ATP-dependent DEAD/H RNA helicase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent DEAD/H RNA helicase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IG57_LEIDO

TriTrypDb:

LdBPK_362660.1 , LdCL_360032600 , LDHU3_36.3620

Length:

783

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	3
GO:0010494	cytoplasmic stress granule	5	1
GO:0034399	nuclear periphery	2	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0097165	nuclear stress granule	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005739	mitochondrion	5	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A0A3Q8IG57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG57

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	1
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902775	mitochondrial large ribosomal subunit assembly	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	22
GO:0003676	nucleic acid binding	3	22
GO:0003824	catalytic activity	1	22
GO:0004386	helicase activity	2	22
GO:0005488	binding	1	22
GO:0005524	ATP binding	5	22
GO:0017076	purine nucleotide binding	4	22
GO:0030554	adenyl nucleotide binding	5	22
GO:0032553	ribonucleotide binding	3	22
GO:0032555	purine ribonucleotide binding	4	22
GO:0032559	adenyl ribonucleotide binding	5	22
GO:0035639	purine ribonucleoside triphosphate binding	4	22
GO:0036094	small molecule binding	2	22
GO:0043167	ion binding	2	22
GO:0043168	anion binding	3	22
GO:0097159	organic cyclic compound binding	2	22
GO:0097367	carbohydrate derivative binding	2	22
GO:0140640	catalytic activity, acting on a nucleic acid	2	22
GO:0140657	ATP-dependent activity	1	22
GO:1901265	nucleoside phosphate binding	3	22
GO:1901363	heterocyclic compound binding	2	22
GO:0016787	hydrolase activity	2	10
GO:0003724	RNA helicase activity	3	6
GO:0003743	translation initiation factor activity	4	5
GO:0008135	translation factor activity, RNA binding	3	5
GO:0008186	ATP-dependent activity, acting on RNA	2	6
GO:0045182	translation regulator activity	1	5
GO:0090079	translation regulator activity, nucleic acid binding	2	5
GO:0140098	catalytic activity, acting on RNA	3	6
GO:0003723	RNA binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.802
CLV_NRD_NRD_1	160	162	PF00675	0.730
CLV_NRD_NRD_1	218	220	PF00675	0.452
CLV_NRD_NRD_1	297	299	PF00675	0.344
CLV_NRD_NRD_1	351	353	PF00675	0.305
CLV_NRD_NRD_1	4	6	PF00675	0.571
CLV_NRD_NRD_1	406	408	PF00675	0.298
CLV_NRD_NRD_1	438	440	PF00675	0.319
