ATP-grasp domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-grasp domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IG99_LEIDO

TriTrypDb:

LdBPK_352310.1 , LdCL_350028000 , LDHU3_35.2940

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IG99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG99

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.355
CLV_C14_Caspase3-7	411	415	PF00656	0.783
CLV_NRD_NRD_1	21	23	PF00675	0.534
CLV_PCSK_KEX2_1	148	150	PF00082	0.419
CLV_PCSK_KEX2_1	21	23	PF00082	0.534
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.419
CLV_PCSK_SKI1_1	114	118	PF00082	0.372
CLV_PCSK_SKI1_1	164	168	PF00082	0.467
CLV_PCSK_SKI1_1	306	310	PF00082	0.378
CLV_PCSK_SKI1_1	370	374	PF00082	0.394
CLV_PCSK_SKI1_1	437	441	PF00082	0.449
CLV_PCSK_SKI1_1	500	504	PF00082	0.461
DEG_APCC_DBOX_1	94	102	PF00400	0.536
DEG_Nend_UBRbox_2	1	3	PF02207	0.507
DEG_SCF_FBW7_2	35	41	PF00400	0.393
DOC_CKS1_1	140	145	PF01111	0.582
DOC_CKS1_1	35	40	PF01111	0.548
DOC_CYCLIN_RxL_1	300	310	PF00134	0.431
DOC_CYCLIN_RxL_1	357	366	PF00134	0.419
DOC_CYCLIN_yClb5_NLxxxL_5	360	368	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.434
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.429
DOC_MAPK_DCC_7	95	103	PF00069	0.512
DOC_MAPK_gen_1	21	30	PF00069	0.387
DOC_MAPK_gen_1	334	342	PF00069	0.335
DOC_MAPK_MEF2A_6	21	30	PF00069	0.395
DOC_MAPK_MEF2A_6	306	313	PF00069	0.266
DOC_MAPK_NFAT4_5	306	314	PF00069	0.266
DOC_PP1_RVXF_1	2	9	PF00149	0.515
DOC_PP2B_LxvP_1	373	376	PF13499	0.514
DOC_PP4_FxxP_1	439	442	PF00568	0.491
DOC_USP7_MATH_1	408	412	PF00917	0.652
DOC_USP7_MATH_1	77	81	PF00917	0.419
DOC_USP7_MATH_2	465	471	PF00917	0.554
DOC_USP7_UBL2_3	169	173	PF12436	0.473
DOC_WW_Pin1_4	125	130	PF00397	0.409
DOC_WW_Pin1_4	139	144	PF00397	0.480
DOC_WW_Pin1_4	186	191	PF00397	0.342
DOC_WW_Pin1_4	34	39	PF00397	0.508
DOC_WW_Pin1_4	403	408	PF00397	0.753
DOC_WW_Pin1_4	96	101	PF00397	0.469
LIG_14-3-3_CanoR_1	10	15	PF00244	0.363
LIG_14-3-3_CanoR_1	118	127	PF00244	0.479
LIG_14-3-3_CanoR_1	198	204	PF00244	0.487
LIG_14-3-3_CanoR_1	21	27	PF00244	0.431
LIG_14-3-3_CanoR_1	513	519	PF00244	0.361
LIG_BRCT_BRCA1_1	156	160	PF00533	0.568
LIG_BRCT_BRCA1_1	275	279	PF00533	0.355
LIG_BRCT_BRCA1_1	435	439	PF00533	0.542
LIG_BRCT_BRCA1_2	156	162	PF00533	0.575
LIG_DLG_GKlike_1	22	30	PF00625	0.314
LIG_EVH1_2	487	491	PF00568	0.468
LIG_FHA_1	52	58	PF00498	0.411
LIG_FHA_1	9	15	PF00498	0.382
LIG_FHA_2	140	146	PF00498	0.586
LIG_FHA_2	200	206	PF00498	0.440
LIG_FHA_2	501	507	PF00498	0.405
LIG_LIR_Apic_2	436	442	PF02991	0.536
LIG_LIR_Gen_1	223	234	PF02991	0.426
LIG_LIR_Gen_1	426	435	PF02991	0.581
LIG_LIR_Nem_3	115	120	PF02991	0.457
LIG_LIR_Nem_3	223	229	PF02991	0.426
LIG_LIR_Nem_3	357	362	PF02991	0.429
LIG_LIR_Nem_3	41	45	PF02991	0.397
LIG_LIR_Nem_3	426	432	PF02991	0.596
LIG_LIR_Nem_3	80	84	PF02991	0.367
LIG_NRBOX	304	310	PF00104	0.312
LIG_PCNA_PIPBox_1	110	119	PF02747	0.351
LIG_PCNA_PIPBox_1	378	387	PF02747	0.462
LIG_PCNA_yPIPBox_3	110	118	PF02747	0.443
