LeishMANIAdb
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HD domain family protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
HD domain family protein
Gene product:
HD domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IGB9_LEIDO
TriTrypDb:
LdBPK_322680.1 * , LdCL_320032600 , LDHU3_32.3350
Length:
673

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Phosphorylation

Promastigote/Amastigote: 422

Expansion

Sequence features

A0A3Q8IGB9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGB9

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 2
GO:0006163 purine nucleotide metabolic process 5 2
GO:0006195 purine nucleotide catabolic process 6 2
GO:0006203 dGTP catabolic process 7 2
GO:0006725 cellular aromatic compound metabolic process 3 2
GO:0006753 nucleoside phosphate metabolic process 4 2
GO:0006793 phosphorus metabolic process 3 2
GO:0006796 phosphate-containing compound metabolic process 4 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 2
GO:0009056 catabolic process 2 2
GO:0009117 nucleotide metabolic process 5 2
GO:0009141 nucleoside triphosphate metabolic process 5 2
GO:0009143 nucleoside triphosphate catabolic process 6 2
GO:0009144 purine nucleoside triphosphate metabolic process 6 2
GO:0009146 purine nucleoside triphosphate catabolic process 7 2
GO:0009151 purine deoxyribonucleotide metabolic process 6 2
GO:0009155 purine deoxyribonucleotide catabolic process 6 2
GO:0009166 nucleotide catabolic process 6 2
GO:0009200 deoxyribonucleoside triphosphate metabolic process 6 2
GO:0009204 deoxyribonucleoside triphosphate catabolic process 7 2
GO:0009215 purine deoxyribonucleoside triphosphate metabolic process 7 2
GO:0009217 purine deoxyribonucleoside triphosphate catabolic process 8 2
GO:0009262 deoxyribonucleotide metabolic process 4 2
GO:0009264 deoxyribonucleotide catabolic process 5 2
GO:0009394 2'-deoxyribonucleotide metabolic process 5 2
GO:0009987 cellular process 1 2
GO:0019439 aromatic compound catabolic process 4 2
GO:0019637 organophosphate metabolic process 3 2
GO:0019692 deoxyribose phosphate metabolic process 4 2
GO:0034641 cellular nitrogen compound metabolic process 3 2
GO:0034655 nucleobase-containing compound catabolic process 4 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044248 cellular catabolic process 3 2
GO:0044270 cellular nitrogen compound catabolic process 4 2
GO:0044281 small molecule metabolic process 2 2
GO:0046070 dGTP metabolic process 7 2
GO:0046386 deoxyribose phosphate catabolic process 5 2
GO:0046434 organophosphate catabolic process 4 2
GO:0046483 heterocycle metabolic process 3 2
GO:0046700 heterocycle catabolic process 4 2
