Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IG17_LEIDO

TriTrypDb:

LdCL_320030800 , LDHU3_32.3160

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IG17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.236
CLV_NRD_NRD_1	134	136	PF00675	0.500
CLV_NRD_NRD_1	164	166	PF00675	0.348
CLV_PCSK_KEX2_1	134	136	PF00082	0.426
CLV_PCSK_SKI1_1	223	227	PF00082	0.446
DOC_CDC14_PxL_1	338	346	PF14671	0.392
DOC_MAPK_gen_1	134	142	PF00069	0.450
DOC_MAPK_gen_1	165	172	PF00069	0.293
DOC_MAPK_gen_1	221	229	PF00069	0.390
DOC_MAPK_MEF2A_6	4	11	PF00069	0.351
DOC_PP2B_LxvP_1	208	211	PF13499	0.453
DOC_USP7_MATH_1	13	17	PF00917	0.488
DOC_USP7_MATH_1	276	280	PF00917	0.594
DOC_WW_Pin1_4	184	189	PF00397	0.563
DOC_WW_Pin1_4	193	198	PF00397	0.617
DOC_WW_Pin1_4	200	205	PF00397	0.621
DOC_WW_Pin1_4	255	260	PF00397	0.383
LIG_14-3-3_CanoR_1	102	111	PF00244	0.523
LIG_14-3-3_CanoR_1	245	254	PF00244	0.591
LIG_14-3-3_CanoR_1	29	33	PF00244	0.475
LIG_14-3-3_CanoR_1	4	10	PF00244	0.381
LIG_CaM_IQ_9	158	173	PF13499	0.353
LIG_FHA_1	19	25	PF00498	0.486
LIG_FHA_1	321	327	PF00498	0.477
LIG_FHA_1	49	55	PF00498	0.339
LIG_FHA_1	96	102	PF00498	0.389
LIG_FHA_2	107	113	PF00498	0.347
LIG_FHA_2	87	93	PF00498	0.557
LIG_Integrin_RGD_1	349	351	PF01839	0.461
LIG_LIR_Apic_2	251	257	PF02991	0.467
LIG_LIR_Gen_1	137	145	PF02991	0.428
LIG_LIR_Gen_1	30	37	PF02991	0.452
LIG_LIR_Gen_1	8	18	PF02991	0.331
LIG_LIR_Gen_1	95	105	PF02991	0.437
LIG_LIR_Nem_3	137	142	PF02991	0.406
LIG_LIR_Nem_3	30	35	PF02991	0.449
LIG_LIR_Nem_3	323	327	PF02991	0.387
LIG_LIR_Nem_3	8	14	PF02991	0.320
LIG_LIR_Nem_3	95	100	PF02991	0.410
LIG_PDZ_Class_1	350	355	PF00595	0.593
LIG_SH2_CRK	254	258	PF00017	0.457
LIG_SH2_NCK_1	105	109	PF00017	0.510
LIG_SH2_NCK_1	254	258	PF00017	0.548
LIG_SH2_STAP1	32	36	PF00017	0.400
LIG_SH2_STAT5	105	108	PF00017	0.367
LIG_SH2_STAT5	139	142	PF00017	0.470
LIG_SH3_3	191	197	PF00018	0.711
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.451
LIG_SUMO_SIM_par_1	5	10	PF11976	0.348
LIG_TRAF2_1	89	92	PF00917	0.517
LIG_WRC_WIRS_1	32	37	PF05994	0.418
LIG_WRC_WIRS_1	93	98	PF05994	0.493
MOD_CK1_1	196	202	PF00069	0.606
MOD_CK1_1	31	37	PF00069	0.372
MOD_CK1_1	340	346	PF00069	0.608
MOD_CK1_1	95	101	PF00069	0.434
MOD_CK2_1	86	92	PF00069	0.523
MOD_GlcNHglycan	175	179	PF01048	0.696
MOD_GlcNHglycan	247	250	PF01048	0.360
MOD_GlcNHglycan	278	281	PF01048	0.507
MOD_GlcNHglycan	339	342	PF01048	0.625
MOD_GlcNHglycan	76	79	PF01048	0.547
MOD_GSK3_1	145	152	PF00069	0.552
MOD_GSK3_1	170	177	PF00069	0.591
MOD_GSK3_1	196	203	PF00069	0.545
MOD_GSK3_1	241	248	PF00069	0.404
MOD_GSK3_1	27	34	PF00069	0.445
MOD_N-GLC_1	48	53	PF02516	0.482
MOD_NEK2_1	101	106	PF00069	0.474
MOD_NEK2_1	145	150	PF00069	0.487
MOD_NEK2_1	213	218	PF00069	0.464
MOD_NEK2_1	326	331	PF00069	0.447
MOD_NEK2_1	337	342	PF00069	0.532
MOD_NEK2_1	43	48	PF00069	0.487
MOD_OFUCOSY	47	52	PF10250	0.468
MOD_PKA_2	101	107	PF00069	0.377
MOD_PKA_2	249	255	PF00069	0.461
MOD_PKA_2	28	34	PF00069	0.499
MOD_Plk_1	174	180	PF00069	0.501
MOD_Plk_4	106	112	PF00069	0.379
MOD_Plk_4	13	19	PF00069	0.346
MOD_Plk_4	149	155	PF00069	0.423
MOD_Plk_4	31	37	PF00069	0.253
MOD_ProDKin_1	184	190	PF00069	0.564
MOD_ProDKin_1	193	199	PF00069	0.614
MOD_ProDKin_1	200	206	PF00069	0.606
MOD_ProDKin_1	255	261	PF00069	0.376
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.484
TRG_ENDOCYTIC_2	139	142	PF00928	0.417
TRG_ENDOCYTIC_2	32	35	PF00928	0.371
TRG_ER_diArg_1	133	135	PF00400	0.495
TRG_ER_diArg_1	220	223	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	22	27	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N9	Leptomonas seymouri	53%	100%
A0A1X0NS57	Trypanosomatidae	29%	100%
A0A422N888	Trypanosoma rangeli	29%	100%
A4HKN1	Leishmania braziliensis	77%	100%
D0AAC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B319	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q535	Leishmania major	91%	100%
V5BCW8	Trypanosoma cruzi	28%	100%