Metal-ion transporter, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGB8_LEIDO

TriTrypDb:

LdBPK_312470.1 , LdCL_310032700 , LDHU3_31.4450

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A0A3Q8IGB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGB8

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006829	zinc ion transport	8	1
GO:0009987	cellular process	1	1
GO:0030001	metal ion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071577	zinc ion transmembrane transport	6	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0022857	transmembrane transporter activity	2	11
GO:0005385	zinc ion transmembrane transporter activity	7	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1
GO:0046873	metal ion transmembrane transporter activity	5	1
GO:0046915	transition metal ion transmembrane transporter activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	51	53	PF00675	0.318
CLV_PCSK_KEX2_1	51	53	PF00082	0.316
CLV_PCSK_SKI1_1	339	343	PF00082	0.295
CLV_PCSK_SKI1_1	56	60	PF00082	0.264
DOC_ANK_TNKS_1	122	129	PF00023	0.447
DOC_CYCLIN_RxL_1	336	344	PF00134	0.320
DOC_MAPK_MEF2A_6	180	187	PF00069	0.403
DOC_USP7_MATH_1	162	166	PF00917	0.312
DOC_USP7_MATH_1	176	180	PF00917	0.324
DOC_USP7_MATH_1	324	328	PF00917	0.295
DOC_WW_Pin1_4	350	355	PF00397	0.511
DOC_WW_Pin1_4	436	441	PF00397	0.622
LIG_14-3-3_CanoR_1	116	120	PF00244	0.488
LIG_AP2alpha_2	323	325	PF02296	0.395
LIG_BIR_II_1	1	5	PF00653	0.776
LIG_BRCT_BRCA1_1	326	330	PF00533	0.276
LIG_FHA_1	139	145	PF00498	0.373
LIG_FHA_1	28	34	PF00498	0.654
LIG_FHA_1	336	342	PF00498	0.276
LIG_FHA_1	418	424	PF00498	0.482
LIG_FHA_1	7	13	PF00498	0.739
LIG_FHA_1	85	91	PF00498	0.349
LIG_FHA_2	32	38	PF00498	0.642
LIG_FHA_2	439	445	PF00498	0.648
LIG_LIR_Gen_1	135	145	PF02991	0.295
LIG_LIR_Gen_1	299	308	PF02991	0.218
LIG_LIR_Gen_1	323	333	PF02991	0.289
LIG_LIR_Gen_1	384	395	PF02991	0.483
LIG_LIR_Nem_3	135	140	PF02991	0.292
LIG_LIR_Nem_3	141	145	PF02991	0.295
LIG_LIR_Nem_3	146	152	PF02991	0.247
LIG_LIR_Nem_3	299	303	PF02991	0.302
LIG_LIR_Nem_3	323	328	PF02991	0.327
LIG_LIR_Nem_3	356	362	PF02991	0.575
LIG_LIR_Nem_3	384	390	PF02991	0.492
LIG_NRBOX	341	347	PF00104	0.332
LIG_Pex14_2	296	300	PF04695	0.374
LIG_Pex14_2	65	69	PF04695	0.295
LIG_PTB_Apo_2	302	309	PF02174	0.324
LIG_PTB_Phospho_1	302	308	PF10480	0.324
LIG_RPA_C_Fungi	46	58	PF08784	0.506
LIG_SH2_PTP2	387	390	PF00017	0.394
LIG_SH2_SRC	314	317	PF00017	0.395
LIG_SH2_STAP1	152	156	PF00017	0.386
LIG_SH2_STAP1	314	318	PF00017	0.355
LIG_SH2_STAP1	99	103	PF00017	0.283
LIG_SH2_STAT5	201	204	PF00017	0.295
LIG_SH2_STAT5	261	264	PF00017	0.218
LIG_SH2_STAT5	302	305	PF00017	0.295
LIG_SH2_STAT5	387	390	PF00017	0.394
LIG_SH3_3	13	19	PF00018	0.716
LIG_SUMO_SIM_anti_2	178	185	PF11976	0.320
LIG_SUMO_SIM_anti_2	344	353	PF11976	0.374
LIG_SUMO_SIM_anti_2	42	49	PF11976	0.318
LIG_SUMO_SIM_anti_2	82	88	PF11976	0.276
LIG_SUMO_SIM_par_1	129	135	PF11976	0.309
LIG_SUMO_SIM_par_1	331	336	PF11976	0.325
LIG_TYR_ITIM	357	362	PF00017	0.348
LIG_UBA3_1	332	339	PF00899	0.385
MOD_CK1_1	132	138	PF00069	0.304
MOD_CK2_1	215	221	PF00069	0.298
MOD_CK2_1	31	37	PF00069	0.537
MOD_GlcNHglycan	164	167	PF01048	0.432
MOD_GlcNHglycan	264	267	PF01048	0.392
MOD_GlcNHglycan	383	386	PF01048	0.481
MOD_GlcNHglycan	434	437	PF01048	0.613
