Sphingosine-1-phosphate phosphatase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sphingosine-1-phosphate phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGA4_LEIDO

TriTrypDb:

LdBPK_322440.1 , LdCL_320029700 , LDHU3_32.3030

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

A0A3Q8IGA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGA4

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0030258	lipid modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046839	phospholipid dephosphorylation	5	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042392	sphingosine-1-phosphate phosphatase activity	7	1
GO:0042577	lipid phosphatase activity	6	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.755
CLV_C14_Caspase3-7	567	571	PF00656	0.712
CLV_NRD_NRD_1	172	174	PF00675	0.390
CLV_PCSK_KEX2_1	172	174	PF00082	0.390
CLV_PCSK_KEX2_1	279	281	PF00082	0.497
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.554
CLV_PCSK_SKI1_1	261	265	PF00082	0.600
CLV_PCSK_SKI1_1	477	481	PF00082	0.346
DEG_COP1_1	16	27	PF00400	0.748
DEG_MDM2_SWIB_1	362	370	PF02201	0.366
DEG_Nend_Nbox_1	1	3	PF02207	0.750
DOC_AGCK_PIF_1	215	220	PF00069	0.413
DOC_CKS1_1	147	152	PF01111	0.728
DOC_CYCLIN_yCln2_LP_2	624	630	PF00134	0.449
DOC_MAPK_DCC_7	202	212	PF00069	0.580
DOC_MAPK_gen_1	172	180	PF00069	0.626
DOC_MAPK_gen_1	490	500	PF00069	0.646
DOC_MAPK_gen_1	515	523	PF00069	0.697
DOC_MAPK_gen_1	95	103	PF00069	0.744
DOC_MAPK_JIP1_4	97	103	PF00069	0.743
DOC_MAPK_MEF2A_6	268	276	PF00069	0.295
DOC_MAPK_MEF2A_6	493	502	PF00069	0.657
DOC_MAPK_MEF2A_6	95	103	PF00069	0.744
DOC_PP1_RVXF_1	174	181	PF00149	0.652
DOC_PP2B_LxvP_1	210	213	PF13499	0.651
DOC_PP2B_LxvP_1	229	232	PF13499	0.338
DOC_PP2B_LxvP_1	237	240	PF13499	0.323
DOC_PP4_FxxP_1	12	15	PF00568	0.799
DOC_PP4_FxxP_1	264	267	PF00568	0.391
DOC_USP7_MATH_1	120	124	PF00917	0.756
DOC_USP7_MATH_1	13	17	PF00917	0.660
DOC_USP7_MATH_1	151	155	PF00917	0.755
DOC_USP7_MATH_1	240	244	PF00917	0.347
DOC_USP7_MATH_1	328	332	PF00917	0.397
DOC_USP7_MATH_1	525	529	PF00917	0.740
DOC_USP7_MATH_1	556	560	PF00917	0.816
DOC_USP7_UBL2_3	477	481	PF12436	0.604
DOC_WW_Pin1_4	146	151	PF00397	0.750
DOC_WW_Pin1_4	157	162	PF00397	0.741
DOC_WW_Pin1_4	23	28	PF00397	0.765
DOC_WW_Pin1_4	373	378	PF00397	0.453
DOC_WW_Pin1_4	394	399	PF00397	0.608
DOC_WW_Pin1_4	631	636	PF00397	0.590
LIG_14-3-3_CanoR_1	173	179	PF00244	0.573
LIG_14-3-3_CanoR_1	490	496	PF00244	0.602
LIG_14-3-3_CanoR_1	515	523	PF00244	0.724
LIG_14-3-3_CanoR_1	560	569	PF00244	0.743
LIG_14-3-3_CanoR_1	595	600	PF00244	0.497
LIG_14-3-3_CanoR_1	97	102	PF00244	0.665
LIG_Actin_WH2_2	463	479	PF00022	0.549
LIG_Actin_WH2_2	602	617	PF00022	0.485
LIG_AP2alpha_1	536	540	PF02296	0.640
LIG_APCC_ABBA_1	309	314	PF00400	0.291
LIG_BRCT_BRCA1_1	296	300	PF00533	0.295
LIG_BRCT_BRCA1_1	407	411	PF00533	0.495
LIG_BRCT_BRCA1_1	446	450	PF00533	0.351
LIG_BRCT_BRCA1_1	526	530	PF00533	0.692
LIG_BRCT_BRCA1_1	532	536	PF00533	0.785
LIG_CtBP_PxDLS_1	98	102	PF00389	0.743
