LIG_SUMO_SIM_anti_2	141	146	PF11976	0.262
LIG_SUMO_SIM_anti_2	236	242	PF11976	0.202
LIG_SUMO_SIM_anti_2	250	256	PF11976	0.279
LIG_SUMO_SIM_par_1	241	247	PF11976	0.223
LIG_SUMO_SIM_par_1	89	94	PF11976	0.364
LIG_TYR_ITIM	153	158	PF00017	0.425
LIG_Vh1_VBS_1	231	249	PF01044	0.425
LIG_WRC_WIRS_1	133	138	PF05994	0.296
LIG_WRC_WIRS_1	166	171	PF05994	0.269
LIG_WRC_WIRS_1	352	357	PF05994	0.246
MOD_CK1_1	165	171	PF00069	0.285
MOD_CK1_1	247	253	PF00069	0.202
MOD_CK1_1	343	349	PF00069	0.263
MOD_CK1_1	64	70	PF00069	0.642
MOD_CK1_1	76	82	PF00069	0.498
MOD_CK2_1	217	223	PF00069	0.654
MOD_CMANNOS	222	225	PF00535	0.370
MOD_GlcNHglycan	105	108	PF01048	0.317
MOD_GlcNHglycan	266	269	PF01048	0.481
MOD_GlcNHglycan	357	360	PF01048	0.476
MOD_GlcNHglycan	75	78	PF01048	0.463
MOD_GSK3_1	164	171	PF00069	0.320
MOD_GSK3_1	217	224	PF00069	0.572
MOD_GSK3_1	340	347	PF00069	0.211
MOD_GSK3_1	351	358	PF00069	0.364
MOD_GSK3_1	368	375	PF00069	0.266
MOD_N-GLC_1	53	58	PF02516	0.561
MOD_N-GLC_2	2	4	PF02516	0.434
MOD_NEK2_1	103	108	PF00069	0.283
MOD_NEK2_1	138	143	PF00069	0.307
MOD_NEK2_1	162	167	PF00069	0.291
MOD_NEK2_1	227	232	PF00069	0.620
MOD_NEK2_1	285	290	PF00069	0.350
MOD_NEK2_1	355	360	PF00069	0.263
MOD_NEK2_1	91	96	PF00069	0.305
MOD_NEK2_2	40	45	PF00069	0.651
MOD_PIKK_1	64	70	PF00454	0.664
MOD_PKA_2	2	8	PF00069	0.633
MOD_Plk_4	132	138	PF00069	0.333
MOD_Plk_4	140	146	PF00069	0.268
MOD_Plk_4	168	174	PF00069	0.333
MOD_Plk_4	227	233	PF00069	0.425
MOD_Plk_4	244	250	PF00069	0.287
MOD_Plk_4	351	357	PF00069	0.222
MOD_Plk_4	40	46	PF00069	0.641
MOD_ProDKin_1	116	122	PF00069	0.147
MOD_ProDKin_1	217	223	PF00069	0.535
MOD_ProDKin_1	247	253	PF00069	0.264
MOD_ProDKin_1	30	36	PF00069	0.647
MOD_ProDKin_1	66	72	PF00069	0.617
MOD_ProDKin_1	76	82	PF00069	0.543
TRG_ENDOCYTIC_2	125	128	PF00928	0.278
TRG_ENDOCYTIC_2	155	158	PF00928	0.389
TRG_ENDOCYTIC_2	367	370	PF00928	0.257
TRG_ENDOCYTIC_2	88	91	PF00928	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P462	Leptomonas seymouri	62%	100%
A0A1X0NID7	Trypanosomatidae	35%	100%
A0A422NPK8	Trypanosoma rangeli	35%	100%
A4HJQ0	Leishmania braziliensis	72%	100%
A4I767	Leishmania infantum	98%	100%
P0CU19	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P0CU20	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q4Q5Z9	Leishmania major	89%	100%