RNA-binding_protein_putative/GeneDB:LmjF.32.2810

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IG48_LEIDO

TriTrypDb:

LdBPK_322950.1 , LdCL_320035500 , LDHU3_32.3730

Length:

448

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA-binding

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote: 94

Expansion

Sequence features

A0A3Q8IG48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG48

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.476
CLV_NRD_NRD_1	24	26	PF00675	0.490
CLV_NRD_NRD_1	294	296	PF00675	0.379
CLV_NRD_NRD_1	326	328	PF00675	0.528
CLV_NRD_NRD_1	400	402	PF00675	0.380
CLV_NRD_NRD_1	56	58	PF00675	0.655
CLV_NRD_NRD_1	61	63	PF00675	0.631
CLV_NRD_NRD_1	7	9	PF00675	0.547
CLV_PCSK_KEX2_1	140	142	PF00082	0.232
CLV_PCSK_KEX2_1	202	204	PF00082	0.470
CLV_PCSK_KEX2_1	250	252	PF00082	0.513
CLV_PCSK_KEX2_1	326	328	PF00082	0.528
CLV_PCSK_KEX2_1	400	402	PF00082	0.382
CLV_PCSK_KEX2_1	424	426	PF00082	0.439
CLV_PCSK_KEX2_1	63	65	PF00082	0.627
CLV_PCSK_KEX2_1	7	9	PF00082	0.546
CLV_PCSK_KEX2_1	82	84	PF00082	0.540
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.304
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.470
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.513
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.504
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.614
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.564
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.467
CLV_PCSK_SKI1_1	140	144	PF00082	0.241
CLV_PCSK_SKI1_1	326	330	PF00082	0.373
CLV_PCSK_SKI1_1	356	360	PF00082	0.228
CLV_PCSK_SKI1_1	40	44	PF00082	0.567
CLV_PCSK_SKI1_1	421	425	PF00082	0.509
CLV_PCSK_SKI1_1	8	12	PF00082	0.600
DOC_CYCLIN_RxL_1	114	125	PF00134	0.428
DOC_MAPK_gen_1	223	232	PF00069	0.527
DOC_MAPK_gen_1	400	406	PF00069	0.336
DOC_PP2B_LxvP_1	269	272	PF13499	0.400
DOC_SPAK_OSR1_1	226	230	PF12202	0.292
DOC_USP7_MATH_1	10	14	PF00917	0.519
DOC_USP7_MATH_1	365	369	PF00917	0.438
DOC_USP7_MATH_1	407	411	PF00917	0.292
DOC_USP7_MATH_1	439	443	PF00917	0.588
DOC_USP7_MATH_1	444	448	PF00917	0.716
DOC_USP7_UBL2_3	249	253	PF12436	0.530
DOC_USP7_UBL2_3	3	7	PF12436	0.649
DOC_USP7_UBL2_3	31	35	PF12436	0.509
DOC_USP7_UBL2_3	36	40	PF12436	0.529
DOC_USP7_UBL2_3	55	59	PF12436	0.481
DOC_WW_Pin1_4	8	13	PF00397	0.504
LIG_14-3-3_CanoR_1	148	154	PF00244	0.464
LIG_14-3-3_CanoR_1	226	230	PF00244	0.300
LIG_14-3-3_CanoR_1	310	314	PF00244	0.409
LIG_14-3-3_CanoR_1	318	325	PF00244	0.427
LIG_14-3-3_CanoR_1	401	407	PF00244	0.349
LIG_Actin_WH2_2	410	426	PF00022	0.562
LIG_AP2alpha_2	217	219	PF02296	0.391
LIG_BIR_II_1	1	5	PF00653	0.588
LIG_BRCT_BRCA1_1	301	305	PF00533	0.405
LIG_CaM_IQ_9	411	427	PF13499	0.375
LIG_FHA_1	154	160	PF00498	0.456
LIG_FHA_1	191	197	PF00498	0.496
LIG_FHA_1	362	368	PF00498	0.525
LIG_FHA_2	121	127	PF00498	0.440
LIG_FHA_2	219	225	PF00498	0.435
LIG_FHA_2	317	323	PF00498	0.429
LIG_FHA_2	342	348	PF00498	0.562
LIG_FHA_2	51	57	PF00498	0.700
LIG_LIR_Gen_1	134	144	PF02991	0.475
LIG_LIR_Gen_1	217	227	PF02991	0.375
LIG_LIR_LC3C_4	267	271	PF02991	0.326
LIG_LIR_Nem_3	134	139	PF02991	0.431
LIG_LIR_Nem_3	224	230	PF02991	0.401
LIG_LIR_Nem_3	347	352	PF02991	0.425
LIG_LIR_Nem_3	368	374	PF02991	0.430
LIG_MLH1_MIPbox_1	301	305	PF16413	0.525
LIG_NRP_CendR_1	445	448	PF00754	0.539
LIG_Pex14_2	132	136	PF04695	0.429
LIG_PTB_Apo_2	298	305	PF02174	0.522
LIG_PTB_Phospho_1	298	304	PF10480	0.515
