LeishMANIAdb
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Cyclin 10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cyclin 10
Gene product:
cyclin 10
Species:
Leishmania donovani
UniProt:
A0A3Q8IG93_LEIDO
TriTrypDb:
LdBPK_241960.1 * , LdCL_240025300 , LDHU3_24.2400
Length:
658

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IG93
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG93

Function

Biological processes
Term Name Level Count
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 6 7
GO:0001932 regulation of protein phosphorylation 7 7
GO:0019220 regulation of phosphate metabolic process 6 7
GO:0019222 regulation of metabolic process 3 7
GO:0031323 regulation of cellular metabolic process 4 7
GO:0031399 regulation of protein modification process 6 7
GO:0042325 regulation of phosphorylation 7 7
GO:0043549 regulation of kinase activity 5 7
GO:0045859 regulation of protein kinase activity 6 7
GO:0050789 regulation of biological process 2 7
GO:0050790 regulation of catalytic activity 3 7
GO:0050794 regulation of cellular process 3 7
GO:0051171 regulation of nitrogen compound metabolic process 4 7
GO:0051174 regulation of phosphorus metabolic process 5 7
GO:0051246 regulation of protein metabolic process 5 7
GO:0051338 regulation of transferase activity 4 7
GO:0051726 regulation of cell cycle 4 7
GO:0060255 regulation of macromolecule metabolic process 4 7
GO:0065007 biological regulation 1 7
GO:0065009 regulation of molecular function 2 7
GO:0071900 regulation of protein serine/threonine kinase activity 7 7
GO:0080090 regulation of primary metabolic process 4 7
GO:1904029 regulation of cyclin-dependent protein kinase activity 5 7
Molecular functions
Term Name Level Count
GO:0005488 binding 1 7
GO:0005515 protein binding 2 7
GO:0019899 enzyme binding 3 7
GO:0019900 kinase binding 4 7
GO:0019901 protein kinase binding 5 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 366 368 PF00675 0.698
CLV_NRD_NRD_1 432 434 PF00675 0.705
CLV_NRD_NRD_1 611 613 PF00675 0.712
CLV_PCSK_FUR_1 364 368 PF00082 0.703
CLV_PCSK_KEX2_1 214 216 PF00082 0.411
CLV_PCSK_KEX2_1 366 368 PF00082 0.698
CLV_PCSK_KEX2_1 432 434 PF00082 0.705
CLV_PCSK_KEX2_1 611 613 PF00082 0.712
CLV_PCSK_KEX2_1 91 93 PF00082 0.642
CLV_PCSK_PC1ET2_1 214 216 PF00082 0.411
CLV_PCSK_PC1ET2_1 91 93 PF00082 0.629
CLV_PCSK_PC7_1 607 613 PF00082 0.701
CLV_PCSK_SKI1_1 215 219 PF00082 0.411
CLV_PCSK_SKI1_1 253 257 PF00082 0.513
CLV_PCSK_SKI1_1 352 356 PF00082 0.653
CLV_PCSK_SKI1_1 394 398 PF00082 0.668
CLV_PCSK_SKI1_1 478 482 PF00082 0.692
CLV_PCSK_SKI1_1 586 590 PF00082 0.795
CLV_PCSK_SKI1_1 611 615 PF00082 0.714
CLV_Separin_Metazoa 130 134 PF03568 0.625
DEG_Nend_UBRbox_3 1 3 PF02207 0.542
DEG_SCF_FBW7_1 336 342 PF00400 0.735
DEG_SCF_FBW7_1 78 84 PF00400 0.770
DEG_SPOP_SBC_1 581 585 PF00917 0.591
DOC_CKS1_1 336 341 PF01111 0.732
