Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IG68_LEIDO

TriTrypDb:

LdBPK_351770.1 , LdCL_350022600 , LDHU3_35.2330

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IG68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	204	210	PF00089	0.566
CLV_NRD_NRD_1	127	129	PF00675	0.607
CLV_NRD_NRD_1	181	183	PF00675	0.554
CLV_NRD_NRD_1	2	4	PF00675	0.548
CLV_PCSK_KEX2_1	129	131	PF00082	0.644
CLV_PCSK_KEX2_1	181	183	PF00082	0.588
CLV_PCSK_KEX2_1	206	208	PF00082	0.530
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.644
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.600
CLV_PCSK_SKI1_1	203	207	PF00082	0.557
CLV_Separin_Metazoa	155	159	PF03568	0.629
DOC_USP7_MATH_1	33	37	PF00917	0.594
DOC_USP7_MATH_1	58	62	PF00917	0.502
DOC_WW_Pin1_4	34	39	PF00397	0.591
DOC_WW_Pin1_4	41	46	PF00397	0.530
LIG_14-3-3_CanoR_1	128	135	PF00244	0.716
LIG_14-3-3_CanoR_1	18	24	PF00244	0.599
LIG_14-3-3_CanoR_1	3	9	PF00244	0.645
LIG_BIR_III_4	82	86	PF00653	0.498
LIG_FHA_1	67	73	PF00498	0.476
LIG_FHA_1	84	90	PF00498	0.407
LIG_FHA_2	21	27	PF00498	0.583
LIG_LIR_Nem_3	36	42	PF02991	0.585
LIG_NRBOX	200	206	PF00104	0.572
LIG_PCNA_PIPBox_1	115	124	PF02747	0.616
LIG_PCNA_yPIPBox_3	110	122	PF02747	0.610
LIG_PCNA_yPIPBox_3	169	178	PF02747	0.508
LIG_Pex14_2	49	53	PF04695	0.623
LIG_SH2_NCK_1	19	23	PF00017	0.592
LIG_SH2_STAP1	152	156	PF00017	0.515
LIG_SH2_STAT5	121	124	PF00017	0.596
LIG_SH2_STAT5	138	141	PF00017	0.636
LIG_SH2_STAT5	75	78	PF00017	0.460
LIG_SH2_STAT5	87	90	PF00017	0.487
LIG_SH3_3	39	45	PF00018	0.574
LIG_SUMO_SIM_anti_2	153	159	PF11976	0.629
MOD_CDK_SPxK_1	34	40	PF00069	0.591
MOD_CDK_SPxxK_3	41	48	PF00069	0.549
MOD_CK1_1	20	26	PF00069	0.633
MOD_CK2_1	20	26	PF00069	0.577
MOD_GlcNHglycan	130	133	PF01048	0.635
MOD_GlcNHglycan	4	7	PF01048	0.564
MOD_GSK3_1	120	127	PF00069	0.621
MOD_N-GLC_1	190	195	PF02516	0.533
MOD_NEK2_1	2	7	PF00069	0.596
MOD_PIKK_1	98	104	PF00454	0.587
MOD_PKA_1	128	134	PF00069	0.664
MOD_PKA_2	17	23	PF00069	0.594
MOD_PKA_2	2	8	PF00069	0.559
MOD_Plk_1	190	196	PF00069	0.515
MOD_Plk_4	190	196	PF00069	0.505
MOD_Plk_4	58	64	PF00069	0.477
MOD_Plk_4	83	89	PF00069	0.526
MOD_ProDKin_1	34	40	PF00069	0.591
MOD_ProDKin_1	41	47	PF00069	0.526
MOD_SUMO_for_1	133	136	PF00179	0.649
MOD_SUMO_rev_2	123	127	PF00179	0.606
MOD_SUMO_rev_2	78	86	PF00179	0.473
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.611
TRG_ER_diArg_1	180	182	PF00400	0.551
TRG_NLS_MonoExtN_4	126	132	PF00514	0.623
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4T0	Leptomonas seymouri	80%	100%
A0A0S4KLR7	Bodo saltans	58%	100%
A0A1X0P7A8	Trypanosomatidae	62%	100%
A4HMJ9	Leishmania braziliensis	87%	100%
A4IB78	Leishmania infantum	100%	100%
C9ZZK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AEZ9	Leishmania major	97%	100%
E9B655	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%