Cytochrome b5-like Heme/Steroid binding domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IG43_LEIDO

TriTrypDb:

LdBPK_311220.1 , LdCL_310018900 , LDHU3_31.1990

Length:

134

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A0A3Q8IG43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG43

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0020037	heme binding	4	2
GO:0046906	tetrapyrrole binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.343
CLV_NRD_NRD_1	128	130	PF00675	0.625
CLV_NRD_NRD_1	95	97	PF00675	0.418
CLV_PCSK_KEX2_1	102	104	PF00082	0.391
CLV_PCSK_KEX2_1	128	130	PF00082	0.567
CLV_PCSK_KEX2_1	95	97	PF00082	0.454
DEG_APCC_DBOX_1	106	114	PF00400	0.590
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.508
DOC_MAPK_gen_1	105	113	PF00069	0.484
DOC_MAPK_MEF2A_6	13	21	PF00069	0.561
DOC_PP2B_LxvP_1	17	20	PF13499	0.498
LIG_14-3-3_CanoR_1	105	111	PF00244	0.452
LIG_14-3-3_CanoR_1	95	104	PF00244	0.685
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_eIF4E_1	12	18	PF01652	0.515
LIG_FHA_1	106	112	PF00498	0.446
LIG_FHA_1	13	19	PF00498	0.501
LIG_FHA_1	96	102	PF00498	0.547
LIG_FHA_2	60	66	PF00498	0.573
LIG_LIR_Gen_1	5	12	PF02991	0.530
LIG_LIR_Gen_1	62	68	PF02991	0.565
LIG_LIR_LC3C_4	15	19	PF02991	0.478
LIG_LIR_Nem_3	5	10	PF02991	0.532
LIG_LIR_Nem_3	62	66	PF02991	0.549
LIG_LIR_Nem_3	70	75	PF02991	0.590
LIG_SH2_GRB2like	38	41	PF00017	0.486
LIG_SH2_NCK_1	76	80	PF00017	0.522
LIG_SH2_PTP2	7	10	PF00017	0.524
LIG_SH2_STAT3	34	37	PF00017	0.486
LIG_SH2_STAT3	38	41	PF00017	0.486
LIG_SH2_STAT5	34	37	PF00017	0.495
LIG_SH2_STAT5	7	10	PF00017	0.543
LIG_SUMO_SIM_anti_2	108	116	PF11976	0.225
LIG_SUMO_SIM_par_1	108	116	PF11976	0.225
LIG_TRAF2_1	62	65	PF00917	0.550
LIG_WRC_WIRS_1	60	65	PF05994	0.573
MOD_CK2_1	59	65	PF00069	0.524
MOD_CK2_1	87	93	PF00069	0.591
MOD_GlcNHglycan	44	47	PF01048	0.279
MOD_GSK3_1	105	112	PF00069	0.504
MOD_N-GLC_1	50	55	PF02516	0.326
MOD_PKA_1	95	101	PF00069	0.612
MOD_PKA_2	106	112	PF00069	0.503
MOD_PKA_2	95	101	PF00069	0.705
MOD_PKB_1	103	111	PF00069	0.587
MOD_Plk_4	106	112	PF00069	0.481
MOD_Plk_4	13	19	PF00069	0.511
MOD_Plk_4	3	9	PF00069	0.620
TRG_ENDOCYTIC_2	7	10	PF00928	0.524
TRG_ER_diArg_1	101	103	PF00400	0.623
TRG_ER_diArg_1	104	107	PF00400	0.636
TRG_ER_diArg_1	127	129	PF00400	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3U0	Leptomonas seymouri	57%	100%
A0A0N1IH82	Leptomonas seymouri	38%	100%
A0A3Q8ICI2	Leishmania donovani	34%	90%
A0A3S7WPP2	Leishmania donovani	28%	100%
A4HJ98	Leishmania braziliensis	32%	93%
A4HJA1	Leishmania braziliensis	81%	99%
A4HT20	Leishmania infantum	28%	100%
A4I6P3	Leishmania infantum	34%	90%
A4I6P6	Leishmania infantum	98%	100%
E9AL09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	94%
E9B1R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q6E3	Leishmania major	94%	100%
Q4Q6E6	Leishmania major	33%	91%