Translation initiation factor IF-2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor IF-2, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IG60_LEIDO

TriTrypDb:

LdBPK_241380.1 , LdCL_240018900 , LDHU3_24.1660

Length:

891

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IG60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG60

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.518
CLV_C14_Caspase3-7	795	799	PF00656	0.621
CLV_C14_Caspase3-7	835	839	PF00656	0.694
CLV_MEL_PAP_1	762	768	PF00089	0.423
CLV_NRD_NRD_1	166	168	PF00675	0.564
CLV_NRD_NRD_1	176	178	PF00675	0.489
CLV_NRD_NRD_1	179	181	PF00675	0.310
CLV_NRD_NRD_1	3	5	PF00675	0.677
CLV_NRD_NRD_1	307	309	PF00675	0.348
CLV_NRD_NRD_1	380	382	PF00675	0.513
CLV_NRD_NRD_1	448	450	PF00675	0.604
CLV_NRD_NRD_1	459	461	PF00675	0.525
CLV_NRD_NRD_1	56	58	PF00675	0.621
CLV_NRD_NRD_1	754	756	PF00675	0.420
CLV_PCSK_FUR_1	177	181	PF00082	0.594
CLV_PCSK_KEX2_1	176	178	PF00082	0.508
CLV_PCSK_KEX2_1	179	181	PF00082	0.342
CLV_PCSK_KEX2_1	2	4	PF00082	0.678
CLV_PCSK_KEX2_1	307	309	PF00082	0.340
CLV_PCSK_KEX2_1	372	374	PF00082	0.654
CLV_PCSK_KEX2_1	450	452	PF00082	0.594
CLV_PCSK_KEX2_1	464	466	PF00082	0.498
CLV_PCSK_KEX2_1	56	58	PF00082	0.599
CLV_PCSK_KEX2_1	686	688	PF00082	0.734
CLV_PCSK_KEX2_1	86	88	PF00082	0.617
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.673
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.622
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.507
CLV_PCSK_PC1ET2_1	686	688	PF00082	0.734
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.617
CLV_PCSK_PC7_1	172	178	PF00082	0.641
CLV_PCSK_PC7_1	446	452	PF00082	0.709
CLV_PCSK_PC7_1	460	466	PF00082	0.472
CLV_PCSK_SKI1_1	104	108	PF00082	0.516
CLV_PCSK_SKI1_1	133	137	PF00082	0.576
CLV_PCSK_SKI1_1	194	198	PF00082	0.391
CLV_PCSK_SKI1_1	219	223	PF00082	0.287
CLV_PCSK_SKI1_1	277	281	PF00082	0.282
CLV_PCSK_SKI1_1	307	311	PF00082	0.385
CLV_PCSK_SKI1_1	437	441	PF00082	0.492
CLV_PCSK_SKI1_1	464	468	PF00082	0.610
CLV_PCSK_SKI1_1	65	69	PF00082	0.542
CLV_PCSK_SKI1_1	686	690	PF00082	0.698
CLV_PCSK_SKI1_1	712	716	PF00082	0.679
CLV_PCSK_SKI1_1	875	879	PF00082	0.637
DEG_APCC_DBOX_1	166	174	PF00400	0.619
DEG_APCC_DBOX_1	306	314	PF00400	0.585
DEG_Nend_UBRbox_1	1	4	PF02207	0.757
DOC_CKS1_1	236	241	PF01111	0.496
DOC_CKS1_1	787	792	PF01111	0.438