CLV_NRD_NRD_1	473	475	PF00675	0.318
CLV_NRD_NRD_1	749	751	PF00675	0.692
CLV_NRD_NRD_1	766	768	PF00675	0.697
CLV_NRD_NRD_1	94	96	PF00675	0.717
CLV_PCSK_FUR_1	747	751	PF00082	0.785
CLV_PCSK_KEX2_1	159	161	PF00082	0.785
CLV_PCSK_KEX2_1	220	222	PF00082	0.430
CLV_PCSK_KEX2_1	297	299	PF00082	0.305
CLV_PCSK_KEX2_1	351	353	PF00082	0.305
CLV_PCSK_KEX2_1	4	6	PF00082	0.571
CLV_PCSK_KEX2_1	473	475	PF00082	0.281
CLV_PCSK_KEX2_1	749	751	PF00082	0.692
CLV_PCSK_KEX2_1	766	768	PF00082	0.684
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.751
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.399
CLV_PCSK_PC7_1	347	353	PF00082	0.344
CLV_PCSK_SKI1_1	223	227	PF00082	0.518
CLV_PCSK_SKI1_1	240	244	PF00082	0.190
CLV_PCSK_SKI1_1	462	466	PF00082	0.243
CLV_PCSK_SKI1_1	477	481	PF00082	0.204
CLV_PCSK_SKI1_1	494	498	PF00082	0.477
CLV_PCSK_SKI1_1	5	9	PF00082	0.530
CLV_PCSK_SKI1_1	502	506	PF00082	0.403
CLV_PCSK_SKI1_1	705	709	PF00082	0.377
CLV_PCSK_SKI1_1	87	91	PF00082	0.553
DEG_APCC_DBOX_1	209	217	PF00400	0.366
DEG_APCC_DBOX_1	406	414	PF00400	0.503
DEG_APCC_DBOX_1	501	509	PF00400	0.450
DEG_APCC_DBOX_1	558	566	PF00400	0.541
DEG_SPOP_SBC_1	43	47	PF00917	0.785
DEG_SPOP_SBC_1	546	550	PF00917	0.481
DOC_CYCLIN_RxL_1	473	483	PF00134	0.449
DOC_CYCLIN_RxL_1	492	500	PF00134	0.414
DOC_CYCLIN_yClb1_LxF_4	475	480	PF00134	0.412
DOC_CYCLIN_yCln2_LP_2	184	190	PF00134	0.542
DOC_CYCLIN_yCln2_LP_2	508	514	PF00134	0.659
DOC_CYCLIN_yCln2_LP_2	720	723	PF00134	0.419
DOC_CYCLIN_yCln2_LP_2	78	84	PF00134	0.516
DOC_MAPK_gen_1	347	356	PF00069	0.491
DOC_MAPK_gen_1	470	480	PF00069	0.481
DOC_MAPK_JIP1_4	474	480	PF00069	0.461
DOC_PP1_RVXF_1	475	481	PF00149	0.405
DOC_PP1_RVXF_1	561	568	PF00149	0.447
DOC_PP1_RVXF_1	575	581	PF00149	0.300
DOC_PP1_RVXF_1	590	597	PF00149	0.537
DOC_PP1_RVXF_1	652	659	PF00149	0.448
DOC_PP1_SILK_1	206	211	PF00149	0.370
DOC_PP2B_LxvP_1	184	187	PF13499	0.556
DOC_PP2B_LxvP_1	508	511	PF13499	0.443
DOC_PP2B_LxvP_1	720	723	PF13499	0.419
DOC_PP4_FxxP_1	332	335	PF00568	0.521
DOC_PP4_FxxP_1	698	701	PF00568	0.357
DOC_PP4_FxxP_1	742	745	PF00568	0.558
DOC_USP7_MATH_1	333	337	PF00917	0.523
DOC_USP7_MATH_1	345	349	PF00917	0.497
DOC_USP7_MATH_1	43	47	PF00917	0.633
DOC_USP7_MATH_1	517	521	PF00917	0.556
DOC_USP7_MATH_1	626	630	PF00917	0.479
DOC_USP7_MATH_1	729	733	PF00917	0.457
DOC_USP7_MATH_1	754	758	PF00917	0.642
DOC_WW_Pin1_4	121	126	PF00397	0.502
DOC_WW_Pin1_4	13	18	PF00397	0.571
DOC_WW_Pin1_4	202	207	PF00397	0.526
DOC_WW_Pin1_4	223	228	PF00397	0.488
