Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IGB0_LEIDO

TriTrypDb:

LdBPK_312310.1 , LdCL_310031100 , LDHU3_31.4140

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3Q8IGB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGB0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.545
CLV_NRD_NRD_1	52	54	PF00675	0.478
CLV_PCSK_KEX2_1	101	103	PF00082	0.560
CLV_PCSK_KEX2_1	47	49	PF00082	0.494
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.494
CLV_PCSK_SKI1_1	47	51	PF00082	0.515
CLV_PCSK_SKI1_1	61	65	PF00082	0.351
DEG_SPOP_SBC_1	5	9	PF00917	0.402
DOC_CKS1_1	68	73	PF01111	0.728
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.529
DOC_PP2B_LxvP_1	14	17	PF13499	0.529
DOC_PP4_FxxP_1	22	25	PF00568	0.426
DOC_USP7_MATH_1	108	112	PF00917	0.816
DOC_USP7_MATH_1	129	133	PF00917	0.674
DOC_WW_Pin1_4	1	6	PF00397	0.443
DOC_WW_Pin1_4	67	72	PF00397	0.726
DOC_WW_Pin1_4	92	97	PF00397	0.808
LIG_eIF4E_1	45	51	PF01652	0.579
LIG_FHA_1	6	12	PF00498	0.487
LIG_FHA_2	5	11	PF00498	0.500
LIG_LIR_Gen_1	9	20	PF02991	0.292
LIG_LIR_Nem_3	77	83	PF02991	0.728
LIG_LIR_Nem_3	9	15	PF02991	0.292
LIG_Pex14_2	22	26	PF04695	0.426
LIG_SH2_CRK	33	37	PF00017	0.663
LIG_SH2_STAP1	45	49	PF00017	0.682
LIG_SH2_STAT5	12	15	PF00017	0.467
LIG_SH3_3	65	71	PF00018	0.722
MOD_CDC14_SPxK_1	99	102	PF00782	0.818
MOD_CDK_SPK_2	67	72	PF00069	0.726
MOD_CDK_SPK_2	96	101	PF00069	0.717
MOD_CDK_SPxK_1	96	102	PF00069	0.820
MOD_CDK_SPxxK_3	67	74	PF00069	0.728
MOD_CK1_1	106	112	PF00069	0.817
MOD_CK1_1	114	120	PF00069	0.746
MOD_CK1_1	4	10	PF00069	0.546
MOD_CK2_1	136	142	PF00069	0.776
MOD_GlcNHglycan	125	128	PF01048	0.633
MOD_GSK3_1	1	8	PF00069	0.494
MOD_GSK3_1	106	113	PF00069	0.724
MOD_GSK3_1	116	123	PF00069	0.739
MOD_GSK3_1	136	143	PF00069	0.806
MOD_GSK3_1	144	151	PF00069	0.713
MOD_GSK3_1	91	98	PF00069	0.833
MOD_N-GLC_1	103	108	PF02516	0.584
MOD_N-GLC_1	123	128	PF02516	0.408
MOD_PIKK_1	116	122	PF00454	0.815
MOD_PKA_2	111	117	PF00069	0.858
MOD_PKA_2	120	126	PF00069	0.742
MOD_Plk_1	103	109	PF00069	0.786
MOD_Plk_1	136	142	PF00069	0.776
MOD_Plk_2-3	136	142	PF00069	0.776
MOD_Plk_2-3	145	151	PF00069	0.690
MOD_Plk_2-3	85	91	PF00069	0.781
MOD_Plk_4	129	135	PF00069	0.774
MOD_Plk_4	136	142	PF00069	0.660
MOD_ProDKin_1	1	7	PF00069	0.437
MOD_ProDKin_1	67	73	PF00069	0.727
MOD_ProDKin_1	92	98	PF00069	0.810
MOD_SUMO_for_1	63	66	PF00179	0.640
TRG_DiLeu_BaEn_1	46	51	PF01217	0.580
TRG_ENDOCYTIC_2	12	15	PF00928	0.323
TRG_ENDOCYTIC_2	33	36	PF00928	0.666
TRG_ER_diArg_1	100	102	PF00400	0.736
TRG_ER_diArg_1	56	59	PF00400	0.693
TRG_NLS_MonoExtC_3	52	57	PF00514	0.659
TRG_NLS_MonoExtN_4	53	58	PF00514	0.661
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I707	Leishmania infantum	100%	100%
E9B225	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q637	Leishmania major	87%	100%