LIG_PCNA_yPIPBox_3	300	309	PF02747	0.334
LIG_PCNA_yPIPBox_3	345	359	PF02747	0.456
LIG_Pex14_2	42	46	PF04695	0.412
LIG_Rb_LxCxE_1	115	131	PF01857	0.494
LIG_SH2_CRK	20	24	PF00017	0.531
LIG_SH2_CRK	359	363	PF00017	0.454
LIG_SH2_SRC	330	333	PF00017	0.480
LIG_SH2_STAT3	452	455	PF00017	0.552
LIG_SH2_STAT5	285	288	PF00017	0.355
LIG_SH2_STAT5	312	315	PF00017	0.385
LIG_SH2_STAT5	338	341	PF00017	0.324
LIG_SH3_3	129	135	PF00018	0.480
LIG_SH3_3	182	188	PF00018	0.312
LIG_SH3_3	278	284	PF00018	0.337
LIG_SH3_3	32	38	PF00018	0.398
LIG_SH3_3	395	401	PF00018	0.654
LIG_SH3_3	481	487	PF00018	0.440
LIG_SH3_3	519	525	PF00018	0.526
LIG_SH3_3	99	105	PF00018	0.384
LIG_SxIP_EBH_1	95	107	PF03271	0.462
LIG_TRAF2_1	376	379	PF00917	0.531
LIG_TRAF2_1	503	506	PF00917	0.428
LIG_UBA3_1	167	173	PF00899	0.329
LIG_WRC_WIRS_1	78	83	PF05994	0.349
LIG_WW_3	406	410	PF00397	0.609
MOD_CDK_SPK_2	125	130	PF00069	0.463
MOD_CDK_SPxK_1	403	409	PF00069	0.748
MOD_CK1_1	128	134	PF00069	0.471
MOD_CK1_1	194	200	PF00069	0.460
MOD_CK1_1	348	354	PF00069	0.393
MOD_CK2_1	139	145	PF00069	0.608
MOD_CK2_1	500	506	PF00069	0.437
MOD_CK2_1	513	519	PF00069	0.453
MOD_CK2_1	77	83	PF00069	0.363
MOD_CMANNOS	211	214	PF00535	0.441
MOD_GlcNHglycan	231	234	PF01048	0.386
MOD_GlcNHglycan	313	316	PF01048	0.310
MOD_GlcNHglycan	347	350	PF01048	0.393
MOD_GlcNHglycan	421	424	PF01048	0.681
MOD_GlcNHglycan	476	479	PF01048	0.454
MOD_GlcNHglycan	64	67	PF01048	0.507
MOD_GSK3_1	167	174	PF00069	0.476
MOD_GSK3_1	194	201	PF00069	0.483
MOD_GSK3_1	212	219	PF00069	0.448
MOD_GSK3_1	419	426	PF00069	0.722
MOD_N-GLC_1	96	101	PF02516	0.536
MOD_NEK2_1	167	172	PF00069	0.445
MOD_NEK2_1	216	221	PF00069	0.368
MOD_NEK2_1	229	234	PF00069	0.443
MOD_NEK2_1	311	316	PF00069	0.412
MOD_NEK2_1	354	359	PF00069	0.383
MOD_NEK2_1	474	479	PF00069	0.538
MOD_NEK2_1	62	67	PF00069	0.536
MOD_NEK2_1	8	13	PF00069	0.349
MOD_PIKK_1	292	298	PF00454	0.266
MOD_PK_1	10	16	PF00069	0.355
MOD_PK_1	271	277	PF00069	0.408
MOD_PKA_2	408	414	PF00069	0.608
MOD_PKA_2	512	518	PF00069	0.510
MOD_PKA_2	9	15	PF00069	0.344
MOD_Plk_1	467	473	PF00069	0.472
MOD_Plk_4	191	197	PF00069	0.327
MOD_Plk_4	354	360	PF00069	0.447
MOD_Plk_4	467	473	PF00069	0.464
MOD_ProDKin_1	125	131	PF00069	0.414
MOD_ProDKin_1	139	145	PF00069	0.482
MOD_ProDKin_1	186	192	PF00069	0.342
MOD_ProDKin_1	34	40	PF00069	0.511
MOD_ProDKin_1	403	409	PF00069	0.756
MOD_ProDKin_1	96	102	PF00069	0.465
MOD_SUMO_rev_2	504	509	PF00179	0.493
TRG_DiLeu_BaEn_1	467	472	PF01217	0.560
TRG_ENDOCYTIC_2	20	23	PF00928	0.379
TRG_ENDOCYTIC_2	359	362	PF00928	0.407
TRG_ER_diArg_1	20	22	PF00400	0.535
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P380	Leptomonas seymouri	57%	99%
A0A0S4JCU0	Bodo saltans	43%	100%
A0A1X0P6I8	Trypanosomatidae	48%	100%
A0A3R7KHD1	Trypanosoma rangeli	47%	100%
A4HMQ0	Leishmania braziliensis	73%	100%
A4IBB8	Leishmania infantum	99%	100%
E9AF50	Leishmania major	88%	100%
E9B6A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BJB2	Trypanosoma cruzi	46%	100%