Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IG27_LEIDO

TriTrypDb:

LdBPK_322650.1 , LdCL_320032300 , LDHU3_32.3320

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IG27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG27

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	1
GO:0005198	structural molecule activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.669
CLV_C14_Caspase3-7	272	276	PF00656	0.773
CLV_C14_Caspase3-7	387	391	PF00656	0.608
CLV_C14_Caspase3-7	75	79	PF00656	0.690
CLV_NRD_NRD_1	138	140	PF00675	0.730
CLV_NRD_NRD_1	16	18	PF00675	0.726
CLV_NRD_NRD_1	184	186	PF00675	0.616
CLV_NRD_NRD_1	255	257	PF00675	0.621
CLV_NRD_NRD_1	304	306	PF00675	0.495
CLV_NRD_NRD_1	426	428	PF00675	0.525
CLV_NRD_NRD_1	618	620	PF00675	0.562
CLV_NRD_NRD_1	642	644	PF00675	0.559
CLV_PCSK_FUR_1	302	306	PF00082	0.498
CLV_PCSK_KEX2_1	137	139	PF00082	0.750
CLV_PCSK_KEX2_1	16	18	PF00082	0.726
CLV_PCSK_KEX2_1	184	186	PF00082	0.616
CLV_PCSK_KEX2_1	254	256	PF00082	0.615
CLV_PCSK_KEX2_1	267	269	PF00082	0.622
CLV_PCSK_KEX2_1	302	304	PF00082	0.530
CLV_PCSK_KEX2_1	348	350	PF00082	0.588
CLV_PCSK_KEX2_1	426	428	PF00082	0.524
CLV_PCSK_KEX2_1	618	620	PF00082	0.567
CLV_PCSK_KEX2_1	642	644	PF00082	0.522
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.703
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.510
CLV_PCSK_PC7_1	134	140	PF00082	0.729
CLV_PCSK_PC7_1	344	350	PF00082	0.595
CLV_PCSK_SKI1_1	125	129	PF00082	0.645
CLV_PCSK_SKI1_1	26	30	PF00082	0.655
CLV_PCSK_SKI1_1	312	316	PF00082	0.561
CLV_PCSK_SKI1_1	34	38	PF00082	0.583
CLV_PCSK_SKI1_1	344	348	PF00082	0.517
CLV_PCSK_SKI1_1	374	378	PF00082	0.498
CLV_PCSK_SKI1_1	511	515	PF00082	0.475
CLV_PCSK_SKI1_1	519	523	PF00082	0.411
CLV_PCSK_SKI1_1	618	622	PF00082	0.621
CLV_PCSK_SKI1_1	94	98	PF00082	0.785
DEG_APCC_DBOX_1	114	122	PF00400	0.632
DEG_COP1_1	582	591	PF00400	0.527
DOC_CYCLIN_RxL_1	120	132	PF00134	0.661
DOC_MAPK_gen_1	618	624	PF00069	0.671
DOC_MAPK_gen_1	642	648	PF00069	0.586
DOC_MAPK_MEF2A_6	174	183	PF00069	0.656
DOC_MAPK_RevD_3	605	619	PF00069	0.520
DOC_PP1_RVXF_1	222	228	PF00149	0.546
DOC_PP1_RVXF_1	517	523	PF00149	0.531
DOC_PP2B_LxvP_1	455	458	PF13499	0.764
DOC_PP2B_LxvP_1	581	584	PF13499	0.482
DOC_PP2B_LxvP_1	586	589	PF13499	0.534
DOC_PP4_FxxP_1	227	230	PF00568	0.715
DOC_PP4_FxxP_1	231	234	PF00568	0.718
DOC_USP7_MATH_1	217	221	PF00917	0.787
DOC_USP7_MATH_1	273	277	PF00917	0.776
DOC_USP7_MATH_1	444	448	PF00917	0.499
DOC_USP7_MATH_1	661	665	PF00917	0.447
DOC_USP7_MATH_1	80	84	PF00917	0.770
DOC_WW_Pin1_4	459	464	PF00397	0.787
DOC_WW_Pin1_4	489	494	PF00397	0.748
DOC_WW_Pin1_4	496	501	PF00397	0.535
LIG_14-3-3_CanoR_1	167	173	PF00244	0.586
LIG_14-3-3_CanoR_1	26	36	PF00244	0.566
LIG_14-3-3_CanoR_1	303	309	PF00244	0.515
LIG_14-3-3_CanoR_1	427	433	PF00244	0.438
LIG_14-3-3_CanoR_1	618	623	PF00244	0.568
LIG_14-3-3_CanoR_1	642	647	PF00244	0.627
LIG_Actin_WH2_2	363	380	PF00022	0.456
LIG_APCC_ABBAyCdc20_2	137	143	PF00400	0.657
LIG_BIR_II_1	1	5	PF00653	0.736
LIG_BIR_III_4	51	55	PF00653	0.588
LIG_Clathr_ClatBox_1	566	570	PF01394	0.547
LIG_Clathr_ClatBox_1	69	73	PF01394	0.614
LIG_FHA_1	145	151	PF00498	0.708
LIG_FHA_1	220	226	PF00498	0.718
LIG_FHA_1	27	33	PF00498	0.655
LIG_FHA_1	420	426	PF00498	0.502
LIG_FHA_1	470	476	PF00498	0.703
LIG_FHA_1	51	57	PF00498	0.726
LIG_FHA_1	602	608	PF00498	0.470
LIG_FHA_1	615	621	PF00498	0.508
LIG_FHA_1	624	630	PF00498	0.526
LIG_FHA_1	632	638	PF00498	0.546
LIG_FHA_2	105	111	PF00498	0.657
LIG_FHA_2	645	651	PF00498	0.582
LIG_FHA_2	95	101	PF00498	0.793
LIG_LIR_Gen_1	395	404	PF02991	0.520
LIG_LIR_Gen_1	502	508	PF02991	0.587
LIG_LIR_Nem_3	395	401	PF02991	0.462
LIG_LIR_Nem_3	502	506	PF02991	0.573
LIG_MYND_1	230	234	PF01753	0.678
LIG_Pex14_2	227	231	PF04695	0.541
LIG_Pex14_2	58	62	PF04695	0.684
LIG_PTAP_UEV_1	462	467	PF05743	0.597
LIG_PTAP_UEV_1	588	593	PF05743	0.535
LIG_SH2_PTP2	327	330	PF00017	0.584
LIG_SH2_STAP1	309	313	PF00017	0.655
LIG_SH2_STAP1	39	43	PF00017	0.496
LIG_SH2_STAP1	398	402	PF00017	0.506
LIG_SH2_STAT3	39	42	PF00017	0.526
LIG_SH2_STAT5	309	312	PF00017	0.515
LIG_SH2_STAT5	327	330	PF00017	0.584
LIG_SH3_3	319	325	PF00018	0.554
LIG_SH3_3	460	466	PF00018	0.765
LIG_SH3_3	492	498	PF00018	0.685
LIG_SH3_3	586	592	PF00018	0.615
LIG_SH3_3	6	12	PF00018	0.687
LIG_SH3_3	617	623	PF00018	0.660
LIG_SUMO_SIM_par_1	603	608	PF11976	0.471
LIG_TRAF2_1	331	334	PF00917	0.604
LIG_WRC_WIRS_1	543	548	PF05994	0.472
LIG_WRC_WIRS_1	576	581	PF05994	0.499
MOD_CK1_1	152	158	PF00069	0.694
MOD_CK1_1	169	175	PF00069	0.582
MOD_CK1_1	243	249	PF00069	0.606
MOD_CK1_1	276	282	PF00069	0.763
MOD_CK1_1	307	313	PF00069	0.616
MOD_CK1_1	447	453	PF00069	0.587
MOD_CK1_1	556	562	PF00069	0.627
MOD_CK1_1	644	650	PF00069	0.588
MOD_CK2_1	151	157	PF00069	0.699
MOD_CK2_1	215	221	PF00069	0.738
MOD_CK2_1	337	343	PF00069	0.586
MOD_CK2_1	579	585	PF00069	0.542
MOD_CK2_1	80	86	PF00069	0.709
MOD_Cter_Amidation	265	268	PF01082	0.810
MOD_GlcNHglycan	131	134	PF01048	0.645
MOD_GlcNHglycan	151	154	PF01048	0.444
MOD_GlcNHglycan	20	23	PF01048	0.735
MOD_GlcNHglycan	242	245	PF01048	0.603
MOD_GlcNHglycan	275	278	PF01048	0.763
MOD_GlcNHglycan	442	445	PF01048	0.501
MOD_GlcNHglycan	452	455	PF01048	0.641
MOD_GlcNHglycan	463	466	PF01048	0.678
MOD_GlcNHglycan	488	492	PF01048	0.744
MOD_GlcNHglycan	527	530	PF01048	0.412
MOD_GlcNHglycan	589	592	PF01048	0.657
MOD_GlcNHglycan	6	9	PF01048	0.727
MOD_GlcNHglycan	631	634	PF01048	0.738
MOD_GlcNHglycan	661	664	PF01048	0.588
MOD_GlcNHglycan	78	81	PF01048	0.664
MOD_GlcNHglycan	82	85	PF01048	0.712
MOD_GSK3_1	104	111	PF00069	0.438
MOD_GSK3_1	145	152	PF00069	0.705
MOD_GSK3_1	215	222	PF00069	0.747
MOD_GSK3_1	273	280	PF00069	0.659
MOD_GSK3_1	440	447	PF00069	0.508
MOD_GSK3_1	46	53	PF00069	0.714
MOD_GSK3_1	545	552	PF00069	0.510
MOD_GSK3_1	575	582	PF00069	0.475
MOD_GSK3_1	610	617	PF00069	0.561
MOD_GSK3_1	625	632	PF00069	0.504
MOD_GSK3_1	638	645	PF00069	0.646
MOD_GSK3_1	76	83	PF00069	0.758
MOD_GSK3_1	84	91	PF00069	0.812
MOD_NEK2_1	149	154	PF00069	0.719
MOD_NEK2_1	193	198	PF00069	0.697
MOD_NEK2_1	296	301	PF00069	0.451
MOD_NEK2_1	326	331	PF00069	0.412
MOD_NEK2_1	384	389	PF00069	0.589
MOD_NEK2_1	440	445	PF00069	0.485
MOD_NEK2_1	448	453	PF00069	0.560
MOD_NEK2_1	553	558	PF00069	0.544
MOD_NEK2_1	579	584	PF00069	0.520
MOD_NEK2_1	624	629	PF00069	0.631
MOD_NEK2_2	54	59	PF00069	0.693
MOD_PIKK_1	296	302	PF00454	0.466
MOD_PIKK_1	384	390	PF00454	0.572
MOD_PIKK_1	448	454	PF00454	0.586
MOD_PIKK_1	545	551	PF00454	0.403
MOD_PKA_1	16	22	PF00069	0.701
MOD_PKA_1	255	261	PF00069	0.768
MOD_PKA_1	304	310	PF00069	0.613
MOD_PKA_1	618	624	PF00069	0.546
MOD_PKA_1	642	648	PF00069	0.488
MOD_PKA_2	16	22	PF00069	0.779
MOD_PKA_2	166	172	PF00069	0.658
MOD_PKA_2	255	261	PF00069	0.706
MOD_PKA_2	304	310	PF00069	0.462
MOD_PKA_2	610	616	PF00069	0.522
MOD_PKA_2	618	624	PF00069	0.515
MOD_PKA_2	641	647	PF00069	0.636
MOD_PKB_1	302	310	PF00069	0.403
MOD_Plk_1	419	425	PF00069	0.385
MOD_Plk_4	145	151	PF00069	0.719
MOD_Plk_4	444	450	PF00069	0.548
MOD_Plk_4	499	505	PF00069	0.655
MOD_Plk_4	553	559	PF00069	0.509
MOD_Plk_4	572	578	PF00069	0.361
MOD_Plk_4	601	607	PF00069	0.443
MOD_Plk_4	625	631	PF00069	0.657
MOD_Plk_4	644	650	PF00069	0.324
MOD_ProDKin_1	459	465	PF00069	0.786
MOD_ProDKin_1	489	495	PF00069	0.745
MOD_ProDKin_1	496	502	PF00069	0.525
MOD_SUMO_for_1	70	73	PF00179	0.789
TRG_DiLeu_BaEn_1	65	70	PF01217	0.611
TRG_DiLeu_BaEn_2	340	346	PF01217	0.600
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.589
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.695
TRG_ENDOCYTIC_2	293	296	PF00928	0.589
TRG_ENDOCYTIC_2	327	330	PF00928	0.412
TRG_ENDOCYTIC_2	398	401	PF00928	0.514
TRG_ER_diArg_1	115	118	PF00400	0.638
TRG_ER_diArg_1	137	139	PF00400	0.737
TRG_ER_diArg_1	183	185	PF00400	0.618
TRG_ER_diArg_1	253	256	PF00400	0.607
TRG_ER_diArg_1	302	305	PF00400	0.495
TRG_ER_diArg_1	425	427	PF00400	0.543
TRG_ER_diArg_1	618	620	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A1	Leptomonas seymouri	45%	100%
A0A1X0NRK2	Trypanosomatidae	32%	100%
A4HKP1	Leishmania braziliensis	73%	100%
A4I872	Leishmania infantum	100%	100%
D0AAE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B330	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q524	Leishmania major	91%	100%
V5AUP9	Trypanosoma cruzi	32%	100%