DUF4200 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4200), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IG83_LEIDO

TriTrypDb:

LdBPK_322110.1 , LdCL_320026500 , LDHU3_32.2620

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A0A3Q8IG83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG83

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	718	722	PF00656	0.664
CLV_NRD_NRD_1	111	113	PF00675	0.339
CLV_NRD_NRD_1	155	157	PF00675	0.248
CLV_NRD_NRD_1	185	187	PF00675	0.247
CLV_NRD_NRD_1	269	271	PF00675	0.674
CLV_NRD_NRD_1	280	282	PF00675	0.691
CLV_NRD_NRD_1	34	36	PF00675	0.584
CLV_NRD_NRD_1	518	520	PF00675	0.670
CLV_NRD_NRD_1	534	536	PF00675	0.632
CLV_NRD_NRD_1	577	579	PF00675	0.705
CLV_NRD_NRD_1	650	652	PF00675	0.464
CLV_NRD_NRD_1	670	672	PF00675	0.482
CLV_NRD_NRD_1	703	705	PF00675	0.596
CLV_PCSK_FUR_1	668	672	PF00082	0.509
CLV_PCSK_KEX2_1	123	125	PF00082	0.262
CLV_PCSK_KEX2_1	155	157	PF00082	0.261
CLV_PCSK_KEX2_1	269	271	PF00082	0.701
CLV_PCSK_KEX2_1	34	36	PF00082	0.547
CLV_PCSK_KEX2_1	352	354	PF00082	0.422
CLV_PCSK_KEX2_1	458	460	PF00082	0.744
CLV_PCSK_KEX2_1	534	536	PF00082	0.694
CLV_PCSK_KEX2_1	577	579	PF00082	0.676
CLV_PCSK_KEX2_1	649	651	PF00082	0.461
CLV_PCSK_KEX2_1	670	672	PF00082	0.507
CLV_PCSK_KEX2_1	703	705	PF00082	0.644
CLV_PCSK_KEX2_1	94	96	PF00082	0.247
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.271
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.674
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.422
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.677
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.247
CLV_PCSK_SKI1_1	164	168	PF00082	0.340
CLV_PCSK_SKI1_1	199	203	PF00082	0.340
CLV_PCSK_SKI1_1	226	230	PF00082	0.485
CLV_PCSK_SKI1_1	27	31	PF00082	0.603
CLV_PCSK_SKI1_1	559	563	PF00082	0.753
CLV_PCSK_SKI1_1	670	674	PF00082	0.503
DEG_Nend_UBRbox_2	1	3	PF02207	0.719
DEG_SPOP_SBC_1	416	420	PF00917	0.467
DOC_ANK_TNKS_1	518	525	PF00023	0.627
DOC_CYCLIN_RxL_1	223	233	PF00134	0.481
DOC_CYCLIN_RxL_1	24	32	PF00134	0.608
DOC_CYCLIN_yCln2_LP_2	626	632	PF00134	0.528
DOC_MAPK_gen_1	136	145	PF00069	0.510
DOC_MAPK_gen_1	162	171	PF00069	0.447
DOC_MAPK_gen_1	186	192	PF00069	0.447
DOC_MAPK_gen_1	352	358	PF00069	0.425
DOC_MAPK_gen_1	649	658	PF00069	0.459
DOC_MAPK_MEF2A_6	299	307	PF00069	0.379
DOC_PIKK_1	36	44	PF02985	0.545
DOC_PP4_FxxP_1	10	13	PF00568	0.624
DOC_USP7_MATH_1	20	24	PF00917	0.611
DOC_USP7_MATH_1	325	329	PF00917	0.403
DOC_USP7_MATH_1	416	420	PF00917	0.493
DOC_USP7_MATH_1	449	453	PF00917	0.697
DOC_USP7_MATH_1	454	458	PF00917	0.711
DOC_USP7_MATH_1	462	466	PF00917	0.764
DOC_USP7_MATH_1	547	551	PF00917	0.778
DOC_USP7_MATH_1	57	61	PF00917	0.675
DOC_USP7_MATH_1	576	580	PF00917	0.722
DOC_USP7_MATH_1	64	68	PF00917	0.688
DOC_USP7_UBL2_3	113	117	PF12436	0.496
DOC_USP7_UBL2_3	348	352	PF12436	0.384
DOC_USP7_UBL2_3	639	643	PF12436	0.486
