Ring finger domain/IQ calmodulin-binding motif containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGA8_LEIDO

TriTrypDb:

LdBPK_352560.1 , LdCL_350030500 , LDHU3_35.3310

Length:

396

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.651
CLV_NRD_NRD_1	130	132	PF00675	0.503
CLV_NRD_NRD_1	159	161	PF00675	0.573
CLV_NRD_NRD_1	230	232	PF00675	0.514
CLV_NRD_NRD_1	262	264	PF00675	0.720
CLV_NRD_NRD_1	287	289	PF00675	0.729
CLV_NRD_NRD_1	296	298	PF00675	0.696
CLV_NRD_NRD_1	364	366	PF00675	0.524
CLV_NRD_NRD_1	90	92	PF00675	0.295
CLV_PCSK_KEX2_1	130	132	PF00082	0.503
CLV_PCSK_KEX2_1	287	289	PF00082	0.711
CLV_PCSK_KEX2_1	296	298	PF00082	0.740
CLV_PCSK_KEX2_1	364	366	PF00082	0.524
CLV_PCSK_KEX2_1	62	64	PF00082	0.452
CLV_PCSK_KEX2_1	90	92	PF00082	0.295
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.445
CLV_PCSK_PC7_1	360	366	PF00082	0.507
CLV_PCSK_SKI1_1	146	150	PF00082	0.498
CLV_PCSK_SKI1_1	62	66	PF00082	0.443
CLV_PCSK_SKI1_1	85	89	PF00082	0.279
DEG_APCC_DBOX_1	363	371	PF00400	0.545
DEG_SPOP_SBC_1	166	170	PF00917	0.673
DOC_CKS1_1	268	273	PF01111	0.594
DOC_MAPK_gen_1	90	98	PF00069	0.543
DOC_MAPK_RevD_3	275	288	PF00069	0.604
DOC_MAPK_RevD_3	75	91	PF00069	0.495
DOC_PP2B_LxvP_1	175	178	PF13499	0.643
DOC_USP7_MATH_1	166	170	PF00917	0.748
DOC_USP7_MATH_1	233	237	PF00917	0.638
DOC_USP7_MATH_1	242	246	PF00917	0.695
DOC_USP7_MATH_1	253	257	PF00917	0.602
DOC_USP7_MATH_1	275	279	PF00917	0.644
DOC_USP7_MATH_1	318	322	PF00917	0.737
DOC_WW_Pin1_4	267	272	PF00397	0.648
LIG_14-3-3_CanoR_1	115	123	PF00244	0.407
LIG_14-3-3_CanoR_1	246	252	PF00244	0.707
LIG_14-3-3_CanoR_1	364	368	PF00244	0.525
LIG_14-3-3_CanoR_1	56	61	PF00244	0.504
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_BIR_III_4	326	330	PF00653	0.619
LIG_BIR_III_4	39	43	PF00653	0.586
LIG_BRCT_BRCA1_1	16	20	PF00533	0.423
LIG_CaM_IQ_9	77	93	PF13499	0.481
LIG_deltaCOP1_diTrp_1	152	159	PF00928	0.535
LIG_eIF4E_1	93	99	PF01652	0.387
LIG_FHA_1	104	110	PF00498	0.504
LIG_FHA_1	42	48	PF00498	0.580
LIG_FHA_2	166	172	PF00498	0.745
LIG_FHA_2	214	220	PF00498	0.552
LIG_LIR_Gen_1	117	125	PF02991	0.536
LIG_LIR_Gen_1	152	163	PF02991	0.486
LIG_LIR_Gen_1	313	322	PF02991	0.703
LIG_LIR_Gen_1	356	363	PF02991	0.408
LIG_LIR_Nem_3	117	123	PF02991	0.424
LIG_LIR_Nem_3	152	158	PF02991	0.447
LIG_LIR_Nem_3	27	31	PF02991	0.448
LIG_LIR_Nem_3	313	319	PF02991	0.655
LIG_LIR_Nem_3	356	361	PF02991	0.434
