FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IG94_LEIDO

TriTrypDb:

LdBPK_322240.1 , LdCL_320027800 , LDHU3_32.2800

Length:

868

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IG94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.563
CLV_C14_Caspase3-7	627	631	PF00656	0.639
CLV_NRD_NRD_1	145	147	PF00675	0.591
CLV_NRD_NRD_1	387	389	PF00675	0.499
CLV_NRD_NRD_1	431	433	PF00675	0.572
CLV_NRD_NRD_1	597	599	PF00675	0.657
CLV_NRD_NRD_1	669	671	PF00675	0.588
CLV_NRD_NRD_1	70	72	PF00675	0.687
CLV_PCSK_KEX2_1	145	147	PF00082	0.602
CLV_PCSK_KEX2_1	431	433	PF00082	0.579
CLV_PCSK_KEX2_1	597	599	PF00082	0.710
CLV_PCSK_KEX2_1	669	671	PF00082	0.588
CLV_PCSK_KEX2_1	865	867	PF00082	0.632
CLV_PCSK_KEX2_1	94	96	PF00082	0.616
CLV_PCSK_PC1ET2_1	865	867	PF00082	0.632
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.616
CLV_PCSK_SKI1_1	190	194	PF00082	0.504
CLV_PCSK_SKI1_1	214	218	PF00082	0.607
CLV_PCSK_SKI1_1	252	256	PF00082	0.668
CLV_PCSK_SKI1_1	310	314	PF00082	0.675
CLV_PCSK_SKI1_1	462	466	PF00082	0.565
CLV_PCSK_SKI1_1	573	577	PF00082	0.725
CLV_PCSK_SKI1_1	587	591	PF00082	0.532
CLV_PCSK_SKI1_1	669	673	PF00082	0.571
CLV_PCSK_SKI1_1	713	717	PF00082	0.599
CLV_PCSK_SKI1_1	774	778	PF00082	0.433
CLV_PCSK_SKI1_1	828	832	PF00082	0.434
DEG_APCC_DBOX_1	94	102	PF00400	0.569
DEG_SCF_FBW7_1	124	129	PF00400	0.719
DEG_SCF_TRCP1_1	31	37	PF00400	0.587
DEG_SPOP_SBC_1	47	51	PF00917	0.604
DEG_SPOP_SBC_1	497	501	PF00917	0.556
DEG_SPOP_SBC_1	526	530	PF00917	0.673
DEG_SPOP_SBC_1	675	679	PF00917	0.585
DOC_CYCLIN_RxL_1	187	198	PF00134	0.500
DOC_CYCLIN_RxL_1	347	360	PF00134	0.565
DOC_CYCLIN_RxL_1	810	819	PF00134	0.457
DOC_CYCLIN_RxL_1	825	835	PF00134	0.425
DOC_MAPK_gen_1	145	152	PF00069	0.567
DOC_MAPK_gen_1	94	100	PF00069	0.613
DOC_MAPK_HePTP_8	649	661	PF00069	0.574
DOC_MAPK_JIP1_4	146	152	PF00069	0.573
DOC_MAPK_MEF2A_6	652	661	PF00069	0.539
DOC_PP1_RVXF_1	826	832	PF00149	0.452
DOC_PP2B_LxvP_1	116	119	PF13499	0.665
DOC_PP2B_LxvP_1	615	618	PF13499	0.668
DOC_PP2B_LxvP_1	661	664	PF13499	0.631
DOC_PP4_FxxP_1	372	375	PF00568	0.641
DOC_PP4_FxxP_1	772	775	PF00568	0.438
DOC_PP4_FxxP_1	817	820	PF00568	0.467
DOC_USP7_MATH_1	126	130	PF00917	0.748
DOC_USP7_MATH_1	17	21	PF00917	0.550
DOC_USP7_MATH_1	241	245	PF00917	0.809
DOC_USP7_MATH_1	272	276	PF00917	0.709
DOC_USP7_MATH_1	29	33	PF00917	0.534
DOC_USP7_MATH_1	367	371	PF00917	0.613
DOC_USP7_MATH_1	397	401	PF00917	0.562
DOC_USP7_MATH_1	47	51	PF00917	0.551