DOC_USP7_UBL2_3	701	705	PF12436	0.625
DOC_WW_Pin1_4	287	292	PF00397	0.594
DOC_WW_Pin1_4	512	517	PF00397	0.664
LIG_14-3-3_CanoR_1	101	111	PF00244	0.541
LIG_14-3-3_CanoR_1	238	243	PF00244	0.429
LIG_14-3-3_CanoR_1	461	471	PF00244	0.709
LIG_14-3-3_CanoR_1	519	523	PF00244	0.762
LIG_14-3-3_CanoR_1	537	542	PF00244	0.762
LIG_14-3-3_CanoR_1	624	629	PF00244	0.561
LIG_14-3-3_CanoR_1	689	694	PF00244	0.665
LIG_Actin_WH2_2	488	505	PF00022	0.627
LIG_EH_1	7	11	PF12763	0.568
LIG_FHA_1	166	172	PF00498	0.540
LIG_FHA_1	222	228	PF00498	0.558
LIG_FHA_1	288	294	PF00498	0.594
LIG_FHA_1	324	330	PF00498	0.465
LIG_FHA_1	409	415	PF00498	0.523
LIG_FHA_1	416	422	PF00498	0.526
LIG_FHA_1	471	477	PF00498	0.617
LIG_FHA_2	241	247	PF00498	0.442
LIG_FHA_2	335	341	PF00498	0.515
LIG_FHA_2	357	363	PF00498	0.486
LIG_FHA_2	487	493	PF00498	0.510
LIG_FHA_2	611	617	PF00498	0.447
LIG_FHA_2	84	90	PF00498	0.577
LIG_HCF-1_HBM_1	308	311	PF13415	0.490
LIG_LIR_Gen_1	137	145	PF02991	0.449
LIG_LIR_Gen_1	200	208	PF02991	0.505
LIG_LIR_Gen_1	308	318	PF02991	0.476
LIG_LIR_Gen_1	366	376	PF02991	0.397
LIG_LIR_Gen_1	496	506	PF02991	0.568
LIG_LIR_Nem_3	137	142	PF02991	0.449
LIG_LIR_Nem_3	200	204	PF02991	0.469
LIG_LIR_Nem_3	308	314	PF02991	0.420
LIG_LIR_Nem_3	366	371	PF02991	0.377
LIG_LIR_Nem_3	496	502	PF02991	0.452
LIG_LIR_Nem_3	620	625	PF02991	0.453
LIG_RPA_C_Fungi	233	245	PF08784	0.462
LIG_SH2_CRK	212	216	PF00017	0.382
LIG_SH2_NCK_1	311	315	PF00017	0.509
LIG_SH2_SRC	19	22	PF00017	0.539
LIG_SH2_STAP1	77	81	PF00017	0.660
LIG_SH2_STAT5	625	628	PF00017	0.460
LIG_SH3_3	684	690	PF00018	0.623
LIG_SH3_3	691	697	PF00018	0.678
LIG_SUMO_SIM_anti_2	200	206	PF11976	0.317
LIG_SUMO_SIM_anti_2	610	616	PF11976	0.436
LIG_SUMO_SIM_anti_2	634	639	PF11976	0.550
LIG_SUMO_SIM_par_1	610	616	PF11976	0.433
LIG_TRAF2_1	243	246	PF00917	0.533
LIG_TRAF2_1	313	316	PF00917	0.447
LIG_TRAF2_1	483	486	PF00917	0.622
LIG_TRAF2_1	659	662	PF00917	0.583
LIG_UBA3_1	611	618	PF00899	0.428
LIG_UBA3_1	680	686	PF00899	0.528
LIG_WRC_WIRS_1	139	144	PF05994	0.290
MOD_CDK_SPxxK_3	512	519	PF00069	0.742
MOD_CK1_1	103	109	PF00069	0.413
MOD_CK1_1	23	29	PF00069	0.563
MOD_CK1_1	452	458	PF00069	0.751
MOD_CK1_1	566	572	PF00069	0.737
MOD_CK1_1	579	585	PF00069	0.715
MOD_CK1_1	60	66	PF00069	0.724
MOD_CK1_1	692	698	PF00069	0.629
MOD_CK2_1	143	149	PF00069	0.342
MOD_CK2_1	176	182	PF00069	0.365
MOD_CK2_1	240	246	PF00069	0.529
MOD_CK2_1	310	316	PF00069	0.470
MOD_CK2_1	417	423	PF00069	0.588
MOD_CK2_1	486	492	PF00069	0.583
MOD_CK2_1	610	616	PF00069	0.474
MOD_CK2_1	83	89	PF00069	0.454
MOD_GlcNHglycan	174	177	PF01048	0.286
MOD_GlcNHglycan	238	241	PF01048	0.485
MOD_GlcNHglycan	275	278	PF01048	0.693
MOD_GlcNHglycan	477	480	PF01048	0.705
MOD_GlcNHglycan	550	553	PF01048	0.771
MOD_GlcNHglycan	573	576	PF01048	0.731
MOD_GlcNHglycan	578	581	PF01048	0.680
MOD_GlcNHglycan	62	65	PF01048	0.766
MOD_GlcNHglycan	67	70	PF01048	0.569
