Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IG37_LEIDO

TriTrypDb:

LdBPK_262570.1 , LdCL_260031600 , LDHU3_26.3320

Length:

695

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IG37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.427
CLV_C14_Caspase3-7	458	462	PF00656	0.565
CLV_NRD_NRD_1	102	104	PF00675	0.583
CLV_NRD_NRD_1	13	15	PF00675	0.625
CLV_NRD_NRD_1	137	139	PF00675	0.454
CLV_NRD_NRD_1	439	441	PF00675	0.480
CLV_NRD_NRD_1	682	684	PF00675	0.622
CLV_PCSK_KEX2_1	102	104	PF00082	0.583
CLV_PCSK_KEX2_1	13	15	PF00082	0.586
CLV_PCSK_KEX2_1	682	684	PF00082	0.640
CLV_PCSK_PC7_1	678	684	PF00082	0.680
CLV_PCSK_SKI1_1	175	179	PF00082	0.561
CLV_PCSK_SKI1_1	519	523	PF00082	0.521
CLV_PCSK_SKI1_1	540	544	PF00082	0.395
CLV_PCSK_SKI1_1	552	556	PF00082	0.579
CLV_PCSK_SKI1_1	563	567	PF00082	0.705
DEG_APCC_DBOX_1	478	486	PF00400	0.464
DEG_Nend_UBRbox_1	1	4	PF02207	0.666
DOC_MAPK_gen_1	575	584	PF00069	0.585
DOC_MAPK_gen_1	618	627	PF00069	0.603
DOC_MAPK_MEF2A_6	205	213	PF00069	0.523
DOC_MAPK_MEF2A_6	395	404	PF00069	0.494
DOC_MAPK_MEF2A_6	528	536	PF00069	0.563
DOC_PP1_RVXF_1	575	582	PF00149	0.545
DOC_PP2B_LxvP_1	317	320	PF13499	0.491
DOC_PP2B_LxvP_1	532	535	PF13499	0.457
DOC_PP2B_LxvP_1	614	617	PF13499	0.500
DOC_PP4_FxxP_1	243	246	PF00568	0.623
DOC_USP7_MATH_1	142	146	PF00917	0.671
DOC_USP7_MATH_1	201	205	PF00917	0.619
DOC_USP7_MATH_1	246	250	PF00917	0.635
DOC_USP7_MATH_1	311	315	PF00917	0.651
DOC_USP7_MATH_1	328	332	PF00917	0.478
DOC_USP7_MATH_1	339	343	PF00917	0.422
DOC_USP7_MATH_1	455	459	PF00917	0.495
DOC_USP7_MATH_1	462	466	PF00917	0.623
DOC_USP7_UBL2_3	413	417	PF12436	0.614
DOC_WW_Pin1_4	248	253	PF00397	0.569
DOC_WW_Pin1_4	41	46	PF00397	0.491
DOC_WW_Pin1_4	5	10	PF00397	0.561
DOC_WW_Pin1_4	639	644	PF00397	0.574
DOC_WW_Pin1_4	80	85	PF00397	0.676
LIG_14-3-3_CanoR_1	110	115	PF00244	0.555
LIG_14-3-3_CanoR_1	281	287	PF00244	0.459
LIG_14-3-3_CanoR_1	4	9	PF00244	0.689
LIG_14-3-3_CanoR_1	519	526	PF00244	0.601
LIG_14-3-3_CanoR_1	528	536	PF00244	0.614
LIG_14-3-3_CanoR_1	682	690	PF00244	0.649
LIG_Actin_WH2_2	535	551	PF00022	0.438
LIG_BIR_III_4	75	79	PF00653	0.521
LIG_BRCT_BRCA1_1	323	327	PF00533	0.415
LIG_BRCT_BRCA1_1	560	564	PF00533	0.521
LIG_Clathr_ClatBox_1	157	161	PF01394	0.384
LIG_deltaCOP1_diTrp_1	234	243	PF00928	0.439
LIG_FHA_1	185	191	PF00498	0.405
LIG_FHA_1	197	203	PF00498	0.592
LIG_FHA_1	228	234	PF00498	0.370
LIG_FHA_1	281	287	PF00498	0.521
LIG_FHA_1	597	603	PF00498	0.539
LIG_FHA_1	640	646	PF00498	0.550
LIG_FHA_1	66	72	PF00498	0.447
LIG_FHA_2	176	182	PF00498	0.586
LIG_FHA_2	251	257	PF00498	0.596
LIG_FHA_2	379	385	PF00498	0.334
LIG_FHA_2	45	51	PF00498	0.559
LIG_FHA_2	553	559	PF00498	0.633
LIG_FHA_2	586	592	PF00498	0.483
LIG_GBD_Chelix_1	474	482	PF00786	0.435
