Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IG16_LEIDO

TriTrypDb:

LdBPK_262260.1 , LdCL_260028300 , LDHU3_26.2950

Length:

825

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IG16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.497
CLV_C14_Caspase3-7	538	542	PF00656	0.558
CLV_NRD_NRD_1	346	348	PF00675	0.738
CLV_NRD_NRD_1	392	394	PF00675	0.763
CLV_NRD_NRD_1	505	507	PF00675	0.644
CLV_NRD_NRD_1	663	665	PF00675	0.634
CLV_NRD_NRD_1	73	75	PF00675	0.614
CLV_PCSK_FUR_1	630	634	PF00082	0.636
CLV_PCSK_FUR_1	70	74	PF00082	0.425
CLV_PCSK_KEX2_1	345	347	PF00082	0.679
CLV_PCSK_KEX2_1	489	491	PF00082	0.544
CLV_PCSK_KEX2_1	504	506	PF00082	0.643
CLV_PCSK_KEX2_1	632	634	PF00082	0.614
CLV_PCSK_KEX2_1	662	664	PF00082	0.700
CLV_PCSK_KEX2_1	72	74	PF00082	0.691
CLV_PCSK_PC1ET2_1	489	491	PF00082	0.544
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.644
CLV_PCSK_PC7_1	485	491	PF00082	0.531
CLV_PCSK_SKI1_1	30	34	PF00082	0.588
CLV_PCSK_SKI1_1	451	455	PF00082	0.767
CLV_PCSK_SKI1_1	465	469	PF00082	0.696
CLV_PCSK_SKI1_1	530	534	PF00082	0.689
CLV_PCSK_SKI1_1	571	575	PF00082	0.557
CLV_PCSK_SKI1_1	633	637	PF00082	0.620
CLV_PCSK_SKI1_1	746	750	PF00082	0.588
CLV_PCSK_SKI1_1	786	790	PF00082	0.540
DEG_COP1_1	686	694	PF00400	0.617
DEG_SPOP_SBC_1	16	20	PF00917	0.675
DOC_CDC14_PxL_1	688	696	PF14671	0.566
DOC_CYCLIN_RxL_1	70	81	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.702
DOC_CYCLIN_yCln2_LP_2	553	559	PF00134	0.567
DOC_MAPK_gen_1	451	460	PF00069	0.612
DOC_MAPK_gen_1	489	497	PF00069	0.579
DOC_MAPK_gen_1	630	638	PF00069	0.581
DOC_MAPK_gen_1	70	78	PF00069	0.494
DOC_PP2B_LxvP_1	138	141	PF13499	0.591
DOC_PP2B_LxvP_1	680	683	PF13499	0.534
DOC_PP4_FxxP_1	477	480	PF00568	0.713
DOC_USP7_MATH_1	117	121	PF00917	0.712
DOC_USP7_MATH_1	133	137	PF00917	0.621
DOC_USP7_MATH_1	264	268	PF00917	0.624
DOC_USP7_MATH_1	508	512	PF00917	0.703
DOC_USP7_MATH_1	579	583	PF00917	0.703
DOC_USP7_UBL2_3	786	790	PF12436	0.555
DOC_WW_Pin1_4	289	294	PF00397	0.762
DOC_WW_Pin1_4	460	465	PF00397	0.732
DOC_WW_Pin1_4	545	550	PF00397	0.687
DOC_WW_Pin1_4	738	743	PF00397	0.677
LIG_14-3-3_CanoR_1	171	177	PF00244	0.674
LIG_14-3-3_CanoR_1	362	366	PF00244	0.606
LIG_14-3-3_CanoR_1	444	453	PF00244	0.736
LIG_14-3-3_CanoR_1	485	489	PF00244	0.533
LIG_14-3-3_CanoR_1	490	497	PF00244	0.575
LIG_14-3-3_CanoR_1	530	535	PF00244	0.689
LIG_14-3-3_CanoR_1	571	576	PF00244	0.606
LIG_14-3-3_CanoR_1	662	670	PF00244	0.581
LIG_14-3-3_CanoR_1	798	807	PF00244	0.571
LIG_BIR_II_1	1	5	PF00653	0.703
LIG_BIR_III_4	395	399	PF00653	0.552
LIG_BRCT_BRCA1_1	135	139	PF00533	0.644
LIG_BRCT_BRCA1_1	455	459	PF00533	0.628
LIG_Clathr_ClatBox_1	494	498	PF01394	0.648
LIG_eIF4E_1	183	189	PF01652	0.547
LIG_FHA_1	108	114	PF00498	0.551
LIG_FHA_1	133	139	PF00498	0.591
LIG_FHA_1	156	162	PF00498	0.699
LIG_FHA_1	17	23	PF00498	0.635
LIG_FHA_1	183	189	PF00498	0.606
LIG_FHA_1	202	208	PF00498	0.549
LIG_FHA_1	702	708	PF00498	0.696
LIG_FHA_1	739	745	PF00498	0.684
LIG_FHA_1	769	775	PF00498	0.645
LIG_FHA_2	19	25	PF00498	0.612
