PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IG98_LEIDO

TriTrypDb:

LdBPK_323780.1 , LdCL_320043800 , LDHU3_32.4780

Length:

272

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IG98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.406
CLV_PCSK_SKI1_1	22	26	PF00082	0.465
DEG_Nend_Nbox_1	1	3	PF02207	0.496
DEG_SPOP_SBC_1	86	90	PF00917	0.598
DOC_CKS1_1	201	206	PF01111	0.466
DOC_PP2B_LxvP_1	180	183	PF13499	0.423
DOC_USP7_UBL2_3	190	194	PF12436	0.443
DOC_WW_Pin1_4	200	205	PF00397	0.458
DOC_WW_Pin1_4	214	219	PF00397	0.483
DOC_WW_Pin1_4	43	48	PF00397	0.764
DOC_WW_Pin1_4	72	77	PF00397	0.747
DOC_WW_Pin1_4	78	83	PF00397	0.669
DOC_WW_Pin1_4	87	92	PF00397	0.699
LIG_14-3-3_CanoR_1	52	61	PF00244	0.605
LIG_BRCT_BRCA1_1	113	117	PF00533	0.561
LIG_BRCT_BRCA1_1	120	124	PF00533	0.399
LIG_deltaCOP1_diTrp_1	158	164	PF00928	0.392
LIG_FHA_1	227	233	PF00498	0.372
LIG_FHA_1	56	62	PF00498	0.564
LIG_FHA_2	201	207	PF00498	0.416
LIG_FHA_2	72	78	PF00498	0.717
LIG_FHA_2	99	105	PF00498	0.517
LIG_LIR_Apic_2	200	204	PF02991	0.466
LIG_LIR_Apic_2	233	238	PF02991	0.512
LIG_LIR_Gen_1	222	232	PF02991	0.386
LIG_LIR_Nem_3	195	199	PF02991	0.412
LIG_LIR_Nem_3	222	227	PF02991	0.426
LIG_LIR_Nem_3	229	234	PF02991	0.386
LIG_Pex14_1	160	164	PF04695	0.490
LIG_SH2_NCK_1	54	58	PF00017	0.578
LIG_SH2_PTP2	128	131	PF00017	0.416
LIG_SH2_PTP2	231	234	PF00017	0.406
LIG_SH2_STAP1	140	144	PF00017	0.467
LIG_SH2_STAT5	128	131	PF00017	0.396
LIG_SH2_STAT5	196	199	PF00017	0.375
LIG_SH2_STAT5	202	205	PF00017	0.446
LIG_SH2_STAT5	231	234	PF00017	0.437
LIG_SH2_STAT5	235	238	PF00017	0.499
LIG_SH3_1	147	153	PF00018	0.500
LIG_SH3_2	47	52	PF14604	0.646
LIG_SH3_3	147	153	PF00018	0.458
LIG_SH3_3	173	179	PF00018	0.409
LIG_SH3_3	44	50	PF00018	0.632
LIG_SH3_3	60	66	PF00018	0.502
LIG_SH3_3	91	97	PF00018	0.730
LIG_SUMO_SIM_par_1	178	185	PF11976	0.392
LIG_SUMO_SIM_par_1	57	62	PF11976	0.485
LIG_TRAF2_1	3	6	PF00917	0.560
LIG_WRC_WIRS_1	161	166	PF05994	0.445
MOD_CDC14_SPxK_1	49	52	PF00782	0.604
MOD_CDC14_SPxK_1	75	78	PF00782	0.674
MOD_CDC14_SPxK_1	90	93	PF00782	0.479
MOD_CDK_SPxK_1	46	52	PF00069	0.784
MOD_CDK_SPxK_1	72	78	PF00069	0.676
MOD_CDK_SPxK_1	87	93	PF00069	0.491
MOD_CDK_SPxxK_3	214	221	PF00069	0.475
MOD_CK1_1	166	172	PF00069	0.455
MOD_CK1_1	46	52	PF00069	0.650
MOD_CK1_1	55	61	PF00069	0.545
MOD_CK1_1	67	73	PF00069	0.662
MOD_CK2_1	1	7	PF00069	0.576
MOD_CK2_1	139	145	PF00069	0.461
MOD_CK2_1	200	206	PF00069	0.458
MOD_CK2_1	214	220	PF00069	0.385
MOD_CK2_1	98	104	PF00069	0.544
MOD_DYRK1A_RPxSP_1	78	82	PF00069	0.635
MOD_GlcNHglycan	113	116	PF01048	0.595
MOD_GlcNHglycan	131	134	PF01048	0.274
MOD_GlcNHglycan	258	261	PF01048	0.662
MOD_GlcNHglycan	54	57	PF01048	0.671
MOD_GlcNHglycan	82	85	PF01048	0.693
MOD_GSK3_1	131	138	PF00069	0.383
MOD_GSK3_1	26	33	PF00069	0.738
MOD_GSK3_1	42	49	PF00069	0.675
MOD_GSK3_1	55	62	PF00069	0.523
MOD_GSK3_1	64	71	PF00069	0.658
MOD_N-GLC_1	192	197	PF02516	0.411
MOD_NEK2_1	15	20	PF00069	0.574
MOD_NEK2_1	213	218	PF00069	0.536
MOD_NEK2_1	256	261	PF00069	0.603
MOD_PIKK_1	1	7	PF00454	0.444
MOD_PIKK_1	26	32	PF00454	0.465
MOD_PK_1	64	70	PF00069	0.755
MOD_PKA_2	111	117	PF00069	0.596
MOD_PKA_2	166	172	PF00069	0.459
MOD_Plk_1	192	198	PF00069	0.405
MOD_Plk_4	103	109	PF00069	0.458
MOD_Plk_4	192	198	PF00069	0.414
MOD_ProDKin_1	200	206	PF00069	0.461
MOD_ProDKin_1	214	220	PF00069	0.479
MOD_ProDKin_1	43	49	PF00069	0.762
MOD_ProDKin_1	72	78	PF00069	0.748
MOD_ProDKin_1	87	93	PF00069	0.701
MOD_SUMO_rev_2	184	192	PF00179	0.432
TRG_DiLeu_BaEn_1	6	11	PF01217	0.615
TRG_DiLeu_BaEn_4	6	12	PF01217	0.567
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.355
TRG_DiLeu_LyEn_5	6	11	PF01217	0.549
TRG_ENDOCYTIC_2	128	131	PF00928	0.396
TRG_ENDOCYTIC_2	196	199	PF00928	0.347
TRG_ENDOCYTIC_2	231	234	PF00928	0.406
TRG_Pf-PMV_PEXEL_1	9	14	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT8	Leptomonas seymouri	56%	95%
A0A0S4IRN5	Bodo saltans	37%	100%
A0A3R7P3C4	Trypanosoma rangeli	42%	100%
A4HL01	Leishmania braziliensis	78%	100%
A4I8I2	Leishmania infantum	99%	100%
E9B3E2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q4R0	Leishmania major	94%	100%