Kinetoplast polyadenylation/uridylation factor 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IG45_LEIDO

TriTrypDb:

LdBPK_321200.1 , LdCL_320017700 , LDHU3_32.1550

Length:

684

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3Q8IG45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG45

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006378	mRNA polyadenylation	7	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009894	regulation of catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043022	ribosome binding	4	1
GO:0044877	protein-containing complex binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	346	350	PF00656	0.723
CLV_C14_Caspase3-7	352	356	PF00656	0.714
CLV_C14_Caspase3-7	452	456	PF00656	0.743
CLV_C14_Caspase3-7	543	547	PF00656	0.509
CLV_C14_Caspase3-7	636	640	PF00656	0.388
CLV_C14_Caspase3-7	76	80	PF00656	0.734
CLV_NRD_NRD_1	100	102	PF00675	0.583
CLV_NRD_NRD_1	167	169	PF00675	0.697
CLV_NRD_NRD_1	183	185	PF00675	0.409
CLV_NRD_NRD_1	268	270	PF00675	0.445

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGR3	Leptomonas seymouri	48%	91%
A0A1X0NVZ4	Trypanosomatidae	30%	100%
A0A3R7NTQ6	Trypanosoma rangeli	31%	100%
A4HKA1	Leishmania braziliensis	68%	100%
A4I7T1	Leishmania infantum	99%	100%
D0A9Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B2N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q5G8	Leishmania major	88%	100%
V5BQR4	Trypanosoma cruzi	30%	100%

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