Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IG54_LEIDO

TriTrypDb:

LdBPK_311410.1 , LdCL_310021000 , LDHU3_31.2290

Length:

773

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IG54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.543
CLV_C14_Caspase3-7	510	514	PF00656	0.467
CLV_C14_Caspase3-7	565	569	PF00656	0.557
CLV_NRD_NRD_1	174	176	PF00675	0.763
CLV_NRD_NRD_1	232	234	PF00675	0.840
CLV_NRD_NRD_1	298	300	PF00675	0.744
CLV_NRD_NRD_1	494	496	PF00675	0.683
CLV_NRD_NRD_1	505	507	PF00675	0.719
CLV_NRD_NRD_1	559	561	PF00675	0.706
CLV_NRD_NRD_1	639	641	PF00675	0.765
CLV_PCSK_KEX2_1	232	234	PF00082	0.840
CLV_PCSK_KEX2_1	298	300	PF00082	0.768
CLV_PCSK_KEX2_1	494	496	PF00082	0.742
CLV_PCSK_KEX2_1	505	507	PF00082	0.748
CLV_PCSK_KEX2_1	558	560	PF00082	0.713
CLV_PCSK_SKI1_1	19	23	PF00082	0.774
CLV_PCSK_SKI1_1	232	236	PF00082	0.758
CLV_PCSK_SKI1_1	669	673	PF00082	0.754
CLV_Separin_Metazoa	555	559	PF03568	0.538
DEG_APCC_DBOX_1	668	676	PF00400	0.550
DEG_APCC_DBOX_1	694	702	PF00400	0.466
DEG_APCC_DBOX_1	761	769	PF00400	0.474
DEG_COP1_1	314	324	PF00400	0.536
DEG_Nend_UBRbox_1	1	4	PF02207	0.561
DEG_SPOP_SBC_1	215	219	PF00917	0.553
DEG_SPOP_SBC_1	386	390	PF00917	0.513
DOC_CYCLIN_RxL_1	16	24	PF00134	0.571
DOC_MAPK_MEF2A_6	327	334	PF00069	0.572
DOC_MAPK_MEF2A_6	594	602	PF00069	0.547
DOC_MAPK_MEF2A_6	718	726	PF00069	0.332
DOC_PP1_RVXF_1	17	23	PF00149	0.489
DOC_PP2B_LxvP_1	455	458	PF13499	0.614
DOC_PP2B_LxvP_1	654	657	PF13499	0.519
DOC_PP4_FxxP_1	425	428	PF00568	0.501
DOC_USP7_MATH_1	155	159	PF00917	0.544
DOC_USP7_MATH_1	214	218	PF00917	0.588
DOC_USP7_MATH_1	225	229	PF00917	0.549
DOC_USP7_MATH_1	268	272	PF00917	0.511
DOC_USP7_MATH_1	307	311	PF00917	0.595
DOC_USP7_MATH_1	320	324	PF00917	0.480
DOC_USP7_MATH_1	330	334	PF00917	0.533
DOC_USP7_MATH_1	338	342	PF00917	0.546
DOC_USP7_MATH_1	374	378	PF00917	0.561
DOC_USP7_MATH_1	514	518	PF00917	0.529
DOC_USP7_MATH_1	585	589	PF00917	0.557
DOC_USP7_MATH_1	627	631	PF00917	0.586
DOC_USP7_MATH_1	676	680	PF00917	0.420
DOC_USP7_MATH_1	688	692	PF00917	0.306
DOC_WW_Pin1_4	232	237	PF00397	0.593
DOC_WW_Pin1_4	250	255	PF00397	0.425
DOC_WW_Pin1_4	258	263	PF00397	0.514
DOC_WW_Pin1_4	282	287	PF00397	0.567
DOC_WW_Pin1_4	370	375	PF00397	0.586
DOC_WW_Pin1_4	389	394	PF00397	0.635
DOC_WW_Pin1_4	538	543	PF00397	0.485
DOC_WW_Pin1_4	657	662	PF00397	0.466
DOC_WW_Pin1_4	74	79	PF00397	0.631
LIG_14-3-3_CanoR_1	239	245	PF00244	0.639
LIG_14-3-3_CanoR_1	385	394	PF00244	0.521
