Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IG15_LEIDO

TriTrypDb:

LdBPK_361990.1 , LdCL_360025400 , LDHU3_36.2590

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IG15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.599
CLV_NRD_NRD_1	160	162	PF00675	0.821
CLV_NRD_NRD_1	3	5	PF00675	0.742
CLV_NRD_NRD_1	313	315	PF00675	0.741
CLV_NRD_NRD_1	380	382	PF00675	0.761
CLV_NRD_NRD_1	396	398	PF00675	0.555
CLV_NRD_NRD_1	409	411	PF00675	0.819
CLV_PCSK_FUR_1	158	162	PF00082	0.744
CLV_PCSK_FUR_1	410	414	PF00082	0.834
CLV_PCSK_KEX2_1	160	162	PF00082	0.858
CLV_PCSK_KEX2_1	2	4	PF00082	0.665
CLV_PCSK_KEX2_1	313	315	PF00082	0.741
CLV_PCSK_KEX2_1	396	398	PF00082	0.770
CLV_PCSK_KEX2_1	409	411	PF00082	0.819
CLV_PCSK_KEX2_1	412	414	PF00082	0.847
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.665
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.847
CLV_PCSK_SKI1_1	136	140	PF00082	0.696
CLV_PCSK_SKI1_1	243	247	PF00082	0.702
CLV_PCSK_SKI1_1	265	269	PF00082	0.793
CLV_PCSK_SKI1_1	41	45	PF00082	0.760
CLV_Separin_Metazoa	42	46	PF03568	0.762
DEG_Nend_UBRbox_1	1	4	PF02207	0.862
DEG_SPOP_SBC_1	147	151	PF00917	0.633
DEG_SPOP_SBC_1	164	168	PF00917	0.688
DOC_CKS1_1	178	183	PF01111	0.620
DOC_CKS1_1	209	214	PF01111	0.832
DOC_CKS1_1	85	90	PF01111	0.670
DOC_CYCLIN_RxL_1	394	404	PF00134	0.784
DOC_MAPK_DCC_7	276	286	PF00069	0.644
DOC_PP1_RVXF_1	395	402	PF00149	0.779
DOC_PP4_FxxP_1	97	100	PF00568	0.801
DOC_USP7_MATH_1	10	14	PF00917	0.835
DOC_USP7_MATH_1	109	113	PF00917	0.645
DOC_USP7_MATH_1	147	151	PF00917	0.633
DOC_USP7_MATH_1	165	169	PF00917	0.742
DOC_USP7_MATH_1	184	188	PF00917	0.665
DOC_USP7_MATH_1	198	202	PF00917	0.590
DOC_USP7_MATH_1	231	235	PF00917	0.721
DOC_USP7_MATH_1	271	275	PF00917	0.800
DOC_USP7_MATH_1	296	300	PF00917	0.815
DOC_USP7_MATH_1	320	324	PF00917	0.591
DOC_USP7_MATH_1	347	351	PF00917	0.802
DOC_USP7_MATH_1	373	377	PF00917	0.827
DOC_USP7_MATH_1	383	387	PF00917	0.648
DOC_USP7_MATH_1	48	52	PF00917	0.790
DOC_USP7_MATH_1	60	64	PF00917	0.637
DOC_USP7_MATH_1	75	79	PF00917	0.749
DOC_USP7_MATH_1	92	96	PF00917	0.545
DOC_WW_Pin1_4	115	120	PF00397	0.537
DOC_WW_Pin1_4	148	153	PF00397	0.838
DOC_WW_Pin1_4	172	177	PF00397	0.778
DOC_WW_Pin1_4	194	199	PF00397	0.788
DOC_WW_Pin1_4	204	209	PF00397	0.716
DOC_WW_Pin1_4	235	240	PF00397	0.663
DOC_WW_Pin1_4	26	31	PF00397	0.823
DOC_WW_Pin1_4	299	304	PF00397	0.741
