Tubulin binding cofactor C, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin binding cofactor c, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IG96_LEIDO

TriTrypDb:

LdBPK_363310.1 , LdCL_360039800 , LDHU3_36.4550

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IG96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG96

PDB structure(s): 5aj8_A , 5aj8_B

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0007023	post-chaperonin tubulin folding pathway	3	12
GO:0009987	cellular process	1	12
GO:0007021	tubulin complex assembly	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.531
CLV_PCSK_KEX2_1	16	18	PF00082	0.531
CLV_PCSK_PC7_1	12	18	PF00082	0.519
CLV_PCSK_SKI1_1	105	109	PF00082	0.531
CLV_PCSK_SKI1_1	175	179	PF00082	0.261
CLV_PCSK_SKI1_1	4	8	PF00082	0.476
DEG_Nend_UBRbox_2	1	3	PF02207	0.525
DEG_SCF_FBW7_1	123	129	PF00400	0.543
DOC_CKS1_1	123	128	PF01111	0.543
DOC_MAPK_gen_1	19	28	PF00069	0.603
DOC_MAPK_gen_1	214	223	PF00069	0.266
DOC_USP7_MATH_1	124	128	PF00917	0.553
DOC_USP7_MATH_1	322	326	PF00917	0.503
DOC_WW_Pin1_4	122	127	PF00397	0.611
DOC_WW_Pin1_4	227	232	PF00397	0.249
DOC_WW_Pin1_4	295	300	PF00397	0.360
DOC_WW_Pin1_4	320	325	PF00397	0.449
LIG_BIR_III_2	120	124	PF00653	0.573
LIG_FHA_1	123	129	PF00498	0.662
LIG_FHA_1	140	146	PF00498	0.735
LIG_FHA_1	21	27	PF00498	0.512
LIG_FHA_1	228	234	PF00498	0.249
LIG_FHA_1	43	49	PF00498	0.421
LIG_FHA_2	163	169	PF00498	0.534
LIG_FHA_2	217	223	PF00498	0.285
LIG_FHA_2	261	267	PF00498	0.377
LIG_FHA_2	75	81	PF00498	0.410
LIG_LIR_Gen_1	2	11	PF02991	0.468
LIG_LIR_Gen_1	281	290	PF02991	0.365
LIG_LIR_Nem_3	154	160	PF02991	0.511
LIG_LIR_Nem_3	2	8	PF02991	0.521
LIG_LIR_Nem_3	281	287	PF02991	0.342
LIG_LIR_Nem_3	288	293	PF02991	0.341
LIG_LIR_Nem_3	298	304	PF02991	0.295
LIG_SH2_CRK	188	192	PF00017	0.325
LIG_SH2_PTP2	284	287	PF00017	0.404
LIG_SH2_STAP1	224	228	PF00017	0.240
LIG_SH2_STAP1	261	265	PF00017	0.454
LIG_SH2_STAP1	33	37	PF00017	0.473
LIG_SH2_STAT5	188	191	PF00017	0.442
LIG_SH2_STAT5	207	210	PF00017	0.130
LIG_SH2_STAT5	284	287	PF00017	0.404
LIG_SH3_3	120	126	PF00018	0.678
LIG_SH3_3	157	163	PF00018	0.489
LIG_SH3_3	312	318	PF00018	0.427
LIG_TRAF2_1	305	308	PF00917	0.437
MOD_CDK_SPxxK_3	295	302	PF00069	0.473
MOD_CK1_1	164	170	PF00069	0.477
MOD_CK1_1	199	205	PF00069	0.309
MOD_CK1_1	20	26	PF00069	0.552
MOD_CK1_1	252	258	PF00069	0.414
MOD_CK1_1	323	329	PF00069	0.519
MOD_CK2_1	116	122	PF00069	0.694
MOD_CK2_1	250	256	PF00069	0.327
MOD_CK2_1	260	266	PF00069	0.257
MOD_CK2_1	74	80	PF00069	0.451
MOD_GlcNHglycan	100	103	PF01048	0.536
MOD_GlcNHglycan	194	197	PF01048	0.410
MOD_GlcNHglycan	295	298	PF01048	0.535
MOD_GSK3_1	122	129	PF00069	0.649
MOD_GSK3_1	133	140	PF00069	0.465
MOD_GSK3_1	147	154	PF00069	0.506
MOD_GSK3_1	192	199	PF00069	0.249
MOD_GSK3_1	20	27	PF00069	0.570
MOD_GSK3_1	322	329	PF00069	0.602
MOD_GSK3_1	68	75	PF00069	0.456
MOD_N-GLC_1	199	204	PF02516	0.401
MOD_N-GLC_1	51	56	PF02516	0.517
MOD_N-GLC_2	180	182	PF02516	0.375
MOD_NEK2_1	107	112	PF00069	0.541
MOD_NEK2_1	128	133	PF00069	0.613
MOD_NEK2_1	169	174	PF00069	0.428
MOD_NEK2_1	250	255	PF00069	0.295
MOD_NEK2_2	311	316	PF00069	0.386
MOD_PIKK_1	42	48	PF00454	0.458
MOD_PIKK_1	53	59	PF00454	0.450
MOD_Plk_1	42	48	PF00069	0.336
MOD_Plk_4	311	317	PF00069	0.486
MOD_ProDKin_1	122	128	PF00069	0.613
MOD_ProDKin_1	227	233	PF00069	0.249
MOD_ProDKin_1	295	301	PF00069	0.356
MOD_ProDKin_1	320	326	PF00069	0.464
MOD_SUMO_rev_2	252	260	PF00179	0.404
MOD_SUMO_rev_2	307	312	PF00179	0.300
TRG_AP2beta_CARGO_1	2	12	PF09066	0.516
TRG_DiLeu_BaEn_1	43	48	PF01217	0.473
TRG_ENDOCYTIC_2	284	287	PF00928	0.343
TRG_ER_diArg_1	16	19	PF00400	0.637
TRG_NLS_MonoExtN_4	104	109	PF00514	0.614
TRG_Pf-PMV_PEXEL_1	302	307	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J8	Leptomonas seymouri	66%	100%
A0A0S4JHW0	Bodo saltans	36%	100%
A0A1X0P3G4	Trypanosomatidae	44%	100%
A0A3R7L226	Trypanosoma rangeli	45%	100%
A4HPI2	Leishmania braziliensis	82%	100%
A4IDA4	Leishmania infantum	99%	100%
D0A8E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AT94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q15814	Homo sapiens	26%	97%
Q3SZE9	Bos taurus	26%	97%
Q4Q1A3	Leishmania major	95%	100%
Q5R5J7	Pongo abelii	27%	97%
Q8VCN9	Mus musculus	25%	98%
Q9SMR2	Arabidopsis thaliana	25%	97%
V5B9L2	Trypanosoma cruzi	44%	100%