LIG_14-3-3_CanoR_1	439	445	PF00244	0.523
LIG_14-3-3_CanoR_1	494	501	PF00244	0.471
LIG_14-3-3_CanoR_1	695	699	PF00244	0.533
LIG_14-3-3_CanoR_1	81	87	PF00244	0.552
LIG_BIR_III_2	317	321	PF00653	0.559
LIG_BIR_III_2	589	593	PF00653	0.601
LIG_BIR_III_4	449	453	PF00653	0.509
LIG_BIR_III_4	61	65	PF00653	0.586
LIG_BRCT_BRCA1_1	157	161	PF00533	0.499
LIG_BRCT_BRCA1_1	227	231	PF00533	0.483
LIG_BRCT_BRCA1_1	307	311	PF00533	0.548
LIG_BRCT_BRCA1_2	157	163	PF00533	0.497
LIG_Clathr_ClatBox_1	730	734	PF01394	0.466
LIG_deltaCOP1_diTrp_1	734	740	PF00928	0.498
LIG_eIF4E_1	667	673	PF01652	0.553
LIG_eIF4E_1	703	709	PF01652	0.654
LIG_FHA_1	289	295	PF00498	0.572
LIG_FHA_1	595	601	PF00498	0.545
LIG_FHA_1	611	617	PF00498	0.394
LIG_FHA_1	623	629	PF00498	0.453
LIG_FHA_1	680	686	PF00498	0.292
LIG_FHA_1	695	701	PF00498	0.341
LIG_FHA_1	717	723	PF00498	0.411
LIG_FHA_1	725	731	PF00498	0.309
LIG_FHA_1	753	759	PF00498	0.521
LIG_FHA_1	83	89	PF00498	0.517
LIG_FHA_2	287	293	PF00498	0.547
LIG_FHA_2	349	355	PF00498	0.475
LIG_FHA_2	40	46	PF00498	0.646
LIG_FHA_2	417	423	PF00498	0.545
LIG_FHA_2	480	486	PF00498	0.490
LIG_FHA_2	508	514	PF00498	0.526
LIG_FHA_2	561	567	PF00498	0.575
LIG_GBD_Chelix_1	708	716	PF00786	0.434
LIG_Integrin_isoDGR_2	638	640	PF01839	0.739
LIG_Integrin_RGD_1	264	266	PF01839	0.684
LIG_IRF3_LxIS_1	596	603	PF10401	0.574
LIG_LIR_Apic_2	422	428	PF02991	0.501
LIG_LIR_Apic_2	665	670	PF02991	0.550
LIG_LIR_Gen_1	351	358	PF02991	0.592
LIG_LIR_Gen_1	691	701	PF02991	0.299
LIG_LIR_Nem_3	351	355	PF02991	0.590
LIG_LIR_Nem_3	691	696	PF02991	0.299
LIG_Pex14_2	421	425	PF04695	0.507
LIG_REV1ctd_RIR_1	488	499	PF16727	0.484
LIG_RPA_C_Fungi	490	502	PF08784	0.590
LIG_SH2_CRK	667	671	PF00017	0.749
LIG_SH2_NCK_1	148	152	PF00017	0.636
LIG_SH2_SRC	106	109	PF00017	0.778
LIG_SH2_SRC	246	249	PF00017	0.718
LIG_SH2_SRC	328	331	PF00017	0.675
LIG_SH2_STAP1	101	105	PF00017	0.777
LIG_SH2_STAP1	246	250	PF00017	0.703
LIG_SH2_STAP1	352	356	PF00017	0.675
LIG_SH2_STAP1	746	750	PF00017	0.680
LIG_SH2_STAT5	12	15	PF00017	0.781
LIG_SH2_STAT5	133	136	PF00017	0.642
LIG_SH2_STAT5	328	331	PF00017	0.675
LIG_SH2_STAT5	667	670	PF00017	0.693
LIG_SH2_STAT5	746	749	PF00017	0.650
LIG_SH3_2	393	398	PF14604	0.810
LIG_SH3_3	196	202	PF00018	0.701
LIG_SH3_3	390	396	PF00018	0.808
LIG_SH3_3	455	461	PF00018	0.759
LIG_SH3_3	522	528	PF00018	0.702
LIG_SH3_3	590	596	PF00018	0.780
LIG_SH3_3	670	676	PF00018	0.628
LIG_SH3_3	73	79	PF00018	0.784
LIG_SUMO_SIM_anti_2	697	702	PF11976	0.416