LIG_SH2_CRK	352	356	PF00017	0.439
LIG_SH2_STAT3	173	176	PF00017	0.524
LIG_SH2_STAT3	263	266	PF00017	0.404
LIG_SH2_STAT5	131	134	PF00017	0.525
LIG_SH2_STAT5	263	266	PF00017	0.387
LIG_SH2_STAT5	284	287	PF00017	0.381
LIG_SH2_STAT5	304	307	PF00017	0.197
LIG_SH2_STAT5	336	339	PF00017	0.491
LIG_SH2_STAT5	47	50	PF00017	0.607
LIG_SH3_3	212	218	PF00018	0.575
LIG_SH3_4	36	43	PF00018	0.567
LIG_TRAF2_1	123	126	PF00917	0.454
LIG_WRC_WIRS_1	403	408	PF05994	0.337
MOD_CK1_1	38	44	PF00069	0.548
MOD_CK1_1	438	444	PF00069	0.630
MOD_CK2_1	120	126	PF00069	0.273
MOD_CK2_1	316	322	PF00069	0.408
MOD_GlcNHglycan	136	139	PF01048	0.446
MOD_GlcNHglycan	153	156	PF01048	0.312
MOD_GlcNHglycan	162	165	PF01048	0.365
MOD_GlcNHglycan	180	184	PF01048	0.350
MOD_GlcNHglycan	242	245	PF01048	0.492
MOD_GlcNHglycan	273	276	PF01048	0.530
MOD_GlcNHglycan	411	414	PF01048	0.448
MOD_GlcNHglycan	437	440	PF01048	0.609
MOD_GlcNHglycan	66	69	PF01048	0.731
MOD_GSK3_1	127	134	PF00069	0.402
MOD_GSK3_1	147	154	PF00069	0.169
MOD_GSK3_1	190	197	PF00069	0.468
MOD_GSK3_1	218	225	PF00069	0.399
MOD_GSK3_1	231	238	PF00069	0.423
MOD_GSK3_1	361	368	PF00069	0.287
MOD_GSK3_1	435	442	PF00069	0.632
MOD_NEK2_1	153	158	PF00069	0.278
MOD_NEK2_1	222	227	PF00069	0.419
MOD_NEK2_1	299	304	PF00069	0.394
MOD_NEK2_1	361	366	PF00069	0.407
MOD_NEK2_1	402	407	PF00069	0.348
MOD_NEK2_2	2	7	PF00069	0.620
MOD_NEK2_2	218	223	PF00069	0.382
MOD_NEK2_2	382	387	PF00069	0.363
MOD_NEK2_2	50	55	PF00069	0.631
MOD_PIKK_1	109	115	PF00454	0.424
MOD_PIKK_1	235	241	PF00454	0.498
MOD_PKA_1	249	255	PF00069	0.538
MOD_PKA_1	35	41	PF00069	0.620
MOD_PKA_1	58	64	PF00069	0.658
MOD_PKA_2	147	153	PF00069	0.334
MOD_PKA_2	222	228	PF00069	0.386
MOD_PKA_2	309	315	PF00069	0.419
MOD_PKA_2	435	441	PF00069	0.523
MOD_PKB_1	62	70	PF00069	0.735
MOD_Plk_1	179	185	PF00069	0.570
MOD_Plk_1	75	81	PF00069	0.704
MOD_Plk_2-3	91	97	PF00069	0.571
MOD_Plk_4	127	133	PF00069	0.408
MOD_Plk_4	209	215	PF00069	0.616
MOD_Plk_4	391	397	PF00069	0.398
MOD_ProDKin_1	8	14	PF00069	0.499
MOD_SUMO_rev_2	182	191	PF00179	0.606
TRG_DiLeu_BaEn_2	110	116	PF01217	0.438
TRG_ENDOCYTIC_2	284	287	PF00928	0.381
TRG_ENDOCYTIC_2	352	355	PF00928	0.286
TRG_ENDOCYTIC_2	371	374	PF00928	0.174
TRG_ER_diArg_1	145	148	PF00400	0.296
TRG_ER_diArg_1	325	327	PF00400	0.510
TRG_ER_diArg_1	400	402	PF00400	0.365
TRG_ER_diArg_1	425	428	PF00400	0.442
TRG_ER_diLys_1	445	448	PF00400	0.639
TRG_NLS_Bipartite_1	7	21	PF00514	0.495
TRG_NLS_MonoCore_2	15	20	PF00514	0.487
TRG_NLS_MonoCore_2	246	251	PF00514	0.523
TRG_NLS_MonoExtC_3	246	251	PF00514	0.506
TRG_NLS_MonoExtC_3	61	66	PF00514	0.603
TRG_NLS_MonoExtN_4	16	21	PF00514	0.484
TRG_NLS_MonoExtN_4	247	254	PF00514	0.511
TRG_NLS_MonoExtN_4	31	38	PF00514	0.553
TRG_NLS_MonoExtN_4	421	428	PF00514	0.492
TRG_NLS_MonoExtN_4	59	66	PF00514	0.631
TRG_Pf-PMV_PEXEL_1	326	331	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	430	434	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M4	Leptomonas seymouri	84%	100%
A0A0S4IWT2	Bodo saltans	57%	100%
A0A1X0NSA9	Trypanosomatidae	65%	100%
A0A3R7N0S8	Trypanosoma rangeli	64%	100%
A4HKS2	Leishmania braziliensis	89%	100%
A4I8A2	Leishmania infantum	100%	100%
D0AAH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9B360	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O74400	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	66%
Q4Q4Z4	Leishmania major	96%	100%
V5BDC2	Trypanosoma cruzi	65%	92%