MOD_GlcNHglycan	73	76	PF01048	0.566
MOD_GSK3_1	172	179	PF00069	0.365
MOD_GSK3_1	19	26	PF00069	0.629
MOD_GSK3_1	236	243	PF00069	0.445
MOD_GSK3_1	271	278	PF00069	0.525
MOD_GSK3_1	449	456	PF00069	0.689
MOD_GSK3_1	514	521	PF00069	0.584
MOD_GSK3_1	529	536	PF00069	0.693
MOD_GSK3_1	548	555	PF00069	0.729
MOD_GSK3_1	559	566	PF00069	0.720
MOD_GSK3_1	576	583	PF00069	0.705
MOD_GSK3_1	60	67	PF00069	0.632
MOD_GSK3_1	81	88	PF00069	0.630
MOD_N-GLC_1	287	292	PF02516	0.677
MOD_N-GLC_1	529	534	PF02516	0.716
MOD_N-GLC_1	713	718	PF02516	0.692
MOD_NEK2_1	102	107	PF00069	0.346
MOD_NEK2_1	143	148	PF00069	0.286
MOD_NEK2_1	185	190	PF00069	0.436
MOD_NEK2_1	211	216	PF00069	0.442
MOD_NEK2_1	356	361	PF00069	0.566
MOD_NEK2_1	417	422	PF00069	0.494
MOD_NEK2_1	548	553	PF00069	0.608
MOD_NEK2_1	673	678	PF00069	0.457
MOD_NEK2_2	325	330	PF00069	0.401
MOD_PIKK_1	566	572	PF00454	0.764
MOD_PIKK_1	594	600	PF00454	0.704
MOD_PIKK_1	673	679	PF00454	0.489
MOD_PK_1	271	277	PF00069	0.657
MOD_PKA_1	172	178	PF00069	0.286
MOD_PKA_1	271	277	PF00069	0.691
MOD_PKA_2	100	106	PF00069	0.404
MOD_PKA_2	185	191	PF00069	0.263
MOD_PKA_2	271	277	PF00069	0.721
MOD_PKA_2	518	524	PF00069	0.759
MOD_PKA_2	533	539	PF00069	0.479
MOD_PKA_2	570	576	PF00069	0.764
MOD_PKB_1	535	543	PF00069	0.615
MOD_Plk_1	20	26	PF00069	0.574
MOD_Plk_1	491	497	PF00069	0.514
MOD_Plk_1	602	608	PF00069	0.730
MOD_Plk_2-3	610	616	PF00069	0.450
MOD_Plk_4	138	144	PF00069	0.290
MOD_Plk_4	610	616	PF00069	0.461
MOD_ProDKin_1	287	293	PF00069	0.591
MOD_ProDKin_1	512	518	PF00069	0.668
MOD_SUMO_rev_2	110	118	PF00179	0.378
MOD_SUMO_rev_2	294	301	PF00179	0.560
MOD_SUMO_rev_2	344	354	PF00179	0.417
MOD_SUMO_rev_2	485	489	PF00179	0.551
MOD_SUMO_rev_2	610	619	PF00179	0.433
MOD_SUMO_rev_2	695	702	PF00179	0.667
TRG_DiLeu_BaEn_3	372	378	PF01217	0.388
TRG_DiLeu_BaEn_3	401	407	PF01217	0.426
TRG_ENDOCYTIC_2	198	201	PF00928	0.296
TRG_ENDOCYTIC_2	212	215	PF00928	0.434
TRG_ENDOCYTIC_2	311	314	PF00928	0.565
TRG_ER_diArg_1	154	156	PF00400	0.305
TRG_ER_diArg_1	270	273	PF00400	0.675
TRG_ER_diArg_1	33	35	PF00400	0.595
TRG_ER_diArg_1	534	537	PF00400	0.566
TRG_ER_diArg_1	649	651	PF00400	0.480
TRG_ER_diArg_1	668	671	PF00400	0.486
TRG_ER_diArg_1	688	691	PF00400	0.551
TRG_NES_CRM1_1	384	398	PF08389	0.421
TRG_NLS_Bipartite_1	172	190	PF00514	0.416
TRG_NLS_Bipartite_1	269	285	PF00514	0.606
TRG_NLS_MonoExtN_4	269	274	PF00514	0.609
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	624	628	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEP4	Leptomonas seymouri	54%	95%
A0A1X0NUV9	Trypanosomatidae	40%	100%
A0A422NB67	Trypanosoma rangeli	40%	100%
A4HKI8	Leishmania braziliensis	74%	100%
A4I820	Leishmania infantum	100%	100%
D0AA86	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B2X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q578	Leishmania major	93%	100%
V5DCC5	Trypanosoma cruzi	38%	100%