Inhibitor_of_apoptosis-promoting_Bax1_putative/Pf am:PF01027

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Inhibitor of apoptosis-promoting Bax1, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IG51_LEIDO

TriTrypDb:

LdBPK_241220.1 , LdCL_240017300 , LDHU3_24.1440

Length:

313

Annotations

Annotations by Jardim et al.

Transporters, Inhibitor of apoptosis-promoting Bax1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3Q8IG51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	99	103	PF00656	0.564
CLV_PCSK_SKI1_1	194	198	PF00082	0.414
DEG_APCC_DBOX_1	108	116	PF00400	0.414
DEG_Nend_Nbox_1	1	3	PF02207	0.620
DEG_SPOP_SBC_1	196	200	PF00917	0.382
DOC_CKS1_1	134	139	PF01111	0.268
DOC_CKS1_1	86	91	PF01111	0.581
DOC_PP4_FxxP_1	160	163	PF00568	0.382
DOC_USP7_MATH_1	13	17	PF00917	0.610
DOC_USP7_MATH_1	164	168	PF00917	0.470
DOC_USP7_MATH_1	219	223	PF00917	0.416
DOC_USP7_MATH_1	29	33	PF00917	0.696
DOC_USP7_MATH_1	58	62	PF00917	0.631
DOC_WW_Pin1_4	102	107	PF00397	0.525
DOC_WW_Pin1_4	133	138	PF00397	0.268
DOC_WW_Pin1_4	85	90	PF00397	0.605
LIG_14-3-3_CanoR_1	114	119	PF00244	0.382
LIG_14-3-3_CanoR_1	220	224	PF00244	0.414
LIG_14-3-3_CanoR_1	24	29	PF00244	0.669
LIG_14-3-3_CanoR_1	8	18	PF00244	0.608
LIG_FHA_1	103	109	PF00498	0.507
LIG_FHA_1	123	129	PF00498	0.126
LIG_FHA_1	196	202	PF00498	0.295
LIG_HP1_1	186	190	PF01393	0.382
LIG_LIR_Apic_2	159	163	PF02991	0.316
LIG_LIR_Gen_1	130	138	PF02991	0.293
LIG_LIR_Gen_1	175	184	PF02991	0.293
LIG_LIR_Nem_3	130	134	PF02991	0.355
LIG_LIR_Nem_3	175	179	PF02991	0.293
LIG_PTB_Apo_2	241	248	PF02174	0.250
LIG_PTB_Phospho_1	241	247	PF10480	0.250
LIG_SH2_CRK	116	120	PF00017	0.250
LIG_SH2_CRK	258	262	PF00017	0.250
LIG_SH2_NCK_1	66	70	PF00017	0.515
LIG_SH2_STAT5	116	119	PF00017	0.331
LIG_SH2_STAT5	216	219	PF00017	0.470
LIG_SH2_STAT5	66	69	PF00017	0.604
LIG_SH3_3	131	137	PF00018	0.382
LIG_SH3_3	160	166	PF00018	0.250
LIG_SH3_3	242	248	PF00018	0.318
LIG_SUMO_SIM_par_1	185	192	PF11976	0.296
LIG_SUMO_SIM_par_1	236	241	PF11976	0.250
LIG_SUMO_SIM_par_1	265	272	PF11976	0.328
LIG_TYR_ITIM	256	261	PF00017	0.250
LIG_UBA3_1	189	194	PF00899	0.318
LIG_WRC_WIRS_1	128	133	PF05994	0.293
LIG_WRC_WIRS_1	173	178	PF05994	0.293
MOD_CDK_SPxxK_3	102	109	PF00069	0.500
MOD_CDK_SPxxK_3	133	140	PF00069	0.270
MOD_CK1_1	34	40	PF00069	0.663
MOD_CK1_1	82	88	PF00069	0.607
MOD_CK1_1	93	99	PF00069	0.593
MOD_GlcNHglycan	15	18	PF01048	0.435
MOD_GlcNHglycan	211	214	PF01048	0.249
MOD_GlcNHglycan	33	36	PF01048	0.481
MOD_GlcNHglycan	92	95	PF01048	0.451
MOD_GSK3_1	197	204	PF00069	0.382
MOD_GSK3_1	9	16	PF00069	0.637
MOD_GSK3_1	92	99	PF00069	0.588
MOD_N-GLC_1	90	95	PF02516	0.403
MOD_NEK2_1	156	161	PF00069	0.268
MOD_NEK2_1	172	177	PF00069	0.366
MOD_NEK2_1	189	194	PF00069	0.232
MOD_NEK2_1	197	202	PF00069	0.258
MOD_NEK2_1	251	256	PF00069	0.288
MOD_NEK2_1	90	95	PF00069	0.571
MOD_PIKK_1	269	275	PF00454	0.250
MOD_PIKK_1	82	88	PF00454	0.702
MOD_PIKK_1	96	102	PF00454	0.656
MOD_PKA_2	219	225	PF00069	0.414
MOD_PKA_2	23	29	PF00069	0.670
MOD_PKA_2	79	85	PF00069	0.696
MOD_Plk_4	114	120	PF00069	0.312
MOD_Plk_4	127	133	PF00069	0.189
MOD_Plk_4	197	203	PF00069	0.382
MOD_Plk_4	219	225	PF00069	0.437
MOD_Plk_4	251	257	PF00069	0.230
MOD_Plk_4	58	64	PF00069	0.592
MOD_ProDKin_1	102	108	PF00069	0.515
MOD_ProDKin_1	133	139	PF00069	0.268
MOD_ProDKin_1	85	91	PF00069	0.604
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.250
TRG_ENDOCYTIC_2	116	119	PF00928	0.279
TRG_ENDOCYTIC_2	258	261	PF00928	0.250

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P543	Leptomonas seymouri	77%	98%
A0A1X0NWZ2	Trypanosomatidae	74%	99%
A0A422NQ32	Trypanosoma rangeli	71%	100%
A4HDH6	Leishmania braziliensis	88%	100%
A4I0V7	Leishmania infantum	100%	100%
D0A788	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AWW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O25578	Helicobacter pylori (strain ATCC 700392 / 26695)	27%	100%
P0DA10	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	26%	100%
P0DA11	Streptococcus pyogenes serotype M3 (strain SSI-1)	26%	100%
P55061	Homo sapiens	29%	100%
P55062	Rattus norvegicus	27%	100%
Q0V882	Bos taurus	29%	100%
Q4QAL3	Leishmania major	96%	100%
Q5R7R1	Pongo abelii	30%	100%
Q5XDQ1	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	26%	100%
Q66RM2	Sus scrofa	29%	100%
Q8P2D4	Streptococcus pyogenes serotype M18 (strain MGAS8232)	26%	100%
Q9A1B9	Streptococcus pyogenes serotype M1	26%	100%
Q9D2C7	Mus musculus	29%	100%
Q9IA79	Paralichthys olivaceus	29%	100%
Q9LD45	Arabidopsis thaliana	34%	100%
Q9MBD8	Oryza sativa subsp. japonica	30%	100%
Q9PIQ8	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	24%	100%
Q9VSH3	Drosophila melanogaster	27%	100%
Q9ZE15	Rickettsia prowazekii (strain Madrid E)	26%	100%
Q9ZKT1	Helicobacter pylori (strain J99 / ATCC 700824)	27%	100%
V5BAK0	Trypanosoma cruzi	72%	100%