LIG_LIR_Nem_3	59	64	PF02991	0.540
LIG_PCNA_yPIPBox_3	74	88	PF02747	0.561
LIG_PTB_Apo_2	98	105	PF02174	0.492
LIG_SH2_CRK	61	65	PF00017	0.524
LIG_SH2_CRK	93	97	PF00017	0.511
LIG_SH2_STAT5	108	111	PF00017	0.494
LIG_SH2_STAT5	31	34	PF00017	0.561
LIG_SH2_STAT5	349	352	PF00017	0.440
LIG_SH2_STAT5	391	394	PF00017	0.348
LIG_SH2_STAT5	93	96	PF00017	0.412
LIG_SH3_3	160	166	PF00018	0.648
LIG_SH3_3	182	188	PF00018	0.550
LIG_SH3_3	265	271	PF00018	0.751
LIG_SH3_3	332	338	PF00018	0.611
LIG_SH3_3	375	381	PF00018	0.510
LIG_SH3_3	43	49	PF00018	0.565
LIG_SUMO_SIM_anti_2	366	371	PF11976	0.455
LIG_TRAF2_1	125	128	PF00917	0.538
LIG_WRC_WIRS_1	25	30	PF05994	0.542
MOD_CDK_SPK_2	267	272	PF00069	0.598
MOD_CK1_1	167	173	PF00069	0.708
MOD_CK1_1	2	8	PF00069	0.677
MOD_CK1_1	236	242	PF00069	0.668
MOD_CK1_1	245	251	PF00069	0.642
MOD_CK2_1	165	171	PF00069	0.729
MOD_Cter_Amidation	294	297	PF01082	0.607
MOD_GlcNHglycan	116	119	PF01048	0.520
MOD_GlcNHglycan	247	250	PF01048	0.735
MOD_GlcNHglycan	255	258	PF01048	0.747
MOD_GlcNHglycan	320	323	PF01048	0.771
MOD_GlcNHglycan	339	342	PF01048	0.423
MOD_GlcNHglycan	388	391	PF01048	0.440
MOD_GSK3_1	167	174	PF00069	0.714
MOD_N-GLC_2	382	384	PF02516	0.482
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_1	14	19	PF00069	0.338
MOD_NEK2_1	300	305	PF00069	0.774
MOD_NEK2_2	275	280	PF00069	0.701
MOD_PIKK_1	194	200	PF00454	0.508
MOD_PIKK_1	54	60	PF00454	0.537
MOD_PKA_2	114	120	PF00069	0.421
MOD_PKA_2	213	219	PF00069	0.564
MOD_PKA_2	245	251	PF00069	0.703
MOD_PKA_2	363	369	PF00069	0.514
MOD_Plk_1	275	281	PF00069	0.602
MOD_Plk_2-3	363	369	PF00069	0.487
MOD_Plk_4	56	62	PF00069	0.496
MOD_ProDKin_1	267	273	PF00069	0.645
MOD_SUMO_rev_2	236	245	PF00179	0.697
MOD_SUMO_rev_2	276	285	PF00179	0.650
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.386
TRG_ENDOCYTIC_2	358	361	PF00928	0.487
TRG_ENDOCYTIC_2	61	64	PF00928	0.522
TRG_ENDOCYTIC_2	93	96	PF00928	0.422
TRG_ER_diArg_1	104	107	PF00400	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8I6	Leptomonas seymouri	45%	72%
A0A1X0P5K1	Trypanosomatidae	33%	89%
A0A3S5IR12	Trypanosoma rangeli	35%	92%
A4IBG1	Leishmania infantum	100%	100%
C9ZZA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	75%
E9AF75	Leishmania major	84%	100%
E9AIW3	Leishmania braziliensis	71%	100%
E9B6D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
V5B3S2	Trypanosoma cruzi	32%	91%