GO:0055086 nucleobase-containing small molecule metabolic process 3 2
GO:0071704 organic substance metabolic process 2 2
GO:0072521 purine-containing compound metabolic process 4 2
GO:0072523 purine-containing compound catabolic process 5 2
GO:1901135 carbohydrate derivative metabolic process 3 2
GO:1901136 carbohydrate derivative catabolic process 4 2
GO:1901292 nucleoside phosphate catabolic process 5 2
GO:1901360 organic cyclic compound metabolic process 3 2
GO:1901361 organic cyclic compound catabolic process 4 2
GO:1901564 organonitrogen compound metabolic process 3 2
GO:1901565 organonitrogen compound catabolic process 4 2
GO:1901575 organic substance catabolic process 3 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0008832 dGTPase activity 6 2
GO:0016787 hydrolase activity 2 2
GO:0016788 hydrolase activity, acting on ester bonds 3 2
GO:0016793 triphosphoric monoester hydrolase activity 5 2
GO:0042578 phosphoric ester hydrolase activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 278 282 PF00656 0.413
CLV_C14_Caspase3-7 92 96 PF00656 0.326
CLV_NRD_NRD_1 13 15 PF00675 0.699
CLV_NRD_NRD_1 158 160 PF00675 0.332
CLV_NRD_NRD_1 170 172 PF00675 0.291
CLV_NRD_NRD_1 376 378 PF00675 0.381
CLV_NRD_NRD_1 384 386 PF00675 0.309
CLV_NRD_NRD_1 620 622 PF00675 0.546
CLV_PCSK_KEX2_1 13 15 PF00082 0.625
CLV_PCSK_KEX2_1 158 160 PF00082 0.316
CLV_PCSK_KEX2_1 227 229 PF00082 0.395
CLV_PCSK_KEX2_1 24 26 PF00082 0.437
CLV_PCSK_KEX2_1 376 378 PF00082 0.403
CLV_PCSK_KEX2_1 384 386 PF00082 0.309
CLV_PCSK_KEX2_1 426 428 PF00082 0.459
CLV_PCSK_KEX2_1 608 610 PF00082 0.585
CLV_PCSK_KEX2_1 620 622 PF00082 0.541
CLV_PCSK_PC1ET2_1 227 229 PF00082 0.395
CLV_PCSK_PC1ET2_1 24 26 PF00082 0.481
CLV_PCSK_PC1ET2_1 426 428 PF00082 0.459
CLV_PCSK_PC1ET2_1 608 610 PF00082 0.585
CLV_PCSK_SKI1_1 384 388 PF00082 0.326
CLV_PCSK_SKI1_1 44 48 PF00082 0.327
CLV_PCSK_SKI1_1 56 60 PF00082 0.288
CLV_PCSK_SKI1_1 608 612 PF00082 0.620
DEG_APCC_DBOX_1 290 298 PF00400 0.385
DEG_APCC_DBOX_1 383 391 PF00400 0.365
DEG_COP1_1 99 109 PF00400 0.267
DEG_SPOP_SBC_1 638 642 PF00917 0.778
DOC_ANK_TNKS_1 90 97 PF00023 0.267
DOC_CKS1_1 247 252 PF01111 0.412
DOC_CKS1_1 528 533 PF01111 0.431
DOC_CKS1_1 645 650 PF01111 0.515
DOC_CYCLIN_RxL_1 605 616 PF00134 0.557
DOC_CYCLIN_yCln2_LP_2 645 651 PF00134 0.519
DOC_MAPK_gen_1 227 233 PF00069 0.381
DOC_MAPK_gen_1 302 312 PF00069 0.365
DOC_MAPK_gen_1 608 614 PF00069 0.561
DOC_MAPK_MEF2A_6 534 541 PF00069 0.528
DOC_PP1_RVXF_1 536 542 PF00149 0.385
DOC_PP2B_PxIxI_1 40 46 PF00149 0.317
DOC_PP4_FxxP_1 104 107 PF00568 0.325
DOC_PP4_FxxP_1 488 491 PF00568 0.436
DOC_PP4_MxPP_1 1 4 PF00568 0.570