LIG_FHA_2	362	368	PF00498	0.636
LIG_FHA_2	417	423	PF00498	0.683
LIG_FHA_2	536	542	PF00498	0.649
LIG_FHA_2	614	620	PF00498	0.518
LIG_LIR_Apic_2	475	480	PF02991	0.630
LIG_LIR_Apic_2	771	776	PF02991	0.652
LIG_LIR_Gen_1	170	181	PF02991	0.664
LIG_LIR_Gen_1	190	201	PF02991	0.364
LIG_LIR_Gen_1	728	738	PF02991	0.666
LIG_LIR_Gen_1	801	812	PF02991	0.691
LIG_LIR_Nem_3	170	176	PF02991	0.670
LIG_LIR_Nem_3	190	196	PF02991	0.372
LIG_LIR_Nem_3	197	202	PF02991	0.457
LIG_LIR_Nem_3	475	481	PF02991	0.554
LIG_LIR_Nem_3	623	627	PF02991	0.626
LIG_LIR_Nem_3	728	734	PF02991	0.491
LIG_LIR_Nem_3	801	807	PF02991	0.604
LIG_LIR_Nem_3	818	824	PF02991	0.461
LIG_LYPXL_yS_3	481	484	PF13949	0.665
LIG_MAD2	369	377	PF02301	0.714
LIG_PTAP_UEV_1	808	813	PF05743	0.536
LIG_PTB_Apo_2	49	56	PF02174	0.553
LIG_SH2_CRK	328	332	PF00017	0.603
LIG_SH2_NCK_1	193	197	PF00017	0.632
LIG_SH2_NCK_1	363	367	PF00017	0.598
LIG_SH2_PTP2	173	176	PF00017	0.672
LIG_SH2_PTP2	374	377	PF00017	0.678
LIG_SH2_PTP2	731	734	PF00017	0.500
LIG_SH2_STAP1	817	821	PF00017	0.623
LIG_SH2_STAT5	173	176	PF00017	0.672
LIG_SH2_STAT5	261	264	PF00017	0.515
LIG_SH2_STAT5	363	366	PF00017	0.615
LIG_SH2_STAT5	374	377	PF00017	0.594
LIG_SH2_STAT5	4	7	PF00017	0.649
LIG_SH2_STAT5	418	421	PF00017	0.605
LIG_SH2_STAT5	731	734	PF00017	0.633
LIG_SH2_STAT5	773	776	PF00017	0.656
LIG_SH2_STAT5	804	807	PF00017	0.677
LIG_SH2_STAT5	817	820	PF00017	0.593
LIG_SH3_1	374	380	PF00018	0.677
LIG_SH3_3	138	144	PF00018	0.702
LIG_SH3_3	215	221	PF00018	0.694
LIG_SH3_3	290	296	PF00018	0.797
LIG_SH3_3	362	368	PF00018	0.628
LIG_SH3_3	374	380	PF00018	0.732
LIG_SH3_3	669	675	PF00018	0.557
LIG_SH3_3	806	812	PF00018	0.509
LIG_SUMO_SIM_par_1	555	561	PF11976	0.664
LIG_TRAF2_2	296	301	PF00917	0.531
LIG_TYR_ITIM	361	366	PF00017	0.637
LIG_TYR_ITIM	819	824	PF00017	0.588
LIG_UBA3_1	27	36	PF00899	0.640
LIG_WRC_WIRS_1	196	201	PF05994	0.494
MOD_CDK_SPK_2	292	297	PF00069	0.777
MOD_CDK_SPK_2	460	465	PF00069	0.714
MOD_CDK_SPxK_1	545	551	PF00069	0.561
MOD_CK1_1	120	126	PF00069	0.695
MOD_CK1_1	18	24	PF00069	0.732
MOD_CK1_1	267	273	PF00069	0.555
MOD_CK1_1	292	298	PF00069	0.742
MOD_CK1_1	34	40	PF00069	0.566
MOD_CK1_1	437	443	PF00069	0.715
MOD_CK1_1	63	69	PF00069	0.630
MOD_CK1_1	701	707	PF00069	0.696
MOD_CK2_1	361	367	PF00069	0.574
MOD_CK2_1	416	422	PF00069	0.662
MOD_CK2_1	513	519	PF00069	0.666
MOD_CK2_1	613	619	PF00069	0.595
MOD_GlcNHglycan	101	104	PF01048	0.714
MOD_GlcNHglycan	107	110	PF01048	0.741
MOD_GlcNHglycan	122	125	PF01048	0.750
MOD_GlcNHglycan	217	221	PF01048	0.579
MOD_GlcNHglycan	270	273	PF01048	0.603
MOD_GlcNHglycan	328	331	PF01048	0.806
MOD_GlcNHglycan	33	36	PF01048	0.599
MOD_GlcNHglycan	389	393	PF01048	0.640
MOD_GlcNHglycan	406	409	PF01048	0.795
MOD_GlcNHglycan	436	439	PF01048	0.689
MOD_GlcNHglycan	510	513	PF01048	0.631
MOD_GlcNHglycan	61	65	PF01048	0.596
MOD_GlcNHglycan	642	645	PF01048	0.714
MOD_GlcNHglycan	666	669	PF01048	0.669
MOD_GlcNHglycan	700	703	PF01048	0.641
MOD_GlcNHglycan	809	812	PF01048	0.537
MOD_GSK3_1	120	127	PF00069	0.570
MOD_GSK3_1	129	136	PF00069	0.594
