NADH-ubiquinone oxidoreductase complex I subunit, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGB6_LEIDO

TriTrypDb:

LdBPK_363680.1 , LdCL_360043800 , LDHU3_36.4970

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A0A3Q8IGB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGB6

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	7	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0019646	aerobic electron transport chain	6	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016491	oxidoreductase activity	2	3
GO:0003954	NADH dehydrogenase activity	4	1
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	5	1
GO:0005215	transporter activity	1	1
GO:0008137	NADH dehydrogenase (ubiquinone) activity	4	1
GO:0009055	electron transfer activity	3	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	5	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	1
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0050136	NADH dehydrogenase (quinone) activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.597
CLV_C14_Caspase3-7	41	45	PF00656	0.630
CLV_NRD_NRD_1	239	241	PF00675	0.412
CLV_NRD_NRD_1	252	254	PF00675	0.462
CLV_NRD_NRD_1	87	89	PF00675	0.560
CLV_PCSK_KEX2_1	239	241	PF00082	0.420
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.420
DEG_SCF_FBW7_2	226	233	PF00400	0.537
DOC_CKS1_1	100	105	PF01111	0.573
DOC_CYCLIN_yCln2_LP_2	97	103	PF00134	0.549
DOC_MAPK_gen_1	64	73	PF00069	0.588
DOC_USP7_UBL2_3	53	57	PF12436	0.591
DOC_WW_Pin1_4	226	231	PF00397	0.505
DOC_WW_Pin1_4	96	101	PF00397	0.503
LIG_14-3-3_CanoR_1	105	110	PF00244	0.622
LIG_14-3-3_CanoR_1	88	94	PF00244	0.621
LIG_APCC_ABBAyCdc20_2	239	245	PF00400	0.409
LIG_deltaCOP1_diTrp_1	121	130	PF00928	0.534
LIG_FHA_1	131	137	PF00498	0.538
LIG_FHA_1	64	70	PF00498	0.639
LIG_FHA_2	106	112	PF00498	0.624
LIG_LIR_Apic_2	127	131	PF02991	0.544
LIG_LIR_Gen_1	149	157	PF02991	0.463
LIG_LIR_Gen_1	26	37	PF02991	0.703
LIG_LIR_Gen_1	63	73	PF02991	0.515
LIG_LIR_Gen_1	87	98	PF02991	0.587
LIG_LIR_Nem_3	145	151	PF02991	0.502
LIG_LIR_Nem_3	26	32	PF02991	0.716
LIG_LIR_Nem_3	63	68	PF02991	0.510
LIG_LIR_Nem_3	87	93	PF02991	0.539
LIG_PDZ_Class_3	254	259	PF00595	0.514
LIG_SH2_CRK	152	156	PF00017	0.429
LIG_SH2_CRK	90	94	PF00017	0.602
LIG_SH2_GRB2like	135	138	PF00017	0.500
LIG_SH2_SRC	109	112	PF00017	0.551
LIG_SH2_SRC	135	138	PF00017	0.500
LIG_SH2_STAP1	148	152	PF00017	0.596
LIG_SH2_STAP1	243	247	PF00017	0.413
LIG_SH2_STAT5	109	112	PF00017	0.551
LIG_SH2_STAT5	135	138	PF00017	0.500
LIG_SH2_STAT5	148	151	PF00017	0.471
LIG_SH2_STAT5	154	157	PF00017	0.367
LIG_SH2_STAT5	168	171	PF00017	0.456
LIG_SH2_STAT5	42	45	PF00017	0.647
LIG_SH2_STAT5	96	99	PF00017	0.501
LIG_SH3_2	100	105	PF14604	0.540
LIG_SH3_3	137	143	PF00018	0.461
LIG_SH3_3	74	80	PF00018	0.574
LIG_SH3_3	97	103	PF00018	0.512
LIG_SH3_4	53	60	PF00018	0.640
LIG_SH3_CIN85_PxpxPR_1	54	59	PF14604	0.529
MOD_CDK_SPxK_1	99	105	PF00069	0.587
MOD_CK1_1	36	42	PF00069	0.548
MOD_CK1_1	9	15	PF00069	0.801
MOD_CK1_1	99	105	PF00069	0.542
MOD_CK2_1	203	209	PF00069	0.421
MOD_CK2_1	57	63	PF00069	0.594
MOD_CMANNOS	125	128	PF00535	0.575
MOD_GlcNHglycan	59	62	PF01048	0.633
MOD_GlcNHglycan	8	11	PF01048	0.648
MOD_GSK3_1	105	112	PF00069	0.662
MOD_NEK2_1	203	208	PF00069	0.422
MOD_NEK2_1	218	223	PF00069	0.406
MOD_NEK2_1	247	252	PF00069	0.457
MOD_PKA_2	63	69	PF00069	0.503
MOD_Plk_4	89	95	PF00069	0.569
MOD_ProDKin_1	226	232	PF00069	0.503
MOD_ProDKin_1	96	102	PF00069	0.506
MOD_SUMO_rev_2	44	54	PF00179	0.680
TRG_ENDOCYTIC_2	152	155	PF00928	0.448
TRG_ENDOCYTIC_2	217	220	PF00928	0.409
TRG_ENDOCYTIC_2	29	32	PF00928	0.636
TRG_ENDOCYTIC_2	90	93	PF00928	0.608
TRG_ER_diArg_1	104	107	PF00400	0.567
TRG_ER_diArg_1	248	251	PF00400	0.489
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M7	Leptomonas seymouri	84%	98%
A0A0S4JE10	Bodo saltans	65%	91%
A0A1X0P3C8	Trypanosomatidae	76%	100%
A4HPL9	Leishmania braziliensis	92%	100%
A4ID45	Leishmania infantum	100%	100%
D0A8J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9ATD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q166	Leishmania major	97%	100%
V5BS71	Trypanosoma cruzi	78%	100%