DOC_USP7_MATH_1 23 27 PF00917 0.440
DOC_USP7_MATH_1 333 337 PF00917 0.320
DOC_USP7_MATH_1 366 370 PF00917 0.487
DOC_USP7_MATH_1 4 8 PF00917 0.611
DOC_USP7_MATH_1 491 495 PF00917 0.514
DOC_USP7_MATH_1 517 521 PF00917 0.431
DOC_USP7_MATH_1 567 571 PF00917 0.751
DOC_USP7_MATH_1 586 590 PF00917 0.479
DOC_USP7_MATH_1 638 642 PF00917 0.763
DOC_USP7_MATH_1 71 75 PF00917 0.368
DOC_USP7_MATH_2 531 537 PF00917 0.386
DOC_WW_Pin1_4 246 251 PF00397 0.448
DOC_WW_Pin1_4 46 51 PF00397 0.349
DOC_WW_Pin1_4 527 532 PF00397 0.450
DOC_WW_Pin1_4 556 561 PF00397 0.496
DOC_WW_Pin1_4 582 587 PF00397 0.745
DOC_WW_Pin1_4 644 649 PF00397 0.515
LIG_14-3-3_CanoR_1 147 155 PF00244 0.313
LIG_14-3-3_CanoR_1 158 167 PF00244 0.308
LIG_14-3-3_CanoR_1 218 224 PF00244 0.360
LIG_14-3-3_CanoR_1 25 30 PF00244 0.428
LIG_14-3-3_CanoR_1 393 402 PF00244 0.424
LIG_14-3-3_CanoR_1 403 410 PF00244 0.418
LIG_14-3-3_CanoR_1 414 419 PF00244 0.475
LIG_14-3-3_CanoR_1 44 52 PF00244 0.354
LIG_14-3-3_CanoR_1 492 501 PF00244 0.512
LIG_14-3-3_CanoR_1 538 548 PF00244 0.461
LIG_14-3-3_CanoR_1 595 601 PF00244 0.637
LIG_Actin_WH2_2 177 194 PF00022 0.360
LIG_Actin_WH2_2 300 318 PF00022 0.366
LIG_BRCT_BRCA1_1 138 142 PF00533 0.290
LIG_BRCT_BRCA1_1 255 259 PF00533 0.302
LIG_Clathr_ClatBox_1 309 313 PF01394 0.351
LIG_FHA_1 218 224 PF00498 0.393
LIG_FHA_1 302 308 PF00498 0.430
LIG_FHA_1 506 512 PF00498 0.505
LIG_FHA_1 595 601 PF00498 0.638
LIG_FHA_1 665 671 PF00498 0.600
LIG_FHA_2 185 191 PF00498 0.430
LIG_FHA_2 360 366 PF00498 0.456
LIG_FHA_2 439 445 PF00498 0.393
LIG_FHA_2 470 476 PF00498 0.479
LIG_FHA_2 528 534 PF00498 0.448
LIG_FHA_2 589 595 PF00498 0.496
LIG_LIR_Apic_2 103 107 PF02991 0.267
LIG_LIR_Apic_2 486 491 PF02991 0.435
LIG_LIR_Apic_2 64 69 PF02991 0.367
LIG_LIR_Gen_1 139 150 PF02991 0.290
LIG_LIR_Gen_1 190 201 PF02991 0.278
LIG_LIR_Gen_1 249 259 PF02991 0.423
LIG_LIR_Gen_1 348 356 PF02991 0.365
LIG_LIR_Gen_1 509 518 PF02991 0.655
LIG_LIR_Gen_1 540 548 PF02991 0.459
LIG_LIR_LC3C_4 519 523 PF02991 0.351
LIG_LIR_Nem_3 139 145 PF02991 0.290
LIG_LIR_Nem_3 190 196 PF02991 0.271
LIG_LIR_Nem_3 31 37 PF02991 0.431
LIG_LIR_Nem_3 348 353 PF02991 0.355
LIG_LIR_Nem_3 38 42 PF02991 0.353
LIG_LIR_Nem_3 540 544 PF02991 0.452
LIG_LIR_Nem_3 64 68 PF02991 0.383
LIG_LIR_Nem_3 88 93 PF02991 0.329
LIG_PCNA_yPIPBox_3 296 307 PF02747 0.396
LIG_PTB_Apo_2 60 67 PF02174 0.378
LIG_PTB_Phospho_1 60 66 PF10480 0.375
LIG_SH2_CRK 396 400 PF00017 0.341
LIG_SH2_CRK 651 655 PF00017 0.572
LIG_SH2_CRK 90 94 PF00017 0.325
LIG_SH2_NCK_1 396 400 PF00017 0.341
LIG_SH2_PTP2 193 196 PF00017 0.348
LIG_SH2_PTP2 66 69 PF00017 0.410
LIG_SH2_SRC 344 347 PF00017 0.294
LIG_SH2_SRC 66 69 PF00017 0.352