DOC_CYCLIN_RxL_1	395	408	PF00134	0.535
DOC_CYCLIN_RxL_1	870	882	PF00134	0.671
DOC_MAPK_gen_1	17	26	PF00069	0.608
DOC_MAPK_gen_1	176	183	PF00069	0.521
DOC_MAPK_gen_1	369	379	PF00069	0.599
DOC_MAPK_gen_1	381	388	PF00069	0.387
DOC_MAPK_gen_1	460	468	PF00069	0.570
DOC_MAPK_gen_1	536	546	PF00069	0.532
DOC_MAPK_gen_1	598	606	PF00069	0.537
DOC_MAPK_gen_1	870	878	PF00069	0.635
DOC_MAPK_MEF2A_6	372	379	PF00069	0.571
DOC_MAPK_MEF2A_6	539	548	PF00069	0.520
DOC_MAPK_MEF2A_6	598	606	PF00069	0.553
DOC_MAPK_RevD_3	288	304	PF00069	0.438
DOC_PP1_RVXF_1	150	157	PF00149	0.454
DOC_PP1_RVXF_1	580	586	PF00149	0.494
DOC_PP1_RVXF_1	753	760	PF00149	0.409
DOC_PP2B_PxIxI_1	284	290	PF00149	0.562
DOC_PP2B_PxIxI_1	850	856	PF00149	0.774
DOC_PP4_FxxP_1	221	224	PF00568	0.505
DOC_PP4_FxxP_1	25	28	PF00568	0.572
DOC_PP4_FxxP_1	787	790	PF00568	0.534
DOC_SPAK_OSR1_1	248	252	PF12202	0.585
DOC_USP7_MATH_1	141	145	PF00917	0.702
DOC_USP7_MATH_1	481	485	PF00917	0.710
DOC_USP7_MATH_1	645	649	PF00917	0.760
DOC_USP7_MATH_1	866	870	PF00917	0.771
DOC_USP7_UBL2_3	34	38	PF12436	0.553
DOC_WW_Pin1_4	143	148	PF00397	0.700
DOC_WW_Pin1_4	235	240	PF00397	0.491
DOC_WW_Pin1_4	470	475	PF00397	0.690
DOC_WW_Pin1_4	56	61	PF00397	0.623
DOC_WW_Pin1_4	77	82	PF00397	0.432
DOC_WW_Pin1_4	786	791	PF00397	0.413
LIG_14-3-3_CanoR_1	104	112	PF00244	0.483
LIG_14-3-3_CanoR_1	381	385	PF00244	0.543
LIG_14-3-3_CanoR_1	477	485	PF00244	0.641
LIG_14-3-3_CanoR_1	491	501	PF00244	0.641
LIG_14-3-3_CanoR_1	687	693	PF00244	0.684
LIG_14-3-3_CanoR_1	712	720	PF00244	0.613
LIG_14-3-3_CanoR_1	788	797	PF00244	0.608
LIG_APCC_ABBA_1	49	54	PF00400	0.602
LIG_APCC_ABBA_1	876	881	PF00400	0.695
LIG_APCC_ABBAyCdc20_2	850	856	PF00400	0.568
LIG_APCC_ABBAyCdc20_2	875	881	PF00400	0.697
LIG_BRCT_BRCA1_1	32	36	PF00533	0.587
LIG_BRCT_BRCA1_1	63	67	PF00533	0.506
LIG_BRCT_BRCA1_1	676	680	PF00533	0.671
LIG_BRCT_BRCA1_2	32	38	PF00533	0.586
LIG_Clathr_ClatBox_1	733	737	PF01394	0.405
LIG_DLG_GKlike_1	128	135	PF00625	0.621
LIG_FHA_1	10	16	PF00498	0.522
LIG_FHA_1	105	111	PF00498	0.486
LIG_FHA_1	193	199	PF00498	0.478
LIG_FHA_1	213	219	PF00498	0.350
LIG_FHA_1	273	279	PF00498	0.512
LIG_FHA_1	501	507	PF00498	0.414
LIG_FHA_1	589	595	PF00498	0.589
LIG_FHA_1	616	622	PF00498	0.547
LIG_FHA_1	683	689	PF00498	0.771
LIG_FHA_1	752	758	PF00498	0.406
LIG_FHA_2	16	22	PF00498	0.604
