Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IG63_LEIDO

TriTrypDb:

LdBPK_321700.1 , LdCL_320022500 , LDHU3_32.2160

Length:

767

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IG63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.374
CLV_C14_Caspase3-7	730	734	PF00656	0.612
CLV_NRD_NRD_1	133	135	PF00675	0.410
CLV_NRD_NRD_1	233	235	PF00675	0.354
CLV_NRD_NRD_1	632	634	PF00675	0.427
CLV_NRD_NRD_1	680	682	PF00675	0.505
CLV_NRD_NRD_1	717	719	PF00675	0.502
CLV_NRD_NRD_1	724	726	PF00675	0.569
CLV_PCSK_KEX2_1	133	135	PF00082	0.410
CLV_PCSK_KEX2_1	233	235	PF00082	0.354
CLV_PCSK_KEX2_1	237	239	PF00082	0.350
CLV_PCSK_KEX2_1	480	482	PF00082	0.429
CLV_PCSK_KEX2_1	632	634	PF00082	0.434
CLV_PCSK_KEX2_1	639	641	PF00082	0.432
CLV_PCSK_KEX2_1	680	682	PF00082	0.726
CLV_PCSK_KEX2_1	717	719	PF00082	0.502
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.350
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.468
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.376
CLV_PCSK_PC7_1	233	239	PF00082	0.348
CLV_PCSK_SKI1_1	234	238	PF00082	0.353
CLV_PCSK_SKI1_1	425	429	PF00082	0.551
CLV_PCSK_SKI1_1	455	459	PF00082	0.391
CLV_PCSK_SKI1_1	506	510	PF00082	0.461
CLV_PCSK_SKI1_1	533	537	PF00082	0.543
CLV_PCSK_SKI1_1	542	546	PF00082	0.461
CLV_PCSK_SKI1_1	726	730	PF00082	0.582
CLV_Separin_Metazoa	249	253	PF03568	0.403
DEG_APCC_DBOX_1	505	513	PF00400	0.468
DEG_COP1_1	616	626	PF00400	0.380
DOC_CYCLIN_RxL_1	503	511	PF00134	0.460
DOC_CYCLIN_RxL_1	530	540	PF00134	0.423
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.486
DOC_CYCLIN_yCln2_LP_2	220	226	PF00134	0.472
DOC_MAPK_DCC_7	237	247	PF00069	0.383
DOC_MAPK_DCC_7	333	343	PF00069	0.355
DOC_MAPK_DCC_7	592	601	PF00069	0.502
DOC_MAPK_gen_1	233	242	PF00069	0.476
DOC_MAPK_gen_1	263	270	PF00069	0.497
DOC_MAPK_gen_1	51	58	PF00069	0.439
DOC_MAPK_MEF2A_6	238	247	PF00069	0.378
DOC_MAPK_MEF2A_6	592	601	PF00069	0.502
DOC_PP1_RVXF_1	131	138	PF00149	0.449
DOC_PP1_RVXF_1	631	638	PF00149	0.424
DOC_PP2B_LxvP_1	240	243	PF13499	0.463
DOC_PP2B_LxvP_1	594	597	PF13499	0.465
DOC_PP4_FxxP_1	682	685	PF00568	0.501
DOC_USP7_MATH_1	18	22	PF00917	0.476
DOC_USP7_MATH_1	355	359	PF00917	0.610
DOC_USP7_MATH_1	42	46	PF00917	0.507
DOC_USP7_MATH_1	491	495	PF00917	0.545
DOC_USP7_MATH_1	555	559	PF00917	0.657
DOC_USP7_MATH_1	618	622	PF00917	0.600
DOC_USP7_MATH_1	626	630	PF00917	0.462
DOC_USP7_UBL2_3	722	726	PF12436	0.627
DOC_WW_Pin1_4	11	16	PF00397	0.414
DOC_WW_Pin1_4	111	116	PF00397	0.539
DOC_WW_Pin1_4	675	680	PF00397	0.501
LIG_14-3-3_CanoR_1	189	197	PF00244	0.468