LIG_SH2_STAT5 193 196 PF00017 0.395
LIG_SH2_STAT5 238 241 PF00017 0.358
LIG_SH2_STAT5 344 347 PF00017 0.375
LIG_SH2_STAT5 396 399 PF00017 0.400
LIG_SH2_STAT5 487 490 PF00017 0.423
LIG_SH2_STAT5 66 69 PF00017 0.395
LIG_SH2_STAT5 84 87 PF00017 0.157
LIG_SH3_3 208 214 PF00018 0.352
LIG_SH3_3 335 341 PF00018 0.381
LIG_SH3_3 525 531 PF00018 0.406
LIG_SUMO_SIM_anti_2 166 171 PF11976 0.337
LIG_SUMO_SIM_anti_2 461 466 PF11976 0.435
LIG_SUMO_SIM_anti_2 519 525 PF11976 0.324
LIG_SUMO_SIM_anti_2 639 647 PF11976 0.535
LIG_SUMO_SIM_par_1 304 311 PF11976 0.299
LIG_TRAF2_1 421 424 PF00917 0.615
LIG_TRAF2_1 530 533 PF00917 0.393
LIG_TYR_ITIM 191 196 PF00017 0.353
LIG_UBA3_1 167 172 PF00899 0.267
LIG_UBA3_1 197 205 PF00899 0.339
LIG_WRC_WIRS_1 142 147 PF05994 0.325
MOD_CDK_SPxxK_3 527 534 PF00069 0.444
MOD_CK1_1 359 365 PF00069 0.459
MOD_CK1_1 369 375 PF00069 0.410
MOD_CK1_1 405 411 PF00069 0.421
MOD_CK1_1 540 546 PF00069 0.446
MOD_CK1_1 554 560 PF00069 0.563
MOD_CK1_1 582 588 PF00069 0.658
MOD_CK1_1 598 604 PF00069 0.624
MOD_CK2_1 359 365 PF00069 0.527
MOD_CK2_1 4 10 PF00069 0.618
MOD_CK2_1 418 424 PF00069 0.640
MOD_CK2_1 433 439 PF00069 0.309
MOD_CK2_1 527 533 PF00069 0.440
MOD_CK2_1 588 594 PF00069 0.521
MOD_CK2_1 616 622 PF00069 0.543
MOD_CK2_1 638 644 PF00069 0.547
MOD_CK2_1 71 77 PF00069 0.345
MOD_GlcNHglycan 148 151 PF01048 0.288
MOD_GlcNHglycan 228 231 PF01048 0.376
MOD_GlcNHglycan 368 371 PF01048 0.513
MOD_GlcNHglycan 483 486 PF01048 0.514
MOD_GlcNHglycan 575 578 PF01048 0.562
MOD_GlcNHglycan 580 584 PF01048 0.618
MOD_GlcNHglycan 600 603 PF01048 0.522
MOD_GSK3_1 141 148 PF00069 0.325
MOD_GSK3_1 25 32 PF00069 0.568
MOD_GSK3_1 394 401 PF00069 0.365
MOD_GSK3_1 4 11 PF00069 0.649
MOD_GSK3_1 414 421 PF00069 0.388
MOD_GSK3_1 439 446 PF00069 0.324
MOD_GSK3_1 501 508 PF00069 0.486
MOD_GSK3_1 533 540 PF00069 0.383
MOD_GSK3_1 548 555 PF00069 0.417
MOD_GSK3_1 582 589 PF00069 0.632
MOD_GSK3_1 594 601 PF00069 0.545
MOD_GSK3_1 664 671 PF00069 0.599
MOD_N-GLC_1 110 115 PF02516 0.344
MOD_N-GLC_1 176 181 PF02516 0.346
MOD_N-GLC_1 359 364 PF02516 0.437
MOD_N-GLC_1 505 510 PF02516 0.522
MOD_NEK2_1 141 146 PF00069 0.337
MOD_NEK2_1 289 294 PF00069 0.416
MOD_NEK2_1 322 327 PF00069 0.395
MOD_NEK2_1 356 361 PF00069 0.391
MOD_NEK2_1 395 400 PF00069 0.410
MOD_NEK2_1 443 448 PF00069 0.372
MOD_NEK2_1 537 542 PF00069 0.472
MOD_NEK2_1 596 601 PF00069 0.621
MOD_NEK2_1 61 66 PF00069 0.361
MOD_NEK2_1 76 81 PF00069 0.365
MOD_NEK2_1 89 94 PF00069 0.318
MOD_PIKK_1 419 425 PF00454 0.568
MOD_PIKK_1 467 473 PF00454 0.440
MOD_PIKK_1 559 565 PF00454 0.593
MOD_PIKK_1 568 574 PF00454 0.563
MOD_PK_1 25 31 PF00069 0.432
MOD_PK_1 414 420 PF00069 0.487