LIG_FHA_2	232	238	PF00498	0.489
LIG_FHA_2	545	551	PF00498	0.434
LIG_FHA_2	826	832	PF00498	0.477
LIG_IRF3_LxIS_1	257	263	PF10401	0.585
LIG_LIR_Apic_2	356	360	PF02991	0.602
LIG_LIR_Gen_1	231	239	PF02991	0.539
LIG_LIR_Gen_1	33	40	PF02991	0.483
LIG_LIR_Gen_1	603	612	PF02991	0.557
LIG_LIR_Gen_1	811	821	PF02991	0.499
LIG_LIR_Nem_3	231	236	PF02991	0.539
LIG_LIR_Nem_3	33	39	PF02991	0.487
LIG_LIR_Nem_3	480	485	PF02991	0.697
LIG_LIR_Nem_3	603	609	PF02991	0.552
LIG_LIR_Nem_3	611	615	PF02991	0.530
LIG_LIR_Nem_3	811	817	PF02991	0.511
LIG_LYPXL_yS_3	541	544	PF13949	0.524
LIG_PCNA_yPIPBox_3	425	437	PF02747	0.565
LIG_Pex14_1	153	157	PF04695	0.554
LIG_SH2_CRK	482	486	PF00017	0.635
LIG_SH2_CRK	612	616	PF00017	0.546
LIG_SH2_CRK	627	631	PF00017	0.605
LIG_SH2_NCK_1	586	590	PF00017	0.585
LIG_SH2_SRC	52	55	PF00017	0.558
LIG_SH2_SRC	586	589	PF00017	0.594
LIG_SH2_SRC	720	723	PF00017	0.560
LIG_SH2_STAP1	157	161	PF00017	0.674
LIG_SH2_STAP1	586	590	PF00017	0.585
LIG_SH2_STAP1	720	724	PF00017	0.488
LIG_SH2_STAT3	776	779	PF00017	0.606
LIG_SH2_STAT5	162	165	PF00017	0.533
LIG_SH2_STAT5	169	172	PF00017	0.500
LIG_SH2_STAT5	357	360	PF00017	0.631
LIG_SH2_STAT5	596	599	PF00017	0.594
LIG_SH2_STAT5	657	660	PF00017	0.583
LIG_SH2_STAT5	758	761	PF00017	0.518
LIG_SH2_STAT5	776	779	PF00017	0.573
LIG_SH2_STAT5	8	11	PF00017	0.739
LIG_SH2_STAT5	800	803	PF00017	0.451
LIG_SH3_1	627	633	PF00018	0.762
LIG_SH3_2	147	152	PF14604	0.648
LIG_SH3_3	144	150	PF00018	0.654
LIG_SH3_3	279	285	PF00018	0.513
LIG_SH3_3	627	633	PF00018	0.762
LIG_SH3_3	675	681	PF00018	0.757
LIG_SUMO_SIM_anti_2	256	263	PF11976	0.483
LIG_SUMO_SIM_par_1	260	266	PF11976	0.491
LIG_TRAF2_1	633	636	PF00917	0.784
LIG_TRAF2_2	768	773	PF00917	0.528
LIG_UBA3_1	119	126	PF00899	0.547
LIG_UBA3_1	774	782	PF00899	0.583
LIG_Vh1_VBS_1	261	279	PF01044	0.444
LIG_WRC_WIRS_1	232	237	PF05994	0.447
MOD_CDK_SPK_2	470	475	PF00069	0.690
MOD_CDK_SPxxK_3	235	242	PF00069	0.323
MOD_CDK_SPxxK_3	470	477	PF00069	0.674
MOD_CK1_1	343	349	PF00069	0.649
MOD_CK1_1	389	395	PF00069	0.578
MOD_CK1_1	473	479	PF00069	0.696
MOD_CK1_1	484	490	PF00069	0.637
MOD_CK1_1	496	502	PF00069	0.468
MOD_CK1_1	552	558	PF00069	0.570
MOD_CK1_1	650	656	PF00069	0.694
MOD_CK1_1	674	680	PF00069	0.729
MOD_CK1_1	738	744	PF00069	0.404
MOD_CK1_1	792	798	PF00069	0.624
MOD_CK1_1	80	86	PF00069	0.478
MOD_CK2_1	128	134	PF00069	0.589
