LeishMANIAdb
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Kinetoplast polyadenylation/uridylation factor 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Kinetoplast polyadenylation/uridylation factor 2, putative
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IG45_LEIDO
TriTrypDb:
LdBPK_321200.1 * , LdCL_320017700 , LDHU3_32.1550
Length:
684

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3Q8IG45
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG45

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006378 mRNA polyadenylation 7 1
GO:0006396 RNA processing 6 1
GO:0006397 mRNA processing 7 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009894 regulation of catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0016070 RNA metabolic process 5 1
GO:0016071 mRNA metabolic process 6 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031123 RNA 3'-end processing 7 1
GO:0031124 mRNA 3'-end processing 8 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031329 regulation of cellular catabolic process 5 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043487 regulation of RNA stability 3 1
GO:0043488 regulation of mRNA stability 4 1
GO:0043631 RNA polyadenylation 6 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0061013 regulation of mRNA catabolic process 6 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1903311 regulation of mRNA metabolic process 6 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0043021 ribonucleoprotein complex binding 3 1
GO:0043022 ribosome binding 4 1
GO:0044877 protein-containing complex binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 346 350 PF00656 0.723
CLV_C14_Caspase3-7 352 356 PF00656 0.714
CLV_C14_Caspase3-7 452 456 PF00656 0.743
CLV_C14_Caspase3-7 543 547 PF00656 0.509
CLV_C14_Caspase3-7 636 640 PF00656 0.388
CLV_C14_Caspase3-7 76 80 PF00656 0.734
CLV_NRD_NRD_1 100 102 PF00675 0.583
CLV_NRD_NRD_1 167 169 PF00675 0.697
CLV_NRD_NRD_1 183 185 PF00675 0.409
CLV_NRD_NRD_1 268 270 PF00675 0.445
CLV_NRD_NRD_1 312 314 PF00675 0.504
CLV_NRD_NRD_1 322 324 PF00675 0.464
CLV_NRD_NRD_1 381 383 PF00675 0.397
CLV_PCSK_KEX2_1 100 102 PF00082 0.721
CLV_PCSK_KEX2_1 167 169 PF00082 0.675
CLV_PCSK_KEX2_1 268 270 PF00082 0.532
CLV_PCSK_KEX2_1 322 324 PF00082 0.514
CLV_PCSK_KEX2_1 381 383 PF00082 0.397
CLV_PCSK_SKI1_1 139 143 PF00082 0.557
CLV_PCSK_SKI1_1 184 188 PF00082 0.487
CLV_PCSK_SKI1_1 227 231 PF00082 0.389
