Tryparedoxin_3_putative/GeneDB:LmjF.31.1960

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tryparedoxin 3, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IG90_LEIDO

TriTrypDb:

LdBPK_312000.1 , LdCL_310027800 , LDHU3_31.3580

Length:

186

Annotations

LeishMANIAdb annotations

A large family of kinetoplastid-specific oxidoreductases. Only expanded in the Leptomonas genus. Localization: ER (by feature) / Mitochondial outer membrane (by feature)

Annotations by Jardim et al.

Redox homeostasis, Tryparedoxin-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	7
GO:0005829	cytosol	2	1
GO:0005634	nucleus	5	2
GO:0032473	cytoplasmic side of mitochondrial outer membrane	4	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098552	side of membrane	2	1
GO:0098562	cytoplasmic side of membrane	3	1

Expansion

Sequence features

A0A3Q8IG90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG90

PDB structure(s): 3s9f_A

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0042743	hydrogen peroxide metabolic process	4	1
GO:0042744	hydrogen peroxide catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0072593	reactive oxygen species metabolic process	3	1
GO:0009892	negative regulation of metabolic process	4	2
GO:0009966	regulation of signal transduction	4	2
GO:0009968	negative regulation of signal transduction	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010646	regulation of cell communication	4	2
GO:0010648	negative regulation of cell communication	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0023051	regulation of signaling	3	2
GO:0023057	negative regulation of signaling	4	2
GO:0030111	regulation of Wnt signaling pathway	5	2
GO:0030178	negative regulation of Wnt signaling pathway	6	2
GO:0031396	regulation of protein ubiquitination	8	2
GO:0031397	negative regulation of protein ubiquitination	9	2
GO:0031399	regulation of protein modification process	6	2
GO:0031400	negative regulation of protein modification process	7	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0048583	regulation of response to stimulus	3	2
GO:0048585	negative regulation of response to stimulus	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051248	negative regulation of protein metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903320	regulation of protein modification by small protein conjugation or removal	7	2
GO:1903321	negative regulation of protein modification by small protein conjugation or removal	8	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004791	thioredoxin-disulfide reductase activity	2	14
GO:0015035	protein-disulfide reductase activity	3	14
GO:0015036	disulfide oxidoreductase activity	4	14
GO:0016209	antioxidant activity	1	14
GO:0016491	oxidoreductase activity	2	14
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	14
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	4	14
GO:0047134	protein-disulfide reductase (NAD(P)) activity	4	14
GO:0140096	catalytic activity, acting on a protein	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.449
CLV_NRD_NRD_1	165	167	PF00675	0.453
CLV_PCSK_KEX2_1	183	185	PF00082	0.328
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.318
CLV_PCSK_SKI1_1	46	50	PF00082	0.257
DEG_Nend_UBRbox_2	1	3	PF02207	0.523
DOC_CDC14_PxL_1	111	119	PF14671	0.457
DOC_MAPK_gen_1	166	174	PF00069	0.439
DOC_MAPK_gen_1	62	69	PF00069	0.465
DOC_MAPK_MEF2A_6	112	119	PF00069	0.482
DOC_MAPK_MEF2A_6	166	174	PF00069	0.398
DOC_MAPK_NFAT4_5	167	175	PF00069	0.396
DOC_PP4_FxxP_1	146	149	PF00568	0.416
DOC_USP7_MATH_1	156	160	PF00917	0.456
DOC_WW_Pin1_4	46	51	PF00397	0.471
LIG_14-3-3_CterR_2	184	186	PF00244	0.366
LIG_AP2alpha_2	140	142	PF02296	0.257
LIG_BIR_III_2	150	154	PF00653	0.321
LIG_Clathr_ClatBox_1	117	121	PF01394	0.462
LIG_FHA_1	106	112	PF00498	0.412
LIG_FHA_1	114	120	PF00498	0.433
LIG_FHA_1	47	53	PF00498	0.457
LIG_GBD_Chelix_1	170	178	PF00786	0.325
LIG_LIR_Apic_2	38	44	PF02991	0.457
LIG_LIR_Apic_2	89	94	PF02991	0.479
LIG_LIR_Gen_1	29	39	PF02991	0.334
LIG_LIR_Gen_1	66	76	PF02991	0.466
LIG_LIR_Nem_3	140	145	PF02991	0.320
LIG_LIR_Nem_3	66	72	PF02991	0.443
LIG_LIR_Nem_3	89	93	PF02991	0.457
LIG_Pex14_1	105	109	PF04695	0.479
LIG_Pex14_2	142	146	PF04695	0.274
LIG_Pex14_2	37	41	PF04695	0.456
LIG_Pex14_2	65	69	PF04695	0.457
LIG_SH2_CRK	91	95	PF00017	0.467
LIG_SH2_SRC	95	98	PF00017	0.402
LIG_SH2_STAP1	164	168	PF00017	0.333
LIG_SH2_STAT5	164	167	PF00017	0.392
LIG_SH2_STAT5	32	35	PF00017	0.458
LIG_SH2_STAT5	36	39	PF00017	0.455
LIG_SH2_STAT5	82	85	PF00017	0.433
LIG_SH2_STAT5	91	94	PF00017	0.479
LIG_SH3_3	150	156	PF00018	0.547
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.324
LIG_SUMO_SIM_par_1	115	121	PF11976	0.457
LIG_SUMO_SIM_par_1	174	180	PF11976	0.419
LIG_TRAF2_1	75	78	PF00917	0.388
LIG_UBA3_1	11	16	PF00899	0.259
LIG_UBA3_1	174	183	PF00899	0.343
LIG_WRC_WIRS_1	52	57	PF05994	0.462
MOD_CDK_SPxxK_3	46	53	PF00069	0.500
MOD_CK2_1	51	57	PF00069	0.462
MOD_CK2_1	72	78	PF00069	0.512
MOD_DYRK1A_RPxSP_1	46	50	PF00069	0.486
MOD_GlcNHglycan	17	21	PF01048	0.402
MOD_GlcNHglycan	37	40	PF01048	0.264
MOD_GSK3_1	179	186	PF00069	0.323
MOD_GSK3_1	51	58	PF00069	0.452
MOD_GSK3_1	68	75	PF00069	0.449
MOD_N-GLC_1	6	11	PF02516	0.419
MOD_NEK2_1	162	167	PF00069	0.472
MOD_NEK2_1	177	182	PF00069	0.321
MOD_NEK2_1	35	40	PF00069	0.469
MOD_NEK2_1	51	56	PF00069	0.391
MOD_NEK2_1	83	88	PF00069	0.402
MOD_PIKK_1	135	141	PF00454	0.465
MOD_PKA_2	83	89	PF00069	0.395
MOD_Plk_4	113	119	PF00069	0.464
MOD_Plk_4	156	162	PF00069	0.513
MOD_Plk_4	51	57	PF00069	0.479
MOD_Plk_4	78	84	PF00069	0.388
MOD_ProDKin_1	46	52	PF00069	0.471
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.479
TRG_ENDOCYTIC_2	32	35	PF00928	0.457
TRG_ENDOCYTIC_2	90	93	PF00928	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT51	Leptomonas seymouri	58%	100%
A0A0N1HZM3	Leptomonas seymouri	39%	100%
A0A1X0P190	Trypanosomatidae	38%	94%
A0A3Q8IED6	Leishmania donovani	40%	100%
A0A3S7X2H1	Leishmania donovani	37%	100%
A0A422MZX1	Trypanosoma rangeli	39%	96%
A0A6L0XIW2	Leishmania infantum	37%	100%
A0A6L0XKX4	Leishmania infantum	40%	100%
A4HHC6	Leishmania braziliensis	37%	100%
A4HHC7	Leishmania braziliensis	36%	100%
A4HHC8	Leishmania braziliensis	36%	100%
A4HJH8	Leishmania braziliensis	81%	100%
A4I6X1	Leishmania infantum	100%	100%
C9ZKL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	94%
C9ZL57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ADX3	Leishmania major	35%	100%
E9ADX4	Leishmania major	39%	100%
E9ALV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9ALV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B1Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B1Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
O77404	Trypanosoma brucei brucei	42%	100%
Q4Q665	Leishmania major	42%	100%
Q4Q666	Leishmania major	90%	100%
Q5VZ03	Homo sapiens	35%	100%
Q9D531	Mus musculus	34%	100%