RNA_recognition_motif._(A.k.a._RRM_RBD_or_RNP_dom ain)/RNA_recognition_motif_(A.k.a._RRM_RBD_or_RNP_domain)_p utative/Pfam:PF00076/Pfam:PF14259/Pfam:PF13893

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IG64_LEIDO

TriTrypDb:

LdBPK_270360.1 , LdCL_270008400 , LDHU3_27.0440

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IG64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG64

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0070717	poly-purine tract binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.445
CLV_NRD_NRD_1	165	167	PF00675	0.589
CLV_NRD_NRD_1	318	320	PF00675	0.468
CLV_NRD_NRD_1	377	379	PF00675	0.484
CLV_PCSK_KEX2_1	165	167	PF00082	0.574
CLV_PCSK_KEX2_1	318	320	PF00082	0.468
CLV_PCSK_KEX2_1	376	378	PF00082	0.512
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.512
CLV_PCSK_SKI1_1	145	149	PF00082	0.476
CLV_PCSK_SKI1_1	215	219	PF00082	0.335
CLV_PCSK_SKI1_1	258	262	PF00082	0.449
CLV_PCSK_SKI1_1	5	9	PF00082	0.592
CLV_PCSK_SKI1_1	75	79	PF00082	0.381
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.486
DOC_MAPK_gen_1	165	173	PF00069	0.491
DOC_MAPK_gen_1	376	382	PF00069	0.475
DOC_MAPK_gen_1	5	15	PF00069	0.568
DOC_MAPK_gen_1	53	62	PF00069	0.419
DOC_MAPK_MEF2A_6	215	222	PF00069	0.272
DOC_MAPK_NFAT4_5	215	223	PF00069	0.282
DOC_PP4_FxxP_1	101	104	PF00568	0.490
DOC_USP7_MATH_1	150	154	PF00917	0.495
DOC_USP7_MATH_1	307	311	PF00917	0.396
DOC_USP7_UBL2_3	53	57	PF12436	0.571
DOC_WW_Pin1_4	100	105	PF00397	0.489
DOC_WW_Pin1_4	140	145	PF00397	0.564
DOC_WW_Pin1_4	166	171	PF00397	0.493
DOC_WW_Pin1_4	182	187	PF00397	0.532
DOC_WW_Pin1_4	197	202	PF00397	0.494
DOC_WW_Pin1_4	338	343	PF00397	0.654
DOC_WW_Pin1_4	486	491	PF00397	0.532
LIG_14-3-3_CanoR_1	120	128	PF00244	0.433
LIG_14-3-3_CanoR_1	290	294	PF00244	0.466
LIG_14-3-3_CanoR_1	319	327	PF00244	0.538
LIG_14-3-3_CanoR_1	447	455	PF00244	0.468
LIG_BIR_III_4	466	470	PF00653	0.472
LIG_BRCT_BRCA1_1	38	42	PF00533	0.660
LIG_eIF4E_1	254	260	PF01652	0.464
LIG_FHA_1	155	161	PF00498	0.413
LIG_FHA_1	208	214	PF00498	0.339
LIG_FHA_1	330	336	PF00498	0.541
LIG_FHA_1	377	383	PF00498	0.297
LIG_FHA_1	94	100	PF00498	0.443
LIG_FHA_2	130	136	PF00498	0.508
LIG_FHA_2	246	252	PF00498	0.297
LIG_FHA_2	303	309	PF00498	0.527
LIG_FHA_2	66	72	PF00498	0.416
LIG_FHA_2	86	92	PF00498	0.425
LIG_LIR_Gen_1	292	301	PF02991	0.354
LIG_LIR_Gen_1	343	353	PF02991	0.658
LIG_LIR_Gen_1	417	427	PF02991	0.450
LIG_LIR_Nem_3	200	206	PF02991	0.417
LIG_LIR_Nem_3	292	297	PF02991	0.367
LIG_LIR_Nem_3	39	45	PF02991	0.645
LIG_LIR_Nem_3	417	422	PF02991	0.450
LIG_LIR_Nem_3	76	81	PF02991	0.443
LIG_LIR_Nem_3	96	101	PF02991	0.433
LIG_LYPXL_SIV_4	252	260	PF13949	0.457
LIG_MYND_1	386	390	PF01753	0.498
LIG_NRBOX	188	194	PF00104	0.334
LIG_NRBOX	213	219	PF00104	0.453
LIG_NRBOX	393	399	PF00104	0.473
LIG_PCNA_yPIPBox_3	358	371	PF02747	0.475
LIG_SH2_CRK	415	419	PF00017	0.442
LIG_SH2_STAT3	369	372	PF00017	0.481
LIG_SH2_STAT5	254	257	PF00017	0.433
LIG_SH2_STAT5	320	323	PF00017	0.552
LIG_SH2_STAT5	381	384	PF00017	0.455
LIG_SH2_STAT5	415	418	PF00017	0.439
LIG_SH3_3	301	307	PF00018	0.514
LIG_SH3_3	336	342	PF00018	0.677
LIG_SH3_3	346	352	PF00018	0.734
LIG_SUMO_SIM_par_1	392	400	PF11976	0.536
LIG_TRAF2_1	132	135	PF00917	0.460
LIG_UBA3_1	242	246	PF00899	0.381
LIG_UBA3_1	313	322	PF00899	0.493
LIG_WRC_WIRS_1	206	211	PF05994	0.395
LIG_WRC_WIRS_1	37	42	PF05994	0.606
MOD_CDK_SPK_2	140	145	PF00069	0.440
MOD_CK1_1	143	149	PF00069	0.418
MOD_CK1_1	18	24	PF00069	0.560
MOD_CK1_1	197	203	PF00069	0.446
MOD_CK1_1	25	31	PF00069	0.565
MOD_CK1_1	289	295	PF00069	0.361
MOD_CK1_1	333	339	PF00069	0.622
MOD_CK1_1	340	346	PF00069	0.615
MOD_CK1_1	51	57	PF00069	0.662
MOD_CK2_1	129	135	PF00069	0.423
MOD_CK2_1	205	211	PF00069	0.415
MOD_CK2_1	24	30	PF00069	0.587
MOD_CK2_1	302	308	PF00069	0.489
MOD_CK2_1	486	492	PF00069	0.501
MOD_CK2_1	67	73	PF00069	0.481
MOD_CK2_1	85	91	PF00069	0.478
MOD_DYRK1A_RPxSP_1	166	170	PF00069	0.400
MOD_GlcNHglycan	160	163	PF01048	0.497
MOD_GlcNHglycan	24	27	PF01048	0.584
MOD_GlcNHglycan	323	326	PF01048	0.615
MOD_GSK3_1	11	18	PF00069	0.558
MOD_GSK3_1	120	127	PF00069	0.544
MOD_GSK3_1	134	141	PF00069	0.347
MOD_GSK3_1	150	157	PF00069	0.409
MOD_GSK3_1	20	27	PF00069	0.523
MOD_GSK3_1	326	333	PF00069	0.631
MOD_GSK3_1	334	341	PF00069	0.578
MOD_GSK3_1	376	383	PF00069	0.377
MOD_GSK3_1	482	489	PF00069	0.497
MOD_LATS_1	316	322	PF00433	0.498
MOD_NEK2_1	15	20	PF00069	0.676
MOD_NEK2_1	213	218	PF00069	0.467
MOD_NEK2_1	245	250	PF00069	0.437
MOD_NEK2_1	276	281	PF00069	0.408
MOD_NEK2_1	334	339	PF00069	0.680
MOD_NEK2_1	397	402	PF00069	0.502
MOD_NEK2_1	477	482	PF00069	0.484
MOD_NEK2_1	65	70	PF00069	0.494
MOD_NEK2_2	414	419	PF00069	0.442
MOD_OFUCOSY	274	280	PF10250	0.438
MOD_PIKK_1	120	126	PF00454	0.422
MOD_PIKK_1	134	140	PF00454	0.416
MOD_PIKK_1	154	160	PF00454	0.466
MOD_PIKK_1	353	359	PF00454	0.532
MOD_PIKK_1	477	483	PF00454	0.422
MOD_PKA_1	318	324	PF00069	0.536
MOD_PKA_1	376	382	PF00069	0.475
MOD_PKA_2	164	170	PF00069	0.587
MOD_PKA_2	289	295	PF00069	0.477
MOD_PKA_2	318	324	PF00069	0.515
MOD_PKA_2	376	382	PF00069	0.435
MOD_Plk_1	11	17	PF00069	0.680
MOD_Plk_1	35	41	PF00069	0.526
MOD_Plk_2-3	423	429	PF00069	0.522
MOD_Plk_4	143	149	PF00069	0.418
MOD_Plk_4	213	219	PF00069	0.496
MOD_Plk_4	289	295	PF00069	0.345
MOD_Plk_4	330	336	PF00069	0.696
MOD_Plk_4	340	346	PF00069	0.662
MOD_Plk_4	36	42	PF00069	0.623
MOD_Plk_4	389	395	PF00069	0.502
MOD_Plk_4	414	420	PF00069	0.442
MOD_Plk_4	73	79	PF00069	0.486
MOD_ProDKin_1	100	106	PF00069	0.490
MOD_ProDKin_1	140	146	PF00069	0.563
MOD_ProDKin_1	166	172	PF00069	0.491
MOD_ProDKin_1	182	188	PF00069	0.528
MOD_ProDKin_1	197	203	PF00069	0.490
MOD_ProDKin_1	338	344	PF00069	0.656
MOD_ProDKin_1	486	492	PF00069	0.538
MOD_SUMO_rev_2	71	77	PF00179	0.496
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.333
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.405
TRG_ENDOCYTIC_2	415	418	PF00928	0.442
TRG_ER_diArg_1	164	166	PF00400	0.577
TRG_ER_diArg_1	317	319	PF00400	0.466
TRG_NES_CRM1_1	211	226	PF08389	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I589	Leptomonas seymouri	67%	97%
A0A1X0P421	Trypanosomatidae	39%	100%
A0A3R7NWC3	Trypanosoma rangeli	41%	100%
A4HFG0	Leishmania braziliensis	76%	100%
A4I2M2	Leishmania infantum	100%	100%
D0A5N4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AD12	Leishmania major	93%	100%
E9AYT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BXF1	Trypanosoma cruzi	41%	100%