LIG_14-3-3_CanoR_1	209	218	PF00244	0.225
LIG_14-3-3_CanoR_1	233	237	PF00244	0.354
LIG_14-3-3_CanoR_1	281	288	PF00244	0.428
LIG_14-3-3_CanoR_1	292	299	PF00244	0.590
LIG_14-3-3_CanoR_1	390	394	PF00244	0.560
LIG_14-3-3_CanoR_1	484	492	PF00244	0.396
LIG_14-3-3_CanoR_1	53	59	PF00244	0.378
LIG_14-3-3_CanoR_1	557	565	PF00244	0.586
LIG_14-3-3_CanoR_1	586	594	PF00244	0.631
LIG_14-3-3_CanoR_1	608	614	PF00244	0.508
LIG_14-3-3_CanoR_1	702	710	PF00244	0.577
LIG_14-3-3_CanoR_1	717	721	PF00244	0.549
LIG_Actin_WH2_2	440	457	PF00022	0.471
LIG_Actin_WH2_2	471	488	PF00022	0.501
LIG_BIR_II_1	1	5	PF00653	0.477
LIG_BIR_III_4	574	578	PF00653	0.422
LIG_CtBP_PxDLS_1	80	84	PF00389	0.373
LIG_deltaCOP1_diTrp_1	404	408	PF00928	0.316
LIG_EH1_1	261	269	PF00400	0.473
LIG_FHA_1	12	18	PF00498	0.559
LIG_FHA_1	26	32	PF00498	0.462
LIG_FHA_1	288	294	PF00498	0.415
LIG_FHA_1	405	411	PF00498	0.293
LIG_FHA_1	416	422	PF00498	0.331
LIG_FHA_1	557	563	PF00498	0.578
LIG_FHA_2	433	439	PF00498	0.522
LIG_FHA_2	447	453	PF00498	0.281
LIG_FHA_2	474	480	PF00498	0.557
LIG_FHA_2	585	591	PF00498	0.571
LIG_FHA_2	728	734	PF00498	0.659
LIG_FHA_2	82	88	PF00498	0.383
LIG_LIR_Gen_1	35	43	PF02991	0.509
LIG_LIR_Gen_1	370	381	PF02991	0.445
LIG_LIR_Gen_1	404	414	PF02991	0.308
LIG_LIR_Gen_1	418	427	PF02991	0.393
LIG_LIR_Gen_1	472	482	PF02991	0.595
LIG_LIR_Nem_3	126	132	PF02991	0.463
LIG_LIR_Nem_3	200	204	PF02991	0.398
LIG_LIR_Nem_3	35	40	PF02991	0.509
LIG_LIR_Nem_3	359	365	PF02991	0.590
LIG_LIR_Nem_3	370	376	PF02991	0.407
LIG_LIR_Nem_3	404	409	PF02991	0.315
LIG_LIR_Nem_3	418	422	PF02991	0.325
LIG_LIR_Nem_3	657	662	PF02991	0.385
LIG_LYPXL_yS_3	201	204	PF13949	0.351
LIG_Pex14_1	380	384	PF04695	0.319
LIG_PTB_Apo_2	507	514	PF02174	0.347
LIG_Rb_pABgroove_1	507	515	PF01858	0.395
LIG_SH2_CRK	132	136	PF00017	0.430
LIG_SH2_CRK	459	463	PF00017	0.373
LIG_SH2_CRK	68	72	PF00017	0.360
LIG_SH2_CRK	690	694	PF00017	0.683
LIG_SH2_NCK_1	690	694	PF00017	0.683
LIG_SH2_SRC	254	257	PF00017	0.526
LIG_SH2_SRC	443	446	PF00017	0.440
LIG_SH2_SRC	690	693	PF00017	0.498
LIG_SH2_STAP1	526	530	PF00017	0.410
LIG_SH2_STAP1	546	550	PF00017	0.226
LIG_SH2_STAP1	72	76	PF00017	0.341
LIG_SH2_STAT5	23	26	PF00017	0.490
LIG_SH2_STAT5	287	290	PF00017	0.438
LIG_SH2_STAT5	373	376	PF00017	0.354
LIG_SH2_STAT5	384	387	PF00017	0.305
LIG_SH2_STAT5	443	446	PF00017	0.562
LIG_SH3_3	220	226	PF00018	0.472
LIG_SH3_3	242	248	PF00018	0.418
LIG_SH3_3	660	666	PF00018	0.493
LIG_SH3_4	425	432	PF00018	0.437
LIG_SUMO_SIM_par_1	28	35	PF11976	0.462
LIG_SUMO_SIM_par_1	79	84	PF11976	0.368