CLV_PCSK_SKI1_1 296 300 PF00082 0.606
CLV_Separin_Metazoa 651 655 PF03568 0.246
DEG_APCC_DBOX_1 106 114 PF00400 0.505
DEG_APCC_DBOX_1 183 191 PF00400 0.458
DEG_Nend_UBRbox_2 1 3 PF02207 0.540
DEG_SPOP_SBC_1 461 465 PF00917 0.628
DOC_ANK_TNKS_1 321 328 PF00023 0.581
DOC_CYCLIN_RxL_1 221 232 PF00134 0.328
DOC_MAPK_gen_1 322 330 PF00069 0.518
DOC_MAPK_gen_1 391 401 PF00069 0.444
DOC_USP7_MATH_1 161 165 PF00917 0.705
DOC_USP7_MATH_1 170 174 PF00917 0.606
DOC_USP7_MATH_1 35 39 PF00917 0.655
DOC_USP7_MATH_1 383 387 PF00917 0.590
DOC_USP7_MATH_1 41 45 PF00917 0.601
DOC_USP7_MATH_1 550 554 PF00917 0.664
DOC_USP7_MATH_1 632 636 PF00917 0.554
DOC_USP7_MATH_1 638 642 PF00917 0.407
DOC_USP7_MATH_1 66 70 PF00917 0.664
DOC_WW_Pin1_4 350 355 PF00397 0.593
DOC_WW_Pin1_4 414 419 PF00397 0.439
DOC_WW_Pin1_4 78 83 PF00397 0.621
LIG_14-3-3_CanoR_1 107 111 PF00244 0.553
LIG_14-3-3_CanoR_1 204 209 PF00244 0.611
LIG_14-3-3_CanoR_1 240 245 PF00244 0.476
LIG_14-3-3_CanoR_1 269 278 PF00244 0.545
LIG_14-3-3_CanoR_1 322 330 PF00244 0.453
LIG_14-3-3_CanoR_1 382 392 PF00244 0.531
LIG_14-3-3_CanoR_1 511 519 PF00244 0.487
LIG_14-3-3_CanoR_1 540 548 PF00244 0.589
LIG_14-3-3_CanoR_1 569 574 PF00244 0.490
LIG_14-3-3_CanoR_1 63 71 PF00244 0.675
LIG_14-3-3_CanoR_1 8 14 PF00244 0.703
LIG_14-3-3_CterR_2 681 684 PF00244 0.532
LIG_Actin_WH2_2 641 656 PF00022 0.247
LIG_APCC_ABBA_1 646 651 PF00400 0.379
LIG_BIR_III_2 79 83 PF00653 0.607
LIG_BRCT_BRCA1_1 176 180 PF00533 0.424
LIG_BRCT_BRCA1_1 55 59 PF00533 0.701
LIG_BRCT_BRCA1_1 640 644 PF00533 0.379
LIG_deltaCOP1_diTrp_1 120 130 PF00928 0.445
LIG_EVH1_2 95 99 PF00568 0.539
LIG_FHA_1 129 135 PF00498 0.436
LIG_FHA_1 230 236 PF00498 0.326
LIG_FHA_1 246 252 PF00498 0.264
LIG_FHA_1 272 278 PF00498 0.549
LIG_FHA_1 387 393 PF00498 0.397
LIG_FHA_1 429 435 PF00498 0.463
LIG_FHA_1 497 503 PF00498 0.381
LIG_FHA_1 519 525 PF00498 0.374
LIG_FHA_1 576 582 PF00498 0.343
LIG_FHA_1 608 614 PF00498 0.371
LIG_FHA_1 661 667 PF00498 0.445
LIG_FHA_2 344 350 PF00498 0.745
LIG_FHA_2 362 368 PF00498 0.431
LIG_FHA_2 424 430 PF00498 0.494
LIG_FHA_2 450 456 PF00498 0.794
LIG_FHA_2 462 468 PF00498 0.537
LIG_FHA_2 471 477 PF00498 0.428
LIG_FHA_2 531 537 PF00498 0.531
LIG_LIR_Apic_2 417 423 PF02991 0.324
LIG_LIR_Gen_1 177 188 PF02991 0.451
LIG_LIR_Gen_1 2 9 PF02991 0.582
LIG_LIR_Gen_1 239 250 PF02991 0.365
LIG_LIR_Gen_1 407 415 PF02991 0.462
LIG_LIR_Gen_1 501 510 PF02991 0.332