LIG_LIR_Apic_2	219	225	PF02991	0.566
LIG_LIR_Apic_2	241	246	PF02991	0.614
LIG_LIR_Gen_1	212	222	PF02991	0.558
LIG_LIR_Gen_1	256	265	PF02991	0.492
LIG_LIR_Gen_1	342	352	PF02991	0.460
LIG_LIR_Gen_1	578	589	PF02991	0.513
LIG_LIR_Gen_1	82	93	PF02991	0.528
LIG_LIR_Nem_3	212	217	PF02991	0.539
LIG_LIR_Nem_3	256	262	PF02991	0.534
LIG_LIR_Nem_3	30	35	PF02991	0.525
LIG_LIR_Nem_3	342	348	PF02991	0.433
LIG_LIR_Nem_3	499	505	PF02991	0.494
LIG_LIR_Nem_3	578	584	PF02991	0.573
LIG_LIR_Nem_3	82	88	PF02991	0.547
LIG_PCNA_PIPBox_1	12	21	PF02747	0.575
LIG_PCNA_yPIPBox_3	6	19	PF02747	0.610
LIG_Rb_pABgroove_1	422	430	PF01858	0.461
LIG_SH2_CRK	214	218	PF00017	0.550
LIG_SH2_CRK	222	226	PF00017	0.320
LIG_SH2_CRK	502	506	PF00017	0.508
LIG_SH2_STAP1	173	177	PF00017	0.556
LIG_SH2_STAP1	214	218	PF00017	0.470
LIG_SH2_STAP1	69	73	PF00017	0.550
LIG_SH2_STAT3	517	520	PF00017	0.561
LIG_SH2_STAT5	18	21	PF00017	0.576
LIG_SH2_STAT5	352	355	PF00017	0.441
LIG_SH2_STAT5	365	368	PF00017	0.409
LIG_SH2_STAT5	481	484	PF00017	0.530
LIG_SH2_STAT5	69	72	PF00017	0.552
LIG_SH3_3	177	183	PF00018	0.606
LIG_SH3_3	431	437	PF00018	0.493
LIG_Sin3_3	606	613	PF02671	0.467
LIG_SUMO_SIM_par_1	128	134	PF11976	0.578
LIG_SUMO_SIM_par_1	68	75	PF11976	0.515
LIG_TRAF2_1	113	116	PF00917	0.552
LIG_TRAF2_1	555	558	PF00917	0.612
LIG_UBA3_1	190	198	PF00899	0.449
LIG_WRC_WIRS_1	345	350	PF05994	0.577
MOD_CDK_SPK_2	639	644	PF00069	0.574
MOD_CDK_SPxxK_3	248	255	PF00069	0.616
MOD_CK1_1	163	169	PF00069	0.479
MOD_CK1_1	239	245	PF00069	0.474
MOD_CK1_1	473	479	PF00069	0.562
MOD_CK1_1	49	55	PF00069	0.513
MOD_CK1_1	503	509	PF00069	0.507
MOD_CK1_1	639	645	PF00069	0.479
MOD_CK2_1	110	116	PF00069	0.558
MOD_CK2_1	21	27	PF00069	0.581
MOD_CK2_1	35	41	PF00069	0.486
MOD_CK2_1	378	384	PF00069	0.409
MOD_CK2_1	44	50	PF00069	0.475
MOD_CK2_1	552	558	PF00069	0.645
MOD_CK2_1	585	591	PF00069	0.526
MOD_CK2_1	651	657	PF00069	0.459
MOD_GlcNHglycan	144	147	PF01048	0.603
MOD_GlcNHglycan	219	222	PF01048	0.440
MOD_GlcNHglycan	238	241	PF01048	0.456
MOD_GlcNHglycan	341	344	PF01048	0.466
MOD_GlcNHglycan	348	351	PF01048	0.508
MOD_GlcNHglycan	355	358	PF01048	0.467
MOD_GlcNHglycan	375	378	PF01048	0.277
MOD_GlcNHglycan	464	467	PF01048	0.643
MOD_GlcNHglycan	468	471	PF01048	0.636
MOD_GlcNHglycan	638	641	PF01048	0.479
MOD_GlcNHglycan	666	670	PF01048	0.593
MOD_GlcNHglycan	686	689	PF01048	0.524
MOD_GSK3_1	192	199	PF00069	0.431
MOD_GSK3_1	246	253	PF00069	0.527
MOD_GSK3_1	306	313	PF00069	0.559
MOD_GSK3_1	346	353	PF00069	0.526
MOD_GSK3_1	46	53	PF00069	0.417
MOD_GSK3_1	462	469	PF00069	0.624
MOD_GSK3_1	496	503	PF00069	0.458
MOD_GSK3_1	548	555	PF00069	0.579
MOD_LATS_1	681	687	PF00433	0.651
MOD_NEK2_1	160	165	PF00069	0.424
MOD_NEK2_1	19	24	PF00069	0.536
MOD_NEK2_1	217	222	PF00069	0.502