LIG_TRAF2_1	174	177	PF00917	0.579
LIG_TRAF2_1	751	754	PF00917	0.784
LIG_TYR_ITIM	441	446	PF00017	0.405
LIG_TYR_ITIM	457	462	PF00017	0.256
LIG_UBA3_1	324	330	PF00899	0.390
LIG_WRC_WIRS_1	405	410	PF05994	0.247
LIG_WRC_WIRS_1	501	506	PF05994	0.326
MOD_CDC14_SPxK_1	678	681	PF00782	0.501
MOD_CDK_SPK_2	675	680	PF00069	0.501
MOD_CDK_SPxK_1	675	681	PF00069	0.500
MOD_CK1_1	110	116	PF00069	0.618
MOD_CK1_1	156	162	PF00069	0.591
MOD_CK1_1	191	197	PF00069	0.393
MOD_CK1_1	309	315	PF00069	0.550
MOD_CK1_1	32	38	PF00069	0.449
MOD_CK1_1	356	362	PF00069	0.566
MOD_CK1_1	584	590	PF00069	0.658
MOD_CK1_1	675	681	PF00069	0.505
MOD_CK1_1	701	707	PF00069	0.642
MOD_CK2_1	432	438	PF00069	0.536
MOD_CK2_1	473	479	PF00069	0.555
MOD_CK2_1	576	582	PF00069	0.644
MOD_CK2_1	584	590	PF00069	0.672
MOD_CK2_1	6	12	PF00069	0.450
MOD_CK2_1	671	677	PF00069	0.621
MOD_CK2_1	748	754	PF00069	0.750
MOD_CK2_1	81	87	PF00069	0.440
MOD_CMANNOS	656	659	PF00535	0.429
MOD_CMANNOS	86	89	PF00535	0.348
MOD_GlcNHglycan	139	142	PF01048	0.533
MOD_GlcNHglycan	155	158	PF01048	0.425
MOD_GlcNHglycan	190	193	PF01048	0.431
MOD_GlcNHglycan	283	286	PF01048	0.479
MOD_GlcNHglycan	299	302	PF01048	0.624
MOD_GlcNHglycan	354	358	PF01048	0.667
MOD_GlcNHglycan	582	586	PF01048	0.684
MOD_GlcNHglycan	609	612	PF01048	0.451
MOD_GlcNHglycan	620	623	PF01048	0.496
MOD_GlcNHglycan	657	662	PF01048	0.368
MOD_GlcNHglycan	674	677	PF01048	0.594
MOD_GlcNHglycan	706	709	PF01048	0.578
MOD_GlcNHglycan	750	753	PF01048	0.742
MOD_GlcNHglycan	754	758	PF01048	0.688
MOD_GlcNHglycan	8	11	PF01048	0.497
MOD_GSK3_1	107	114	PF00069	0.609
MOD_GSK3_1	156	163	PF00069	0.530
MOD_GSK3_1	25	32	PF00069	0.489
MOD_GSK3_1	271	278	PF00069	0.490
MOD_GSK3_1	287	294	PF00069	0.416
MOD_GSK3_1	380	387	PF00069	0.414
MOD_GSK3_1	432	439	PF00069	0.563
MOD_GSK3_1	469	476	PF00069	0.469
MOD_GSK3_1	480	487	PF00069	0.429
MOD_GSK3_1	581	588	PF00069	0.491
MOD_GSK3_1	657	664	PF00069	0.493
MOD_GSK3_1	671	678	PF00069	0.669
MOD_GSK3_1	741	748	PF00069	0.641
MOD_N-GLC_1	25	30	PF02516	0.433
MOD_N-GLC_1	365	370	PF02516	0.431
MOD_NEK2_1	109	114	PF00069	0.623
MOD_NEK2_1	124	129	PF00069	0.409
MOD_NEK2_1	212	217	PF00069	0.462
MOD_NEK2_1	275	280	PF00069	0.369
MOD_NEK2_1	293	298	PF00069	0.361
MOD_NEK2_1	306	311	PF00069	0.573
MOD_NEK2_1	365	370	PF00069	0.415
MOD_NEK2_1	513	518	PF00069	0.562
MOD_NEK2_1	545	550	PF00069	0.459
MOD_NEK2_1	761	766	PF00069	0.638
MOD_NEK2_1	81	86	PF00069	0.434
MOD_NEK2_2	626	631	PF00069	0.353
MOD_NEK2_2	72	77	PF00069	0.429
MOD_PIKK_1	25	31	PF00454	0.528
MOD_PIKK_1	365	371	PF00454	0.455
