Kinesin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinesin, putative

Gene product:

kinesin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IG88_LEIDO

TriTrypDb:

LdBPK_352090.1 , LdCL_350026100 , LDHU3_35.2700

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 31
NetGPI	no	yes: 0, no: 31

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	15
GO:0099080	supramolecular complex	2	15
GO:0099081	supramolecular polymer	3	15
GO:0099512	supramolecular fiber	4	15
GO:0099513	polymeric cytoskeletal fiber	5	15
GO:0110165	cellular anatomical entity	1	19
GO:0005737	cytoplasm	2	6
GO:0005871	kinesin complex	3	2
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2

Expansion

Sequence features

A0A3Q8IG88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG88

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	32
GO:0007018	microtubule-based movement	3	32
GO:0009987	cellular process	1	32
GO:0006810	transport	3	2
GO:0030705	cytoskeleton-dependent intracellular transport	4	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	32
GO:0003774	cytoskeletal motor activity	1	32
GO:0003777	microtubule motor activity	2	32
GO:0003824	catalytic activity	1	14
GO:0005488	binding	1	32
GO:0005515	protein binding	2	32
GO:0005524	ATP binding	5	32
GO:0008017	microtubule binding	5	32
GO:0008092	cytoskeletal protein binding	3	32
GO:0015631	tubulin binding	4	32
GO:0016787	hydrolase activity	2	14
GO:0017076	purine nucleotide binding	4	32
GO:0030554	adenyl nucleotide binding	5	32
GO:0032553	ribonucleotide binding	3	32
GO:0032555	purine ribonucleotide binding	4	32
GO:0032559	adenyl ribonucleotide binding	5	32
GO:0035639	purine ribonucleoside triphosphate binding	4	32
GO:0036094	small molecule binding	2	32
GO:0043167	ion binding	2	32
GO:0043168	anion binding	3	32
GO:0097159	organic cyclic compound binding	2	32
GO:0097367	carbohydrate derivative binding	2	32
GO:0140657	ATP-dependent activity	1	32
GO:1901265	nucleoside phosphate binding	3	32
GO:1901363	heterocyclic compound binding	2	32
GO:0008574	plus-end-directed microtubule motor activity	3	2
GO:0016462	pyrophosphatase activity	5	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.295
CLV_MEL_PAP_1	365	371	PF00089	0.235
CLV_NRD_NRD_1	216	218	PF00675	0.298
CLV_NRD_NRD_1	462	464	PF00675	0.566
CLV_NRD_NRD_1	491	493	PF00675	0.519
CLV_PCSK_KEX2_1	216	218	PF00082	0.238
CLV_PCSK_KEX2_1	278	280	PF00082	0.509
CLV_PCSK_KEX2_1	462	464	PF00082	0.521
CLV_PCSK_KEX2_1	491	493	PF00082	0.545
CLV_PCSK_KEX2_1	652	654	PF00082	0.519
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.509
CLV_PCSK_PC1ET2_1	652	654	PF00082	0.519
CLV_PCSK_SKI1_1	106	110	PF00082	0.367
CLV_PCSK_SKI1_1	144	148	PF00082	0.315
CLV_PCSK_SKI1_1	16	20	PF00082	0.267
CLV_PCSK_SKI1_1	167	171	PF00082	0.260
CLV_PCSK_SKI1_1	198	202	PF00082	0.339
CLV_PCSK_SKI1_1	317	321	PF00082	0.317
CLV_PCSK_SKI1_1	374	378	PF00082	0.280
CLV_PCSK_SKI1_1	386	390	PF00082	0.233
CLV_PCSK_SKI1_1	414	418	PF00082	0.382
CLV_PCSK_SKI1_1	482	486	PF00082	0.706
CLV_PCSK_SKI1_1	640	644	PF00082	0.517
CLV_PCSK_SKI1_1	652	656	PF00082	0.460
DEG_SCF_FBW7_1	624	631	PF00400	0.446
DOC_CYCLIN_yClb5_NLxxxL_5	368	376	PF00134	0.308
DOC_MAPK_gen_1	144	154	PF00069	0.282
DOC_MAPK_gen_1	479	488	PF00069	0.690
DOC_MAPK_gen_1	517	525	PF00069	0.632
DOC_MAPK_MEF2A_6	147	156	PF00069	0.252
DOC_MAPK_MEF2A_6	8	15	PF00069	0.330
DOC_PP1_RVXF_1	426	432	PF00149	0.523
DOC_PP4_FxxP_1	304	307	PF00568	0.384
DOC_PP4_FxxP_1	380	383	PF00568	0.279
DOC_USP7_MATH_1	221	225	PF00917	0.396
DOC_USP7_MATH_1	247	251	PF00917	0.471
DOC_USP7_MATH_1	266	270	PF00917	0.570
DOC_USP7_MATH_1	451	455	PF00917	0.599
DOC_USP7_MATH_1	484	488	PF00917	0.603
DOC_USP7_MATH_1	495	499	PF00917	0.478
DOC_USP7_MATH_1	55	59	PF00917	0.308
DOC_USP7_UBL2_3	485	489	PF12436	0.584
DOC_WW_Pin1_4	391	396	PF00397	0.313
DOC_WW_Pin1_4	624	629	PF00397	0.471
LIG_14-3-3_CanoR_1	133	141	PF00244	0.311
LIG_14-3-3_CanoR_1	491	500	PF00244	0.583
LIG_14-3-3_CanoR_1	653	658	PF00244	0.577
LIG_14-3-3_CanoR_1	8	14	PF00244	0.406
LIG_Actin_WH2_2	362	379	PF00022	0.430
LIG_Actin_WH2_2	535	551	PF00022	0.556
LIG_Actin_WH2_2	6	22	PF00022	0.292
LIG_APCC_ABBA_1	159	164	PF00400	0.288
LIG_APCC_ABBA_1	74	79	PF00400	0.279
LIG_APCC_ABBAyCdc20_2	468	474	PF00400	0.483
LIG_BIR_III_4	496	500	PF00653	0.435
LIG_BRCT_BRCA1_1	127	131	PF00533	0.272
LIG_BRCT_BRCA1_1	57	61	PF00533	0.299
LIG_Clathr_ClatBox_1	234	238	PF01394	0.279
LIG_Clathr_ClatBox_1	60	64	PF01394	0.414
LIG_CSK_EPIYA_1	311	315	PF00017	0.364
LIG_deltaCOP1_diTrp_1	294	299	PF00928	0.447
LIG_FHA_1	105	111	PF00498	0.289
LIG_FHA_1	313	319	PF00498	0.426
LIG_FHA_1	371	377	PF00498	0.299
LIG_FHA_1	455	461	PF00498	0.585
LIG_FHA_1	8	14	PF00498	0.416
LIG_FHA_2	184	190	PF00498	0.208
LIG_FHA_2	397	403	PF00498	0.232
LIG_FHA_2	420	426	PF00498	0.507
LIG_FHA_2	625	631	PF00498	0.706
LIG_FHA_2	70	76	PF00498	0.324
LIG_LIR_Apic_2	294	298	PF02991	0.629
LIG_LIR_Apic_2	302	307	PF02991	0.502
LIG_LIR_Gen_1	107	116	PF02991	0.266
LIG_LIR_Gen_1	128	139	PF02991	0.328
LIG_LIR_Gen_1	584	594	PF02991	0.510
LIG_LIR_Gen_1	62	67	PF02991	0.344
LIG_LIR_Gen_1	663	672	PF02991	0.630
LIG_LIR_Nem_3	107	111	PF02991	0.283
LIG_LIR_Nem_3	128	134	PF02991	0.307
LIG_LIR_Nem_3	361	367	PF02991	0.270
LIG_LIR_Nem_3	62	66	PF02991	0.325
LIG_LIR_Nem_3	663	667	PF02991	0.632
LIG_NRBOX	371	377	PF00104	0.280
LIG_PCNA_yPIPBox_3	163	173	PF02747	0.427
LIG_Pex14_1	295	299	PF04695	0.456
LIG_Pex14_2	63	67	PF04695	0.317
LIG_SH2_CRK	440	444	PF00017	0.551
LIG_SH2_CRK	664	668	PF00017	0.532
LIG_SH2_SRC	191	194	PF00017	0.350
LIG_SH2_SRC	77	80	PF00017	0.318
LIG_SH2_STAP1	314	318	PF00017	0.430
LIG_SH2_STAP1	440	444	PF00017	0.489
LIG_SH2_STAP1	473	477	PF00017	0.668
LIG_SH2_STAP1	77	81	PF00017	0.299
LIG_SH2_STAT5	191	194	PF00017	0.391
LIG_SH2_STAT5	314	317	PF00017	0.231
LIG_SH2_STAT5	593	596	PF00017	0.612
LIG_SH2_STAT5	65	68	PF00017	0.417
LIG_SH3_2	52	57	PF14604	0.329
LIG_SH3_3	187	193	PF00018	0.304
LIG_SH3_3	287	293	PF00018	0.616
LIG_SH3_3	49	55	PF00018	0.349
LIG_SUMO_SIM_anti_2	236	241	PF11976	0.389
LIG_SUMO_SIM_anti_2	250	255	PF11976	0.407
LIG_SUMO_SIM_anti_2	384	391	PF11976	0.261
LIG_SUMO_SIM_anti_2	520	527	PF11976	0.356
LIG_UBA3_1	511	519	PF00899	0.391
LIG_UBA3_1	589	595	PF00899	0.382
LIG_WRC_WIRS_1	60	65	PF05994	0.300
LIG_WRC_WIRS_1	654	659	PF05994	0.388
MOD_CK1_1	104	110	PF00069	0.307
MOD_CK1_1	219	225	PF00069	0.320
MOD_CK1_1	226	232	PF00069	0.305
MOD_CK1_1	282	288	PF00069	0.628
MOD_CK1_1	332	338	PF00069	0.304
MOD_CK1_1	344	350	PF00069	0.353
MOD_CK1_1	370	376	PF00069	0.313
MOD_CK1_1	381	387	PF00069	0.354
MOD_CK1_1	454	460	PF00069	0.579
MOD_CK1_1	59	65	PF00069	0.298
MOD_CK1_1	606	612	PF00069	0.551
MOD_CK1_1	644	650	PF00069	0.616
MOD_CK2_1	154	160	PF00069	0.257
MOD_CK2_1	355	361	PF00069	0.312
MOD_CK2_1	396	402	PF00069	0.279
MOD_CK2_1	419	425	PF00069	0.549
MOD_CK2_1	526	532	PF00069	0.566
MOD_CK2_1	607	613	PF00069	0.505
MOD_CK2_1	624	630	PF00069	0.631
MOD_CK2_1	69	75	PF00069	0.306
MOD_GlcNHglycan	103	106	PF01048	0.321
MOD_GlcNHglycan	127	130	PF01048	0.259
MOD_GlcNHglycan	175	178	PF01048	0.487
MOD_GlcNHglycan	23	26	PF01048	0.385
MOD_GlcNHglycan	244	247	PF01048	0.513
MOD_GlcNHglycan	284	287	PF01048	0.663
MOD_GlcNHglycan	331	334	PF01048	0.352
MOD_GlcNHglycan	435	438	PF01048	0.572
MOD_GlcNHglycan	474	478	PF01048	0.685
MOD_GlcNHglycan	493	496	PF01048	0.638
MOD_GlcNHglycan	497	500	PF01048	0.638
MOD_GlcNHglycan	528	531	PF01048	0.608
MOD_GlcNHglycan	570	573	PF01048	0.517
MOD_GSK3_1	219	226	PF00069	0.332
MOD_GSK3_1	340	347	PF00069	0.305
MOD_GSK3_1	363	370	PF00069	0.287
MOD_GSK3_1	378	385	PF00069	0.315
MOD_GSK3_1	396	403	PF00069	0.315
MOD_GSK3_1	491	498	PF00069	0.528
MOD_GSK3_1	517	524	PF00069	0.500
MOD_GSK3_1	55	62	PF00069	0.327
MOD_GSK3_1	603	610	PF00069	0.406
MOD_GSK3_1	624	631	PF00069	0.664
MOD_N-GLC_1	345	350	PF02516	0.294
MOD_N-GLC_1	370	375	PF02516	0.306
MOD_N-GLC_1	628	633	PF02516	0.735
MOD_N-GLC_1	674	679	PF02516	0.647
MOD_N-GLC_1	92	97	PF02516	0.266
MOD_NEK2_1	123	128	PF00069	0.377
MOD_NEK2_1	254	259	PF00069	0.566
MOD_NEK2_1	299	304	PF00069	0.500
MOD_NEK2_1	400	405	PF00069	0.284
MOD_NEK2_1	416	421	PF00069	0.440
MOD_NEK2_1	433	438	PF00069	0.538
MOD_NEK2_1	568	573	PF00069	0.559
MOD_NEK2_2	41	46	PF00069	0.322
MOD_NEK2_2	484	489	PF00069	0.641
MOD_PIKK_1	223	229	PF00454	0.417
MOD_PIKK_1	393	399	PF00454	0.305
MOD_PIKK_1	451	457	PF00454	0.588
MOD_PIKK_1	561	567	PF00454	0.600
MOD_PIKK_1	613	619	PF00454	0.609
MOD_PIKK_1	69	75	PF00454	0.281
MOD_PKA_1	216	222	PF00069	0.279
MOD_PKA_1	491	497	PF00069	0.621
MOD_PKA_2	216	222	PF00069	0.283
MOD_PKA_2	367	373	PF00069	0.294
MOD_PKA_2	491	497	PF00069	0.583
MOD_PKA_2	622	628	PF00069	0.663
MOD_PKA_2	7	13	PF00069	0.387
MOD_Plk_1	198	204	PF00069	0.285
MOD_Plk_1	340	346	PF00069	0.302
MOD_Plk_1	370	376	PF00069	0.327
MOD_Plk_1	400	406	PF00069	0.261
MOD_Plk_1	41	47	PF00069	0.269
MOD_Plk_1	521	527	PF00069	0.583
MOD_Plk_1	603	609	PF00069	0.491
MOD_Plk_1	674	680	PF00069	0.650
MOD_Plk_1	69	75	PF00069	0.279
MOD_Plk_1	92	98	PF00069	0.262
MOD_Plk_4	191	197	PF00069	0.323
MOD_Plk_4	299	305	PF00069	0.500
MOD_Plk_4	467	473	PF00069	0.662
MOD_Plk_4	56	62	PF00069	0.317
MOD_Plk_4	585	591	PF00069	0.567
MOD_Plk_4	674	680	PF00069	0.631
MOD_Plk_4	92	98	PF00069	0.272
MOD_ProDKin_1	391	397	PF00069	0.313
MOD_ProDKin_1	624	630	PF00069	0.471
MOD_SUMO_for_1	45	48	PF00179	0.327
MOD_SUMO_rev_2	136	143	PF00179	0.299
MOD_SUMO_rev_2	257	266	PF00179	0.583
MOD_SUMO_rev_2	268	274	PF00179	0.546
MOD_SUMO_rev_2	544	551	PF00179	0.548
MOD_SUMO_rev_2	633	642	PF00179	0.692
MOD_SUMO_rev_2	693	698	PF00179	0.411
TRG_DiLeu_BaEn_1	507	512	PF01217	0.570
TRG_DiLeu_BaEn_3	584	590	PF01217	0.574
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.279
TRG_ENDOCYTIC_2	440	443	PF00928	0.534
TRG_ENDOCYTIC_2	664	667	PF00928	0.555
TRG_ER_diArg_1	13	16	PF00400	0.311
TRG_ER_diArg_1	216	218	PF00400	0.385
TRG_ER_diArg_1	461	463	PF00400	0.509
TRG_ER_diArg_1	491	493	PF00400	0.678
TRG_NLS_MonoExtC_3	681	687	PF00514	0.378
TRG_NLS_MonoExtN_4	680	686	PF00514	0.400
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.246
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.677
TRG_Pf-PMV_PEXEL_1	491	496	PF00026	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P672	Leptomonas seymouri	34%	66%
A0A0N1HVM1	Leptomonas seymouri	29%	75%
A0A0N1IM30	Leptomonas seymouri	73%	100%
A0A0S4IXS6	Bodo saltans	39%	68%
A0A0S4JN49	Bodo saltans	50%	96%
A0A1X0NQ03	Trypanosomatidae	24%	84%
A0A1X0P5Y8	Trypanosomatidae	60%	100%
A0A3Q8IBS7	Leishmania donovani	24%	100%
A0A3S7WX05	Leishmania donovani	30%	79%
A0A422MZ05	Trypanosoma rangeli	56%	100%
A0A422NEF2	Trypanosoma rangeli	36%	69%
A4HAQ7	Leishmania braziliensis	26%	100%
A4HHY2	Leishmania braziliensis	26%	100%
A4HMM9	Leishmania braziliensis	77%	99%
A4HZT3	Leishmania infantum	30%	79%
A4I562	Leishmania infantum	24%	100%
A4IBA7	Leishmania infantum	100%	100%
C9ZU98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	86%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	93%
C9ZVT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	69%
C9ZZN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AF32	Leishmania major	92%	100%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B687	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4Q7S4	Leishmania major	26%	100%
Q4QBU1	Leishmania major	31%	78%
V5B8X9	Trypanosoma cruzi	58%	99%
V5D733	Trypanosoma cruzi	25%	93%
V5DFA7	Trypanosoma cruzi	28%	100%
V5DQN8	Trypanosoma cruzi	32%	67%