LIG_SUMO_SIM_par_1	427	435	PF11976	0.717
LIG_SUMO_SIM_par_1	741	747	PF11976	0.595
LIG_TRAF2_1	563	566	PF00917	0.726
LIG_WW_3	78	82	PF00397	0.776
MOD_CDC14_SPxK_1	261	264	PF00782	0.714
MOD_CDC14_SPxK_1	395	398	PF00782	0.808
MOD_CDK_SPK_2	282	287	PF00069	0.714
MOD_CDK_SPK_2	370	375	PF00069	0.710
MOD_CDK_SPxK_1	258	264	PF00069	0.724
MOD_CDK_SPxK_1	392	398	PF00069	0.809
MOD_CDK_SPxxK_3	232	239	PF00069	0.749
MOD_CDK_SPxxK_3	74	81	PF00069	0.783
MOD_CK1_1	10	16	PF00069	0.746
MOD_CK1_1	218	224	PF00069	0.690
MOD_CK1_1	387	393	PF00069	0.805
MOD_CK1_1	508	514	PF00069	0.573
MOD_CK1_1	573	579	PF00069	0.727
MOD_CK1_1	679	685	PF00069	0.468
MOD_CK1_1	744	750	PF00069	0.684
MOD_CK2_1	370	376	PF00069	0.794
MOD_CK2_1	39	45	PF00069	0.759
MOD_CK2_1	438	444	PF00069	0.706
MOD_CK2_1	479	485	PF00069	0.605
MOD_CK2_1	514	520	PF00069	0.643
MOD_CK2_1	560	566	PF00069	0.729
MOD_CK2_1	608	614	PF00069	0.689
MOD_CK2_1	757	763	PF00069	0.672
MOD_CMANNOS	737	740	PF00535	0.632
MOD_Cter_Amidation	492	495	PF01082	0.684
MOD_Cter_Amidation	638	641	PF01082	0.710
MOD_GlcNHglycan	157	160	PF01048	0.613
MOD_GlcNHglycan	218	221	PF01048	0.730
MOD_GlcNHglycan	270	273	PF01048	0.791
MOD_GlcNHglycan	322	325	PF01048	0.684
MOD_GlcNHglycan	336	339	PF01048	0.653
MOD_GlcNHglycan	356	359	PF01048	0.734
MOD_GlcNHglycan	416	419	PF01048	0.728
MOD_GlcNHglycan	477	480	PF01048	0.822
MOD_GlcNHglycan	48	53	PF01048	0.782
MOD_GlcNHglycan	491	494	PF01048	0.582
MOD_GlcNHglycan	496	499	PF01048	0.691
MOD_GlcNHglycan	507	510	PF01048	0.540
MOD_GlcNHglycan	516	519	PF01048	0.662
MOD_GlcNHglycan	572	575	PF01048	0.737
MOD_GlcNHglycan	657	660	PF01048	0.730
MOD_GlcNHglycan	690	693	PF01048	0.433
MOD_GSK3_1	214	221	PF00069	0.704
MOD_GSK3_1	250	257	PF00069	0.732
MOD_GSK3_1	268	275	PF00069	0.550
MOD_GSK3_1	27	34	PF00069	0.820
MOD_GSK3_1	282	289	PF00069	0.600
MOD_GSK3_1	307	314	PF00069	0.695
MOD_GSK3_1	330	337	PF00069	0.809
MOD_GSK3_1	35	42	PF00069	0.774
MOD_GSK3_1	350	357	PF00069	0.764
MOD_GSK3_1	370	377	PF00069	0.770
MOD_GSK3_1	384	391	PF00069	0.763
MOD_GSK3_1	397	404	PF00069	0.726
MOD_GSK3_1	475	482	PF00069	0.654
MOD_GSK3_1	508	515	PF00069	0.667
MOD_GSK3_1	581	588	PF00069	0.733
MOD_GSK3_1	594	601	PF00069	0.538
MOD_GSK3_1	616	623	PF00069	0.701
MOD_GSK3_1	627	634	PF00069	0.707
MOD_GSK3_1	676	683	PF00069	0.609
MOD_N-GLC_1	35	40	PF02516	0.673
MOD_N-GLC_1	608	613	PF02516	0.668
MOD_N-GLC_1	7	12	PF02516	0.705
MOD_N-GLC_1	752	757	PF02516	0.567