DOC_CKS1_1 78 83 PF01111 0.670
DOC_CYCLIN_yClb1_LxF_4 287 293 PF00134 0.411
DOC_CYCLIN_yClb1_LxF_4 299 304 PF00134 0.492
DOC_CYCLIN_yCln2_LP_2 245 251 PF00134 0.513
DOC_MAPK_gen_1 632 642 PF00069 0.735
DOC_MAPK_MEF2A_6 202 209 PF00069 0.411
DOC_PP1_RVXF_1 299 305 PF00149 0.591
DOC_PP2B_LxvP_1 522 525 PF13499 0.802
DOC_PP2B_LxvP_1 649 652 PF13499 0.798
DOC_PP2B_PxIxI_1 204 210 PF00149 0.411
DOC_PP4_FxxP_1 113 116 PF00568 0.458
DOC_SPAK_OSR1_1 112 116 PF12202 0.475
DOC_USP7_MATH_1 140 144 PF00917 0.756
DOC_USP7_MATH_1 146 150 PF00917 0.713
DOC_USP7_MATH_1 163 167 PF00917 0.712
DOC_USP7_MATH_1 21 25 PF00917 0.620
DOC_USP7_MATH_1 34 38 PF00917 0.587
DOC_USP7_MATH_1 381 385 PF00917 0.720
DOC_USP7_MATH_1 388 392 PF00917 0.676
DOC_USP7_MATH_1 399 403 PF00917 0.589
DOC_USP7_MATH_1 427 431 PF00917 0.769
DOC_USP7_MATH_1 529 533 PF00917 0.750
DOC_USP7_MATH_1 580 584 PF00917 0.656
DOC_USP7_MATH_1 65 69 PF00917 0.660
DOC_USP7_MATH_1 81 85 PF00917 0.503
DOC_USP7_MATH_2 339 345 PF00917 0.826
DOC_USP7_UBL2_3 214 218 PF12436 0.375
DOC_WW_Pin1_4 12 17 PF00397 0.732
DOC_WW_Pin1_4 141 146 PF00397 0.677
DOC_WW_Pin1_4 159 164 PF00397 0.775
DOC_WW_Pin1_4 188 193 PF00397 0.513
DOC_WW_Pin1_4 220 225 PF00397 0.411
DOC_WW_Pin1_4 335 340 PF00397 0.726
DOC_WW_Pin1_4 384 389 PF00397 0.699
DOC_WW_Pin1_4 438 443 PF00397 0.714
DOC_WW_Pin1_4 454 459 PF00397 0.712
DOC_WW_Pin1_4 495 500 PF00397 0.798
DOC_WW_Pin1_4 53 58 PF00397 0.725
DOC_WW_Pin1_4 565 570 PF00397 0.699
DOC_WW_Pin1_4 605 610 PF00397 0.693
DOC_WW_Pin1_4 77 82 PF00397 0.628
LIG_14-3-3_CanoR_1 405 410 PF00244 0.825
LIG_14-3-3_CanoR_1 478 487 PF00244 0.761
LIG_14-3-3_CanoR_1 518 523 PF00244 0.743
LIG_14-3-3_CanoR_1 586 595 PF00244 0.801
LIG_14-3-3_CanoR_1 629 639 PF00244 0.782
LIG_BIR_III_4 534 538 PF00653 0.783
LIG_Clathr_ClatBox_1 506 510 PF01394 0.757
LIG_EH1_1 291 299 PF00400 0.563
LIG_eIF4E_1 249 255 PF01652 0.499
LIG_EVH1_1 63 67 PF00568 0.608
LIG_EVH1_1 649 653 PF00568 0.800
LIG_FAT_LD_1 290 298 PF03623 0.556
LIG_FHA_1 199 205 PF00498 0.411
LIG_FHA_1 266 272 PF00498 0.411
LIG_FHA_1 409 415 PF00498 0.825
LIG_FHA_1 481 487 PF00498 0.797
LIG_FHA_1 502 508 PF00498 0.755
LIG_FHA_1 553 559 PF00498 0.704
LIG_FHA_1 58 64 PF00498 0.756
LIG_FHA_1 78 84 PF00498 0.440
LIG_FHA_2 100 106 PF00498 0.555
LIG_FHA_2 155 161 PF00498 0.672
LIG_FHA_2 281 287 PF00498 0.408
LIG_FHA_2 306 312 PF00498 0.589
LIG_FHA_2 332 338 PF00498 0.793
LIG_FHA_2 496 502 PF00498 0.762
LIG_FHA_2 67 73 PF00498 0.644
LIG_Integrin_RGD_1 512 514 PF01839 0.718
LIG_LIR_Apic_2 110 116 PF02991 0.478
LIG_LIR_Apic_2 220 224 PF02991 0.411
LIG_LIR_Apic_2 310 315 PF02991 0.467
LIG_LIR_Gen_1 275 282 PF02991 0.353
LIG_LIR_Gen_1 291 298 PF02991 0.397
LIG_LIR_Nem_3 110 114 PF02991 0.486
LIG_LIR_Nem_3 275 279 PF02991 0.353
LIG_LIR_Nem_3 291 295 PF02991 0.454
LIG_LIR_Nem_3 307 312 PF02991 0.290