DOC_USP7_MATH_1	497	501	PF00917	0.754
DOC_USP7_MATH_1	508	512	PF00917	0.600
DOC_USP7_MATH_1	525	529	PF00917	0.567
DOC_USP7_MATH_1	675	679	PF00917	0.609
DOC_USP7_MATH_1	794	798	PF00917	0.427
DOC_USP7_MATH_1	90	94	PF00917	0.665
DOC_USP7_UBL2_3	385	389	PF12436	0.516
DOC_USP7_UBL2_3	713	717	PF12436	0.551
DOC_WW_Pin1_4	110	115	PF00397	0.692
DOC_WW_Pin1_4	120	125	PF00397	0.692
DOC_WW_Pin1_4	236	241	PF00397	0.744
DOC_WW_Pin1_4	330	335	PF00397	0.732
DOC_WW_Pin1_4	580	585	PF00397	0.661
DOC_WW_Pin1_4	588	593	PF00397	0.694
DOC_WW_Pin1_4	643	648	PF00397	0.615
DOC_WW_Pin1_4	66	71	PF00397	0.679
DOC_WW_Pin1_4	80	85	PF00397	0.660
DOC_WW_Pin1_4	93	98	PF00397	0.581
LIG_14-3-3_CanoR_1	135	140	PF00244	0.617
LIG_14-3-3_CanoR_1	168	173	PF00244	0.586
LIG_14-3-3_CanoR_1	236	240	PF00244	0.583
LIG_14-3-3_CanoR_1	310	315	PF00244	0.591
LIG_14-3-3_CanoR_1	598	608	PF00244	0.713
LIG_14-3-3_CanoR_1	676	685	PF00244	0.673
LIG_14-3-3_CanoR_1	705	712	PF00244	0.509
LIG_14-3-3_CanoR_1	783	789	PF00244	0.408
LIG_14-3-3_CanoR_1	95	101	PF00244	0.615
LIG_APCC_ABBA_1	213	218	PF00400	0.613
LIG_APCC_ABBA_1	814	819	PF00400	0.465
LIG_APCC_ABBAyCdc20_2	582	588	PF00400	0.570
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BRCT_BRCA1_1	31	35	PF00533	0.649
LIG_BRCT_BRCA1_1	369	373	PF00533	0.615
LIG_BRCT_BRCA1_1	403	407	PF00533	0.463
LIG_BRCT_BRCA1_1	723	727	PF00533	0.521
LIG_deltaCOP1_diTrp_1	401	407	PF00928	0.460
LIG_deltaCOP1_diTrp_1	518	521	PF00928	0.539
LIG_eIF4E_1	651	657	PF01652	0.564
LIG_EVH1_1	617	621	PF00568	0.522
LIG_FHA_1	1	7	PF00498	0.615
LIG_FHA_1	111	117	PF00498	0.715
LIG_FHA_1	304	310	PF00498	0.593
LIG_FHA_1	377	383	PF00498	0.515
LIG_FHA_1	468	474	PF00498	0.626
LIG_FHA_1	47	53	PF00498	0.605
LIG_FHA_1	538	544	PF00498	0.642
LIG_FHA_1	588	594	PF00498	0.826
LIG_FHA_1	639	645	PF00498	0.611
LIG_FHA_1	72	78	PF00498	0.662
LIG_FHA_1	750	756	PF00498	0.582
LIG_FHA_1	821	827	PF00498	0.429
LIG_FHA_2	311	317	PF00498	0.672
LIG_LIR_Apic_2	370	375	PF02991	0.640
LIG_LIR_Gen_1	253	259	PF02991	0.597
LIG_LIR_Gen_1	399	408	PF02991	0.487
LIG_LIR_Gen_1	443	451	PF02991	0.512
LIG_LIR_Gen_1	724	734	PF02991	0.578
LIG_LIR_Nem_3	253	258	PF02991	0.671
LIG_LIR_Nem_3	399	405	PF02991	0.485
LIG_LIR_Nem_3	443	447	PF02991	0.557
LIG_LIR_Nem_3	650	654	PF02991	0.704
LIG_LIR_Nem_3	665	671	PF02991	0.492
LIG_LIR_Nem_3	709	715	PF02991	0.492
LIG_LIR_Nem_3	724	730	PF02991	0.525
LIG_MLH1_MIPbox_1	369	373	PF16413	0.615
LIG_MLH1_MIPbox_1	403	407	PF16413	0.463
LIG_NRP_CendR_1	865	868	PF00754	0.575
LIG_PCNA_PIPBox_1	433	442	PF02747	0.575
LIG_PCNA_yPIPBox_3	190	203	PF02747	0.522
LIG_PCNA_yPIPBox_3	431	440	PF02747	0.574
LIG_Pex14_1	402	406	PF04695	0.459
LIG_Pex14_2	772	776	PF04695	0.416
LIG_SH2_CRK	668	672	PF00017	0.563
LIG_SH2_NCK_1	16	20	PF00017	0.550
LIG_SH2_SRC	16	19	PF00017	0.533
LIG_SH2_SRC	43	46	PF00017	0.671
LIG_SH2_STAP1	48	52	PF00017	0.572
LIG_SH2_STAT3	420	423	PF00017	0.556
LIG_SH2_STAT3	695	698	PF00017	0.537
LIG_SH2_STAT3	809	812	PF00017	0.513
LIG_SH2_STAT5	233	236	PF00017	0.654
LIG_SH2_STAT5	43	46	PF00017	0.671
LIG_SH2_STAT5	444	447	PF00017	0.659
LIG_SH2_STAT5	48	51	PF00017	0.616
LIG_SH2_STAT5	695	698	PF00017	0.537
LIG_SH2_STAT5	718	721	PF00017	0.499
LIG_SH2_STAT5	809	812	PF00017	0.441
LIG_SH2_STAT5	821	824	PF00017	0.457
LIG_SH2_STAT5	834	837	PF00017	0.459
LIG_SH3_2	67	72	PF14604	0.665
LIG_SH3_3	141	147	PF00018	0.607
LIG_SH3_3	39	45	PF00018	0.583
LIG_SH3_3	615	621	PF00018	0.575
LIG_SH3_3	64	70	PF00018	0.673
LIG_SH3_3	641	647	PF00018	0.649
LIG_SH3_3	693	699	PF00018	0.560
LIG_SH3_3	752	758	PF00018	0.584
LIG_SUMO_SIM_anti_2	96	102	PF11976	0.570
LIG_SUMO_SIM_par_1	96	102	PF11976	0.679
LIG_TRAF2_1	318	321	PF00917	0.595
LIG_TYR_ITIM	649	654	PF00017	0.578
LIG_UBA3_1	427	435	PF00899	0.503
LIG_WRC_WIRS_1	369	374	PF05994	0.639
LIG_WRPW_2	773	776	PF00400	0.378
MOD_CDC14_SPxK_1	69	72	PF00782	0.676
MOD_CDK_SPK_2	66	71	PF00069	0.628
MOD_CDK_SPxK_1	66	72	PF00069	0.671
MOD_CDK_SPxxK_3	580	587	PF00069	0.631
MOD_CK1_1	120	126	PF00069	0.652
MOD_CK1_1	162	168	PF00069	0.649
MOD_CK1_1	195	201	PF00069	0.532
MOD_CK1_1	273	279	PF00069	0.786
MOD_CK1_1	368	374	PF00069	0.561
MOD_CK1_1	376	382	PF00069	0.517
MOD_CK1_1	46	52	PF00069	0.709
MOD_CK1_1	500	506	PF00069	0.741
MOD_CK1_1	510	516	PF00069	0.694
MOD_CK1_1	529	535	PF00069	0.616
MOD_CK1_1	538	544	PF00069	0.585
MOD_CK1_1	59	65	PF00069	0.647
MOD_CK1_1	636	642	PF00069	0.688
MOD_CK1_1	690	696	PF00069	0.659
MOD_CK1_1	75	81	PF00069	0.732
MOD_CK1_1	93	99	PF00069	0.635
MOD_CK2_1	104	110	PF00069	0.673
MOD_CK2_1	310	316	PF00069	0.682
MOD_CK2_1	508	514	PF00069	0.693
MOD_CK2_1	840	846	PF00069	0.511
MOD_CK2_1	96	102	PF00069	0.788
MOD_DYRK1A_RPxSP_1	236	240	PF00069	0.583
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.599
MOD_GlcNHglycan	161	164	PF01048	0.597
MOD_GlcNHglycan	183	186	PF01048	0.725
MOD_GlcNHglycan	272	275	PF01048	0.749
MOD_GlcNHglycan	284	287	PF01048	0.590
MOD_GlcNHglycan	303	306	PF01048	0.666
MOD_GlcNHglycan	31	34	PF01048	0.652
MOD_GlcNHglycan	321	326	PF01048	0.527
MOD_GlcNHglycan	449	452	PF01048	0.515
MOD_GlcNHglycan	45	48	PF01048	0.569
MOD_GlcNHglycan	503	506	PF01048	0.730
MOD_GlcNHglycan	523	526	PF01048	0.550
MOD_GlcNHglycan	529	532	PF01048	0.604
MOD_GlcNHglycan	540	543	PF01048	0.698
MOD_GlcNHglycan	58	61	PF01048	0.675
MOD_GlcNHglycan	679	682	PF01048	0.675
MOD_GlcNHglycan	79	82	PF01048	0.742
MOD_GlcNHglycan	794	797	PF01048	0.481
MOD_GSK3_1	120	127	PF00069	0.778
MOD_GSK3_1	131	138	PF00069	0.606
MOD_GSK3_1	155	162	PF00069	0.725
MOD_GSK3_1	181	188	PF00069	0.538
MOD_GSK3_1	217	224	PF00069	0.573
MOD_GSK3_1	227	234	PF00069	0.673
MOD_GSK3_1	236	243	PF00069	0.812
MOD_GSK3_1	272	279	PF00069	0.644
MOD_GSK3_1	332	339	PF00069	0.644
MOD_GSK3_1	392	399	PF00069	0.486
MOD_GSK3_1	43	50	PF00069	0.625
MOD_GSK3_1	492	499	PF00069	0.647
MOD_GSK3_1	503	510	PF00069	0.611
MOD_GSK3_1	521	528	PF00069	0.599
MOD_GSK3_1	529	536	PF00069	0.747
MOD_GSK3_1	538	545	PF00069	0.612
MOD_GSK3_1	62	69	PF00069	0.648
MOD_GSK3_1	635	642	PF00069	0.675
MOD_GSK3_1	643	650	PF00069	0.592
MOD_GSK3_1	670	677	PF00069	0.594
MOD_GSK3_1	71	78	PF00069	0.648
MOD_GSK3_1	784	791	PF00069	0.562
MOD_GSK3_1	80	87	PF00069	0.627
MOD_GSK3_1	832	839	PF00069	0.486
MOD_GSK3_1	848	855	PF00069	0.378
MOD_N-GLC_1	336	341	PF02516	0.616
MOD_N-GLC_1	410	415	PF02516	0.518
MOD_N-GLC_1	481	486	PF02516	0.686
MOD_N-GLC_1	742	747	PF02516	0.504
MOD_NEK2_1	131	136	PF00069	0.702
MOD_NEK2_1	159	164	PF00069	0.569
MOD_NEK2_1	181	186	PF00069	0.515
MOD_NEK2_1	192	197	PF00069	0.524
MOD_NEK2_1	217	222	PF00069	0.660
MOD_NEK2_1	446	451	PF00069	0.513
MOD_NEK2_1	61	66	PF00069	0.568
MOD_NEK2_1	633	638	PF00069	0.685
MOD_NEK2_1	77	82	PF00069	0.594
MOD_NEK2_1	784	789	PF00069	0.466
MOD_NEK2_1	848	853	PF00069	0.371
MOD_NEK2_2	48	53	PF00069	0.632
MOD_NEK2_2	556	561	PF00069	0.580
MOD_NEK2_2	722	727	PF00069	0.595
MOD_PIKK_1	117	123	PF00454	0.585
MOD_PIKK_1	192	198	PF00454	0.527
MOD_PIKK_1	276	282	PF00454	0.570
MOD_PK_1	492	498	PF00069	0.675
MOD_PK_1	72	78	PF00069	0.638
MOD_PKA_1	71	77	PF00069	0.663
MOD_PKA_2	131	137	PF00069	0.671
MOD_PKA_2	173	179	PF00069	0.606
MOD_PKA_2	218	224	PF00069	0.658
MOD_PKA_2	227	233	PF00069	0.624
MOD_PKA_2	235	241	PF00069	0.540
MOD_PKA_2	376	382	PF00069	0.517
MOD_PKA_2	482	488	PF00069	0.784
MOD_PKA_2	538	544	PF00069	0.634
MOD_PKA_2	675	681	PF00069	0.615