DOC_WW_Pin1_4	343	348	PF00397	0.750
DOC_WW_Pin1_4	84	89	PF00397	0.739
DOC_WW_Pin1_4	96	101	PF00397	0.621
LIG_14-3-3_CanoR_1	148	152	PF00244	0.780
LIG_14-3-3_CanoR_1	322	326	PF00244	0.630
LIG_14-3-3_CanoR_1	375	379	PF00244	0.821
LIG_14-3-3_CanoR_1	65	73	PF00244	0.730
LIG_Actin_WH2_2	29	47	PF00022	0.778
LIG_BRCT_BRCA1_1	233	237	PF00533	0.698
LIG_CSL_BTD_1	97	100	PF09270	0.762
LIG_FHA_1	188	194	PF00498	0.603
LIG_FHA_1	33	39	PF00498	0.723
LIG_FHA_1	375	381	PF00498	0.661
LIG_FHA_2	217	223	PF00498	0.618
LIG_GSK3_LRP6_1	208	213	PF00069	0.615
LIG_KLC1_Yacidic_2	218	222	PF13176	0.600
LIG_LIR_Apic_2	175	181	PF02991	0.614
LIG_LIR_Apic_2	94	100	PF02991	0.806
LIG_LIR_Gen_1	140	147	PF02991	0.706
LIG_LIR_Gen_1	338	347	PF02991	0.740
LIG_LIR_Nem_3	140	145	PF02991	0.675
LIG_LIR_Nem_3	338	343	PF02991	0.659
LIG_MYND_1	115	119	PF01753	0.806
LIG_NRP_CendR_1	412	414	PF00754	0.769
LIG_PCNA_TLS_4	214	221	PF02747	0.747
LIG_PCNA_yPIPBox_3	349	358	PF02747	0.735
LIG_Pex14_1	282	286	PF04695	0.694
LIG_Pex14_1	98	102	PF04695	0.803
LIG_SH2_CRK	366	370	PF00017	0.820
LIG_SH2_CRK	68	72	PF00017	0.735
LIG_SH2_NCK_1	68	72	PF00017	0.735
LIG_SH2_SRC	220	223	PF00017	0.695
LIG_SH2_STAP1	68	72	PF00017	0.735
LIG_SH2_STAT5	220	223	PF00017	0.734
LIG_SH2_STAT5	68	71	PF00017	0.774
LIG_SH3_2	209	214	PF14604	0.754
LIG_SH3_2	77	82	PF14604	0.851
LIG_SH3_3	113	119	PF00018	0.538
LIG_SH3_3	206	212	PF00018	0.770
LIG_SH3_3	3	9	PF00018	0.803
LIG_SH3_3	354	360	PF00018	0.776
LIG_SH3_3	74	80	PF00018	0.839
LIG_SH3_3	86	92	PF00018	0.618
LIG_SH3_3	97	103	PF00018	0.689
LIG_WRC_WIRS_1	188	193	PF05994	0.603
LIG_WW_3	79	83	PF00397	0.789
MOD_CDC14_SPxK_1	346	349	PF00782	0.755
MOD_CDK_SPxK_1	208	214	PF00069	0.752
MOD_CDK_SPxK_1	343	349	PF00069	0.752
MOD_CDK_SPxxK_3	148	155	PF00069	0.778
MOD_CK1_1	151	157	PF00069	0.833
MOD_CK1_1	163	169	PF00069	0.859
MOD_CK1_1	17	23	PF00069	0.791
MOD_CK1_1	187	193	PF00069	0.686
MOD_CK1_1	200	206	PF00069	0.775
MOD_CK1_1	254	260	PF00069	0.572
MOD_CK1_1	26	32	PF00069	0.647
MOD_CK1_1	299	305	PF00069	0.811
MOD_CK1_1	307	313	PF00069	0.680
MOD_CK1_1	338	344	PF00069	0.807
MOD_CK1_1	350	356	PF00069	0.631
MOD_CK2_1	198	204	PF00069	0.752
MOD_CK2_1	244	250	PF00069	0.479
MOD_GlcNHglycan	111	114	PF01048	0.775
MOD_GlcNHglycan	139	142	PF01048	0.725
MOD_GlcNHglycan	227	230	PF01048	0.674
MOD_GlcNHglycan	256	259	PF01048	0.625