DOC_WW_Pin1_4	420	425	PF00397	0.501
DOC_WW_Pin1_4	50	55	PF00397	0.703
DOC_WW_Pin1_4	527	532	PF00397	0.758
DOC_WW_Pin1_4	58	63	PF00397	0.665
DOC_WW_Pin1_4	755	760	PF00397	0.650
LIG_14-3-3_CanoR_1	104	110	PF00244	0.748
LIG_14-3-3_CanoR_1	433	439	PF00244	0.509
LIG_14-3-3_CanoR_1	639	647	PF00244	0.546
LIG_14-3-3_CanoR_1	9	19	PF00244	0.552
LIG_Actin_WH2_2	129	147	PF00022	0.533
LIG_Actin_WH2_2	254	269	PF00022	0.475
LIG_Actin_WH2_2	71	89	PF00022	0.510
LIG_AP2alpha_1	733	737	PF02296	0.557
LIG_APCC_ABBA_1	313	318	PF00400	0.544
LIG_BIR_III_2	122	126	PF00653	0.499
LIG_BIR_III_4	113	117	PF00653	0.659
LIG_BIR_III_4	182	186	PF00653	0.559
LIG_BRCT_BRCA1_1	381	385	PF00533	0.432
LIG_BRCT_BRCA1_1	499	503	PF00533	0.421
LIG_EH1_1	391	399	PF00400	0.451
LIG_eIF4E_1	256	262	PF01652	0.544
LIG_FHA_1	53	59	PF00498	0.630
LIG_FHA_1	582	588	PF00498	0.480
LIG_FHA_1	642	648	PF00498	0.459
LIG_FHA_1	756	762	PF00498	0.723
LIG_FHA_2	280	286	PF00498	0.520
LIG_FHA_2	669	675	PF00498	0.466
LIG_LIR_Apic_2	330	335	PF02991	0.521
LIG_LIR_Apic_2	697	701	PF02991	0.351
LIG_LIR_Apic_2	740	745	PF02991	0.543
LIG_LIR_Gen_1	197	206	PF02991	0.555
LIG_LIR_Gen_1	500	511	PF02991	0.465
LIG_LIR_Gen_1	732	741	PF02991	0.622
LIG_LIR_Nem_3	173	179	PF02991	0.464
LIG_LIR_Nem_3	197	201	PF02991	0.500
LIG_LIR_Nem_3	238	242	PF02991	0.519
LIG_LIR_Nem_3	382	388	PF02991	0.575
LIG_LIR_Nem_3	500	506	PF02991	0.434
LIG_LIR_Nem_3	657	661	PF02991	0.440
LIG_LIR_Nem_3	732	736	PF02991	0.603
LIG_LIR_Nem_3	98	103	PF02991	0.743
LIG_NRBOX	260	266	PF00104	0.544
LIG_OCRL_FandH_1	384	396	PF00620	0.451
LIG_PCNA_PIPBox_1	773	782	PF02747	0.578
LIG_Pex14_2	733	737	PF04695	0.557
LIG_PTB_Apo_2	736	743	PF02174	0.587
LIG_SH2_CRK	176	180	PF00017	0.497
LIG_SH2_CRK	222	226	PF00017	0.570
LIG_SH2_CRK	258	262	PF00017	0.506
LIG_SH2_CRK	667	671	PF00017	0.501
LIG_SH2_NCK_1	667	671	PF00017	0.501
LIG_SH2_SRC	256	259	PF00017	0.566
LIG_SH2_STAP1	258	262	PF00017	0.544
LIG_SH2_STAT3	713	716	PF00017	0.474
LIG_SH2_STAT3	728	731	PF00017	0.359
LIG_SH2_STAT5	256	259	PF00017	0.501
LIG_SH2_STAT5	316	319	PF00017	0.461
LIG_SH2_STAT5	409	412	PF00017	0.534
LIG_SH2_STAT5	605	608	PF00017	0.487
LIG_SH2_STAT5	663	666	PF00017	0.492
LIG_SH2_STAT5	694	697	PF00017	0.343
LIG_SH2_STAT5	713	716	PF00017	0.519
LIG_SH3_2	745	750	PF14604	0.622
LIG_SH3_3	137	143	PF00018	0.769
LIG_SH3_3	161	167	PF00018	0.606
LIG_SH3_3	360	366	PF00018	0.499
LIG_SH3_3	367	373	PF00018	0.534
LIG_SH3_3	418	424	PF00018	0.563
