Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IG72_LEIDO

TriTrypDb:

LdBPK_321840.1 , LdCL_320023900 , LDHU3_32.2330

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IG72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	434	438	PF00656	0.713
CLV_NRD_NRD_1	205	207	PF00675	0.626
CLV_NRD_NRD_1	295	297	PF00675	0.444
CLV_NRD_NRD_1	362	364	PF00675	0.635
CLV_NRD_NRD_1	400	402	PF00675	0.599
CLV_PCSK_FUR_1	349	353	PF00082	0.627
CLV_PCSK_KEX2_1	118	120	PF00082	0.528
CLV_PCSK_KEX2_1	205	207	PF00082	0.626
CLV_PCSK_KEX2_1	295	297	PF00082	0.494
CLV_PCSK_KEX2_1	351	353	PF00082	0.608
CLV_PCSK_KEX2_1	362	364	PF00082	0.679
CLV_PCSK_KEX2_1	488	490	PF00082	0.580
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.504
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.608
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.580
CLV_PCSK_PC7_1	114	120	PF00082	0.533
CLV_PCSK_PC7_1	347	353	PF00082	0.624
CLV_PCSK_SKI1_1	217	221	PF00082	0.616
CLV_PCSK_SKI1_1	23	27	PF00082	0.638
CLV_PCSK_SKI1_1	368	372	PF00082	0.529
CLV_PCSK_SKI1_1	468	472	PF00082	0.717
DEG_APCC_DBOX_1	233	241	PF00400	0.712
DEG_APCC_KENBOX_2	180	184	PF00400	0.504
DEG_Nend_UBRbox_1	1	4	PF02207	0.580
DEG_SPOP_SBC_1	428	432	PF00917	0.658
DOC_ANK_TNKS_1	332	339	PF00023	0.532
DOC_MAPK_gen_1	293	300	PF00069	0.427
DOC_MAPK_gen_1	301	309	PF00069	0.400
DOC_MAPK_MEF2A_6	142	151	PF00069	0.457
DOC_USP7_MATH_1	221	225	PF00917	0.624
DOC_USP7_MATH_1	230	234	PF00917	0.532
DOC_USP7_MATH_1	24	28	PF00917	0.704
DOC_USP7_MATH_1	397	401	PF00917	0.654
DOC_USP7_MATH_1	428	432	PF00917	0.667
DOC_USP7_UBL2_3	128	132	PF12436	0.467
DOC_USP7_UBL2_3	367	371	PF12436	0.678
DOC_WW_Pin1_4	11	16	PF00397	0.680
DOC_WW_Pin1_4	191	196	PF00397	0.532
DOC_WW_Pin1_4	25	30	PF00397	0.641
DOC_WW_Pin1_4	424	429	PF00397	0.730
DOC_WW_Pin1_4	437	442	PF00397	0.625
LIG_14-3-3_CanoR_1	23	29	PF00244	0.575
LIG_14-3-3_CanoR_1	401	410	PF00244	0.592
LIG_APCC_ABBA_1	136	141	PF00400	0.611
LIG_BRCT_BRCA1_1	27	31	PF00533	0.682
LIG_Clathr_ClatBox_1	146	150	PF01394	0.536
LIG_EH1_1	30	38	PF00400	0.624
LIG_FHA_1	249	255	PF00498	0.486
LIG_FHA_1	270	276	PF00498	0.623
LIG_FHA_1	469	475	PF00498	0.655
LIG_FHA_1	87	93	PF00498	0.447
LIG_FHA_2	259	265	PF00498	0.537
LIG_FHA_2	330	336	PF00498	0.446
LIG_FHA_2	432	438	PF00498	0.737
LIG_FHA_2	450	456	PF00498	0.762
LIG_FHA_2	473	479	PF00498	0.729
LIG_LIR_Gen_1	150	159	PF02991	0.483
LIG_LIR_Gen_1	294	305	PF02991	0.520
LIG_LIR_Gen_1	463	474	PF02991	0.681
LIG_LIR_Gen_1	54	64	PF02991	0.579
LIG_LIR_Gen_1	85	96	PF02991	0.499
LIG_LIR_Nem_3	150	154	PF02991	0.486
LIG_LIR_Nem_3	294	300	PF02991	0.519
LIG_LIR_Nem_3	437	442	PF02991	0.616
LIG_LIR_Nem_3	463	469	PF02991	0.688
LIG_LIR_Nem_3	54	60	PF02991	0.589
LIG_LIR_Nem_3	85	91	PF02991	0.501
LIG_NRBOX	236	242	PF00104	0.583
LIG_Pex14_2	57	61	PF04695	0.574
LIG_REV1ctd_RIR_1	58	66	PF16727	0.537
LIG_SH2_PTP2	297	300	PF00017	0.403
LIG_SH2_STAT3	236	239	PF00017	0.644
LIG_SH2_STAT3	340	343	PF00017	0.603
LIG_SH2_STAT5	236	239	PF00017	0.586
LIG_SH2_STAT5	297	300	PF00017	0.601
LIG_SH2_STAT5	466	469	PF00017	0.707
LIG_SH3_1	26	32	PF00018	0.589
LIG_SH3_2	29	34	PF14604	0.614
LIG_SH3_3	26	32	PF00018	0.640
LIG_Sin3_3	109	116	PF02671	0.584
LIG_SUMO_SIM_par_1	145	150	PF11976	0.448
LIG_SUMO_SIM_par_1	255	261	PF11976	0.564
LIG_SUMO_SIM_par_1	305	311	PF11976	0.437
LIG_TRAF2_1	341	344	PF00917	0.664
LIG_TRAF2_1	403	406	PF00917	0.734
LIG_TRAF2_1	71	74	PF00917	0.563
LIG_TRAF2_1	82	85	PF00917	0.430
LIG_TYR_ITIM	464	469	PF00017	0.571
LIG_UBA3_1	126	132	PF00899	0.522
MOD_CK1_1	199	205	PF00069	0.632
MOD_CK1_1	244	250	PF00069	0.639
MOD_CK1_1	400	406	PF00069	0.701
MOD_CK1_1	427	433	PF00069	0.661
MOD_CK1_1	440	446	PF00069	0.629
MOD_CK2_1	191	197	PF00069	0.491
MOD_CK2_1	329	335	PF00069	0.449
MOD_CK2_1	400	406	PF00069	0.836
MOD_CK2_1	449	455	PF00069	0.732
MOD_CK2_1	472	478	PF00069	0.551
MOD_CK2_1	68	74	PF00069	0.566
MOD_GlcNHglycan	353	357	PF01048	0.560
MOD_GlcNHglycan	442	445	PF01048	0.710
MOD_GlcNHglycan	483	486	PF01048	0.572
MOD_GlcNHglycan	70	73	PF01048	0.498
MOD_GlcNHglycan	8	11	PF01048	0.652
MOD_GSK3_1	221	228	PF00069	0.650
MOD_GSK3_1	243	250	PF00069	0.578
MOD_GSK3_1	269	276	PF00069	0.609
MOD_GSK3_1	397	404	PF00069	0.767
MOD_GSK3_1	424	431	PF00069	0.662
MOD_GSK3_1	468	475	PF00069	0.714
MOD_N-GLC_1	437	442	PF02516	0.660
MOD_NEK2_1	213	218	PF00069	0.678
MOD_NEK2_1	241	246	PF00069	0.582
MOD_NEK2_1	269	274	PF00069	0.721
MOD_NEK2_1	329	334	PF00069	0.518
MOD_PKA_1	205	211	PF00069	0.634
MOD_PKA_1	401	407	PF00069	0.596
MOD_PKA_2	199	205	PF00069	0.645
MOD_PKA_2	225	231	PF00069	0.606
MOD_PKA_2	400	406	PF00069	0.725
MOD_Plk_1	196	202	PF00069	0.603
MOD_Plk_4	161	167	PF00069	0.347
MOD_ProDKin_1	11	17	PF00069	0.680
MOD_ProDKin_1	191	197	PF00069	0.532
MOD_ProDKin_1	25	31	PF00069	0.641
MOD_ProDKin_1	424	430	PF00069	0.730
MOD_ProDKin_1	437	443	PF00069	0.626
MOD_SUMO_for_1	487	490	PF00179	0.511
TRG_DiLeu_BaEn_1	107	112	PF01217	0.587
TRG_DiLeu_BaEn_1	150	155	PF01217	0.546
TRG_DiLeu_BaEn_3	121	127	PF01217	0.436
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.625
TRG_ENDOCYTIC_2	297	300	PF00928	0.515
TRG_ENDOCYTIC_2	466	469	PF00928	0.699
TRG_ER_diArg_1	286	289	PF00400	0.545
TRG_ER_diArg_1	295	297	PF00400	0.530
TRG_ER_diArg_1	375	378	PF00400	0.651
TRG_NES_CRM1_1	124	140	PF08389	0.497
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMW1	Leptomonas seymouri	41%	85%
A0A3R7MFC1	Trypanosoma rangeli	29%	82%
A4HKG3	Leishmania braziliensis	62%	100%
A4I7Z1	Leishmania infantum	99%	100%
E9B2V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q5A4	Leishmania major	85%	100%