MOD_CK2_1	15	21	PF00069	0.573
MOD_CK2_1	260	266	PF00069	0.378
MOD_CK2_1	713	719	PF00069	0.639
MOD_CK2_1	796	802	PF00069	0.608
MOD_CK2_1	825	831	PF00069	0.463
MOD_CK2_1	854	860	PF00069	0.717
MOD_CMANNOS	153	156	PF00535	0.539
MOD_Cter_Amidation	165	168	PF01082	0.661
MOD_GlcNHglycan	143	146	PF01048	0.662
MOD_GlcNHglycan	388	391	PF01048	0.377
MOD_GlcNHglycan	479	482	PF01048	0.584
MOD_GlcNHglycan	554	557	PF01048	0.542
MOD_GlcNHglycan	647	650	PF01048	0.775
MOD_GlcNHglycan	706	709	PF01048	0.573
MOD_GlcNHglycan	791	794	PF01048	0.545
MOD_GlcNHglycan	845	849	PF01048	0.655
MOD_GlcNHglycan	862	865	PF01048	0.622
MOD_GSK3_1	231	238	PF00069	0.385
MOD_GSK3_1	26	33	PF00069	0.592
MOD_GSK3_1	294	301	PF00069	0.418
MOD_GSK3_1	330	337	PF00069	0.430
MOD_GSK3_1	339	346	PF00069	0.593
MOD_GSK3_1	415	422	PF00069	0.549
MOD_GSK3_1	473	480	PF00069	0.657
MOD_GSK3_1	492	499	PF00069	0.370
MOD_GSK3_1	565	572	PF00069	0.495
MOD_GSK3_1	670	677	PF00069	0.688
MOD_GSK3_1	682	689	PF00069	0.642
MOD_GSK3_1	747	754	PF00069	0.459
MOD_GSK3_1	77	84	PF00069	0.434
MOD_GSK3_1	792	799	PF00069	0.624
MOD_GSK3_1	808	815	PF00069	0.452
MOD_N-GLC_1	492	497	PF02516	0.622
MOD_NEK2_1	201	206	PF00069	0.371
MOD_NEK2_1	244	249	PF00069	0.364
MOD_NEK2_1	260	265	PF00069	0.284
MOD_NEK2_1	380	385	PF00069	0.458
MOD_NEK2_1	415	420	PF00069	0.621
MOD_NEK2_1	433	438	PF00069	0.353
MOD_NEK2_1	500	505	PF00069	0.430
MOD_NEK2_1	544	549	PF00069	0.474
MOD_NEK2_1	602	607	PF00069	0.573
MOD_NEK2_1	670	675	PF00069	0.726
MOD_NEK2_1	701	706	PF00069	0.487
MOD_NEK2_1	854	859	PF00069	0.700
MOD_NEK2_1	9	14	PF00069	0.670
MOD_NEK2_2	481	486	PF00069	0.531
MOD_NEK2_2	81	86	PF00069	0.553
MOD_OFUCOSY	409	414	PF10250	0.581
MOD_PIKK_1	212	218	PF00454	0.323
MOD_PIKK_1	267	273	PF00454	0.354
MOD_PIKK_1	484	490	PF00454	0.738
MOD_PIKK_1	686	692	PF00454	0.692
MOD_PIKK_1	713	719	PF00454	0.558
MOD_PIKK_1	868	874	PF00454	0.787
MOD_PKA_1	686	692	PF00069	0.713
MOD_PKA_2	141	147	PF00069	0.700
MOD_PKA_2	171	177	PF00069	0.605
MOD_PKA_2	380	386	PF00069	0.549
MOD_PKA_2	493	499	PF00069	0.630
MOD_PKA_2	662	668	PF00069	0.710
MOD_PKA_2	686	692	PF00069	0.713
MOD_PKB_1	475	483	PF00069	0.685
MOD_Plk_1	128	134	PF00069	0.613
MOD_Plk_1	549	555	PF00069	0.560
MOD_Plk_1	602	608	PF00069	0.569
MOD_Plk_1	650	656	PF00069	0.615
MOD_Plk_1	701	707	PF00069	0.351
MOD_Plk_1	747	753	PF00069	0.493
MOD_Plk_1	90	96	PF00069	0.609
MOD_Plk_2-3	134	140	PF00069	0.650
MOD_Plk_2-3	231	237	PF00069	0.447
MOD_Plk_2-3	796	802	PF00069	0.608
MOD_Plk_4	26	32	PF00069	0.487
MOD_Plk_4	496	502	PF00069	0.461
MOD_Plk_4	544	550	PF00069	0.428
MOD_Plk_4	796	802	PF00069	0.511
MOD_ProDKin_1	143	149	PF00069	0.695
MOD_ProDKin_1	235	241	PF00069	0.347
MOD_ProDKin_1	470	476	PF00069	0.683
MOD_ProDKin_1	56	62	PF00069	0.625
MOD_ProDKin_1	77	83	PF00069	0.431
MOD_ProDKin_1	786	792	PF00069	0.419
MOD_SUMO_for_1	135	138	PF00179	0.517
MOD_SUMO_for_1	45	48	PF00179	0.571
MOD_SUMO_for_1	85	88	PF00179	0.563
MOD_SUMO_rev_2	129	137	PF00179	0.575
MOD_SUMO_rev_2	29	36	PF00179	0.593
MOD_SUMO_rev_2	860	869	PF00179	0.690
TRG_DiLeu_BaEn_2	20	26	PF01217	0.465
TRG_DiLeu_BaEn_2	512	518	PF01217	0.536
TRG_DiLeu_BaEn_4	442	448	PF01217	0.676
TRG_DiLeu_BaLyEn_6	394	399	PF01217	0.488
TRG_DiLeu_BaLyEn_6	872	877	PF01217	0.669
TRG_ENDOCYTIC_2	482	485	PF00928	0.638
TRG_ENDOCYTIC_2	52	55	PF00928	0.599
TRG_ENDOCYTIC_2	541	544	PF00928	0.500
TRG_ENDOCYTIC_2	586	589	PF00928	0.536
TRG_ENDOCYTIC_2	612	615	PF00928	0.543
TRG_ENDOCYTIC_2	758	761	PF00928	0.486
TRG_ER_diArg_1	1	4	PF00400	0.739
TRG_ER_diArg_1	176	179	PF00400	0.529
TRG_ER_diArg_1	306	308	PF00400	0.417
TRG_ER_diArg_1	474	477	PF00400	0.677
TRG_ER_diArg_1	55	57	PF00400	0.587
TRG_ER_diArg_1	573	576	PF00400	0.484
TRG_ER_diArg_1	579	582	PF00400	0.456
TRG_ER_diArg_1	597	600	PF00400	0.449
TRG_ER_diArg_1	849	852	PF00400	0.709
TRG_ER_diArg_1	873	876	PF00400	0.651
TRG_NES_CRM1_1	252	266	PF08389	0.361
TRG_NES_CRM1_1	312	326	PF08389	0.447
TRG_NLS_MonoExtN_4	446	453	PF00514	0.710
TRG_Pf-PMV_PEXEL_1	133	138	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	712	717	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	743	748	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	832	836	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	875	880	PF00026	0.762

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH60	Leptomonas seymouri	65%	100%
A0A1X0NVX3	Trypanosomatidae	47%	100%
A0A3R7MK23	Trypanosoma rangeli	45%	100%
A4HDK8	Leishmania braziliensis	89%	100%
A4I0X3	Leishmania infantum	99%	100%
C9ZWH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AWX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
Q4QAJ7	Leishmania major	96%	100%
V5BFL2	Trypanosoma cruzi	46%	100%