LIG_deltaCOP1_diTrp_1	182	188	PF00928	0.580
LIG_EH1_1	339	347	PF00400	0.524
LIG_eIF4E_1	385	391	PF01652	0.445
LIG_FHA_1	134	140	PF00498	0.660
LIG_FHA_1	232	238	PF00498	0.365
LIG_FHA_1	29	35	PF00498	0.673
LIG_FHA_1	385	391	PF00498	0.473
LIG_FHA_1	410	416	PF00498	0.485
LIG_FHA_1	417	423	PF00498	0.304
LIG_FHA_1	561	567	PF00498	0.746
LIG_FHA_1	573	579	PF00498	0.629
LIG_FHA_1	615	621	PF00498	0.412
LIG_FHA_2	161	167	PF00498	0.693
LIG_FHA_2	33	39	PF00498	0.795
LIG_FHA_2	395	401	PF00498	0.610
LIG_FHA_2	563	569	PF00498	0.736
LIG_LIR_Apic_2	10	15	PF02991	0.790
LIG_LIR_Apic_2	262	267	PF02991	0.391
LIG_LIR_Apic_2	284	290	PF02991	0.295
LIG_LIR_Gen_1	20	29	PF02991	0.670
LIG_LIR_Gen_1	225	235	PF02991	0.352
LIG_LIR_Gen_1	297	308	PF02991	0.313
LIG_LIR_Gen_1	331	339	PF02991	0.433
LIG_LIR_Gen_1	376	386	PF02991	0.356
LIG_LIR_Gen_1	596	606	PF02991	0.394
LIG_LIR_Nem_3	20	24	PF02991	0.816
LIG_LIR_Nem_3	223	229	PF02991	0.409
LIG_LIR_Nem_3	297	303	PF02991	0.300
LIG_LIR_Nem_3	331	335	PF02991	0.419
LIG_LIR_Nem_3	375	381	PF02991	0.352
LIG_MYND_1	209	213	PF01753	0.600
LIG_MYND_1	635	639	PF01753	0.415
LIG_PCNA_PIPBox_1	296	305	PF02747	0.328
LIG_PCNA_yPIPBox_3	296	307	PF02747	0.250
LIG_Pex14_1	251	255	PF04695	0.340
LIG_Pex14_2	226	230	PF04695	0.324
LIG_Pex14_2	362	366	PF04695	0.349
LIG_Pex14_2	446	450	PF04695	0.357
LIG_Pex14_2	536	540	PF04695	0.718
LIG_Pex14_2	604	608	PF04695	0.393
LIG_RPA_C_Fungi	460	472	PF08784	0.449
LIG_SH2_CRK	287	291	PF00017	0.351
LIG_SH2_CRK	305	309	PF00017	0.351
LIG_SH2_CRK	429	433	PF00017	0.463
LIG_SH2_GRB2like	572	575	PF00017	0.591
LIG_SH2_PTP2	385	388	PF00017	0.467
LIG_SH2_SRC	405	408	PF00017	0.416
LIG_SH2_STAT5	184	187	PF00017	0.418
LIG_SH2_STAT5	214	217	PF00017	0.351
LIG_SH2_STAT5	255	258	PF00017	0.351
LIG_SH2_STAT5	305	308	PF00017	0.442
LIG_SH2_STAT5	326	329	PF00017	0.469
LIG_SH2_STAT5	336	339	PF00017	0.329
LIG_SH2_STAT5	381	384	PF00017	0.347
LIG_SH2_STAT5	385	388	PF00017	0.330
LIG_SH2_STAT5	405	408	PF00017	0.187
LIG_SH2_STAT5	499	502	PF00017	0.480
LIG_SH2_STAT5	572	575	PF00017	0.591
LIG_SH3_3	155	161	PF00018	0.667
LIG_SH3_3	203	209	PF00018	0.521
LIG_SH3_3	21	27	PF00018	0.766
LIG_SH3_3	264	270	PF00018	0.333
LIG_SH3_3	395	401	PF00018	0.511
LIG_SH3_3	563	569	PF00018	0.657
LIG_SH3_3	629	635	PF00018	0.794
LIG_SUMO_SIM_par_1	135	141	PF11976	0.580
LIG_SUMO_SIM_par_1	160	166	PF11976	0.662
LIG_SUMO_SIM_par_1	30	35	PF11976	0.601
LIG_SxIP_EBH_1	515	527	PF03271	0.650
LIG_TRAF2_1	565	568	PF00917	0.704
LIG_TYR_ITIM	212	217	PF00017	0.433
LIG_TYR_ITIM	383	388	PF00017	0.485
LIG_Vh1_VBS_1	460	478	PF01044	0.472
LIG_WRC_WIRS_1	217	222	PF05994	0.375
LIG_WRC_WIRS_1	299	304	PF05994	0.465
LIG_WRC_WIRS_1	605	610	PF05994	0.433
MOD_CK1_1	114	120	PF00069	0.772
MOD_CK1_1	160	166	PF00069	0.619
MOD_CK1_1	291	297	PF00069	0.352
MOD_CK1_1	580	586	PF00069	0.473
MOD_CK1_1	93	99	PF00069	0.786
MOD_CK2_1	160	166	PF00069	0.641
MOD_CK2_1	32	38	PF00069	0.665
MOD_CK2_1	558	564	PF00069	0.782
MOD_CMANNOS	587	590	PF00535	0.412
MOD_Cter_Amidation	277	280	PF01082	0.385