MOD_PK_1 8 14 PF00069 0.609
MOD_PKA_1 158 164 PF00069 0.267
MOD_PKA_2 146 152 PF00069 0.252
MOD_PKA_2 158 164 PF00069 0.235
MOD_PKA_2 217 223 PF00069 0.387
MOD_PKA_2 240 246 PF00069 0.330
MOD_PKA_2 29 35 PF00069 0.358
MOD_PKA_2 301 307 PF00069 0.375
MOD_PKA_2 402 408 PF00069 0.492
MOD_PKA_2 491 497 PF00069 0.505
MOD_PKA_2 537 543 PF00069 0.468
MOD_PKA_2 594 600 PF00069 0.656
MOD_Plk_1 269 275 PF00069 0.416
MOD_Plk_1 359 365 PF00069 0.527
MOD_Plk_1 405 411 PF00069 0.534
MOD_Plk_1 438 444 PF00069 0.438
MOD_Plk_1 551 557 PF00069 0.491
MOD_Plk_1 76 82 PF00069 0.290
MOD_Plk_2-3 308 314 PF00069 0.296
MOD_Plk_2-3 433 439 PF00069 0.398
MOD_Plk_4 141 147 PF00069 0.325
MOD_Plk_4 163 169 PF00069 0.325
MOD_Plk_4 248 254 PF00069 0.436
MOD_Plk_4 29 35 PF00069 0.569
MOD_Plk_4 405 411 PF00069 0.446
MOD_Plk_4 483 489 PF00069 0.406
MOD_Plk_4 507 513 PF00069 0.495
MOD_Plk_4 517 523 PF00069 0.321
MOD_Plk_4 61 67 PF00069 0.372
MOD_ProDKin_1 246 252 PF00069 0.443
MOD_ProDKin_1 46 52 PF00069 0.346
MOD_ProDKin_1 527 533 PF00069 0.444
MOD_ProDKin_1 556 562 PF00069 0.501
MOD_ProDKin_1 582 588 PF00069 0.742
MOD_ProDKin_1 644 650 PF00069 0.516
MOD_SUMO_for_1 425 428 PF00179 0.468
MOD_SUMO_rev_2 16 26 PF00179 0.561
MOD_SUMO_rev_2 613 619 PF00179 0.484
TRG_DiLeu_BaEn_3 15 21 PF01217 0.508
TRG_DiLeu_BaEn_4 665 671 PF01217 0.600
TRG_ENDOCYTIC_2 193 196 PF00928 0.348
TRG_ENDOCYTIC_2 34 37 PF00928 0.376
TRG_ENDOCYTIC_2 396 399 PF00928 0.309
TRG_ENDOCYTIC_2 651 654 PF00928 0.570
TRG_ENDOCYTIC_2 84 87 PF00928 0.326
TRG_ENDOCYTIC_2 90 93 PF00928 0.331
TRG_ER_diArg_1 12 14 PF00400 0.519
TRG_ER_diArg_1 157 159 PF00400 0.297
TRG_ER_diArg_1 384 386 PF00400 0.383
TRG_NLS_MonoExtC_3 607 613 PF00514 0.617
TRG_NLS_MonoExtN_4 605 612 PF00514 0.578
TRG_Pf-PMV_PEXEL_1 384 388 PF00026 0.371
TRG_Pf-PMV_PEXEL_1 44 48 PF00026 0.355
TRG_Pf-PMV_PEXEL_1 56 60 PF00026 0.357
TRG_Pf-PMV_PEXEL_1 91 95 PF00026 0.341

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD02 Leptomonas seymouri 68% 100%
A0A0S4J2F4 Bodo saltans 31% 100%
A0A0S4J714 Bodo saltans 34% 95%
A0A3R7LQB8 Trypanosoma rangeli 34% 89%
A0A3S7WPC5 Leishmania donovani 35% 100%
A4H4I2 Leishmania braziliensis 36% 100%
A4HKP4 Leishmania braziliensis 89% 100%
A4HSQ7 Leishmania infantum 35% 100%
A4I875 Leishmania infantum 100% 100%
C9ZTA3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9AKP4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B333 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q09374 Caenorhabditis elegans 28% 100%
Q4Q521 Leishmania major 96% 100%
Q4QJ63 Leishmania major 35% 100%
Q6INN8 Xenopus laevis 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS