Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IG29_LEIDO

TriTrypDb:

LdBPK_240820.1 , LdCL_240013200 , LDHU3_24.0950

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IG29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.639
CLV_C14_Caspase3-7	325	329	PF00656	0.687
CLV_C14_Caspase3-7	38	42	PF00656	0.591
CLV_NRD_NRD_1	104	106	PF00675	0.651
CLV_NRD_NRD_1	186	188	PF00675	0.633
CLV_NRD_NRD_1	217	219	PF00675	0.639
CLV_NRD_NRD_1	23	25	PF00675	0.687
CLV_NRD_NRD_1	26	28	PF00675	0.665
CLV_NRD_NRD_1	315	317	PF00675	0.697
CLV_NRD_NRD_1	323	325	PF00675	0.612
CLV_NRD_NRD_1	412	414	PF00675	0.629
CLV_NRD_NRD_1	56	58	PF00675	0.689
CLV_NRD_NRD_1	80	82	PF00675	0.709
CLV_PCSK_FUR_1	24	28	PF00082	0.695
CLV_PCSK_KEX2_1	104	106	PF00082	0.651
CLV_PCSK_KEX2_1	128	130	PF00082	0.673
CLV_PCSK_KEX2_1	186	188	PF00082	0.633
CLV_PCSK_KEX2_1	217	219	PF00082	0.639
CLV_PCSK_KEX2_1	23	25	PF00082	0.687
CLV_PCSK_KEX2_1	26	28	PF00082	0.665
CLV_PCSK_KEX2_1	314	316	PF00082	0.697
CLV_PCSK_KEX2_1	323	325	PF00082	0.602
CLV_PCSK_KEX2_1	412	414	PF00082	0.625
CLV_PCSK_KEX2_1	56	58	PF00082	0.689
CLV_PCSK_KEX2_1	80	82	PF00082	0.709
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.673
CLV_PCSK_PC7_1	319	325	PF00082	0.680
CLV_PCSK_SKI1_1	412	416	PF00082	0.656
DOC_ANK_TNKS_1	323	330	PF00023	0.688
DOC_ANK_TNKS_1	80	87	PF00023	0.684
DOC_CKS1_1	354	359	PF01111	0.638
DOC_CYCLIN_yClb5_NLxxxL_5	142	148	PF00134	0.616
DOC_MAPK_gen_1	104	111	PF00069	0.586
DOC_MAPK_gen_1	186	193	PF00069	0.629
DOC_MAPK_gen_1	529	536	PF00069	0.615
DOC_MAPK_gen_1	80	89	PF00069	0.604
DOC_MAPK_MEF2A_6	80	89	PF00069	0.604
DOC_MIT_MIM_1	237	247	PF04212	0.446
DOC_PP2B_LxvP_1	545	548	PF13499	0.612
DOC_PP4_FxxP_1	147	150	PF00568	0.640
DOC_USP7_MATH_1	100	104	PF00917	0.633
DOC_USP7_MATH_1	2	6	PF00917	0.632
DOC_USP7_MATH_1	261	265	PF00917	0.581
DOC_USP7_MATH_1	284	288	PF00917	0.666
DOC_USP7_MATH_1	317	321	PF00917	0.654
DOC_USP7_MATH_1	390	394	PF00917	0.619
DOC_USP7_MATH_1	397	401	PF00917	0.601
DOC_USP7_MATH_1	406	410	PF00917	0.535
DOC_USP7_MATH_1	479	483	PF00917	0.636
DOC_USP7_MATH_1	502	506	PF00917	0.653
DOC_USP7_MATH_1	524	528	PF00917	0.664
DOC_USP7_MATH_1	59	63	PF00917	0.648
DOC_WW_Pin1_4	198	203	PF00397	0.636
DOC_WW_Pin1_4	229	234	PF00397	0.595
DOC_WW_Pin1_4	353	358	PF00397	0.682
DOC_WW_Pin1_4	500	505	PF00397	0.700
DOC_WW_Pin1_4	520	525	PF00397	0.667
DOC_WW_Pin1_4	562	567	PF00397	0.646
LIG_14-3-3_CanoR_1	104	112	PF00244	0.647
LIG_14-3-3_CanoR_1	190	194	PF00244	0.673
LIG_14-3-3_CanoR_1	24	30	PF00244	0.793
LIG_14-3-3_CanoR_1	319	323	PF00244	0.645
LIG_14-3-3_CanoR_1	32	39	PF00244	0.662
LIG_14-3-3_CanoR_1	358	364	PF00244	0.723
LIG_14-3-3_CanoR_1	453	461	PF00244	0.556
LIG_14-3-3_CanoR_1	480	486	PF00244	0.663
LIG_14-3-3_CanoR_1	497	504	PF00244	0.530
LIG_14-3-3_CanoR_1	531	537	PF00244	0.685
LIG_Actin_WH2_1	243	261	PF00022	0.485
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_BIR_III_2	446	450	PF00653	0.684
LIG_BIR_III_3	1	5	PF00653	0.649
LIG_BRCT_BRCA1_1	199	203	PF00533	0.611
LIG_BRCT_BRCA1_1	454	458	PF00533	0.690
LIG_BRCT_BRCA1_1	564	568	PF00533	0.626
LIG_BRCT_BRCA1_1	9	13	PF00533	0.582
LIG_deltaCOP1_diTrp_1	340	344	PF00928	0.580
LIG_FHA_1	119	125	PF00498	0.651
LIG_FHA_1	291	297	PF00498	0.619
LIG_FHA_1	350	356	PF00498	0.565
LIG_FHA_1	433	439	PF00498	0.727
LIG_FHA_2	16	22	PF00498	0.697
LIG_FHA_2	26	32	PF00498	0.726
LIG_FHA_2	533	539	PF00498	0.686
LIG_FHA_2	582	588	PF00498	0.636
LIG_LIR_Apic_2	455	460	PF02991	0.686
LIG_LIR_Nem_3	173	177	PF02991	0.814
LIG_LIR_Nem_3	415	421	PF02991	0.671
LIG_LIR_Nem_3	455	461	PF02991	0.688
LIG_PALB2_WD40_1	453	461	PF16756	0.689
LIG_PDZ_Class_2	594	599	PF00595	0.468
LIG_SH2_NCK_1	223	227	PF00017	0.629
LIG_SH2_SRC	209	212	PF00017	0.577
LIG_SH2_SRC	223	226	PF00017	0.584
LIG_SH2_SRC	332	335	PF00017	0.632
LIG_SH2_STAP1	174	178	PF00017	0.578
LIG_SH2_STAP1	209	213	PF00017	0.575
LIG_SH2_STAT3	249	252	PF00017	0.447
LIG_SH2_STAT5	19	22	PF00017	0.671
LIG_SH2_STAT5	249	252	PF00017	0.447
LIG_SH3_3	216	222	PF00018	0.669
LIG_SH3_3	351	357	PF00018	0.629
LIG_SH3_3	446	452	PF00018	0.689
LIG_SH3_3	79	85	PF00018	0.693
LIG_TRAF2_1	47	50	PF00917	0.679
LIG_TRAF2_1	484	487	PF00917	0.547
MOD_CDK_SPK_2	353	358	PF00069	0.636
MOD_CDK_SPxxK_3	229	236	PF00069	0.588
MOD_CDK_SPxxK_3	353	360	PF00069	0.640
MOD_CK1_1	103	109	PF00069	0.641
MOD_CK1_1	201	207	PF00069	0.653
MOD_CK1_1	232	238	PF00069	0.610
MOD_CK1_1	35	41	PF00069	0.625
MOD_CK1_1	372	378	PF00069	0.618
MOD_CK1_1	422	428	PF00069	0.676
MOD_CK1_1	43	49	PF00069	0.602
MOD_CK1_1	500	506	PF00069	0.702
MOD_CK1_1	509	515	PF00069	0.632
MOD_CK1_1	527	533	PF00069	0.664
MOD_CK1_1	561	567	PF00069	0.657
MOD_CK1_1	6	12	PF00069	0.649
MOD_CK2_1	15	21	PF00069	0.642
MOD_CK2_1	25	31	PF00069	0.603
MOD_CK2_1	43	49	PF00069	0.689
MOD_CK2_1	481	487	PF00069	0.560
MOD_CMANNOS	341	344	PF00535	0.576
MOD_Cter_Amidation	21	24	PF01082	0.670
MOD_Cter_Amidation	215	218	PF01082	0.542
MOD_GlcNHglycan	105	108	PF01048	0.619
MOD_GlcNHglycan	156	159	PF01048	0.706
MOD_GlcNHglycan	205	208	PF01048	0.658
MOD_GlcNHglycan	263	266	PF01048	0.529
MOD_GlcNHglycan	302	305	PF01048	0.625
MOD_GlcNHglycan	365	368	PF01048	0.600
MOD_GlcNHglycan	381	385	PF01048	0.572
MOD_GlcNHglycan	399	402	PF01048	0.594
MOD_GlcNHglycan	406	409	PF01048	0.596
MOD_GlcNHglycan	420	424	PF01048	0.566
MOD_GlcNHglycan	454	457	PF01048	0.681
MOD_GlcNHglycan	474	477	PF01048	0.476
MOD_GlcNHglycan	499	502	PF01048	0.616
MOD_GlcNHglycan	504	507	PF01048	0.610
MOD_GlcNHglycan	526	529	PF01048	0.708
MOD_GlcNHglycan	560	563	PF01048	0.683
MOD_GlcNHglycan	571	574	PF01048	0.589
MOD_GlcNHglycan	594	597	PF01048	0.545
MOD_GlcNHglycan	61	64	PF01048	0.646
MOD_GSK3_1	172	179	PF00069	0.788
MOD_GSK3_1	197	204	PF00069	0.656
MOD_GSK3_1	2	9	PF00069	0.653
MOD_GSK3_1	284	291	PF00069	0.575
MOD_GSK3_1	349	356	PF00069	0.643
MOD_GSK3_1	359	366	PF00069	0.669
MOD_GSK3_1	40	47	PF00069	0.561
MOD_GSK3_1	433	440	PF00069	0.669
MOD_GSK3_1	502	509	PF00069	0.686
MOD_GSK3_1	520	527	PF00069	0.684
MOD_GSK3_1	534	541	PF00069	0.535
MOD_GSK3_1	558	565	PF00069	0.636
MOD_LATS_1	410	416	PF00433	0.650
MOD_N-GLC_1	32	37	PF02516	0.712
MOD_N-GLC_1	372	377	PF02516	0.625
MOD_N-GLC_1	44	49	PF02516	0.525
MOD_N-GLC_1	592	597	PF02516	0.505
MOD_NEK2_1	172	177	PF00069	0.700
MOD_NEK2_1	203	208	PF00069	0.610
MOD_NEK2_1	363	368	PF00069	0.677
MOD_NEK2_1	558	563	PF00069	0.664
MOD_NEK2_1	567	572	PF00069	0.624
MOD_NEK2_1	592	597	PF00069	0.541
MOD_NEK2_1	8	13	PF00069	0.541
MOD_NEK2_2	581	586	PF00069	0.579
MOD_PIKK_1	177	183	PF00454	0.654
MOD_PIKK_1	32	38	PF00454	0.695
MOD_PKA_1	412	418	PF00069	0.637
MOD_PKA_2	103	109	PF00069	0.641
MOD_PKA_2	189	195	PF00069	0.741
MOD_PKA_2	235	241	PF00069	0.505
MOD_PKA_2	25	31	PF00069	0.804
MOD_PKA_2	318	324	PF00069	0.696
MOD_PKA_2	359	365	PF00069	0.722
MOD_PKA_2	412	418	PF00069	0.637
MOD_PKA_2	452	458	PF00069	0.555
MOD_PKA_2	479	485	PF00069	0.668
MOD_PKA_2	76	82	PF00069	0.692
MOD_PKB_1	257	265	PF00069	0.564
MOD_Plk_1	253	259	PF00069	0.490
MOD_Plk_1	317	323	PF00069	0.646
MOD_Plk_1	32	38	PF00069	0.731
MOD_Plk_1	44	50	PF00069	0.526
MOD_Plk_1	592	598	PF00069	0.506
MOD_Plk_2-3	15	21	PF00069	0.596
MOD_Plk_4	15	21	PF00069	0.614
MOD_Plk_4	235	241	PF00069	0.520
MOD_ProDKin_1	198	204	PF00069	0.635
MOD_ProDKin_1	229	235	PF00069	0.590
MOD_ProDKin_1	353	359	PF00069	0.684
MOD_ProDKin_1	500	506	PF00069	0.702
MOD_ProDKin_1	520	526	PF00069	0.667
MOD_ProDKin_1	562	568	PF00069	0.649
TRG_DiLeu_BaEn_1	242	247	PF01217	0.425
TRG_DiLeu_BaEn_1	50	55	PF01217	0.626
TRG_DiLeu_LyEn_5	242	247	PF01217	0.425
TRG_ENDOCYTIC_2	418	421	PF00928	0.727
TRG_ER_diArg_1	217	219	PF00400	0.579
TRG_ER_diArg_1	23	26	PF00400	0.691
TRG_ER_diArg_1	243	246	PF00400	0.500
TRG_ER_diArg_1	255	258	PF00400	0.415
TRG_ER_diArg_1	313	316	PF00400	0.692
TRG_ER_diArg_1	322	324	PF00400	0.607
TRG_ER_diArg_1	357	360	PF00400	0.721
TRG_ER_diArg_1	411	413	PF00400	0.618
TRG_ER_diArg_1	55	57	PF00400	0.734
TRG_ER_diArg_1	80	83	PF00400	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HDD8	Leishmania braziliensis	58%	99%
A4I0R9	Leishmania infantum	99%	100%
E9AWS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QAQ3	Leishmania major	84%	100%