MOD_GlcNHglycan	75	78	PF01048	0.389
MOD_GSK3_1	19	26	PF00069	0.534
MOD_GSK3_1	202	209	PF00069	0.295
MOD_GSK3_1	211	218	PF00069	0.295
MOD_GSK3_1	27	34	PF00069	0.491
MOD_GSK3_1	310	317	PF00069	0.265
MOD_GSK3_1	331	338	PF00069	0.276
MOD_GSK3_1	349	356	PF00069	0.370
MOD_GSK3_1	432	439	PF00069	0.541
MOD_GSK3_1	6	13	PF00069	0.692
MOD_GSK3_1	91	98	PF00069	0.372
MOD_N-GLC_1	310	315	PF02516	0.239
MOD_NEK2_1	202	207	PF00069	0.307
MOD_NEK2_1	211	216	PF00069	0.279
MOD_NEK2_1	262	267	PF00069	0.387
MOD_NEK2_1	296	301	PF00069	0.218
MOD_NEK2_1	335	340	PF00069	0.295
MOD_NEK2_1	349	354	PF00069	0.372
MOD_NEK2_2	27	32	PF00069	0.573
MOD_NEK2_2	314	319	PF00069	0.316
MOD_NEK2_2	371	376	PF00069	0.356
MOD_PKA_1	51	57	PF00069	0.409
MOD_PKA_2	115	121	PF00069	0.339
MOD_PKA_2	51	57	PF00069	0.409
MOD_PKA_2	6	12	PF00069	0.745
MOD_Plk_1	310	316	PF00069	0.349
MOD_Plk_1	37	43	PF00069	0.553
MOD_Plk_2-3	37	43	PF00069	0.553
MOD_Plk_4	126	132	PF00069	0.292
MOD_Plk_4	138	144	PF00069	0.284
MOD_Plk_4	195	201	PF00069	0.354
MOD_Plk_4	296	302	PF00069	0.310
MOD_Plk_4	314	320	PF00069	0.257
MOD_Plk_4	324	330	PF00069	0.272
MOD_Plk_4	344	350	PF00069	0.127
MOD_Plk_4	43	49	PF00069	0.336
MOD_ProDKin_1	350	356	PF00069	0.391
MOD_ProDKin_1	436	442	PF00069	0.538
MOD_SUMO_rev_2	53	59	PF00179	0.400
TRG_DiLeu_BaEn_1	55	60	PF01217	0.377
TRG_ENDOCYTIC_2	359	362	PF00928	0.345
TRG_ENDOCYTIC_2	387	390	PF00928	0.335
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.294
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYQ8	Leptomonas seymouri	67%	100%
A0A0N1I8K4	Leptomonas seymouri	33%	98%
A4HFQ2	Leishmania braziliensis	23%	68%
A4HJM3	Leishmania braziliensis	81%	98%
A4I745	Leishmania infantum	99%	100%
A4IFD7	Bos taurus	26%	100%
C9ZME5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	96%
C9ZWN8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	97%
E9B239	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O13918	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
O14863	Homo sapiens	26%	100%
O35149	Mus musculus	27%	100%
O55174	Rattus norvegicus	27%	100%
P0CE46	Rattus norvegicus	29%	100%
P20107	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P32798	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P97441	Mus musculus	29%	100%
Q08E25	Bos taurus	28%	100%
Q2HJ10	Mus musculus	30%	100%
Q3UVU3	Mus musculus	24%	96%
Q4Q622	Leishmania major	93%	100%
Q4R6K2	Macaca fascicularis	25%	89%
Q54QU8	Dictyostelium discoideum	33%	83%
Q5BJM8	Rattus norvegicus	23%	100%
Q5I020	Xenopus laevis	29%	100%
Q5MNV6	Gallus gallus	28%	100%
Q5R617	Pongo abelii	29%	100%
Q5XHB4	Xenopus tropicalis	30%	100%
Q60738	Mus musculus	24%	90%
Q62720	Rattus norvegicus	24%	89%
Q688R1	Oryza sativa subsp. japonica	32%	100%
Q6QIX3	Rattus norvegicus	28%	100%
Q6XR72	Homo sapiens	24%	93%
Q8BGG0	Mus musculus	28%	100%
Q8H329	Oryza sativa subsp. japonica	25%	100%
Q8IWU4	Homo sapiens	28%	100%
Q8NEW0	Homo sapiens	26%	100%
Q95QW4	Caenorhabditis elegans	22%	80%
Q99726	Homo sapiens	29%	100%
Q9JKN1	Mus musculus	25%	100%
Q9LXS1	Arabidopsis thaliana	30%	100%
Q9M271	Arabidopsis thaliana	29%	100%
Q9TTF3	Bos taurus	25%	100%
Q9Y6M5	Homo sapiens	23%	89%
Q9ZT63	Arabidopsis thaliana	30%	100%
V5AMB7	Trypanosoma cruzi	55%	96%
V5BV32	Trypanosoma cruzi	36%	100%