MOD_NEK2_1	21	26	PF00069	0.812
MOD_NEK2_1	216	221	PF00069	0.645
MOD_NEK2_1	311	316	PF00069	0.684
MOD_NEK2_1	421	426	PF00069	0.715
MOD_NEK2_1	531	536	PF00069	0.685
MOD_NEK2_1	598	603	PF00069	0.718
MOD_NEK2_1	680	685	PF00069	0.509
MOD_NEK2_1	694	699	PF00069	0.279
MOD_NEK2_1	708	713	PF00069	0.558
MOD_NEK2_1	716	721	PF00069	0.418
MOD_NEK2_1	724	729	PF00069	0.284
MOD_NEK2_1	757	762	PF00069	0.673
MOD_NEK2_2	227	232	PF00069	0.680
MOD_NEK2_2	254	259	PF00069	0.723
MOD_NEK2_2	676	681	PF00069	0.497
MOD_NEK2_2	741	746	PF00069	0.630
MOD_OFUCOSY	629	636	PF10250	0.582
MOD_PIKK_1	2	8	PF00454	0.749
MOD_PIKK_1	305	311	PF00454	0.717
MOD_PIKK_1	31	37	PF00454	0.798
MOD_PIKK_1	356	362	PF00454	0.688
MOD_PKA_1	494	500	PF00069	0.662
MOD_PKA_1	505	511	PF00069	0.695
MOD_PKA_2	10	16	PF00069	0.662
MOD_PKA_2	384	390	PF00069	0.640
MOD_PKA_2	397	403	PF00069	0.834
MOD_PKA_2	438	444	PF00069	0.656
MOD_PKA_2	494	500	PF00069	0.708
MOD_PKA_2	505	511	PF00069	0.695
MOD_PKA_2	536	542	PF00069	0.698
MOD_PKA_2	551	557	PF00069	0.576
MOD_PKA_2	580	586	PF00069	0.736
MOD_PKA_2	632	638	PF00069	0.697
MOD_PKA_2	694	700	PF00069	0.416
MOD_PKB_1	524	532	PF00069	0.610
MOD_PKB_1	558	566	PF00069	0.623
MOD_Plk_1	146	152	PF00069	0.606
MOD_Plk_1	421	427	PF00069	0.679
MOD_Plk_1	7	13	PF00069	0.703
MOD_Plk_1	752	758	PF00069	0.566
MOD_Plk_4	421	427	PF00069	0.663
MOD_Plk_4	662	668	PF00069	0.688
MOD_Plk_4	680	686	PF00069	0.226
MOD_Plk_4	708	714	PF00069	0.530
MOD_Plk_4	741	747	PF00069	0.667
MOD_Plk_4	752	758	PF00069	0.597
MOD_ProDKin_1	232	238	PF00069	0.749
MOD_ProDKin_1	250	256	PF00069	0.519
MOD_ProDKin_1	258	264	PF00069	0.638
MOD_ProDKin_1	282	288	PF00069	0.714
MOD_ProDKin_1	370	376	PF00069	0.741
MOD_ProDKin_1	389	395	PF00069	0.809
MOD_ProDKin_1	538	544	PF00069	0.601
MOD_ProDKin_1	657	663	PF00069	0.571
MOD_ProDKin_1	74	80	PF00069	0.803
TRG_DiLeu_BaLyEn_6	667	672	PF01217	0.695
TRG_ENDOCYTIC_2	352	355	PF00928	0.672
TRG_ER_diArg_1	231	233	PF00400	0.820
TRG_ER_diArg_1	524	527	PF00400	0.586
TRG_ER_diArg_1	550	553	PF00400	0.689
TRG_ER_diArg_1	557	560	PF00400	0.673
TRG_ER_diArg_1	9	12	PF00400	0.735
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.756
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.706
TRG_Pf-PMV_PEXEL_1	669	674	PF00026	0.696

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HJC2	Leishmania braziliensis	49%	99%
A4I6R5	Leishmania infantum	99%	100%
E9B1T7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q6C4	Leishmania major	82%	99%