MOD_PKA_2	743	749	PF00069	0.712
MOD_PKA_2	761	767	PF00069	0.452
MOD_Plk_1	155	161	PF00069	0.522
MOD_Plk_1	17	23	PF00069	0.549
MOD_Plk_1	321	327	PF00069	0.676
MOD_Plk_1	336	342	PF00069	0.529
MOD_Plk_1	722	728	PF00069	0.597
MOD_Plk_2-3	104	110	PF00069	0.538
MOD_Plk_2-3	292	298	PF00069	0.599
MOD_Plk_4	155	161	PF00069	0.522
MOD_Plk_4	168	174	PF00069	0.570
MOD_Plk_4	18	24	PF00069	0.550
MOD_Plk_4	250	256	PF00069	0.653
MOD_Plk_4	303	309	PF00069	0.553
MOD_Plk_4	368	374	PF00069	0.561
MOD_Plk_4	401	407	PF00069	0.460
MOD_Plk_4	639	645	PF00069	0.653
MOD_Plk_4	72	78	PF00069	0.611
MOD_Plk_4	722	728	PF00069	0.639
MOD_Plk_4	761	767	PF00069	0.492
MOD_Plk_4	96	102	PF00069	0.649
MOD_ProDKin_1	110	116	PF00069	0.697
MOD_ProDKin_1	120	126	PF00069	0.689
MOD_ProDKin_1	236	242	PF00069	0.743
MOD_ProDKin_1	330	336	PF00069	0.734
MOD_ProDKin_1	580	586	PF00069	0.661
MOD_ProDKin_1	588	594	PF00069	0.695
MOD_ProDKin_1	643	649	PF00069	0.611
MOD_ProDKin_1	66	72	PF00069	0.683
MOD_ProDKin_1	80	86	PF00069	0.657
MOD_ProDKin_1	93	99	PF00069	0.581
MOD_SUMO_rev_2	104	113	PF00179	0.648
MOD_SUMO_rev_2	28	37	PF00179	0.641
MOD_SUMO_rev_2	341	348	PF00179	0.578
MOD_SUMO_rev_2	570	575	PF00179	0.622
TRG_DiLeu_BaEn_3	321	327	PF01217	0.603
TRG_DiLeu_BaLyEn_6	589	594	PF01217	0.581
TRG_ENDOCYTIC_2	16	19	PF00928	0.533
TRG_ENDOCYTIC_2	387	390	PF00928	0.490
TRG_ENDOCYTIC_2	437	440	PF00928	0.573
TRG_ENDOCYTIC_2	444	447	PF00928	0.509
TRG_ENDOCYTIC_2	651	654	PF00928	0.730
TRG_ENDOCYTIC_2	668	671	PF00928	0.483
TRG_ENDOCYTIC_2	712	715	PF00928	0.523
TRG_ENDOCYTIC_2	773	776	PF00928	0.445
TRG_ENDOCYTIC_2	808	811	PF00928	0.425
TRG_ER_diArg_1	130	133	PF00400	0.650
TRG_ER_diArg_1	144	146	PF00400	0.515
TRG_ER_diArg_1	430	432	PF00400	0.522
TRG_ER_diArg_1	668	670	PF00400	0.558
TRG_ER_diArg_1	759	762	PF00400	0.613
TRG_ER_diArg_1	866	868	PF00400	0.579
TRG_ER_diLys_1	864	868	PF00400	0.681
TRG_NES_CRM1_1	414	426	PF08389	0.629
TRG_NLS_Bipartite_1	849	868	PF00514	0.536
TRG_NLS_MonoCore_2	863	868	PF00514	0.630
TRG_NLS_MonoExtC_3	863	868	PF00514	0.570
TRG_NLS_MonoExtN_4	861	868	PF00514	0.618
TRG_Pf-PMV_PEXEL_1	828	832	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	842	846	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P5	Leptomonas seymouri	47%	100%
A4HKK1	Leishmania braziliensis	67%	100%
A4I833	Leishmania infantum	99%	100%
E9B2Z1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q565	Leishmania major	91%	100%