MOD_GSK3_1	142	149	PF00069	0.516
MOD_GSK3_1	179	186	PF00069	0.570
MOD_GSK3_1	259	266	PF00069	0.643
MOD_GSK3_1	299	306	PF00069	0.634
MOD_GSK3_1	309	316	PF00069	0.607
MOD_GSK3_1	34	41	PF00069	0.640
MOD_GSK3_1	430	437	PF00069	0.703
MOD_GSK3_1	454	461	PF00069	0.675
MOD_GSK3_1	530	537	PF00069	0.704
MOD_GSK3_1	579	586	PF00069	0.724
MOD_GSK3_1	658	665	PF00069	0.697
MOD_GSK3_1	690	697	PF00069	0.662
MOD_GSK3_1	698	705	PF00069	0.616
MOD_GSK3_1	740	747	PF00069	0.773
MOD_N-GLC_1	183	188	PF02516	0.550
MOD_N-GLC_1	411	416	PF02516	0.574
MOD_N-GLC_1	434	439	PF02516	0.615
MOD_N-GLC_1	48	53	PF02516	0.587
MOD_N-GLC_1	534	539	PF02516	0.575
MOD_N-GLC_1	545	550	PF02516	0.554
MOD_N-GLC_1	683	688	PF02516	0.611
MOD_NEK2_1	105	110	PF00069	0.507
MOD_NEK2_1	161	166	PF00069	0.575
MOD_NEK2_1	195	200	PF00069	0.496
MOD_NEK2_1	31	36	PF00069	0.602
MOD_NEK2_1	416	421	PF00069	0.641
MOD_NEK2_1	425	430	PF00069	0.676
MOD_NEK2_1	534	539	PF00069	0.691
MOD_NEK2_1	563	568	PF00069	0.672
MOD_NEK2_1	694	699	PF00069	0.723
MOD_NEK2_1	91	96	PF00069	0.601
MOD_PIKK_1	133	139	PF00454	0.639
MOD_PIKK_1	259	265	PF00454	0.705
MOD_PIKK_1	416	422	PF00454	0.651
MOD_PIKK_1	613	619	PF00454	0.562
MOD_PKA_1	489	495	PF00069	0.502
MOD_PKA_1	662	668	PF00069	0.561
MOD_PKA_2	264	270	PF00069	0.613
MOD_PKA_2	361	367	PF00069	0.588
MOD_PKA_2	484	490	PF00069	0.535
MOD_PKA_2	539	545	PF00069	0.561
MOD_PKA_2	563	569	PF00069	0.683
MOD_PKA_2	662	668	PF00069	0.608
MOD_PKA_2	91	97	PF00069	0.707
MOD_PKB_1	662	670	PF00069	0.558
MOD_Plk_1	133	139	PF00069	0.639
MOD_Plk_1	183	189	PF00069	0.547
MOD_Plk_1	2	8	PF00069	0.560
MOD_Plk_1	595	601	PF00069	0.550
MOD_Plk_1	721	727	PF00069	0.628
MOD_Plk_4	172	178	PF00069	0.578
MOD_Plk_4	361	367	PF00069	0.668
MOD_Plk_4	454	460	PF00069	0.647
MOD_Plk_4	513	519	PF00069	0.678
MOD_Plk_4	571	577	PF00069	0.564
MOD_Plk_4	607	613	PF00069	0.616
MOD_ProDKin_1	289	295	PF00069	0.763
MOD_ProDKin_1	460	466	PF00069	0.732
MOD_ProDKin_1	545	551	PF00069	0.686
MOD_ProDKin_1	738	744	PF00069	0.679
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.545
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.625
TRG_ENDOCYTIC_2	173	176	PF00928	0.540
TRG_ENDOCYTIC_2	193	196	PF00928	0.370
TRG_ENDOCYTIC_2	363	366	PF00928	0.576
TRG_ENDOCYTIC_2	481	484	PF00928	0.533
TRG_ENDOCYTIC_2	731	734	PF00928	0.500
TRG_ENDOCYTIC_2	804	807	PF00928	0.599
TRG_ENDOCYTIC_2	821	824	PF00928	0.456
TRG_ER_diArg_1	345	347	PF00400	0.674
TRG_ER_diArg_1	504	506	PF00400	0.685
TRG_ER_diArg_1	662	664	PF00400	0.613
TRG_ER_diArg_1	72	74	PF00400	0.480
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	551	555	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z2	Leptomonas seymouri	55%	99%
A0A1X0P794	Trypanosomatidae	33%	100%
A0A3R7KYT8	Trypanosoma rangeli	35%	100%
A4HF69	Leishmania braziliensis	76%	98%
A4I2F2	Leishmania infantum	100%	100%
C9ZX52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AYK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q8W7	Leishmania major	92%	100%
V5AUK1	Trypanosoma cruzi	35%	100%