Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGB2_LEIDO

TriTrypDb:

LdBPK_323890.1 , LdCL_320044900 , LDHU3_32.5020

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	128	130	PF00082	0.491
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.434
DOC_CKS1_1	79	84	PF01111	0.443
DOC_MAPK_gen_1	17	26	PF00069	0.420
DOC_MAPK_gen_1	61	69	PF00069	0.504
DOC_PP2B_LxvP_1	67	70	PF13499	0.605
DOC_WW_Pin1_4	54	59	PF00397	0.516
DOC_WW_Pin1_4	75	80	PF00397	0.437
LIG_14-3-3_CanoR_1	110	118	PF00244	0.566
LIG_14-3-3_CanoR_1	137	142	PF00244	0.487
LIG_BIR_II_1	1	5	PF00653	0.502
LIG_BRCT_BRCA1_1	139	143	PF00533	0.490
LIG_CSL_BTD_1	79	82	PF09270	0.414
LIG_DLG_GKlike_1	137	145	PF00625	0.495
LIG_FHA_1	110	116	PF00498	0.463
LIG_Integrin_isoDGR_2	104	106	PF01839	0.531
LIG_LIR_Gen_1	2	11	PF02991	0.473
LIG_LIR_Gen_1	38	46	PF02991	0.558
LIG_LIR_Gen_1	96	107	PF02991	0.428
LIG_LIR_Nem_3	2	7	PF02991	0.484
LIG_LIR_Nem_3	38	44	PF02991	0.544
LIG_LIR_Nem_3	55	59	PF02991	0.418
LIG_LIR_Nem_3	96	102	PF02991	0.415
LIG_PTB_Apo_2	101	108	PF02174	0.506
LIG_PTB_Apo_2	68	75	PF02174	0.505
LIG_PTB_Phospho_1	68	74	PF10480	0.504
LIG_SH2_GRB2like	74	77	PF00017	0.581
LIG_SH2_STAT5	141	144	PF00017	0.399
LIG_SH2_STAT5	36	39	PF00017	0.449
LIG_SH2_STAT5	52	55	PF00017	0.453
LIG_SH2_STAT5	74	77	PF00017	0.498
LIG_SH2_STAT5	99	102	PF00017	0.528
LIG_SH3_3	146	152	PF00018	0.519
LIG_SH3_3	76	82	PF00018	0.424
LIG_SH3_4	61	68	PF00018	0.632
LIG_TRAF2_1	120	123	PF00917	0.467
LIG_WRC_WIRS_1	7	12	PF05994	0.561
MOD_CDK_SPK_2	78	83	PF00069	0.452
MOD_CDK_SPxxK_3	54	61	PF00069	0.518
MOD_CK1_1	6	12	PF00069	0.468
MOD_CK1_1	78	84	PF00069	0.482
MOD_CK2_1	124	130	PF00069	0.573
MOD_GlcNHglycan	26	29	PF01048	0.341
MOD_GSK3_1	109	116	PF00069	0.573
MOD_GSK3_1	137	144	PF00069	0.580
MOD_GSK3_1	6	13	PF00069	0.551
MOD_N-GLC_1	75	80	PF02516	0.448
MOD_NEK2_1	10	15	PF00069	0.506
MOD_PKA_2	109	115	PF00069	0.488
MOD_PKB_1	135	143	PF00069	0.461
MOD_Plk_4	113	119	PF00069	0.624
MOD_Plk_4	137	143	PF00069	0.512
MOD_Plk_4	6	12	PF00069	0.490
MOD_ProDKin_1	54	60	PF00069	0.516
MOD_ProDKin_1	75	81	PF00069	0.436
TRG_DiLeu_BaLyEn_6	134	139	PF01217	0.487
TRG_ENDOCYTIC_2	41	44	PF00928	0.525
TRG_ENDOCYTIC_2	99	102	PF00928	0.528
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W3	Leptomonas seymouri	80%	100%
A0A1X0NRY2	Trypanosomatidae	69%	100%
A0A3R7N368	Trypanosoma rangeli	57%	100%
A4HL11	Leishmania braziliensis	84%	100%
A4I8J2	Leishmania infantum	100%	100%
D0AAM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9B3F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q4P8	Leishmania major	93%	100%
V5DME5	Trypanosoma cruzi	63%	100%