LIG_SH3_3	469	475	PF00018	0.554
LIG_SH3_3	528	534	PF00018	0.749
LIG_SH3_3	742	748	PF00018	0.576
LIG_SH3_3	78	84	PF00018	0.578
LIG_SUMO_SIM_par_1	177	182	PF11976	0.384
LIG_SUMO_SIM_par_1	199	205	PF11976	0.499
LIG_SUMO_SIM_par_1	233	238	PF11976	0.446
LIG_TRAF2_1	402	405	PF00917	0.461
LIG_TYR_ITIM	237	242	PF00017	0.544
LIG_TYR_ITIM	487	492	PF00017	0.438
LIG_UBA3_1	261	267	PF00899	0.544
LIG_UBA3_1	427	435	PF00899	0.461
LIG_UBA3_1	464	470	PF00899	0.448
LIG_WRC_WIRS_1	300	305	PF05994	0.451
LIG_WRC_WIRS_1	695	700	PF05994	0.433
LIG_WW_3	721	725	PF00397	0.359
MOD_CDC14_SPxK_1	530	533	PF00782	0.562
MOD_CDK_SPxK_1	527	533	PF00069	0.561
MOD_CK1_1	108	114	PF00069	0.834
MOD_CK1_1	13	19	PF00069	0.478
MOD_CK1_1	379	385	PF00069	0.445
MOD_CK1_1	423	429	PF00069	0.451
MOD_CK1_1	45	51	PF00069	0.581
MOD_CK1_1	521	527	PF00069	0.630
MOD_CK1_1	624	630	PF00069	0.450
MOD_CK2_1	317	323	PF00069	0.498
MOD_CK2_1	333	339	PF00069	0.469
MOD_CK2_1	359	365	PF00069	0.457
MOD_CK2_1	398	404	PF00069	0.449
MOD_CK2_1	626	632	PF00069	0.451
MOD_CK2_1	668	674	PF00069	0.449
MOD_DYRK1A_RPxSP_1	223	227	PF00069	0.366
MOD_GlcNHglycan	107	110	PF01048	0.750
MOD_GlcNHglycan	171	175	PF01048	0.507
MOD_GlcNHglycan	335	338	PF01048	0.232
MOD_GlcNHglycan	381	384	PF01048	0.344
MOD_GlcNHglycan	401	404	PF01048	0.208
MOD_GlcNHglycan	628	631	PF01048	0.286
MOD_GlcNHglycan	63	66	PF01048	0.819
MOD_GlcNHglycan	97	100	PF01048	0.798
MOD_GSK3_1	104	111	PF00069	0.801
MOD_GSK3_1	13	20	PF00069	0.515
MOD_GSK3_1	204	211	PF00069	0.504
MOD_GSK3_1	42	49	PF00069	0.578
MOD_GSK3_1	517	524	PF00069	0.679
MOD_GSK3_1	545	552	PF00069	0.614
MOD_GSK3_1	617	624	PF00069	0.449
MOD_GSK3_1	637	644	PF00069	0.459
MOD_GSK3_1	646	653	PF00069	0.513
MOD_GSK3_1	668	675	PF00069	0.486
MOD_GSK3_1	91	98	PF00069	0.646
MOD_N-GLC_1	29	34	PF02516	0.735
MOD_N-GLC_1	617	622	PF02516	0.339
MOD_N-GLC_1	737	742	PF02516	0.598
MOD_N-GLC_1	755	760	PF02516	0.792
MOD_NEK2_1	18	23	PF00069	0.660
MOD_NEK2_1	359	364	PF00069	0.497
MOD_NEK2_1	480	485	PF00069	0.504
MOD_NEK2_1	522	527	PF00069	0.562
MOD_NEK2_1	547	552	PF00069	0.552
MOD_NEK2_1	581	586	PF00069	0.492
MOD_NEK2_1	596	601	PF00069	0.489
MOD_NEK2_1	637	642	PF00069	0.479
MOD_NEK2_1	737	742	PF00069	0.540
MOD_NEK2_2	694	699	PF00069	0.324
MOD_PIKK_1	126	132	PF00454	0.728
MOD_PIKK_1	146	152	PF00454	0.538
MOD_PIKK_1	153	159	PF00454	0.640
MOD_PIKK_1	208	214	PF00454	0.605
MOD_PIKK_1	376	382	PF00454	0.463
MOD_PIKK_1	612	618	PF00454	0.561
MOD_PK_1	160	166	PF00069	0.575
MOD_PKA_1	160	166	PF00069	0.575
MOD_PKA_1	95	101	PF00069	0.508
MOD_PKA_2	160	166	PF00069	0.606
MOD_PKA_2	398	404	PF00069	0.461
MOD_Plk_1	317	323	PF00069	0.521
MOD_Plk_1	617	623	PF00069	0.521
MOD_Plk_1	737	743	PF00069	0.599
MOD_Plk_2-3	668	674	PF00069	0.474
MOD_Plk_4	204	210	PF00069	0.522
MOD_Plk_4	257	263	PF00069	0.435
MOD_Plk_4	299	305	PF00069	0.451
MOD_Plk_4	423	429	PF00069	0.471
MOD_Plk_4	440	446	PF00069	0.539
MOD_Plk_4	642	648	PF00069	0.518
MOD_Plk_4	694	700	PF00069	0.388
MOD_Plk_4	729	735	PF00069	0.495
MOD_Plk_4	737	743	PF00069	0.518
MOD_ProDKin_1	121	127	PF00069	0.496
MOD_ProDKin_1	13	19	PF00069	0.574
MOD_ProDKin_1	202	208	PF00069	0.528
MOD_ProDKin_1	223	229	PF00069	0.389
MOD_ProDKin_1	420	426	PF00069	0.501
MOD_ProDKin_1	50	56	PF00069	0.705
MOD_ProDKin_1	527	533	PF00069	0.759
MOD_ProDKin_1	58	64	PF00069	0.663
MOD_ProDKin_1	755	761	PF00069	0.651
TRG_DiLeu_BaEn_1	365	370	PF01217	0.448
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.597
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.448
TRG_ENDOCYTIC_2	176	179	PF00928	0.474
TRG_ENDOCYTIC_2	222	225	PF00928	0.537
TRG_ENDOCYTIC_2	239	242	PF00928	0.544
TRG_ENDOCYTIC_2	258	261	PF00928	0.544
TRG_ENDOCYTIC_2	316	319	PF00928	0.461
TRG_ENDOCYTIC_2	489	492	PF00928	0.406
TRG_ENDOCYTIC_2	696	699	PF00928	0.393
TRG_ER_diArg_1	219	222	PF00400	0.499
TRG_ER_diArg_1	3	5	PF00400	0.540
TRG_ER_diArg_1	472	474	PF00400	0.399
TRG_ER_diArg_1	723	726	PF00400	0.582
TRG_ER_diArg_1	747	750	PF00400	0.732
TRG_ER_diArg_1	765	767	PF00400	0.681
TRG_NLS_MonoExtN_4	219	224	PF00514	0.404
TRG_Pf-PMV_PEXEL_1	386	391	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I458	Leptomonas seymouri	74%	100%
A0A0N1I5R1	Leptomonas seymouri	21%	99%
A0A0S4JPF4	Bodo saltans	39%	100%
A0A1X0P7J3	Trypanosomatidae	56%	100%
A0A3Q8ID91	Leishmania donovani	26%	100%
A0A3Q8IF94	Leishmania donovani	26%	100%
A4HGR1	Leishmania braziliensis	27%	100%
A4HK20	Leishmania braziliensis	26%	100%
A4HPB9	Leishmania braziliensis	86%	100%
A4I3T6	Leishmania infantum	26%	100%
A4I7K4	Leishmania infantum	26%	100%
A4ICF9	Leishmania infantum	100%	100%
D0A3C9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AT30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
E9B028	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B2G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q1G8	Leishmania major	94%	99%
Q4Q5P5	Leishmania major	26%	100%
Q4Q858	Leishmania major	26%	100%
V5D8J9	Trypanosoma cruzi	57%	100%