Cytochrome b5-like Heme/Steroid binding domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGB7_LEIDO

TriTrypDb:

LdBPK_311210.1 , LdCL_310018800 , LDHU3_31.1970

Length:

130

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8IGB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGB7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0020037	heme binding	4	2
GO:0046906	tetrapyrrole binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.568
CLV_NRD_NRD_1	39	41	PF00675	0.260
CLV_PCSK_KEX2_1	39	41	PF00082	0.260
CLV_PCSK_SKI1_1	12	16	PF00082	0.334
CLV_PCSK_SKI1_1	46	50	PF00082	0.296
CLV_PCSK_SKI1_1	54	58	PF00082	0.266
CLV_PCSK_SKI1_1	71	75	PF00082	0.284
DEG_APCC_DBOX_1	70	78	PF00400	0.460
DOC_CYCLIN_RxL_1	65	78	PF00134	0.460
DOC_MAPK_gen_1	29	37	PF00069	0.460
DOC_MAPK_gen_1	67	76	PF00069	0.460
DOC_PIKK_1	78	86	PF02985	0.553
DOC_PP2B_LxvP_1	47	50	PF13499	0.491
DOC_USP7_MATH_1	18	22	PF00917	0.490
DOC_USP7_MATH_1	63	67	PF00917	0.535
DOC_WW_Pin1_4	7	12	PF00397	0.615
LIG_14-3-3_CanoR_1	32	38	PF00244	0.500
LIG_FHA_1	28	34	PF00498	0.479
LIG_FHA_1	4	10	PF00498	0.622
LIG_FHA_2	11	17	PF00498	0.583
LIG_LIR_Apic_2	30	34	PF02991	0.506
LIG_LIR_Nem_3	20	26	PF02991	0.459
LIG_PCNA_PIPBox_1	70	79	PF02747	0.533
LIG_SH2_CRK	31	35	PF00017	0.479
LIG_SH2_GRB2like	51	54	PF00017	0.505
LIG_SH2_NCK_1	60	64	PF00017	0.462
LIG_SH2_STAP1	100	104	PF00017	0.576
LIG_SH2_STAT5	100	103	PF00017	0.568
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.321
LIG_TRAF2_1	82	85	PF00917	0.560
MOD_CDK_SPK_2	7	12	PF00069	0.579
MOD_CK1_1	110	116	PF00069	0.286
MOD_CK1_1	3	9	PF00069	0.686
MOD_CK2_1	79	85	PF00069	0.566
MOD_GSK3_1	3	10	PF00069	0.646
MOD_N-GLC_2	103	105	PF02516	0.274
MOD_NEK2_1	77	82	PF00069	0.579
MOD_PIKK_1	54	60	PF00454	0.509
MOD_Plk_1	77	83	PF00069	0.546
MOD_Plk_2-3	79	85	PF00069	0.561
MOD_Plk_4	107	113	PF00069	0.307
MOD_Plk_4	18	24	PF00069	0.564
MOD_Plk_4	33	39	PF00069	0.442
MOD_ProDKin_1	7	13	PF00069	0.607
TRG_DiLeu_BaEn_4	84	90	PF01217	0.541
TRG_ER_diArg_1	38	40	PF00400	0.460
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.270
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX76	Leptomonas seymouri	54%	92%
A0A0N1IH82	Leptomonas seymouri	36%	100%
A0A3Q8ICI2	Leishmania donovani	36%	100%
A4HJ97	Leishmania braziliensis	39%	100%
A4HJ98	Leishmania braziliensis	36%	100%
A4HJA0	Leishmania braziliensis	81%	100%
A4HJA2	Leishmania braziliensis	82%	100%
A4I6P3	Leishmania infantum	36%	100%
A4I6P5	Leishmania infantum	99%	100%
E9B1R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B1R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q6E4	Leishmania major	86%	100%
Q4Q6E6	Leishmania major	36%	100%