LIG_LIR_Gen_1 514 524 PF02991 0.330
LIG_LIR_Gen_1 578 586 PF02991 0.325
LIG_LIR_Nem_3 177 183 PF02991 0.443
LIG_LIR_Nem_3 2 6 PF02991 0.649
LIG_LIR_Nem_3 248 253 PF02991 0.403
LIG_LIR_Nem_3 375 379 PF02991 0.398
LIG_LIR_Nem_3 407 411 PF02991 0.411
LIG_LIR_Nem_3 473 478 PF02991 0.537
LIG_LIR_Nem_3 501 506 PF02991 0.406
LIG_LIR_Nem_3 514 519 PF02991 0.298
LIG_LIR_Nem_3 578 582 PF02991 0.336
LIG_LIR_Nem_3 593 599 PF02991 0.300
LIG_NRBOX 505 511 PF00104 0.453
LIG_RPA_C_Fungi 317 329 PF08784 0.518
LIG_SH2_CRK 408 412 PF00017 0.402
LIG_SH2_PTP2 420 423 PF00017 0.454
LIG_SH2_STAP1 408 412 PF00017 0.402
LIG_SH2_STAP1 579 583 PF00017 0.334
LIG_SH2_STAP1 599 603 PF00017 0.211
LIG_SH2_STAP1 614 618 PF00017 0.384
LIG_SH2_STAP1 649 653 PF00017 0.241
LIG_SH2_STAT3 108 111 PF00017 0.517
LIG_SH2_STAT3 588 591 PF00017 0.491
LIG_SH2_STAT5 223 226 PF00017 0.334
LIG_SH2_STAT5 420 423 PF00017 0.456
LIG_SH2_STAT5 508 511 PF00017 0.462
LIG_SH2_STAT5 588 591 PF00017 0.442
LIG_SH3_3 138 144 PF00018 0.502
LIG_SH3_3 189 195 PF00018 0.551
LIG_SH3_3 281 287 PF00018 0.570
LIG_SUMO_SIM_anti_2 615 620 PF11976 0.426
LIG_SUMO_SIM_par_1 615 620 PF11976 0.426
LIG_TRAF2_1 426 429 PF00917 0.560
LIG_TRAF2_2 192 197 PF00917 0.550
LIG_TYR_ITIM 406 411 PF00017 0.411
LIG_UBA3_1 298 304 PF00899 0.519
LIG_UBA3_1 395 403 PF00899 0.492
LIG_UBA3_1 506 513 PF00899 0.410
LIG_WRC_WIRS_1 659 664 PF05994 0.516
LIG_WW_3 190 194 PF00397 0.529
LIG_WW_3 94 98 PF00397 0.545
MOD_CK1_1 271 277 PF00069 0.550
MOD_CK1_1 289 295 PF00069 0.614
MOD_CK1_1 386 392 PF00069 0.420
MOD_CK1_1 459 465 PF00069 0.726
MOD_CK1_1 559 565 PF00069 0.619
MOD_CK1_1 69 75 PF00069 0.749
MOD_CK2_1 361 367 PF00069 0.568
MOD_CK2_1 423 429 PF00069 0.579
MOD_CK2_1 470 476 PF00069 0.463
MOD_CK2_1 530 536 PF00069 0.472
MOD_CMANNOS 570 573 PF00535 0.454
MOD_GlcNHglycan 131 134 PF01048 0.402
MOD_GlcNHglycan 154 157 PF01048 0.664
MOD_GlcNHglycan 345 349 PF01048 0.813
MOD_GlcNHglycan 37 40 PF01048 0.665
MOD_GlcNHglycan 43 46 PF01048 0.647
MOD_GlcNHglycan 458 461 PF01048 0.647
MOD_GlcNHglycan 467 471 PF01048 0.476
MOD_GlcNHglycan 47 50 PF01048 0.637
MOD_GlcNHglycan 552 555 PF01048 0.623
MOD_GlcNHglycan 561 564 PF01048 0.523
MOD_GlcNHglycan 68 71 PF01048 0.681
MOD_GSK3_1 170 177 PF00069 0.619
MOD_GSK3_1 200 207 PF00069 0.525
MOD_GSK3_1 267 274 PF00069 0.527
MOD_GSK3_1 286 293 PF00069 0.568
MOD_GSK3_1 382 389 PF00069 0.390
MOD_GSK3_1 41 48 PF00069 0.639
MOD_GSK3_1 456 463 PF00069 0.781