MOD_GlcNHglycan	26	29	PF01048	0.800
MOD_GlcNHglycan	293	296	PF01048	0.805
MOD_GlcNHglycan	298	301	PF01048	0.737
MOD_GlcNHglycan	306	309	PF01048	0.603
MOD_GlcNHglycan	5	9	PF01048	0.623
MOD_GlcNHglycan	62	65	PF01048	0.716
MOD_GlcNHglycan	73	76	PF01048	0.626
MOD_GSK3_1	10	17	PF00069	0.722
MOD_GSK3_1	120	127	PF00069	0.720
MOD_GSK3_1	130	137	PF00069	0.671
MOD_GSK3_1	147	154	PF00069	0.792
MOD_GSK3_1	156	163	PF00069	0.660
MOD_GSK3_1	19	26	PF00069	0.778
MOD_GSK3_1	194	201	PF00069	0.705
MOD_GSK3_1	204	211	PF00069	0.651
MOD_GSK3_1	231	238	PF00069	0.653
MOD_GSK3_1	261	268	PF00069	0.622
MOD_GSK3_1	338	345	PF00069	0.701
MOD_GSK3_1	383	390	PF00069	0.692
MOD_GSK3_1	44	51	PF00069	0.768
MOD_GSK3_1	71	78	PF00069	0.767
MOD_GSK3_1	92	99	PF00069	0.740
MOD_LATS_1	263	269	PF00433	0.712
MOD_NEK2_1	216	221	PF00069	0.674
MOD_NEK2_1	291	296	PF00069	0.800
MOD_NEK2_1	335	340	PF00069	0.773
MOD_NEK2_1	44	49	PF00069	0.698
MOD_NEK2_2	241	246	PF00069	0.706
MOD_PIKK_1	347	353	PF00454	0.621
MOD_PIKK_1	75	81	PF00454	0.804
MOD_PK_1	160	166	PF00069	0.688
MOD_PKA_1	160	166	PF00069	0.786
MOD_PKA_2	147	153	PF00069	0.778
MOD_PKA_2	160	166	PF00069	0.616
MOD_PKA_2	321	327	PF00069	0.765
MOD_PKA_2	374	380	PF00069	0.824
MOD_PKA_2	44	50	PF00069	0.665
MOD_PKA_2	66	72	PF00069	0.713
MOD_PKB_1	158	166	PF00069	0.744
MOD_Plk_1	120	126	PF00069	0.718
MOD_Plk_1	373	379	PF00069	0.657
MOD_Plk_1	93	99	PF00069	0.698
MOD_Plk_4	120	126	PF00069	0.649
MOD_Plk_4	134	140	PF00069	0.706
MOD_Plk_4	216	222	PF00069	0.637
MOD_Plk_4	244	250	PF00069	0.615
MOD_Plk_4	93	99	PF00069	0.811
MOD_ProDKin_1	115	121	PF00069	0.536
MOD_ProDKin_1	148	154	PF00069	0.840
MOD_ProDKin_1	172	178	PF00069	0.782
MOD_ProDKin_1	194	200	PF00069	0.792
MOD_ProDKin_1	204	210	PF00069	0.714
MOD_ProDKin_1	235	241	PF00069	0.658
MOD_ProDKin_1	26	32	PF00069	0.820
MOD_ProDKin_1	299	305	PF00069	0.737
MOD_ProDKin_1	343	349	PF00069	0.752
MOD_ProDKin_1	84	90	PF00069	0.738
MOD_ProDKin_1	96	102	PF00069	0.621
TRG_ENDOCYTIC_2	68	71	PF00928	0.774
TRG_ER_diArg_1	157	160	PF00400	0.776
TRG_ER_diArg_1	395	397	PF00400	0.761
TRG_ER_diArg_1	409	411	PF00400	0.819
TRG_ER_diArg_1	65	68	PF00400	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HP55	Leishmania braziliensis	60%	100%
E9AG15	Leishmania major	87%	100%
E9AHX3	Leishmania infantum	99%	100%
E9ASW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%