Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IG78_LEIDO

TriTrypDb:

LdBPK_351910.1 , LdCL_350024300 , LDHU3_35.2510

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IG78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG78

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.782
CLV_C14_Caspase3-7	8	12	PF00656	0.686
CLV_NRD_NRD_1	32	34	PF00675	0.490
CLV_NRD_NRD_1	93	95	PF00675	0.513
CLV_PCSK_KEX2_1	32	34	PF00082	0.478
CLV_PCSK_KEX2_1	93	95	PF00082	0.506
CLV_PCSK_PC7_1	28	34	PF00082	0.485
CLV_PCSK_SKI1_1	303	307	PF00082	0.769
CLV_PCSK_SKI1_1	81	85	PF00082	0.527
DEG_Nend_Nbox_1	1	3	PF02207	0.731
DOC_CKS1_1	172	177	PF01111	0.774
DOC_CKS1_1	52	57	PF01111	0.706
DOC_MAPK_MEF2A_6	256	264	PF00069	0.504
DOC_PP2B_LxvP_1	135	138	PF13499	0.810
DOC_USP7_MATH_1	129	133	PF00917	0.769
DOC_USP7_MATH_1	195	199	PF00917	0.792
DOC_USP7_MATH_1	200	204	PF00917	0.627
DOC_USP7_MATH_1	220	224	PF00917	0.582
DOC_USP7_MATH_1	50	54	PF00917	0.762
DOC_WW_Pin1_4	171	176	PF00397	0.771
DOC_WW_Pin1_4	222	227	PF00397	0.756
DOC_WW_Pin1_4	44	49	PF00397	0.809
DOC_WW_Pin1_4	51	56	PF00397	0.750
LIG_14-3-3_CanoR_1	81	89	PF00244	0.762
LIG_Actin_WH2_2	12	30	PF00022	0.678
LIG_BIR_III_4	63	67	PF00653	0.732
LIG_BIR_III_4	70	74	PF00653	0.682
LIG_deltaCOP1_diTrp_1	97	108	PF00928	0.694
LIG_FHA_1	167	173	PF00498	0.773
LIG_FHA_1	82	88	PF00498	0.686
LIG_FHA_2	316	322	PF00498	0.430
LIG_LIR_Gen_1	149	160	PF02991	0.675
LIG_LIR_Gen_1	174	180	PF02991	0.749
LIG_LIR_Gen_1	21	31	PF02991	0.685
LIG_LIR_Nem_3	149	155	PF02991	0.677
LIG_LIR_Nem_3	174	179	PF02991	0.745
LIG_LIR_Nem_3	21	27	PF02991	0.677
LIG_LIR_Nem_3	77	82	PF02991	0.702
LIG_NRBOX	312	318	PF00104	0.494
LIG_PDZ_Class_1	321	326	PF00595	0.553
LIG_Pex14_1	108	112	PF04695	0.683
LIG_Pex14_1	259	263	PF04695	0.512
LIG_PTB_Apo_2	170	177	PF02174	0.699
LIG_SH2_CRK	156	160	PF00017	0.689
LIG_SH2_CRK	24	28	PF00017	0.675
LIG_SH2_NCK_1	186	190	PF00017	0.645
LIG_SH2_SRC	186	189	PF00017	0.704
LIG_SH2_STAP1	156	160	PF00017	0.689
LIG_SH2_STAP1	294	298	PF00017	0.573
LIG_SH2_STAT5	178	181	PF00017	0.638
LIG_SH2_STAT5	24	27	PF00017	0.686
LIG_SH2_STAT5	79	82	PF00017	0.702
LIG_SH3_3	169	175	PF00018	0.769
MOD_CDC14_SPxK_1	225	228	PF00782	0.788
MOD_CDK_SPxK_1	222	228	PF00069	0.788
MOD_CK1_1	273	279	PF00069	0.512
MOD_CK1_1	315	321	PF00069	0.428
MOD_CK2_1	201	207	PF00069	0.790
MOD_CK2_1	315	321	PF00069	0.428
MOD_CK2_1	50	56	PF00069	0.833
MOD_GlcNHglycan	125	128	PF01048	0.530
MOD_GlcNHglycan	130	134	PF01048	0.568
MOD_GlcNHglycan	197	200	PF01048	0.571
MOD_GlcNHglycan	239	244	PF01048	0.503
MOD_GlcNHglycan	276	279	PF01048	0.438
MOD_GlcNHglycan	295	298	PF01048	0.551
MOD_GlcNHglycan	70	74	PF01048	0.536
MOD_GSK3_1	18	25	PF00069	0.657
MOD_GSK3_1	220	227	PF00069	0.756
MOD_GSK3_1	270	277	PF00069	0.418
MOD_GSK3_1	315	322	PF00069	0.428
MOD_GSK3_1	50	57	PF00069	0.828
MOD_NEK2_1	252	257	PF00069	0.708
MOD_NEK2_1	26	31	PF00069	0.694
MOD_NEK2_1	274	279	PF00069	0.516
MOD_NEK2_1	293	298	PF00069	0.449
MOD_NEK2_1	305	310	PF00069	0.492
MOD_NEK2_1	320	325	PF00069	0.507
MOD_PIKK_1	117	123	PF00454	0.717
MOD_PIKK_1	201	207	PF00454	0.799
MOD_PIKK_1	305	311	PF00454	0.494
MOD_PKA_1	93	99	PF00069	0.767
MOD_PKA_2	93	99	PF00069	0.767
MOD_Plk_1	22	28	PF00069	0.663
MOD_Plk_1	239	245	PF00069	0.776
MOD_Plk_1	320	326	PF00069	0.435
MOD_Plk_4	22	28	PF00069	0.677
MOD_Plk_4	312	318	PF00069	0.572
MOD_ProDKin_1	171	177	PF00069	0.771
MOD_ProDKin_1	222	228	PF00069	0.757
MOD_ProDKin_1	44	50	PF00069	0.810
MOD_ProDKin_1	51	57	PF00069	0.750
TRG_DiLeu_BaEn_1	22	27	PF01217	0.675
TRG_DiLeu_BaEn_4	97	103	PF01217	0.765
TRG_ENDOCYTIC_2	156	159	PF00928	0.690
TRG_ENDOCYTIC_2	24	27	PF00928	0.686
TRG_ER_diArg_1	249	252	PF00400	0.714
TRG_ER_diArg_1	31	33	PF00400	0.693
TRG_ER_diArg_1	87	90	PF00400	0.731
TRG_NES_CRM1_1	8	22	PF08389	0.680
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9K1	Leptomonas seymouri	41%	98%
A4HML3	Leishmania braziliensis	70%	99%
A4IB90	Leishmania infantum	99%	100%
E9AF14	Leishmania major	90%	100%
E9B670	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%