MOD_GSK3_1 466 473 PF00069 0.572
MOD_GSK3_1 658 665 PF00069 0.419
MOD_GSK3_1 66 73 PF00069 0.702
MOD_GSK3_1 670 677 PF00069 0.419
MOD_N-GLC_1 101 106 PF02516 0.634
MOD_N-GLC_1 171 176 PF02516 0.585
MOD_NEK2_1 129 134 PF00069 0.374
MOD_NEK2_1 215 220 PF00069 0.409
MOD_NEK2_1 229 234 PF00069 0.311
MOD_NEK2_1 245 250 PF00069 0.462
MOD_NEK2_1 267 272 PF00069 0.539
MOD_NEK2_1 288 293 PF00069 0.527
MOD_NEK2_1 468 473 PF00069 0.505
MOD_NEK2_1 602 607 PF00069 0.446
MOD_NEK2_1 662 667 PF00069 0.496
MOD_NEK2_2 449 454 PF00069 0.542
MOD_PIKK_1 21 27 PF00454 0.720
MOD_PIKK_1 70 76 PF00454 0.698
MOD_PK_1 204 210 PF00069 0.499
MOD_PK_1 240 246 PF00069 0.442
MOD_PKA_1 268 274 PF00069 0.479
MOD_PKA_2 106 112 PF00069 0.573
MOD_PKA_2 197 203 PF00069 0.635
MOD_PKA_2 215 221 PF00069 0.312
MOD_PKA_2 267 273 PF00069 0.471
MOD_PKA_2 321 327 PF00069 0.519
MOD_PKA_2 343 349 PF00069 0.651
MOD_PKA_2 383 389 PF00069 0.511
MOD_PKA_2 539 545 PF00069 0.559
MOD_PKA_2 559 565 PF00069 0.631
MOD_PKA_2 568 574 PF00069 0.498
MOD_PKA_2 607 613 PF00069 0.366
MOD_PKA_2 7 13 PF00069 0.704
MOD_PKB_1 674 682 PF00069 0.480
MOD_Plk_1 256 262 PF00069 0.473
MOD_Plk_4 407 413 PF00069 0.456
MOD_Plk_4 518 524 PF00069 0.507
MOD_Plk_4 561 567 PF00069 0.473
MOD_Plk_4 640 646 PF00069 0.532
MOD_ProDKin_1 350 356 PF00069 0.592
MOD_ProDKin_1 414 420 PF00069 0.438
MOD_ProDKin_1 78 84 PF00069 0.616
TRG_DiLeu_BaEn_1 505 510 PF01217 0.446
TRG_ENDOCYTIC_2 222 225 PF00928 0.337
TRG_ENDOCYTIC_2 408 411 PF00928 0.404
TRG_ENDOCYTIC_2 579 582 PF00928 0.335
TRG_ENDOCYTIC_2 599 602 PF00928 0.203
TRG_ENDOCYTIC_2 614 617 PF00928 0.314
TRG_ENDOCYTIC_2 649 652 PF00928 0.371
TRG_ER_diArg_1 166 168 PF00400 0.681
TRG_ER_diArg_1 267 269 PF00400 0.523
TRG_ER_diArg_1 380 382 PF00400 0.393
TRG_ER_diArg_1 585 588 PF00400 0.469
TRG_ER_diArg_1 99 101 PF00400 0.608
TRG_NES_CRM1_1 390 404 PF08389 0.442
TRG_Pf-PMV_PEXEL_1 227 231 PF00026 0.469
TRG_Pf-PMV_PEXEL_1 286 290 PF00026 0.681

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PGR3 Leptomonas seymouri 48% 91%
A0A1X0NVZ4 Trypanosomatidae 30% 100%
A0A3R7NTQ6 Trypanosoma rangeli 31% 100%
A4HKA1 Leishmania braziliensis 68% 100%
A4I7T1 Leishmania infantum 99% 100%
D0A9Z2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9B2N9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4Q5G8 Leishmania major 88% 100%
V5BQR4 Trypanosoma cruzi 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS