Zinc_finger_C-x8-C-x5-C-x3-H_type_(And_similar)_p utative/Pfam:PF00642

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger CCCH domain containing protein 11

Species:

Leishmania donovani

UniProt:

A0A3Q8IG28_LEIDO

TriTrypDb:

LdBPK_351060.1 , LdCL_350015400 , LDHU3_35.1360

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IG28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG28

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0009266	response to temperature stimulus	3	1
GO:0009408	response to heat	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050896	response to stimulus	1	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003729	mRNA binding	5	7
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.662
CLV_NRD_NRD_1	100	102	PF00675	0.571
CLV_PCSK_KEX2_1	21	23	PF00082	0.630
CLV_PCSK_KEX2_1	99	101	PF00082	0.564
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.630
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.526
CLV_PCSK_SKI1_1	101	105	PF00082	0.634
CLV_PCSK_SKI1_1	35	39	PF00082	0.645
CLV_PCSK_SKI1_1	61	65	PF00082	0.404
DOC_CDC14_PxL_1	239	247	PF14671	0.749
DOC_MAPK_gen_1	149	157	PF00069	0.738
DOC_USP7_MATH_1	266	270	PF00917	0.695
DOC_USP7_MATH_1	288	292	PF00917	0.654
DOC_USP7_MATH_1	301	305	PF00917	0.698
LIG_14-3-3_CanoR_1	117	125	PF00244	0.766
LIG_14-3-3_CanoR_1	294	301	PF00244	0.671
LIG_14-3-3_CanoR_1	72	78	PF00244	0.546
LIG_Actin_WH2_2	56	74	PF00022	0.411
LIG_APCC_ABBA_1	206	211	PF00400	0.734
LIG_FHA_1	11	17	PF00498	0.793
LIG_FHA_2	24	30	PF00498	0.757
LIG_FHA_2	294	300	PF00498	0.618
LIG_FHA_2	71	77	PF00498	0.543
LIG_IBAR_NPY_1	192	194	PF08397	0.626
LIG_LIR_Apic_2	228	233	PF02991	0.709
LIG_LIR_Nem_3	247	253	PF02991	0.767
LIG_LIR_Nem_3	286	292	PF02991	0.698
LIG_PCNA_PIPBox_1	182	191	PF02747	0.649
LIG_SH2_CRK	289	293	PF00017	0.702
LIG_SH2_SRC	209	212	PF00017	0.618
LIG_SH2_STAT3	253	256	PF00017	0.691
LIG_SH2_STAT5	189	192	PF00017	0.625
LIG_SH2_STAT5	194	197	PF00017	0.630
LIG_SH2_STAT5	231	234	PF00017	0.660
LIG_SH2_STAT5	250	253	PF00017	0.692
LIG_SH2_STAT5	50	53	PF00017	0.513
LIG_SH3_3	161	167	PF00018	0.799
LIG_SH3_3	237	243	PF00018	0.645
LIG_SH3_3	307	313	PF00018	0.630
LIG_TRAF2_1	159	162	PF00917	0.752
LIG_TRAF2_1	225	228	PF00917	0.629
LIG_TRAF2_1	272	275	PF00917	0.790
LIG_TRFH_1	196	200	PF08558	0.724
MOD_CK1_1	24	30	PF00069	0.670
MOD_CK1_1	244	250	PF00069	0.763
MOD_CK1_1	267	273	PF00069	0.796
MOD_CK1_1	281	287	PF00069	0.488
MOD_CK1_1	5	11	PF00069	0.650
MOD_CK2_1	12	18	PF00069	0.713
MOD_CK2_1	269	275	PF00069	0.789
MOD_CK2_1	293	299	PF00069	0.620
MOD_GlcNHglycan	182	185	PF01048	0.554
MOD_GlcNHglycan	266	269	PF01048	0.740
MOD_GlcNHglycan	271	274	PF01048	0.650
MOD_GlcNHglycan	282	286	PF01048	0.650
MOD_GSK3_1	10	17	PF00069	0.744
MOD_GSK3_1	113	120	PF00069	0.646
MOD_GSK3_1	280	287	PF00069	0.695
MOD_LATS_1	115	121	PF00433	0.578
MOD_NEK2_1	10	15	PF00069	0.648
MOD_PIKK_1	244	250	PF00454	0.763
MOD_PKA_1	21	27	PF00069	0.673
MOD_PKA_2	21	27	PF00069	0.635
MOD_PKA_2	293	299	PF00069	0.674
MOD_PKA_2	71	77	PF00069	0.522
MOD_Plk_4	241	247	PF00069	0.657
MOD_Plk_4	5	11	PF00069	0.565
MOD_SUMO_for_1	52	55	PF00179	0.383
MOD_SUMO_rev_2	29	37	PF00179	0.636
TRG_DiLeu_BaEn_3	32	38	PF01217	0.711
TRG_DiLeu_BaEn_4	33	39	PF01217	0.690
TRG_ENDOCYTIC_2	209	212	PF00928	0.734
TRG_ENDOCYTIC_2	289	292	PF00928	0.780
TRG_ER_diArg_1	146	149	PF00400	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D6	Leptomonas seymouri	44%	100%
A4HMD4	Leishmania braziliensis	77%	97%
A4IB01	Leishmania infantum	100%	100%
E9AES9	Leishmania major	94%	100%
E9B5Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%