Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGC1_LEIDO

TriTrypDb:

LdBPK_352700.1 , LdCL_350031900 , LDHU3_35.3450

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGC1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.558
CLV_C14_Caspase3-7	413	417	PF00656	0.627
CLV_NRD_NRD_1	209	211	PF00675	0.595
CLV_NRD_NRD_1	225	227	PF00675	0.703
CLV_NRD_NRD_1	228	230	PF00675	0.401
CLV_NRD_NRD_1	250	252	PF00675	0.460
CLV_NRD_NRD_1	456	458	PF00675	0.633
CLV_NRD_NRD_1	492	494	PF00675	0.583
CLV_NRD_NRD_1	515	517	PF00675	0.444
CLV_NRD_NRD_1	636	638	PF00675	0.478
CLV_PCSK_FUR_1	207	211	PF00082	0.569
CLV_PCSK_FUR_1	226	230	PF00082	0.517
CLV_PCSK_KEX2_1	206	208	PF00082	0.598
CLV_PCSK_KEX2_1	209	211	PF00082	0.584
CLV_PCSK_KEX2_1	227	229	PF00082	0.519
CLV_PCSK_KEX2_1	364	366	PF00082	0.457
CLV_PCSK_KEX2_1	456	458	PF00082	0.633
CLV_PCSK_KEX2_1	636	638	PF00082	0.478
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.602
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.580
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.522
CLV_PCSK_SKI1_1	252	256	PF00082	0.463
CLV_PCSK_SKI1_1	260	264	PF00082	0.452
CLV_PCSK_SKI1_1	374	378	PF00082	0.470
DEG_Nend_UBRbox_4	1	3	PF02207	0.580
DEG_SCF_FBW7_1	195	200	PF00400	0.522
DEG_SPOP_SBC_1	338	342	PF00917	0.625
DEG_SPOP_SBC_1	445	449	PF00917	0.644
DEG_SPOP_SBC_1	554	558	PF00917	0.493
DOC_CKS1_1	423	428	PF01111	0.612
DOC_CYCLIN_RxL_1	260	271	PF00134	0.505
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.527
DOC_CYCLIN_yCln2_LP_2	269	275	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	280	286	PF00134	0.536
DOC_MAPK_DCC_7	265	275	PF00069	0.457
DOC_MAPK_gen_1	526	536	PF00069	0.432
DOC_MAPK_RevD_3	193	207	PF00069	0.530
DOC_PP1_RVXF_1	646	653	PF00149	0.548
DOC_PP2B_LxvP_1	267	270	PF13499	0.520
DOC_PP4_FxxP_1	423	426	PF00568	0.591
DOC_USP7_MATH_1	133	137	PF00917	0.653
DOC_USP7_MATH_1	177	181	PF00917	0.596
DOC_USP7_MATH_1	197	201	PF00917	0.456
DOC_USP7_MATH_1	338	342	PF00917	0.584
DOC_USP7_MATH_1	44	48	PF00917	0.711
DOC_USP7_MATH_1	444	448	PF00917	0.625
DOC_USP7_MATH_1	474	478	PF00917	0.733
DOC_USP7_MATH_1	489	493	PF00917	0.504
DOC_USP7_MATH_1	554	558	PF00917	0.544
DOC_USP7_MATH_1	575	579	PF00917	0.598
DOC_USP7_MATH_1	618	622	PF00917	0.528
DOC_USP7_MATH_1	82	86	PF00917	0.756
DOC_USP7_UBL2_3	223	227	PF12436	0.561
DOC_WW_Pin1_4	111	116	PF00397	0.648
DOC_WW_Pin1_4	193	198	PF00397	0.524
DOC_WW_Pin1_4	2	7	PF00397	0.690
DOC_WW_Pin1_4	268	273	PF00397	0.529
DOC_WW_Pin1_4	305	310	PF00397	0.789
DOC_WW_Pin1_4	313	318	PF00397	0.692
DOC_WW_Pin1_4	321	326	PF00397	0.619
DOC_WW_Pin1_4	331	336	PF00397	0.563
DOC_WW_Pin1_4	342	347	PF00397	0.605
DOC_WW_Pin1_4	35	40	PF00397	0.595
DOC_WW_Pin1_4	407	412	PF00397	0.577
DOC_WW_Pin1_4	422	427	PF00397	0.565
DOC_WW_Pin1_4	446	451	PF00397	0.616
DOC_WW_Pin1_4	485	490	PF00397	0.578
DOC_WW_Pin1_4	72	77	PF00397	0.603
DOC_WW_Pin1_4	88	93	PF00397	0.564
LIG_14-3-3_CanoR_1	176	182	PF00244	0.535
LIG_14-3-3_CanoR_1	265	270	PF00244	0.534
LIG_14-3-3_CanoR_1	412	419	PF00244	0.674
LIG_14-3-3_CanoR_1	636	642	PF00244	0.560
LIG_BRCT_BRCA1_1	323	327	PF00533	0.639
LIG_BRCT_BRCA1_1	585	589	PF00533	0.672
LIG_CaM_IQ_9	357	372	PF13499	0.518
LIG_CSL_BTD_1	343	346	PF09270	0.571
LIG_deltaCOP1_diTrp_1	169	174	PF00928	0.669
LIG_EVH1_1	112	116	PF00568	0.579
LIG_EVH1_2	115	119	PF00568	0.619
LIG_FHA_1	194	200	PF00498	0.663
LIG_FHA_1	264	270	PF00498	0.650
LIG_FHA_1	275	281	PF00498	0.483
LIG_FHA_1	383	389	PF00498	0.609
LIG_FHA_1	547	553	PF00498	0.501
LIG_FHA_1	614	620	PF00498	0.692
LIG_FHA_1	644	650	PF00498	0.605
LIG_FHA_2	411	417	PF00498	0.626
LIG_FHA_2	423	429	PF00498	0.527
LIG_FHA_2	463	469	PF00498	0.639
LIG_FHA_2	486	492	PF00498	0.644
LIG_FHA_2	51	57	PF00498	0.733
LIG_FHA_2	658	664	PF00498	0.594
LIG_Integrin_RGD_1	568	570	PF01839	0.661
LIG_LIR_Apic_2	422	426	PF02991	0.602
LIG_LIR_Nem_3	591	597	PF02991	0.710
LIG_Pex14_1	170	174	PF04695	0.718
LIG_Pex14_2	590	594	PF04695	0.623
LIG_PTAP_UEV_1	5	10	PF05743	0.612
LIG_SH2_STAT5	597	600	PF00017	0.509
LIG_SH3_3	110	116	PF00018	0.567
LIG_SH3_3	16	22	PF00018	0.512
LIG_SH3_3	3	9	PF00018	0.661
LIG_SH3_3	311	317	PF00018	0.683
LIG_SH3_3	386	392	PF00018	0.511
LIG_SH3_3	447	453	PF00018	0.586
LIG_SH3_3	559	565	PF00018	0.595
LIG_SUMO_SIM_anti_2	29	35	PF11976	0.552
LIG_SUMO_SIM_par_1	264	271	PF11976	0.521
LIG_TRAF2_1	495	498	PF00917	0.689
LIG_WRC_WIRS_1	482	487	PF05994	0.617
LIG_WRC_WIRS_1	638	643	PF05994	0.513
LIG_WW_2	19	22	PF00397	0.535
MOD_CDK_SPK_2	407	412	PF00069	0.558
MOD_CDK_SPxxK_3	407	414	PF00069	0.535
MOD_CDK_SPxxK_3	449	456	PF00069	0.567
MOD_CK1_1	100	106	PF00069	0.560
MOD_CK1_1	134	140	PF00069	0.581
MOD_CK1_1	165	171	PF00069	0.547
MOD_CK1_1	268	274	PF00069	0.555
MOD_CK1_1	316	322	PF00069	0.582
MOD_CK1_1	328	334	PF00069	0.599
MOD_CK1_1	336	342	PF00069	0.493
MOD_CK1_1	35	41	PF00069	0.597
MOD_CK1_1	410	416	PF00069	0.590
MOD_CK1_1	448	454	PF00069	0.626
MOD_CK1_1	484	490	PF00069	0.573
MOD_CK1_1	548	554	PF00069	0.497
MOD_CK1_1	557	563	PF00069	0.466
MOD_CK1_1	583	589	PF00069	0.634
MOD_CK1_1	657	663	PF00069	0.591
MOD_CK1_1	7	13	PF00069	0.606
MOD_CK2_1	115	121	PF00069	0.751
MOD_CK2_1	133	139	PF00069	0.603
MOD_CK2_1	205	211	PF00069	0.532
MOD_CK2_1	462	468	PF00069	0.653
MOD_CK2_1	472	478	PF00069	0.577
MOD_CK2_1	485	491	PF00069	0.520
MOD_CK2_1	575	581	PF00069	0.625
MOD_CK2_1	657	663	PF00069	0.591
MOD_GlcNHglycan	133	136	PF01048	0.588
MOD_GlcNHglycan	199	202	PF01048	0.587
MOD_GlcNHglycan	336	339	PF01048	0.549
MOD_GlcNHglycan	34	37	PF01048	0.598
MOD_GlcNHglycan	341	344	PF01048	0.518
MOD_GlcNHglycan	416	419	PF01048	0.601
MOD_GlcNHglycan	572	575	PF01048	0.630
MOD_GlcNHglycan	577	580	PF01048	0.749
MOD_GlcNHglycan	581	585	PF01048	0.535
MOD_GlcNHglycan	6	9	PF01048	0.607
MOD_GlcNHglycan	620	623	PF01048	0.553
MOD_GlcNHglycan	627	630	PF01048	0.471
MOD_GSK3_1	111	118	PF00069	0.612
MOD_GSK3_1	193	200	PF00069	0.600
MOD_GSK3_1	261	268	PF00069	0.481
MOD_GSK3_1	282	289	PF00069	0.538
MOD_GSK3_1	292	299	PF00069	0.615
MOD_GSK3_1	305	312	PF00069	0.564
MOD_GSK3_1	321	328	PF00069	0.584
MOD_GSK3_1	333	340	PF00069	0.616
MOD_GSK3_1	35	42	PF00069	0.598
MOD_GSK3_1	370	377	PF00069	0.469
MOD_GSK3_1	380	387	PF00069	0.512
MOD_GSK3_1	410	417	PF00069	0.581
MOD_GSK3_1	444	451	PF00069	0.625
MOD_GSK3_1	481	488	PF00069	0.577
MOD_GSK3_1	553	560	PF00069	0.563
MOD_GSK3_1	570	577	PF00069	0.528
MOD_GSK3_1	637	644	PF00069	0.705
MOD_GSK3_1	657	664	PF00069	0.451
MOD_GSK3_1	96	103	PF00069	0.565
MOD_N-GLC_1	105	110	PF02516	0.588
MOD_N-GLC_1	642	647	PF02516	0.688
MOD_NEK2_1	1	6	PF00069	0.599
MOD_NEK2_1	104	109	PF00069	0.655
MOD_NEK2_1	187	192	PF00069	0.712
MOD_NEK2_1	243	248	PF00069	0.445
MOD_NEK2_1	263	268	PF00069	0.441
MOD_NEK2_1	292	297	PF00069	0.595
MOD_NEK2_1	376	381	PF00069	0.468
MOD_NEK2_1	382	387	PF00069	0.524
MOD_NEK2_1	472	477	PF00069	0.595
MOD_NEK2_1	641	646	PF00069	0.535
MOD_PIKK_1	105	111	PF00454	0.610
MOD_PIKK_1	14	20	PF00454	0.607
MOD_PIKK_1	243	249	PF00454	0.433
MOD_PIKK_1	374	380	PF00454	0.469
MOD_PIKK_1	501	507	PF00454	0.562
MOD_PIKK_1	643	649	PF00454	0.605
MOD_PIKK_1	80	86	PF00454	0.611
MOD_PKA_1	205	211	PF00069	0.532
MOD_PKB_1	412	420	PF00069	0.606
MOD_Plk_1	100	106	PF00069	0.547
MOD_Plk_1	29	35	PF00069	0.572
MOD_Plk_1	630	636	PF00069	0.472
MOD_Plk_4	177	183	PF00069	0.612
MOD_Plk_4	29	35	PF00069	0.584
MOD_Plk_4	328	334	PF00069	0.601
MOD_Plk_4	45	51	PF00069	0.724
MOD_ProDKin_1	111	117	PF00069	0.651
MOD_ProDKin_1	193	199	PF00069	0.524
MOD_ProDKin_1	2	8	PF00069	0.689
MOD_ProDKin_1	268	274	PF00069	0.534
MOD_ProDKin_1	305	311	PF00069	0.789
MOD_ProDKin_1	313	319	PF00069	0.691
MOD_ProDKin_1	321	327	PF00069	0.624
MOD_ProDKin_1	331	337	PF00069	0.563
MOD_ProDKin_1	342	348	PF00069	0.599
MOD_ProDKin_1	35	41	PF00069	0.597
MOD_ProDKin_1	407	413	PF00069	0.575
MOD_ProDKin_1	422	428	PF00069	0.564
MOD_ProDKin_1	446	452	PF00069	0.616
MOD_ProDKin_1	485	491	PF00069	0.577
MOD_ProDKin_1	72	78	PF00069	0.605
MOD_ProDKin_1	88	94	PF00069	0.564
MOD_SUMO_for_1	27	30	PF00179	0.512
MOD_SUMO_rev_2	54	59	PF00179	0.579
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.590
TRG_ER_diArg_1	207	210	PF00400	0.609
TRG_ER_diArg_1	226	229	PF00400	0.656
TRG_ER_diArg_1	411	414	PF00400	0.603
TRG_ER_diArg_1	456	458	PF00400	0.633
TRG_ER_diArg_1	635	637	PF00400	0.602
TRG_NLS_Bipartite_1	209	231	PF00514	0.561
TRG_NLS_MonoExtC_3	204	209	PF00514	0.654
TRG_NLS_MonoExtC_3	226	232	PF00514	0.527
TRG_NLS_MonoExtC_3	363	369	PF00514	0.523
TRG_NLS_MonoExtN_4	205	210	PF00514	0.657
TRG_NLS_MonoExtN_4	226	231	PF00514	0.576
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	526	531	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR5	Leptomonas seymouri	41%	100%
A4HMT4	Leishmania braziliensis	62%	100%
A4IBD3	Leishmania infantum	99%	100%
E9AF89	Leishmania major	86%	100%
E9B6E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%