LIG_MYND_1 61 65 PF01753 0.736
LIG_NRBOX 233 239 PF00104 0.411
LIG_Pex14_2 113 117 PF04695 0.559
LIG_PTB_Apo_2 270 277 PF02174 0.353
LIG_PTB_Apo_2 297 304 PF02174 0.477
LIG_PTB_Phospho_1 297 303 PF10480 0.480
LIG_SH2_CRK 111 115 PF00017 0.478
LIG_SH2_CRK 219 223 PF00017 0.454
LIG_SH2_CRK 312 316 PF00017 0.467
LIG_SH2_PTP2 221 224 PF00017 0.411
LIG_SH2_STAP1 376 380 PF00017 0.687
LIG_SH2_STAT5 212 215 PF00017 0.411
LIG_SH2_STAT5 219 222 PF00017 0.411
LIG_SH2_STAT5 233 236 PF00017 0.411
LIG_SH2_STAT5 303 306 PF00017 0.436
LIG_SH2_STAT5 312 315 PF00017 0.433
LIG_SH3_3 139 145 PF00018 0.759
LIG_SH3_3 347 353 PF00018 0.714
LIG_SH3_3 392 398 PF00018 0.710
LIG_SH3_3 439 445 PF00018 0.688
LIG_SH3_3 58 64 PF00018 0.667
LIG_SH3_3 647 653 PF00018 0.709
LIG_SH3_3 75 81 PF00018 0.567
LIG_SUMO_SIM_par_1 504 511 PF11976 0.732
LIG_TRAF2_1 102 105 PF00917 0.550
LIG_TRAF2_1 508 511 PF00917 0.731
LIG_TRFH_1 77 81 PF08558 0.641
LIG_TYR_ITIM 217 222 PF00017 0.411
LIG_WW_2 64 67 PF00397 0.627
MOD_CDC14_SPxK_1 387 390 PF00782 0.705
MOD_CDK_SPK_2 159 164 PF00069 0.751
MOD_CDK_SPxK_1 384 390 PF00069 0.702
MOD_CDK_SPxK_1 605 611 PF00069 0.696
MOD_CDK_SPxxK_3 605 612 PF00069 0.700
MOD_CK1_1 11 17 PF00069 0.785
MOD_CK1_1 144 150 PF00069 0.718
MOD_CK1_1 179 185 PF00069 0.309
MOD_CK1_1 305 311 PF00069 0.488
MOD_CK1_1 365 371 PF00069 0.723
MOD_CK1_1 379 385 PF00069 0.781
MOD_CK1_1 400 406 PF00069 0.798
MOD_CK1_1 408 414 PF00069 0.689
MOD_CK1_1 426 432 PF00069 0.813
MOD_CK1_1 546 552 PF00069 0.697
MOD_CK1_1 605 611 PF00069 0.690
MOD_CK1_1 615 621 PF00069 0.693
MOD_CK1_1 630 636 PF00069 0.621
MOD_CK1_1 90 96 PF00069 0.611
MOD_CK2_1 154 160 PF00069 0.678
MOD_CK2_1 197 203 PF00069 0.411
MOD_CK2_1 305 311 PF00069 0.548
MOD_CK2_1 331 337 PF00069 0.786
MOD_CK2_1 369 375 PF00069 0.697
MOD_CK2_1 66 72 PF00069 0.642
MOD_CK2_1 99 105 PF00069 0.566
MOD_GlcNHglycan 148 151 PF01048 0.731
MOD_GlcNHglycan 17 20 PF01048 0.750
MOD_GlcNHglycan 181 184 PF01048 0.399
MOD_GlcNHglycan 23 26 PF01048 0.683
MOD_GlcNHglycan 343 346 PF01048 0.822
MOD_GlcNHglycan 36 39 PF01048 0.486
MOD_GlcNHglycan 383 386 PF01048 0.693
MOD_GlcNHglycan 390 393 PF01048 0.709
MOD_GlcNHglycan 399 402 PF01048 0.715
MOD_GlcNHglycan 41 45 PF01048 0.576
MOD_GlcNHglycan 425 428 PF01048 0.772
MOD_GlcNHglycan 429 432 PF01048 0.783
MOD_GlcNHglycan 466 469 PF01048 0.727
MOD_GlcNHglycan 471 474 PF01048 0.710
MOD_GlcNHglycan 501 504 PF01048 0.830
MOD_GlcNHglycan 522 525 PF01048 0.766
MOD_GlcNHglycan 57 60 PF01048 0.539
MOD_GlcNHglycan 590 593 PF01048 0.745
MOD_GlcNHglycan 629 632 PF01048 0.790
MOD_GlcNHglycan 634 638 PF01048 0.813
MOD_GlcNHglycan 92 95 PF01048 0.671
MOD_GSK3_1 140 147 PF00069 0.674
MOD_GSK3_1 159 166 PF00069 0.777
MOD_GSK3_1 169 176 PF00069 0.621
MOD_GSK3_1 17 24 PF00069 0.610
MOD_GSK3_1 177 184 PF00069 0.478
MOD_GSK3_1 256 263 PF00069 0.411
MOD_GSK3_1 321 328 PF00069 0.611
MOD_GSK3_1 331 338 PF00069 0.640
MOD_GSK3_1 358 365 PF00069 0.700
MOD_GSK3_1 36 43 PF00069 0.558
MOD_GSK3_1 384 391 PF00069 0.815
MOD_GSK3_1 399 406 PF00069 0.717
MOD_GSK3_1 419 426 PF00069 0.737
MOD_GSK3_1 478 485 PF00069 0.728
MOD_GSK3_1 495 502 PF00069 0.596
MOD_GSK3_1 516 523 PF00069 0.810
MOD_GSK3_1 529 536 PF00069 0.691
MOD_GSK3_1 53 60 PF00069 0.549
MOD_GSK3_1 582 589 PF00069 0.722
MOD_GSK3_1 596 603 PF00069 0.681
MOD_GSK3_1 7 14 PF00069 0.731
MOD_GSK3_1 77 84 PF00069 0.757
MOD_N-GLC_1 174 179 PF02516 0.701
MOD_N-GLC_1 358 363 PF02516 0.804
MOD_N-GLC_1 8 13 PF02516 0.699
MOD_N-GLC_1 97 102 PF02516 0.584
MOD_N-GLC_2 570 572 PF02516 0.723
MOD_NEK2_1 254 259 PF00069 0.411
MOD_NEK2_1 436 441 PF00069 0.722
MOD_NEK2_1 543 548 PF00069 0.680
MOD_NEK2_1 600 605 PF00069 0.775
MOD_NEK2_2 205 210 PF00069 0.411
MOD_NEK2_2 8 13 PF00069 0.718
MOD_PIKK_1 369 375 PF00454 0.697
MOD_PIKK_1 379 385 PF00454 0.689
MOD_PK_1 366 372 PF00069 0.700
MOD_PK_1 405 411 PF00069 0.824
MOD_PK_1 516 522 PF00069 0.710
MOD_PKA_1 366 372 PF00069 0.701
MOD_PKA_2 163 169 PF00069 0.737
MOD_PKA_2 305 311 PF00069 0.590
MOD_PKA_2 365 371 PF00069 0.701
MOD_PKA_2 537 543 PF00069 0.797
MOD_PKA_2 87 93 PF00069 0.612
MOD_PKB_1 364 372 PF00069 0.700
MOD_PKB_1 516 524 PF00069 0.808
MOD_Plk_1 122 128 PF00069 0.461
MOD_Plk_1 274 280 PF00069 0.411
MOD_Plk_1 374 380 PF00069 0.690
MOD_Plk_1 8 14 PF00069 0.624
MOD_Plk_2-3 99 105 PF00069 0.566
MOD_Plk_4 217 223 PF00069 0.411
MOD_Plk_4 366 372 PF00069 0.679
MOD_Plk_4 482 488 PF00069 0.721
MOD_Plk_4 50 56 PF00069 0.652
MOD_Plk_4 501 507 PF00069 0.512
MOD_Plk_4 596 602 PF00069 0.799
MOD_Plk_4 635 641 PF00069 0.733
MOD_ProDKin_1 12 18 PF00069 0.732
MOD_ProDKin_1 141 147 PF00069 0.682
MOD_ProDKin_1 159 165 PF00069 0.774
MOD_ProDKin_1 188 194 PF00069 0.513
MOD_ProDKin_1 220 226 PF00069 0.411
MOD_ProDKin_1 335 341 PF00069 0.730
MOD_ProDKin_1 384 390 PF00069 0.702
MOD_ProDKin_1 438 444 PF00069 0.715
MOD_ProDKin_1 454 460 PF00069 0.714
MOD_ProDKin_1 495 501 PF00069 0.801
MOD_ProDKin_1 53 59 PF00069 0.724
MOD_ProDKin_1 565 571 PF00069 0.700
MOD_ProDKin_1 605 611 PF00069 0.696
MOD_ProDKin_1 77 83 PF00069 0.632
TRG_DiLeu_BaEn_1 110 115 PF01217 0.583
TRG_DiLeu_BaLyEn_6 233 238 PF01217 0.411
TRG_DiLeu_BaLyEn_6 538 543 PF01217 0.759
TRG_DiLeu_BaLyEn_6 92 97 PF01217 0.707
TRG_ENDOCYTIC_2 111 114 PF00928 0.485
TRG_ENDOCYTIC_2 219 222 PF00928 0.454
TRG_ENDOCYTIC_2 249 252 PF00928 0.445
TRG_ER_diArg_1 364 367 PF00400 0.689
TRG_NES_CRM1_1 285 296 PF08389 0.411
TRG_Pf-PMV_PEXEL_1 314 319 PF00026 0.618
TRG_Pf-PMV_PEXEL_1 95 99 PF00026 0.597

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0K2 Leptomonas seymouri 51% 94%
A4HDQ0 Leishmania braziliensis 79% 100%
A4I0Z6 Leishmania infantum 99% 100%
E9AX34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QAE2 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS