Glycerophosphoryl diester phosphodiesterase family, putative

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glycerophosphoryl diester phosphodiesterase family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGB4_LEIDO

TriTrypDb:

LdBPK_242250.1 , LdCL_240028100 , LDHU3_24.2770

Length:

334

Annotations

Annotations by Jardim et al.

Lipid Metabolism, Glycerophosphoryl diester phosphodiesterase family

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IGB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGB4

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0006066	alcohol metabolic process	3	1
GO:0006576	biogenic amine metabolic process	5	1
GO:0006580	ethanolamine metabolic process	5	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009308	amine metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034308	primary alcohol metabolic process	4	1
GO:0042439	ethanolamine-containing compound metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0070291	N-acylethanolamine metabolic process	5	1
GO:1901160	primary amino compound metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008081	phosphoric diester hydrolase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0008889	glycerophosphodiester phosphodiesterase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.337
CLV_NRD_NRD_1	186	188	PF00675	0.398
CLV_NRD_NRD_1	260	262	PF00675	0.349
CLV_NRD_NRD_1	99	101	PF00675	0.363
CLV_PCSK_KEX2_1	149	151	PF00082	0.300
CLV_PCSK_KEX2_1	163	165	PF00082	0.228
CLV_PCSK_KEX2_1	191	193	PF00082	0.403
CLV_PCSK_KEX2_1	259	261	PF00082	0.370
CLV_PCSK_KEX2_1	328	330	PF00082	0.412
CLV_PCSK_KEX2_1	99	101	PF00082	0.286
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.387
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.393
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.484
CLV_PCSK_PC7_1	187	193	PF00082	0.341
CLV_PCSK_SKI1_1	146	150	PF00082	0.378
CLV_PCSK_SKI1_1	2	6	PF00082	0.423
CLV_PCSK_SKI1_1	261	265	PF00082	0.456
DEG_Nend_UBRbox_1	1	4	PF02207	0.442
DEG_SCF_FBW7_1	46	53	PF00400	0.385
DOC_CKS1_1	279	284	PF01111	0.494
DOC_CKS1_1	300	305	PF01111	0.498
DOC_MAPK_gen_1	187	195	PF00069	0.268
DOC_MAPK_gen_1	73	83	PF00069	0.278
DOC_MAPK_gen_1	99	106	PF00069	0.293
DOC_MAPK_MEF2A_6	205	212	PF00069	0.291
DOC_MAPK_NFAT4_5	205	213	PF00069	0.298
DOC_PP1_RVXF_1	28	34	PF00149	0.329
DOC_PP4_FxxP_1	300	303	PF00568	0.462
DOC_USP7_MATH_1	60	64	PF00917	0.341
DOC_WW_Pin1_4	278	283	PF00397	0.478
DOC_WW_Pin1_4	299	304	PF00397	0.495
DOC_WW_Pin1_4	46	51	PF00397	0.385
LIG_14-3-3_CanoR_1	110	115	PF00244	0.341
LIG_Actin_WH2_2	136	151	PF00022	0.398
LIG_Actin_WH2_2	7	22	PF00022	0.530
LIG_AP2alpha_1	83	87	PF02296	0.398
LIG_APCC_ABBA_1	80	85	PF00400	0.278
LIG_APCC_ABBAyCdc20_2	250	256	PF00400	0.400
LIG_eIF4E_1	170	176	PF01652	0.385
LIG_FHA_1	117	123	PF00498	0.278
LIG_FHA_1	153	159	PF00498	0.379
LIG_FHA_1	171	177	PF00498	0.134
LIG_FHA_1	262	268	PF00498	0.339
LIG_FHA_1	96	102	PF00498	0.269
LIG_FHA_2	103	109	PF00498	0.343
LIG_FHA_2	124	130	PF00498	0.278
LIG_LIR_Apic_2	298	303	PF02991	0.437
LIG_LIR_Gen_1	206	215	PF02991	0.485
LIG_LIR_Nem_3	160	165	PF02991	0.278
LIG_LIR_Nem_3	206	210	PF02991	0.470
LIG_MYND_3	124	128	PF01753	0.269
LIG_Pex14_2	83	87	PF04695	0.398
LIG_SH2_STAP1	199	203	PF00017	0.459
LIG_SH2_STAP1	234	238	PF00017	0.245
LIG_SH2_STAT5	152	155	PF00017	0.390
LIG_SH2_STAT5	18	21	PF00017	0.399
LIG_SH2_STAT5	270	273	PF00017	0.426
LIG_SH2_STAT5	280	283	PF00017	0.459
LIG_SH3_2	25	30	PF14604	0.336
LIG_SH3_3	119	125	PF00018	0.385
LIG_SH3_3	22	28	PF00018	0.342
LIG_SH3_3	300	306	PF00018	0.483
LIG_SUMO_SIM_par_1	141	147	PF11976	0.278
LIG_TRAF2_1	126	129	PF00917	0.300
LIG_WRC_WIRS_1	175	180	PF05994	0.335
LIG_WW_1	306	309	PF00397	0.607
MOD_CDK_SPK_2	299	304	PF00069	0.530
MOD_CDK_SPxxK_3	278	285	PF00069	0.518
MOD_CK1_1	177	183	PF00069	0.424
MOD_CK2_1	102	108	PF00069	0.335
MOD_CK2_1	123	129	PF00069	0.293
MOD_CK2_1	289	295	PF00069	0.486
MOD_GlcNHglycan	179	182	PF01048	0.424
MOD_GlcNHglycan	62	65	PF01048	0.341
MOD_GSK3_1	112	119	PF00069	0.318
MOD_GSK3_1	148	155	PF00069	0.341
MOD_GSK3_1	170	177	PF00069	0.335
MOD_GSK3_1	199	206	PF00069	0.272
MOD_GSK3_1	46	53	PF00069	0.385
MOD_N-GLC_2	266	268	PF02516	0.434
MOD_NEK2_1	14	19	PF00069	0.402
MOD_NEK2_1	148	153	PF00069	0.341
MOD_NEK2_1	203	208	PF00069	0.456
MOD_NEK2_1	6	11	PF00069	0.370
MOD_PKA_2	72	78	PF00069	0.278
MOD_PKB_1	259	267	PF00069	0.458
MOD_Plk_1	102	108	PF00069	0.300
MOD_Plk_1	170	176	PF00069	0.278
MOD_Plk_1	50	56	PF00069	0.278
MOD_Plk_2-3	102	108	PF00069	0.335
MOD_Plk_4	102	108	PF00069	0.312
MOD_Plk_4	171	177	PF00069	0.279
MOD_Plk_4	199	205	PF00069	0.405
MOD_Plk_4	242	248	PF00069	0.304
MOD_ProDKin_1	278	284	PF00069	0.472
MOD_ProDKin_1	299	305	PF00069	0.498
MOD_ProDKin_1	46	52	PF00069	0.385
MOD_SUMO_rev_2	144	151	PF00179	0.398
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.444
TRG_ENDOCYTIC_2	234	237	PF00928	0.399
TRG_ENDOCYTIC_2	309	312	PF00928	0.533
TRG_ER_diArg_1	162	164	PF00400	0.343
TRG_ER_diArg_1	259	261	PF00400	0.374
TRG_ER_diArg_1	329	332	PF00400	0.443
TRG_ER_diArg_1	99	101	PF00400	0.362
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.278
TRG_Pf-PMV_PEXEL_1	317	322	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S0	Leptomonas seymouri	74%	100%
A0A0S4KJA2	Bodo saltans	50%	100%
A0A1X0NVZ2	Trypanosomatidae	56%	100%
A0A422NWY6	Trypanosoma rangeli	55%	100%
A4HDS7	Leishmania braziliensis	80%	100%
A4I125	Leishmania infantum	100%	100%
C9ZW84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AX62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q3T0T0	Bos taurus	26%	100%
Q4QAB4	Leishmania major	94%	100%
Q9JL55	Rattus norvegicus	25%	100%
Q9JL56	Mus musculus	25%	100%
Q9NZC3	Homo sapiens	24%	100%
V5B577	Trypanosoma cruzi	55%	97%