MOD_NEK2_1	306	311	PF00069	0.544
MOD_NEK2_1	344	349	PF00069	0.415
MOD_NEK2_1	404	409	PF00069	0.401
MOD_NEK2_1	427	432	PF00069	0.583
MOD_NEK2_1	504	509	PF00069	0.490
MOD_NEK2_1	51	56	PF00069	0.434
MOD_NEK2_1	543	548	PF00069	0.469
MOD_NEK2_2	350	355	PF00069	0.458
MOD_NEK2_2	365	370	PF00069	0.499
MOD_NEK2_2	481	486	PF00069	0.554
MOD_NEK2_2	512	517	PF00069	0.471
MOD_NEK2_2	585	590	PF00069	0.479
MOD_NEK2_2	689	694	PF00069	0.502
MOD_PIKK_1	378	384	PF00454	0.465
MOD_PIKK_1	404	410	PF00454	0.515
MOD_PIKK_1	504	510	PF00454	0.529
MOD_PIKK_1	519	525	PF00454	0.555
MOD_PKA_2	109	115	PF00069	0.586
MOD_PKA_2	19	25	PF00069	0.519
MOD_PKA_2	280	286	PF00069	0.465
MOD_PKA_2	487	493	PF00069	0.479
MOD_PKA_2	527	533	PF00069	0.612
MOD_PKA_2	548	554	PF00069	0.559
MOD_PKA_2	684	690	PF00069	0.731
MOD_PKB_1	2	10	PF00069	0.638
MOD_Plk_1	125	131	PF00069	0.506
MOD_Plk_1	160	166	PF00069	0.403
MOD_Plk_1	175	181	PF00069	0.489
MOD_Plk_1	306	312	PF00069	0.546
MOD_Plk_4	125	131	PF00069	0.487
MOD_Plk_4	239	245	PF00069	0.626
MOD_Plk_4	321	327	PF00069	0.405
MOD_Plk_4	443	449	PF00069	0.388
MOD_Plk_4	470	476	PF00069	0.578
MOD_Plk_4	481	487	PF00069	0.476
MOD_Plk_4	500	506	PF00069	0.232
MOD_Plk_4	51	57	PF00069	0.434
MOD_Plk_4	512	518	PF00069	0.360
MOD_Plk_4	543	549	PF00069	0.497
MOD_Plk_4	659	665	PF00069	0.607
MOD_Plk_4	689	695	PF00069	0.717
MOD_ProDKin_1	248	254	PF00069	0.564
MOD_ProDKin_1	41	47	PF00069	0.485
MOD_ProDKin_1	5	11	PF00069	0.555
MOD_ProDKin_1	639	645	PF00069	0.565
MOD_ProDKin_1	80	86	PF00069	0.671
MOD_SUMO_rev_2	384	393	PF00179	0.455
MOD_SUMO_rev_2	457	465	PF00179	0.561
TRG_AP2beta_CARGO_1	346	355	PF09066	0.561
TRG_DiLeu_BaEn_1	30	35	PF01217	0.577
TRG_DiLeu_BaEn_1	500	505	PF01217	0.507
TRG_DiLeu_BaEn_2	559	565	PF01217	0.554
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.361
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.608
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.360
TRG_DiLeu_BaLyEn_6	641	646	PF01217	0.571
TRG_ENDOCYTIC_2	214	217	PF00928	0.511
TRG_ENDOCYTIC_2	345	348	PF00928	0.550
TRG_ENDOCYTIC_2	502	505	PF00928	0.503
TRG_ER_diArg_1	102	104	PF00400	0.579
TRG_ER_diArg_1	13	15	PF00400	0.615
TRG_ER_diArg_1	263	266	PF00400	0.504
TRG_ER_diArg_1	617	620	PF00400	0.640
TRG_ER_diArg_1	682	685	PF00400	0.661
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7K6	Leptomonas seymouri	68%	89%
A0A0S4JKX7	Bodo saltans	28%	84%
A0A1X0P8M4	Trypanosomatidae	39%	92%
A0A3S5ISN2	Trypanosoma rangeli	44%	89%
A4HF99	Leishmania braziliensis	84%	100%
A4I2H6	Leishmania infantum	100%	100%
C9ZX12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	95%
E9AYN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q8T7	Leishmania major	94%	100%
V5AS65	Trypanosoma cruzi	44%	89%