MOD_PIKK_1	436	442	PF00454	0.324
MOD_PKA_1	480	486	PF00069	0.476
MOD_PKA_2	188	194	PF00069	0.430
MOD_PKA_2	232	238	PF00069	0.353
MOD_PKA_2	291	297	PF00069	0.659
MOD_PKA_2	389	395	PF00069	0.534
MOD_PKA_2	480	486	PF00069	0.429
MOD_PKA_2	556	562	PF00069	0.628
MOD_PKA_2	585	591	PF00069	0.456
MOD_PKA_2	607	613	PF00069	0.421
MOD_PKA_2	698	704	PF00069	0.660
MOD_PKA_2	716	722	PF00069	0.355
MOD_Plk_1	306	312	PF00069	0.537
MOD_Plk_1	72	78	PF00069	0.345
MOD_Plk_2-3	651	657	PF00069	0.413
MOD_Plk_4	124	130	PF00069	0.541
MOD_Plk_4	160	166	PF00069	0.658
MOD_Plk_4	212	218	PF00069	0.387
MOD_Plk_4	275	281	PF00069	0.483
MOD_Plk_4	32	38	PF00069	0.517
MOD_Plk_4	323	329	PF00069	0.460
MOD_Plk_4	380	386	PF00069	0.402
MOD_Plk_4	42	48	PF00069	0.377
MOD_Plk_4	457	463	PF00069	0.436
MOD_Plk_4	491	497	PF00069	0.411
MOD_Plk_4	545	551	PF00069	0.501
MOD_Plk_4	626	632	PF00069	0.433
MOD_Plk_4	651	657	PF00069	0.542
MOD_ProDKin_1	11	17	PF00069	0.410
MOD_ProDKin_1	111	117	PF00069	0.525
MOD_ProDKin_1	675	681	PF00069	0.500
MOD_SUMO_rev_2	255	264	PF00179	0.446
MOD_SUMO_rev_2	538	544	PF00179	0.465
MOD_SUMO_rev_2	584	594	PF00179	0.484
TRG_DiLeu_BaEn_1	590	595	PF01217	0.432
TRG_DiLeu_BaEn_1	658	663	PF01217	0.489
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.360
TRG_DiLeu_LyEn_5	12	17	PF01217	0.399
TRG_ENDOCYTIC_2	128	131	PF00928	0.460
TRG_ENDOCYTIC_2	132	135	PF00928	0.459
TRG_ENDOCYTIC_2	201	204	PF00928	0.367
TRG_ENDOCYTIC_2	37	40	PF00928	0.414
TRG_ENDOCYTIC_2	373	376	PF00928	0.436
TRG_ENDOCYTIC_2	443	446	PF00928	0.401
TRG_ENDOCYTIC_2	459	462	PF00928	0.263
TRG_ENDOCYTIC_2	546	549	PF00928	0.481
TRG_ENDOCYTIC_2	68	71	PF00928	0.319
TRG_ER_diArg_1	132	134	PF00400	0.406
TRG_ER_diArg_1	232	234	PF00400	0.363
TRG_ER_diArg_1	58	61	PF00400	0.418
TRG_ER_diArg_1	631	633	PF00400	0.437
TRG_ER_diArg_1	679	681	PF00400	0.514
TRG_NES_CRM1_1	540	553	PF08389	0.496
TRG_NES_CRM1_1	560	574	PF08389	0.252
TRG_NLS_MonoExtN_4	759	766	PF00514	0.682
TRG_Pf-PMV_PEXEL_1	318	322	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	506	511	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	533	538	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P980	Leptomonas seymouri	41%	100%
A0A1X0NUC5	Trypanosomatidae	25%	100%
A0A422NL86	Trypanosoma rangeli	29%	100%
A4HKE9	Leishmania braziliensis	71%	100%
A4I7X7	Leishmania infantum	99%	100%
D0AA42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B2T8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q5B9	Leishmania major	91%	100%
V5AZI4	Trypanosoma cruzi	27%	100%