MOD_DYRK1A_RPxSP_1	23	27	PF00069	0.593
MOD_DYRK1A_RPxSP_1	373	377	PF00069	0.479
MOD_GlcNHglycan	153	156	PF01048	0.633
MOD_GlcNHglycan	16	19	PF01048	0.783
MOD_GlcNHglycan	296	299	PF01048	0.433
MOD_GlcNHglycan	46	49	PF01048	0.795
MOD_GlcNHglycan	483	486	PF01048	0.527
MOD_GlcNHglycan	73	76	PF01048	0.752
MOD_GlcNHglycan	92	95	PF01048	0.482
MOD_GSK3_1	19	26	PF00069	0.704
MOD_GSK3_1	28	35	PF00069	0.778
MOD_GSK3_1	294	301	PF00069	0.381
MOD_GSK3_1	3	10	PF00069	0.699
MOD_GSK3_1	405	412	PF00069	0.462
MOD_GSK3_1	44	51	PF00069	0.678
MOD_GSK3_1	461	468	PF00069	0.520
MOD_GSK3_1	521	528	PF00069	0.690
MOD_GSK3_1	554	561	PF00069	0.713
MOD_GSK3_1	631	638	PF00069	0.757
MOD_GSK3_1	93	100	PF00069	0.740
MOD_LATS_1	277	283	PF00433	0.419
MOD_LATS_1	593	599	PF00433	0.433
MOD_N-GLC_1	114	119	PF02516	0.696
MOD_N-GLC_1	525	530	PF02516	0.617
MOD_N-GLC_1	55	60	PF02516	0.610
MOD_N-GLC_1	554	559	PF02516	0.603
MOD_N-GLC_1	71	76	PF02516	0.709
MOD_N-GLC_1	88	93	PF02516	0.630
MOD_NEK2_1	2	7	PF00069	0.724
MOD_NEK2_1	32	37	PF00069	0.794
MOD_NEK2_1	384	389	PF00069	0.375
MOD_NEK2_1	409	414	PF00069	0.360
MOD_NEK2_1	416	421	PF00069	0.333
MOD_NEK2_1	444	449	PF00069	0.382
MOD_NEK2_1	604	609	PF00069	0.419
MOD_NEK2_1	614	619	PF00069	0.464
MOD_NEK2_2	183	188	PF00069	0.552
MOD_NEK2_2	298	303	PF00069	0.375
MOD_NEK2_2	405	410	PF00069	0.383
MOD_NEK2_2	525	530	PF00069	0.628
MOD_PIKK_1	572	578	PF00454	0.630
MOD_PKA_1	279	285	PF00069	0.419
MOD_PKA_2	111	117	PF00069	0.608
MOD_PKA_2	279	285	PF00069	0.373
MOD_PKA_2	409	415	PF00069	0.433
MOD_PKA_2	514	520	PF00069	0.723
MOD_PKA_2	614	620	PF00069	0.477
MOD_Plk_1	19	25	PF00069	0.779
MOD_Plk_1	366	372	PF00069	0.473
MOD_Plk_1	465	471	PF00069	0.547
MOD_Plk_1	525	531	PF00069	0.620
MOD_Plk_4	143	149	PF00069	0.676
MOD_Plk_4	245	251	PF00069	0.415
MOD_Plk_4	352	358	PF00069	0.419
MOD_Plk_4	366	372	PF00069	0.279
MOD_Plk_4	446	452	PF00069	0.334
MOD_Plk_4	466	472	PF00069	0.463
MOD_Plk_4	525	531	PF00069	0.673
MOD_Plk_4	604	610	PF00069	0.400
MOD_ProDKin_1	146	152	PF00069	0.706
MOD_ProDKin_1	157	163	PF00069	0.688
MOD_ProDKin_1	23	29	PF00069	0.729
MOD_ProDKin_1	373	379	PF00069	0.572
MOD_ProDKin_1	394	400	PF00069	0.509
MOD_ProDKin_1	631	637	PF00069	0.749
MOD_SUMO_rev_2	538	547	PF00179	0.652
TRG_DiLeu_BaEn_1	466	471	PF01217	0.530
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.471
TRG_ENDOCYTIC_2	214	217	PF00928	0.351
TRG_ENDOCYTIC_2	227	230	PF00928	0.351
TRG_ENDOCYTIC_2	305	308	PF00928	0.351
TRG_ENDOCYTIC_2	336	339	PF00928	0.433
TRG_ENDOCYTIC_2	381	384	PF00928	0.445
TRG_ENDOCYTIC_2	385	388	PF00928	0.419
TRG_ENDOCYTIC_2	429	432	PF00928	0.461
TRG_ENDOCYTIC_2	499	502	PF00928	0.499
TRG_ENDOCYTIC_2	599	602	PF00928	0.359
TRG_ER_diArg_1	171	173	PF00400	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9L1	Leptomonas seymouri	54%	100%
A0A1X0NUR9	Trypanosomatidae	36%	100%
A0A422MU49	Trypanosoma rangeli	38%	100%
A4HKM0	Leishmania braziliensis	65%	100%
A4I852	Leishmania infantum	99%	100%
Q4Q546	Leishmania major	89%	100%